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Aliases for MYD88 Gene

Aliases for MYD88 Gene

  • Myeloid Differentiation Primary Response 88 2 3
  • Myeloid Differentiation Primary Response Gene (88) 2 3
  • MYD88D 3 6
  • Myeloid Differentiation Primary Response Protein MyD88 3

External Ids for MYD88 Gene

Summaries for MYD88 Gene

Entrez Gene Summary for MYD88 Gene

  • This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for MYD88 Gene

MYD88 (Myeloid Differentiation Primary Response 88) is a Protein Coding gene. Diseases associated with MYD88 include macroglobulinemia, waldenstrom, somatic and waldenstrom macroglobulinemia. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include identical protein binding and TIR domain binding.

UniProtKB/Swiss-Prot for MYD88 Gene

  • Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gene Wiki entry for MYD88 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYD88 Gene

Genomics for MYD88 Gene

Genomic Location for MYD88 Gene

Start:
38,138,478 bp from pter
End:
38,143,022 bp from pter
Size:
4,545 bases
Orientation:
Plus strand

Genomic View for MYD88 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYD88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYD88 Gene

Regulatory Elements for MYD88 Gene

Proteins for MYD88 Gene

  • Protein details for MYD88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99836-MYD88_HUMAN
    Recommended name:
    Myeloid differentiation primary response protein MyD88
    Protein Accession:
    Q99836
    Secondary Accessions:
    • B4DKH8
    • B4DKU4
    • B4DQ60
    • B4DQ72
    • J3KPU4
    • J3KQ87
    • J3KQJ6
    • P78397
    • Q53XS7

    Protein attributes for MYD88 Gene

    Size:
    296 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.
    SequenceCaution:
    • Sequence=BAG60822.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG60834.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW64521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYD88 Gene

    Alternative splice isoforms for MYD88 Gene

neXtProt entry for MYD88 Gene

Proteomics data for MYD88 Gene at MOPED

Post-translational modifications for MYD88 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys95, Lys119, Lys231, and Lys282

Other Protein References for MYD88 Gene

No data available for DME Specific Peptides for MYD88 Gene

Domains for MYD88 Gene

Protein Domains for MYD88 Gene

Graphical View of Domain Structure for InterPro Entry

Q99836

UniProtKB/Swiss-Prot:

MYD88_HUMAN
Domain:
  • The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.:
    • Q99836
  • Contains 1 death domain.:
    • Q99836
  • Contains 1 TIR domain.:
    • Q99836
genes like me logo Genes that share domains with MYD88: view

No data available for Gene Families for MYD88 Gene

Function for MYD88 Gene

Molecular function for MYD88 Gene

GENATLAS Biochemistry: myeloid differentiation primary response gene,88,binding the cytoplasmic tail of TLR proteins leading to their activation,initiating an intracellular signaling pathway to NFKB and its target genes
UniProtKB/Swiss-Prot Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gene Ontology (GO) - Molecular Function for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005121 Toll binding --
GO:0005123 death receptor binding TAS 9374458
GO:0005149 interleukin-1 receptor binding --
GO:0005515 protein binding IPI 10880445
genes like me logo Genes that share ontologies with MYD88: view
genes like me logo Genes that share phenotypes with MYD88: view

Animal Models for MYD88 Gene

MGI Knock Outs for MYD88:

miRNA for MYD88 Gene

miRTarBase miRNAs that target MYD88

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MYD88 Gene

Localization for MYD88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYD88 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYD88 Gene COMPARTMENTS Subcellular localization image for MYD88 gene
Compartment Confidence
cytosol 4
endosome 4
plasma membrane 4
nucleus 3
extracellular 2
vacuole 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
GO:0014069 postsynaptic density --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with MYD88: view

Pathways for MYD88 Gene

SuperPathways for MYD88 Gene

Superpath Contained pathways
1 Toll Like Receptor 7/8 (TLR7/8) Cascade
2 NOD-like Receptor Signaling Pathways
3 Cytosolic sensors of pathogen-associated DNA
4 Toll-like receptor signaling pathway
5 Toll Comparative Pathway
genes like me logo Genes that share pathways with MYD88: view

Gene Ontology (GO) - Biological Process for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002238 response to molecule of fungal origin --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction NAS 9013863
genes like me logo Genes that share ontologies with MYD88: view

Compounds for MYD88 Gene

(21) Novoseek inferred chemical compound relationships for MYD88 Gene

Compound -log(P) Hits PubMed IDs
lipoteichoic acid 69.3 4
tab-2 69.1 2
flagellin 63.2 10
peptidoglycan 57.4 5
endotoxin 45.2 3
genes like me logo Genes that share compounds with MYD88: view

Transcripts for MYD88 Gene

Unigene Clusters for MYD88 Gene

Myeloid differentiation primary response 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYD88 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: -
SP9:

