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Aliases for MYD88 Gene

Aliases for MYD88 Gene

  • Myeloid Differentiation Primary Response 88 2 3 5
  • Myeloid Differentiation Primary Response Gene (88) 2 3
  • MYD88D 3

External Ids for MYD88 Gene

Previous GeneCards Identifiers for MYD88 Gene

  • GC03P037467
  • GC03M038006
  • GC03P037993
  • GC03P038140
  • GC03P038155

Summaries for MYD88 Gene

Entrez Gene Summary for MYD88 Gene

  • This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

GeneCards Summary for MYD88 Gene

MYD88 (Myeloid Differentiation Primary Response 88) is a Protein Coding gene. Diseases associated with MYD88 include myd88 deficiency and macroglobulinemia, waldenstrom 1. Among its related pathways are African trypanosomiasis and Toll-like receptor signaling pathway. GO annotations related to this gene include identical protein binding and death receptor binding.

UniProtKB/Swiss-Prot for MYD88 Gene

  • Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gene Wiki entry for MYD88 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYD88 Gene

Genomics for MYD88 Gene

Regulatory Elements for MYD88 Gene

Enhancers for MYD88 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYD88 on UCSC Golden Path with GeneCards custom track

Genomic Location for MYD88 Gene

Chromosome:
3
Start:
38,138,478 bp from pter
End:
38,143,022 bp from pter
Size:
4,545 bases
Orientation:
Plus strand

Genomic View for MYD88 Gene

Genes around MYD88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYD88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYD88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYD88 Gene

Proteins for MYD88 Gene

  • Protein details for MYD88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99836-MYD88_HUMAN
    Recommended name:
    Myeloid differentiation primary response protein MyD88
    Protein Accession:
    Q99836
    Secondary Accessions:
    • B4DKH8
    • B4DKU4
    • B4DQ60
    • B4DQ72
    • J3KPU4
    • J3KQ87
    • J3KQJ6
    • P78397
    • Q53XS7

    Protein attributes for MYD88 Gene

    Size:
    296 amino acids
    Molecular mass:
    33233 Da
    Quaternary structure:
    • Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL18R1. Interacts with BMX, IL1RL1, IKBKE and IRF7. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist. Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding. Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.
    SequenceCaution:
    • Sequence=BAG60822.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG60834.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=EAW64521.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MYD88 Gene

    Alternative splice isoforms for MYD88 Gene

neXtProt entry for MYD88 Gene

Proteomics data for MYD88 Gene at MOPED

Post-translational modifications for MYD88 Gene

  • Ubiquitination at Lys 95, Lys 119, Lys 231, and Lys 282
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYD88 (MYD88)

No data available for DME Specific Peptides for MYD88 Gene

Domains & Families for MYD88 Gene

Protein Domains for MYD88 Gene

Graphical View of Domain Structure for InterPro Entry

Q99836

UniProtKB/Swiss-Prot:

MYD88_HUMAN :
  • The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
Domain:
  • The intermediate domain (ID) is required for the phosphorylation and activation of IRAK.
  • Contains 1 death domain.
  • Contains 1 TIR domain.
genes like me logo Genes that share domains with MYD88: view

No data available for Gene Families for MYD88 Gene

Function for MYD88 Gene

Molecular function for MYD88 Gene

GENATLAS Biochemistry:
myeloid differentiation primary response gene,88,binding the cytoplasmic tail of TLR proteins leading to their activation,initiating an intracellular signaling pathway to NFKB and its target genes
UniProtKB/Swiss-Prot Function:
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

Gene Ontology (GO) - Molecular Function for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005121 Toll binding IEA --
genes like me logo Genes that share ontologies with MYD88: view
genes like me logo Genes that share phenotypes with MYD88: view

Human Phenotype Ontology for MYD88 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYD88 Gene

MGI Knock Outs for MYD88:

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MYD88 Gene

Localization for MYD88 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYD88 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYD88 Gene COMPARTMENTS Subcellular localization image for MYD88 gene
Compartment Confidence
cytosol 5
endosome 5
plasma membrane 5
extracellular 3
nucleus 3
lysosome 2
vacuole 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with MYD88: view

Pathways & Interactions for MYD88 Gene

SuperPathways for MYD88 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 Toll-Like receptor Signaling Pathways
3 Cytosolic sensors of pathogen-associated DNA
4 Diseases associated with the TLR signaling cascade
5 Toll-like receptor signaling pathway
genes like me logo Genes that share pathways with MYD88: view

SIGNOR curated interactions for MYD88 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for MYD88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA,TAS --
GO:0006954 inflammatory response IEA --
GO:0007165 signal transduction IEA,NAS 9013863
GO:0007254 JNK cascade IEA --
genes like me logo Genes that share ontologies with MYD88: view

Drugs & Compounds for MYD88 Gene

(9) Drugs for MYD88 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(12) Additional Compounds for MYD88 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYD88: view

Transcripts for MYD88 Gene

Unigene Clusters for MYD88 Gene

Myeloid differentiation primary response 88:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYD88 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - -
SP2: - -
SP3: - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: -
SP9:

Relevant External Links for MYD88 Gene

GeneLoc Exon Structure for
MYD88
ECgene alternative splicing isoforms for
MYD88

Expression for MYD88 Gene

mRNA expression in normal human tissues for MYD88 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYD88 Gene

This gene is overexpressed in Whole Blood (x17.2).

