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Aliases for ZFHX3 Gene

Aliases for ZFHX3 Gene

  • Zinc Finger Homeobox 3 2 3
  • AT-Binding Transcription Factor 1 2 3 4
  • ATBF1 3 4 6
  • Alpha-Fetoprotein Enhancer-Binding Protein 3 4
  • Zinc Finger Homeodomain Protein 3 3 4
  • AT Motif-Binding Factor 1 3 4
  • ZFH-3 3 4
  • Alpha-Fetoprotein Enhancer Binding Protein 3
  • Zinc Finger Homeobox Protein 3 3
  • ZNF927 3
  • ATBT 3

External Ids for ZFHX3 Gene

Previous Symbols for ZFHX3 Gene

  • ATBF1

Summaries for ZFHX3 Gene

Entrez Gene Summary for ZFHX3 Gene

  • This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ZFHX3 Gene

ZFHX3 (Zinc Finger Homeobox 3) is a Protein Coding gene. Diseases associated with ZFHX3 include prostate cancer and atrial fibrillation. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding. An important paralog of this gene is ZFHX4.

UniProtKB/Swiss-Prot for ZFHX3 Gene

  • Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.

Gene Wiki entry for ZFHX3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZFHX3 Gene

Genomics for ZFHX3 Gene

Genomic Location for ZFHX3 Gene

Start:
72,782,885 bp from pter
End:
73,059,698 bp from pter
Size:
276,814 bases
Orientation:
Minus strand

Genomic View for ZFHX3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ZFHX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZFHX3 Gene

Regulatory Elements for ZFHX3 Gene

Proteins for ZFHX3 Gene

  • Protein details for ZFHX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15911-ZFHX3_HUMAN
    Recommended name:
    Zinc finger homeobox protein 3
    Protein Accession:
    Q15911
    Secondary Accessions:
    • D3DWS8
    • O15101
    • Q13719

    Protein attributes for ZFHX3 Gene

    Size:
    3703 amino acids
    Molecular mass:
    404419 Da
    Quaternary structure:
    • Interacts with FNBP3 (By similarity). Interacts with ALKBH4 and PIAS3.

    Three dimensional structures from OCA and Proteopedia for ZFHX3 Gene

    Alternative splice isoforms for ZFHX3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZFHX3 Gene

Proteomics data for ZFHX3 Gene at MOPED

Post-translational modifications for ZFHX3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZFHX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZFHX3 Gene

Domains for ZFHX3 Gene

Gene Families for ZFHX3 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type
  • ZFHX :Homeoboxes / ZF class

UniProtKB/Swiss-Prot:

ZFHX3_HUMAN
Domain:
  • Contains 4 homeobox DNA-binding domains.:
    • Q15911
Similarity:
  • Contains 22 C2H2-type zinc fingers.:
    • Q15911
genes like me logo Genes that share domains with ZFHX3: view

Function for ZFHX3 Gene

Molecular function for ZFHX3 Gene

UniProtKB/Swiss-Prot Function: Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer.

Gene Ontology (GO) - Molecular Function for ZFHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity NAS 1719379
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity TAS 1719379
GO:0003779 actin binding --
genes like me logo Genes that share ontologies with ZFHX3: view
genes like me logo Genes that share phenotypes with ZFHX3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ZFHX3 Gene

Localization for ZFHX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZFHX3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ZFHX3 Gene COMPARTMENTS Subcellular localization image for ZFHX3 gene
Compartment Confidence
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for ZFHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 1719379
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IDA 10318867
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ZFHX3: view

Pathways for ZFHX3 Gene

genes like me logo Genes that share pathways with ZFHX3: view

Pathways by source for ZFHX3 Gene

Gene Ontology (GO) - Biological Process for ZFHX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IGI 10318867
GO:0006355 regulation of transcription, DNA-templated TAS 1719379
GO:0006366 transcription from RNA polymerase II promoter TAS 1719379
GO:0007010 cytoskeleton organization --
GO:0007050 cell cycle arrest IEA --
genes like me logo Genes that share ontologies with ZFHX3: view

Compounds for ZFHX3 Gene

(2) Novoseek inferred chemical compound relationships for ZFHX3 Gene

Compound -log(P) Hits PubMed IDs
zinc 30.4 2
chloramphenicol 29.5 1
genes like me logo Genes that share compounds with ZFHX3: view

Transcripts for ZFHX3 Gene

Unigene Clusters for ZFHX3 Gene

Zinc finger homeobox 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ZFHX3 Gene

No ASD Table

Relevant External Links for ZFHX3 Gene

GeneLoc Exon Structure for
ZFHX3
ECgene alternative splicing isoforms for
ZFHX3

Expression for ZFHX3 Gene

mRNA expression in normal human tissues for ZFHX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZFHX3 Gene

