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Aliases for MYH1 Gene

Aliases for MYH1 Gene

  • Myosin, Heavy Chain 1, Skeletal Muscle, Adult 2 3
  • Myosin Heavy Chain IIx/D 2 3 4
  • Myosin, Heavy Polypeptide 1, Skeletal Muscle, Adult 2 3
  • Myosin Heavy Chain, Skeletal Muscle, Adult 1 3 4
  • Myosin Heavy Chain 2x 3 4
  • Myosin Heavy Chain 1 3 4
  • MyHC-IIx/D 3 4
  • MyHC-2x 3 4
  • Epididymis Luminal Protein 71 3
  • MyHC-2X/D 3
  • Myosin-1 3
  • MYHSA1 3
  • HEL71 3
  • MYHa 3

External Ids for MYH1 Gene

Previous GeneCards Identifiers for MYH1 Gene

  • GC17U990062
  • GC17M011510
  • GC17M010338
  • GC17M010596
  • GC17M010336

Summaries for MYH1 Gene

Entrez Gene Summary for MYH1 Gene

  • Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYH1 Gene

MYH1 (Myosin, Heavy Chain 1, Skeletal Muscle, Adult) is a Protein Coding gene. Diseases associated with MYH1 include familial gastric cancer. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include actin binding and motor activity. An important paralog of this gene is MYH4.

UniProtKB/Swiss-Prot for MYH1 Gene

  • Muscle contraction

Tocris Summary for MYH1 Gene

  • Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name), almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II. Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by intracellular Ca2+ concentrations.

Gene Wiki entry for MYH1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYH1 Gene

Genomics for MYH1 Gene

Regulatory Elements for MYH1 Gene

Genomic Location for MYH1 Gene

Start:
10,492,307 bp from pter
End:
10,518,543 bp from pter
Size:
26,237 bases
Orientation:
Minus strand

Genomic View for MYH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYH1 Gene

Proteins for MYH1 Gene

  • Protein details for MYH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12882-MYH1_HUMAN
    Recommended name:
    Myosin-1
    Protein Accession:
    P12882
    Secondary Accessions:
    • Q14CA4
    • Q9Y622

    Protein attributes for MYH1 Gene

    Size:
    1939 amino acids
    Molecular mass:
    223145 Da
    Quaternary structure:
    • Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2)

neXtProt entry for MYH1 Gene

Proteomics data for MYH1 Gene at MOPED

Post-translational modifications for MYH1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYH1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYH1 Gene

Domains for MYH1 Gene

Gene Families for MYH1 Gene

HGNC:
  • MYHII :Myosins / Myosin superfamily : Class II

Suggested Antigen Peptide Sequences for MYH1 Gene

Graphical View of Domain Structure for InterPro Entry

P12882

UniProtKB/Swiss-Prot:

MYH1_HUMAN :
  • P12882
Domain:
  • The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils
  • Each myosin heavy chain can be split into 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be split further into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2)
  • Contains 1 IQ domain.
  • Contains 1 myosin motor domain.
Family:
  • Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
genes like me logo Genes that share domains with MYH1: view

Function for MYH1 Gene

Molecular function for MYH1 Gene

GENATLAS Biochemistry: myosin,motor contractile protein moving towards the "plus" end of actin track,heavy polypeptide 1,skeletal muscle,adult
UniProtKB/Swiss-Prot Function: Muscle contraction

Gene Ontology (GO) - Molecular Function for MYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003774 motor activity IEA --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with MYH1: view
genes like me logo Genes that share phenotypes with MYH1: view

Animal Models for MYH1 Gene

MGI Knock Outs for MYH1:

miRNA for MYH1 Gene

miRTarBase miRNAs that target MYH1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MYH1 Gene

Localization for MYH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYH1 Gene

Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYH1 Gene COMPARTMENTS Subcellular localization image for MYH1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for MYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005859 muscle myosin complex IDA 18310078
GO:0014704 intercalated disc IEA --
GO:0016459 myosin complex --
GO:0031672 A band IEA --
GO:0032982 myosin filament IEA --
genes like me logo Genes that share ontologies with MYH1: view

Pathways for MYH1 Gene

genes like me logo Genes that share pathways with MYH1: view

Gene Ontology (GO) - Biological Process for MYH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IEA --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MYH1: view

