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Aliases for MYF5 Gene

Aliases for MYF5 Gene

  • Myogenic Factor 5 2 3
  • Class C Basic Helix-Loop-Helix Protein 2 3 4
  • BHLHc2 3 4
  • Myf-5 3 4

External Ids for MYF5 Gene

Previous GeneCards Identifiers for MYF5 Gene

  • GC12P081085
  • GC12P081474
  • GC12P079613
  • GC12P078167

Summaries for MYF5 Gene

GeneCards Summary for MYF5 Gene

MYF5 (Myogenic Factor 5) is a Protein Coding gene. Diseases associated with MYF5 include botryoid rhabdomyosarcoma and skeletal muscle neoplasm. Among its related pathways are Developmental Biology and Signaling pathways regulating pluripotency of stem cells. GO annotations related to this gene include sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYOD1.

UniProtKB/Swiss-Prot for MYF5 Gene

  • Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYF5 Gene

Genomics for MYF5 Gene

Regulatory Elements for MYF5 Gene

Transcription factor binding sites by QIAGEN in the MYF5 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MYF5 Gene

Chromosome:
12
Start:
80,716,912 bp from pter
End:
80,719,673 bp from pter
Size:
2,762 bases
Orientation:
Plus strand

Genomic View for MYF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYF5 Gene

Proteins for MYF5 Gene

  • Protein details for MYF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13349-MYF5_HUMAN
    Recommended name:
    Myogenic factor 5
    Protein Accession:
    P13349
    Secondary Accessions:
    • Q6ISR9

    Protein attributes for MYF5 Gene

    Size:
    255 amino acids
    Molecular mass:
    28296 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein

neXtProt entry for MYF5 Gene

Proteomics data for MYF5 Gene at MOPED

Post-translational modifications for MYF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MYF5 Gene

Domains & Families for MYF5 Gene

Gene Families for MYF5 Gene

Suggested Antigen Peptide Sequences for MYF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13349

UniProtKB/Swiss-Prot:

MYF5_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYF5: view

Function for MYF5 Gene

Molecular function for MYF5 Gene

GENATLAS Biochemistry:
myogenic factor 5,transcription activator
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein

Gene Ontology (GO) - Molecular Function for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003677 DNA binding --
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS 2311584
GO:0005515 protein binding IPI 19829708
genes like me logo Genes that share ontologies with MYF5: view
genes like me logo Genes that share phenotypes with MYF5: view

Animal Models for MYF5 Gene

MGI Knock Outs for MYF5:

Animal Model Products

miRNA for MYF5 Gene

miRTarBase miRNAs that target MYF5
Targeted motifs for MYF5 Gene
HOMER Transcription Factor Regulatory Elements motif MYF5
  • Consensus sequence: BAACAGCTGT Submotif: canonical Cell Type: GM GEO ID: GSE24852

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for MYF5 Gene

Localization for MYF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYF5 Gene COMPARTMENTS Subcellular localization image for MYF5 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0090575 RNA polymerase II transcription factor complex ISS 8035824
genes like me logo Genes that share ontologies with MYF5: view

Pathways & Interactions for MYF5 Gene

genes like me logo Genes that share pathways with MYF5: view

PCR Array Products

SIGNOR curated interactions for MYF5 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MYF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation IEA --
GO:0001503 ossification IEA --
GO:0001756 somitogenesis IEA --
GO:0001952 regulation of cell-matrix adhesion IEA --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with MYF5: view

Drugs & Compounds for MYF5 Gene

(4) Drugs for MYF5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Acetylcholine Experimental Pharma Full agonist, Agonist 104
bromodeoxyuridine Pharma 4
Calcium Nutra 0
serine Nutra 420

(3) Additional Compounds for MYF5 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
glutamate
retinoic acid
302-79-4
genes like me logo Genes that share compounds with MYF5: view

Transcripts for MYF5 Gene

mRNA/cDNA for MYF5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MYF5 Gene

Myogenic factor 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MYF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MYF5 Gene

No ASD Table

Relevant External Links for MYF5 Gene

GeneLoc Exon Structure for
MYF5
ECgene alternative splicing isoforms for
MYF5

Expression for MYF5 Gene

mRNA expression in normal human tissues for MYF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYF5 Gene

This gene is overexpressed in Muscle - Skeletal (x50.0).