This gene is overexpressed in Artery - Tibial (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZFHX3 Gene

SOURCE GeneReport for Unigene cluster for ZFHX3 Gene Hs.598297

mRNA Expression by UniProt/SwissProt for ZFHX3 Gene

Q15911-ZFHX3_HUMAN
Tissue specificity: Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level).
genes like me logo Genes that share expressions with ZFHX3: view

Orthologs for ZFHX3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZFHX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZFHX3 36
  • 98.67 (n)
  • 98.56 (a)
ZFHX3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZFHX3 36
  • 91.35 (n)
  • 94.7 (a)
ZFHX3 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZFHX3 36
  • 92.65 (n)
  • 96 (a)
ZFHX3 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfhx3 36
  • 89.93 (n)
  • 94.66 (a)
Zfhx3 16
Zfhx3 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZFHX3 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZFHX3 37
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfhx3 36
  • 89.9 (n)
  • 94.82 (a)
chicken
(Gallus gallus)
Aves ZFHX3 36
  • 82.49 (n)
  • 87.9 (a)
ZFHX3 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZFHX3 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.31945 36
tropical clawed frog
(Silurana tropicalis)
Amphibia zfhx3 36
  • 72.83 (n)
  • 77.17 (a)
zebrafish
(Danio rerio)
Actinopterygii zfhx3 36
  • 67.38 (n)
  • 69.35 (a)
zfhx3 37
  • 64 (a)
OneToMany
ZFHX3 (2 of 2) 37
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta zfh2 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zfh-2 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 25 (a)
ManyToMany
-- 37
  • 32 (a)
ManyToMany
Species with no ortholog for ZFHX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZFHX3 Gene

ENSEMBL:
Gene Tree for ZFHX3 (if available)
TreeFam:
Gene Tree for ZFHX3 (if available)

Paralogs for ZFHX3 Gene

Paralogs for ZFHX3 Gene

Selected SIMAP similar genes for ZFHX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZFHX3: view

Variants for ZFHX3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ZFHX3 Gene

Q15911-ZFHX3_HUMAN
Genetic variations in ZFHX3 are associated with atrial fibrillation and ischemic stroke in individuals of European ancestry

Sequence variations from dbSNP and Humsavar for ZFHX3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs699444 -- 72,793,859(+) CGATC(C/T)CCGCT reference, synonymous-codon
rs719353 -- 73,008,652(+) CATAT(A/G)CTGCT intron-variant
rs719354 -- 73,009,030(+) CAGTA(C/T)AGTAG intron-variant
rs721823 -- 72,914,408(+) TATCT(A/C)CTACA intron-variant
rs721824 -- 72,914,202(+) TGGCA(C/T)TGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ZFHX3 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv1868 CNV Loss 18451855
esv259436 OTHER Complex 20981092
nsv819379 CNV Gain 19587683
nsv906898 CNV Loss 21882294
esv2672800 CNV Deletion 23128226
nsv1869 CNV Insertion 18451855
dgv487n67 CNV Gain 20364138
nsv827733 CNV Gain 20364138
esv268829 CNV Insertion 20981092
nsv827734 CNV Gain 20364138
esv29824 CNV Loss 19812545

Relevant External Links for ZFHX3 Gene

HapMap Linkage Disequilibrium report
ZFHX3
Human Gene Mutation Database (HGMD)
ZFHX3

Disorders for ZFHX3 Gene

(1) OMIM Diseases for ZFHX3 Gene (104155)

(7) Novoseek inferred disease relationships for ZFHX3 Gene

Disease -log(P) Hits PubMed IDs
somatic mutations 56.6 5
gastric cancer 48.8 10
prostate cancer 32.7 6
tumors 16.6 4
cancer 11.5 4

Relevant External Links for ZFHX3

Genetic Association Database (GAD)
ZFHX3
Human Genome Epidemiology (HuGE) Navigator
ZFHX3
genes like me logo Genes that share disorders with ZFHX3: view

No data available for UniProtKB/Swiss-Prot for ZFHX3 Gene

Publications for ZFHX3 Gene

  1. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. (PMID: 1719379) Morinaga T. … Tamaoki T. (Mol. Cell. Biol. 1991) 2 3 4 23
  2. Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. (PMID: 7592926) Miura Y. … Tamaoki T. (J. Biol. Chem. 1995) 2 3 4 23
  3. Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. (PMID: 11312261) Berry F.B. … Tamaoki T. (J. Biol. Chem. 2001) 3 4 23
  4. Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. (PMID: 17330845) Mori Y. … Joh T. (Int. J. Cancer 2007) 3 4 23
  5. Germline ATBF1 mutations and prostate cancer risk. (PMID: 16637072) Xu J. … Isaacs W.B. (Prostate 2006) 3 23 49

Products for ZFHX3 Gene

Sources for ZFHX3 Gene

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