Compounds for MYH1 Gene

(4) Tocris Compounds for MYH1 Gene

Compound Action Cas Number
(�)-Blebbistatin Selective inhibitor of myosin II ATPase activity [674289-55-5]
(R)-(+)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (�)-blebbistatin (Cat. No. 1760) [1177356-70-5]
(S)-(-)-Blebbistatin Selective inhibitor of myosin II ATPase activity. Active enantiomer of (�)-blebbistatin (Cat. No. 1760) [856925-71-8]
BTS Selective inhibitor of skeletal muscle myosin II ATPase activity [1576-37-0]

(1) Novoseek inferred chemical compound relationships for MYH1 Gene

Compound -log(P) Hits PubMed IDs
atp 8.67 2
genes like me logo Genes that share compounds with MYH1: view

Transcripts for MYH1 Gene

mRNA/cDNA for MYH1 Gene

(360) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYH1 Gene

Myosin, heavy chain 1, skeletal muscle, adult:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -

Relevant External Links for MYH1 Gene

GeneLoc Exon Structure for
MYH1
ECgene alternative splicing isoforms for
MYH1

Expression for MYH1 Gene

mRNA expression in normal human tissues for MYH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYH1 Gene

This gene is overexpressed in Muscle - Skeletal (52.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYH1 Gene

SOURCE GeneReport for Unigene cluster for MYH1 Gene Hs.689619

genes like me logo Genes that share expressions with MYH1: view

No data available for mRNA Expression by UniProt/SwissProt for MYH1 Gene

Orthologs for MYH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYH1 35
  • 99.43 (n)
  • 99.79 (a)
MYH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYH1 35
  • 91.33 (n)
  • 96.65 (a)
MYH1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYH1 35
  • 91.61 (n)
  • 97.06 (a)
MYH1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myh1 35
  • 90.82 (n)
  • 96.75 (a)
Myh1 16
Myh1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
ManyToMany
-- 36
  • 87 (a)
ManyToMany
-- 36
  • 95 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Myh1 35
  • 91.27 (n)
  • 96.85 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 91 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495638 35
  • 77.26 (n)
  • 83.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mhc 37
  • 50 (a)
Prm 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea myo-3 37
  • 47 (a)
hcp-1 37
  • 20 (a)
F58G4.1 37
  • 48 (a)
F45G2.2 37
  • 44 (a)
hcp-2 37
  • 20 (a)
Y11D7A.14 37
  • 29 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2731 35
Species with no ortholog for MYH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MYH1 Gene

ENSEMBL:
Gene Tree for MYH1 (if available)
TreeFam:
Gene Tree for MYH1 (if available)

Paralogs for MYH1 Gene

Paralogs for MYH1 Gene

Selected SIMAP similar genes for MYH1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MYH1: view

Variants for MYH1 Gene

Sequence variations from dbSNP and Humsavar for MYH1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_030193 -
VAR_030194 -
VAR_030195 -
VAR_036003 A breast cancer sample
VAR_036004 A breast cancer sample

Structural Variations from Database of Genomic Variants (DGV) for MYH1 Gene

Variant ID Type Subtype PubMed ID
nsv907673 CNV Gain 21882294
nsv520771 CNV Gain+Loss 19592680
nsv907679 CNV Gain 21882294
nsv833366 CNV Gain 17160897
nsv907681 CNV Loss 21882294

Relevant External Links for MYH1 Gene

HapMap Linkage Disequilibrium report
MYH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYH1 Gene

Disorders for MYH1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MYH1 Gene including...

Search for MYH1 Gene in MalaCards »

Relevant External Links for MYH1

Genetic Association Database (GAD)
MYH1
Human Genome Epidemiology (HuGE) Navigator
MYH1
genes like me logo Genes that share disorders with MYH1: view

No data available for UniProtKB/Swiss-Prot for MYH1 Gene

Publications for MYH1 Gene

  1. Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle. (PMID: 2421254) Saez L. … Leinwand L.A. (Nucleic Acids Res. 1986) 3 4
  2. Isolation and characterization of human myosin heavy chain genes. (PMID: 6304733) Leinwand L.A. … Nadal-Ginard B. (Proc. Natl. Acad. Sci. U.S.A. 1983) 2 3
  3. Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. (PMID: 10388558) Weiss A. … Leinwand L.A. (J. Mol. Biol. 1999) 3 4
  4. Role of inherited defects of MYH in the development of sporadic colorectal cancer. (PMID: 15034862) Kambara T. … Jass J.R. (Genes Chromosomes Cancer 2004) 3 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MYH1 Gene

Sources for MYH1 Gene

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