Protein differential expression in normal tissues from HIPED for MYD88 Gene

This gene is overexpressed in Monocytes (13.1), Peripheral blood mononuclear cells (10.3), and Lymph node (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYD88 Gene



SOURCE GeneReport for Unigene cluster for MYD88 Gene Hs.82116

mRNA Expression by UniProt/SwissProt for MYD88 Gene

Q99836-MYD88_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with MYD88: view

Protein tissue co-expression partners for MYD88 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MYD88 Gene

This gene was present in the common ancestor of animals.

Orthologs for MYD88 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MYD88 35
  • 86.15 (n)
  • 85.47 (a)
MYD88 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYD88 35
  • 89.64 (n)
  • 91.22 (a)
MYD88 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Myd88 35
  • 82.37 (n)
  • 84.53 (a)
Myd88 16
Myd88 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MYD88 35
  • 99.21 (n)
  • 98.99 (a)
MYD88 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myd88 35
  • 81.29 (n)
  • 83.81 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia MYD88 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYD88 35
  • 71.45 (n)
  • 71.69 (a)
MYD88 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYD88 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia myd88 35
  • 66.54 (n)
  • 66.17 (a)
Str.11893 35
African clawed frog
(Xenopus laevis)
Amphibia myd88-A 35
zebrafish
(Danio rerio)
Actinopterygii myd88 35
  • 63.02 (n)
  • 64.23 (a)
myd88 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta MYD 35
  • 44.86 (n)
  • 31.58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Myd88 36
  • 15 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2481 36
  • 19 (a)
OneToOne
Species with no ortholog for MYD88:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYD88 Gene

ENSEMBL:
Gene Tree for MYD88 (if available)
TreeFam:
Gene Tree for MYD88 (if available)

Paralogs for MYD88 Gene

No data available for Paralogs for MYD88 Gene

Variants for MYD88 Gene

Sequence variations from dbSNP and Humsavar for MYD88 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_047953 MYD88 deficiency (MYD88D)
VAR_047954 MYD88 deficiency (MYD88D)
VAR_072893 -
VAR_072895 -
VAR_072896 -

Variation tolerance for MYD88 Gene

Residual Variation Intolerance Score: 30.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.85; 17.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYD88 Gene

HapMap Linkage Disequilibrium report
MYD88
Human Gene Mutation Database (HGMD)
MYD88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYD88 Gene

Disorders for MYD88 Gene

MalaCards: The human disease database

(30) MalaCards diseases for MYD88 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myd88 deficiency
  • pyogenic bacterial infections due to myd88 deficiency
macroglobulinemia, waldenstrom 1
  • macroglobulinemia, waldenstrom, somatic
waldenstrom macroglobulinemia
  • lymphoplasmacytic lymphoma
macroglobulinemia
  • waldenstrom macroglobulinemia
central nervous system lymphoma
  • microglioma
- elite association - COSMIC cancer census association via MalaCards
Search MYD88 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYD88_HUMAN
  • MYD88 deficiency (MYD88D) [MIM:612260]: Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age. {ECO:0000269 PubMed:18669862, ECO:0000269 PubMed:21057262, ECO:0000269 PubMed:24316379}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=Defects in MYD88 are frequently found in many hematological malignancies, such as activated B-cell type diffuse large B-cell lymphoma (ABC-DLBCL), Waldenstroems macroglobulinemia, cutaneous diffuse large B cell lymphoma (CBCL) and primary central nervous system lymphoma (PCNSL). {ECO:0000269 PubMed:21179087, ECO:0000269 PubMed:22931316}.

Relevant External Links for MYD88

Genetic Association Database (GAD)
MYD88
Human Genome Epidemiology (HuGE) Navigator
MYD88
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYD88
genes like me logo Genes that share disorders with MYD88: view

No data available for Genatlas for MYD88 Gene

Publications for MYD88 Gene

  1. The cloning and characterization of human MyD88: a member of an IL-1 receptor related family. (PMID: 9013863) Bonnert T.P. … Sims J.E. (FEBS Lett. 1997) 2 3 4 67
  2. High expression of Toll-like receptor 4/myeloid differentiation factor 88 signals correlates with poor prognosis in colorectal cancer. (PMID: 20145615) Wang E.L. … Sano T. (Br. J. Cancer 2010) 3 23
  3. Cooperation of TLR2 with MyD88, PI3K, and Rac1 in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses. (PMID: 20167866) Lee I.T. … Yang C.M. (Am. J. Pathol. 2010) 3 23
  4. Myeloid differentiation factor 88 regulates basal and UV-induced expressions of IL-6 and MMP-1 in human epidermal keratinocytes. (PMID: 18719610) Lee Y. … Chung J.H. (J. Invest. Dermatol. 2009) 3 23
  5. Contribution of globular death domains and unstructured linkers to MyD88.IRAK-4 heterodimer formation: an explanation for the antagonistic activity of MyD88s. (PMID: 19167362) Mendoza-BarberA! E. … Fuentes-Prior P. (Biochem. Biophys. Res. Commun. 2009) 3 23

Products for MYD88 Gene

Sources for MYD88 Gene

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