Aliases for MYCN Gene
External Ids for MYCN Gene
Previous HGNC Symbols for MYCN Gene
Previous GeneCards Identifiers for MYCN Gene
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
GeneCards Summary for MYCN Gene
MYCN (V-Myc Avian Myelocytomatosis Viral Oncogene Neuroblastoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCN include feingold syndrome and familial retinoblastoma. Among its related pathways are Neuroscience and Transcriptional misregulation in cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MYC.
UniProtKB/Swiss-Prot for MYCN Gene
Positively regulates the transcription of NCYM in neuroblastoma cells (PubMed:24391509).