Relevant External Links for MYD88 Gene

GeneLoc Exon Structure for
MYD88
ECgene alternative splicing isoforms for
MYD88

Expression for MYD88 Gene

mRNA expression in normal human tissues for MYD88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYD88 Gene

This gene is overexpressed in Whole Blood (17.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYD88 Gene

SOURCE GeneReport for Unigene cluster for MYD88 Gene Hs.82116

mRNA Expression by UniProt/SwissProt for MYD88 Gene

Q99836-MYD88_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with MYD88: view

Orthologs for MYD88 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYD88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYD88 35
  • 99.21 (n)
  • 98.99 (a)
MYD88 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYD88 35
  • 86.15 (n)
  • 85.47 (a)
MYD88 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYD88 35
  • 89.64 (n)
  • 91.22 (a)
MYD88 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myd88 35
  • 82.37 (n)
  • 84.53 (a)
Myd88 16
Myd88 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MYD88 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myd88 35
  • 81.29 (n)
  • 83.81 (a)
chicken
(Gallus gallus)
Aves MYD88 35
  • 71.45 (n)
  • 71.69 (a)
MYD88 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYD88 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia myd88-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia myd88 35
  • 66.54 (n)
  • 66.17 (a)
Str.11893 35
zebrafish
(Danio rerio)
Actinopterygii myd88 35
  • 63.02 (n)
  • 64.23 (a)
myd88 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MYD 35
  • 44.86 (n)
  • 31.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myd88 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2481 36
  • 19 (a)
OneToOne
Species with no ortholog for MYD88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYD88 Gene

ENSEMBL:
Gene Tree for MYD88 (if available)
TreeFam:
Gene Tree for MYD88 (if available)

Paralogs for MYD88 Gene

No data available for Paralogs for MYD88 Gene

Variants for MYD88 Gene

Sequence variations from dbSNP and Humsavar for MYD88 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs6853 -- 38,142,879(+) ATCTC(A/G)AGAGG utr-variant-3-prime
rs7744 -- 38,142,530(+) CTCTA(A/G)TGAAG utr-variant-3-prime
rs1804725 -- 38,142,646(+) GCTGT(A/C)CTCTG utr-variant-3-prime
rs1804726 -- 38,142,594(+) CAGCT(A/G)TTCTC utr-variant-3-prime
rs2200055 -- 38,140,915(+) TCAGC(C/T)TTCCC intron-variant

Relevant External Links for MYD88 Gene

HapMap Linkage Disequilibrium report
MYD88
Human Gene Mutation Database (HGMD)
MYD88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYD88 Gene

Disorders for MYD88 Gene

(2) OMIM Diseases for MYD88 Gene (602170)

UniProtKB/Swiss-Prot

MYD88_HUMAN
  • MYD88 deficiency (MYD88D) [MIM:612260]: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age. {ECO:0000269 PubMed:18669862, ECO:0000269 PubMed:21057262, ECO:0000269 PubMed:24316379}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in MYD88 are frequently found in many hematological malignancies, such as activated B-cell type diffuse large B-cell lymphoma (ABC-DLBCL), Waldenstroems macroglobulinemia, cutaneous diffuse large B cell lymphoma (CBCL) and primary central nervous system lymphoma (PCNSL). {ECO:0000269 PubMed:21179087, ECO:0000269 PubMed:22931316}.

(1) University of Copenhagen DISEASES for MYD88 Gene

(17) Novoseek inferred disease relationships for MYD88 Gene

Disease -log(P) Hits PubMed IDs
necrosis 50.2 25
inflammation 47.8 7
bacterial infections 33.1 1
anaplasmosis 30.3 1
tumors 28.9 29

Relevant External Links for MYD88

Genetic Association Database (GAD)
MYD88
Human Genome Epidemiology (HuGE) Navigator
MYD88
genes like me logo Genes that share disorders with MYD88: view

Publications for MYD88 Gene

  1. Molecular characterization and modular analysis of human MyD88. (PMID: 8957090) Hardiman G. … Bazan J.F. (Oncogene 1996) 3 4 23
  2. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. (PMID: 15361868) Kawai T. … Akira S. (Nat. Immunol. 2004) 3 4 23
  3. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. (PMID: 18292575) Semaan N. … Sibilia J. (J. Immunol. 2008) 3 4 23
  4. Modulation of TLR signaling by multiple MyD88-interacting partners including leucine-rich repeat Fli-I-interacting proteins. (PMID: 19265123) Dai P. … Chen X. (J. Immunol. 2009) 3 4 23
  5. Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling. (PMID: 19506249) Ohnishi H. … Shirakawa M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 23

Products for MYD88 Gene

  • Addgene plasmids for MYD88

Sources for MYD88 Gene

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