SOURCE GeneReport for Unigene cluster for MYF5 Gene Hs.178023

genes like me logo Genes that share expression patterns with MYF5: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MYF5 Gene

Orthologs for MYF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYF5 35
  • 91.37 (n)
  • 94.51 (a)
MYF5 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYF5 35
  • 87.19 (n)
  • 87.84 (a)
MYF5 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myf5 35
  • 86.67 (n)
  • 89.41 (a)
Myf5 16
Myf5 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYF5 35
  • 98.95 (n)
  • 100 (a)
MYF5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myf5 35
  • 86.8 (n)
  • 89.8 (a)
oppossum
(Monodelphis domestica)
Mammalia MYF5 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYF5 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYF5 35
  • 72.55 (n)
  • 71.76 (a)
MYF5 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYF5 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76020 35
myf5 35
  • 67.19 (n)
  • 71.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia XMyf-5 35
zebrafish
(Danio rerio)
Actinopterygii myf5 35
  • 65.25 (n)
  • 61.86 (a)
myf5 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nau 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea hlh-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
OneToMany
Species with no ortholog for MYF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MYF5 Gene

ENSEMBL:
Gene Tree for MYF5 (if available)
TreeFam:
Gene Tree for MYF5 (if available)

Paralogs for MYF5 Gene

Paralogs for MYF5 Gene

(4) SIMAP similar genes for MYF5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MYF5: view

Variants for MYF5 Gene

Sequence variations from dbSNP and Humsavar for MYF5 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1163259 -- 80,715,402(+) AAAAT(A/G)ATTCT upstream-variant-2KB
rs1163260 -- 80,716,448(+) ATTGC(C/T)GGAAA upstream-variant-2KB
rs1163261 -- 80,716,986(+) TGCCC(A/G)TCGGC utr-variant-5-prime
rs1163262 -- 80,718,523(+) TTGGG(A/G)AAGGG intron-variant
rs1163263 -- 80,720,051(+) GTTAA(A/G)TCATA downstream-variant-500B

Variation tolerance for MYF5 Gene

Residual Variation Intolerance Score: 14.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYF5 Gene

HapMap Linkage Disequilibrium report
MYF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYF5 Gene

Disorders for MYF5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for MYF5 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
botryoid rhabdomyosarcoma
  • botryoid-type embryonal rhabdomyosarcoma
skeletal muscle neoplasm
  • tumor of skeletal muscle
extraosseous ewing's sarcoma
  • extraosseous ewings sarcoma-primitive neuroepithelial tumor
rhabdomyosarcoma
- elite association
Search MYF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYF5

Genetic Association Database (GAD)
MYF5
Human Genome Epidemiology (HuGE) Navigator
MYF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYF5
genes like me logo Genes that share disorders with MYF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYF5 Gene

Publications for MYF5 Gene

  1. The myogenic basic helix-loop-helix family of transcription factors shows similar requirements for SWI/SNF chromatin remodeling enzymes during muscle differentiation in culture. (PMID: 12105204) Roy K. … Imbalzano A.N. (J. Biol. Chem. 2002) 2 23 67
  2. Assignment of the human myogenic factors 5 and 6 (MYF5, MYF6) gene cluster to 12q21 by in situ hybridization and physical mapping of the locus between D12S350 and D12S106. (PMID: 8978788) Cupelli L. … Krauter K. (Cytogenet. Cell Genet. 1996) 2 23 67
  3. Retinoic acid is both necessary for and inhibits myogenic commitment and differentiation in the chick limb. (PMID: 19757389) Reijntjes S. … Mankoo B.S. (Int. J. Dev. Biol. 2010) 23 67
  4. Exclusion of MYF5, GSC, RUNX2, and TCOF1 mutation in a case of cerebro-costo-mandibular syndrome. (PMID: 20177378) Su P.H. … Chen S.J. (Clin. Dysmorphol. 2010) 23 67
  5. A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis. (PMID: 20368965) Sato T. … Buckingham M. (PLoS Genet. 2010) 23 67

Products for MYF5 Gene

Sources for MYF5 Gene

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