Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MYCL Gene

Aliases for MYCL Gene

  • V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 38 3 4
  • Myc-Related Gene From Lung Cancer 2 3
  • Protein L-Myc-1 3 4
  • BHLHe38 3 4
  • MYCL1 3 4
  • LMYC 3 4
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 2
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 4
  • L-Myc-1 Proto-Oncogene 3
  • L-Myc Protein 2
  • Oncogene Lmyc 2
  • L-Myc 3

External Ids for MYCL Gene

Previous HGNC Symbols for MYCL Gene

  • MYCL1

Previous GeneCards Identifiers for MYCL Gene

  • GC01M040362

Summaries for MYCL Gene

GeneCards Summary for MYCL Gene

MYCL (V-Myc Avian Myelocytomatosis Viral Oncogene Lung Carcinoma Derived Homolog) is a Protein Coding gene. Diseases associated with MYCL include lower lip cancer and apocrine adenosis of breast. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein dimerization activity. An important paralog of this gene is MYC.

Gene Wiki entry for MYCL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYCL Gene

Genomics for MYCL Gene

Regulatory Elements for MYCL Gene

Promoters for MYCL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYCL on UCSC Golden Path with GeneCards custom track

Genomic Location for MYCL Gene

Chromosome:
1
Start:
39,895,424 bp from pter
End:
39,902,256 bp from pter
Size:
6,833 bases
Orientation:
Minus strand

Genomic View for MYCL Gene

Genes around MYCL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYCL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYCL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYCL Gene

Proteins for MYCL Gene

  • Protein details for MYCL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12524-MYCL_HUMAN
    Recommended name:
    Protein L-Myc
    Protein Accession:
    P12524
    Secondary Accessions:
    • A2A2C9
    • B4DJH2
    • Q14897
    • Q5QPL0
    • Q5QPL1
    • Q9NUE9

    Protein attributes for MYCL Gene

    Size:
    364 amino acids
    Molecular mass:
    40327 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX.
    SequenceCaution:
    • Sequence=AAH11864.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30248.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for MYCL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYCL Gene

Proteomics data for MYCL Gene at MOPED

Post-translational modifications for MYCL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYCL Gene

No data available for DME Specific Peptides for MYCL Gene

Domains & Families for MYCL Gene

Gene Families for MYCL Gene

Graphical View of Domain Structure for InterPro Entry

P12524

UniProtKB/Swiss-Prot:

MYCL_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYCL: view

Function for MYCL Gene

Gene Ontology (GO) - Molecular Function for MYCL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 10597290
GO:0005515 protein binding IEA --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MYCL: view
genes like me logo Genes that share phenotypes with MYCL: view

Animal Models for MYCL Gene

MGI Knock Outs for MYCL:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MYCL Gene

Localization for MYCL Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYCL Gene

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for MYCL Gene

Pathways & Interactions for MYCL Gene

SuperPathways for MYCL Gene

No Data Available

Interacting Proteins for MYCL Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000380494%0d%0a9606.ENSP00000351490%0d%0a9606.ENSP00000264444%0d%0a
Selected Interacting proteins: P12524-MYCL_HUMAN ENSP00000380494 for MYCL Gene via I2D STRING

Gene Ontology (GO) - Biological Process for MYCL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for MYCL Gene

Drugs & Compounds for MYCL Gene

(1) Drugs for MYCL Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for MYCL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MYCL: view

Transcripts for MYCL Gene

Alternative Splicing Database (ASD) splice patterns (SP) for MYCL Gene

No ASD Table

Relevant External Links for MYCL Gene

GeneLoc Exon Structure for
MYCL
ECgene alternative splicing isoforms for
MYCL

Expression for MYCL Gene

mRNA expression in normal human tissues for MYCL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYCL Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x9.8), Skin - Not Sun Exposed (Suprapubic) (x7.9), Pancreas (x5.9), Bladder (x5.3), and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for MYCL Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MYCL Gene



genes like me logo Genes that share expression patterns with MYCL: view

Protein tissue co-expression partners for MYCL Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MYCL Gene

Orthologs for MYCL Gene

This gene was present in the common ancestor of animals.

Orthologs for MYCL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYCL1 35
  • 99.43 (n)
  • 98.86 (a)
MYCL 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYCL 36
  • 76 (a)
OneToOne
MYCL 35
  • 90.27 (n)
  • 90.61 (a)
dog
(Canis familiaris)
Mammalia MYCL 35
  • 90.59 (n)
  • 92.62 (a)
MYCL1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mycl 16
Mycl 35
  • 86.26 (n)
  • 89.56 (a)
Mycl 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYCL 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mycl 35
  • 85.81 (n)
  • 89.84 (a)
chicken
(Gallus gallus)
Aves MYCL1 35
  • 65.89 (n)
  • 61.92 (a)
MYCL 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYCL 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mycl 35
  • 57.11 (n)
  • 56.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mycla 36
  • 38 (a)
OneToMany
myclb 36
  • 42 (a)
OneToMany
myclb 35
  • 59.19 (n)
  • 55.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta dm 36
  • 9 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 9 (a)
OneToMany
Species with no ortholog for MYCL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYCL Gene

ENSEMBL:
Gene Tree for MYCL (if available)
TreeFam:
Gene Tree for MYCL (if available)

Paralogs for MYCL Gene

Paralogs for MYCL Gene

(1) SIMAP similar genes for MYCL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for MYCL Gene

genes like me logo Genes that share paralogs with MYCL: view

Variants for MYCL Gene

Sequence variations from dbSNP and Humsavar for MYCL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_027802 -
rs804719 -- 39,901,920(+) ctcac(A/G)agcgc utr-variant-5-prime
rs3117088 -- 39,903,560(+) TCAGC(C/T)AACCA upstream-variant-2KB
rs3131648 -- 39,903,005(-) AGGAG(A/T)TCGAG upstream-variant-2KB
rs7548524 -- 39,903,233(+) GGTGT(C/T)TGTCT upstream-variant-2KB

Variation tolerance for MYCL Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYCL Gene

HapMap Linkage Disequilibrium report
MYCL
Human Gene Mutation Database (HGMD)
MYCL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MYCL Gene

Disorders for MYCL Gene

MalaCards: The human disease database

(7) MalaCards diseases for MYCL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lower lip cancer
apocrine adenosis of breast
  • apocrine adenosis of the breast
non-proliferative fibrocystic change of the breast
  • non-proliferative fibrocystic change
cerebral primitive neuroectodermal tumor
  • pnet of cerebrum
small cell neuroendocrine carcinoma
  • carcinoma, small cell
- elite association - COSMIC cancer census association via MalaCards
Search MYCL in MalaCards View complete list of genes associated with diseases

Relevant External Links for MYCL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYCL
genes like me logo Genes that share disorders with MYCL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MYCL Gene

Publications for MYCL Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. (PMID: 19020549) Paulson K.G. … Nghiem P. (J. Invest. Dermatol. 2009) 3 23
  3. L-myc polymorphism in head and neck nonmelanoma skin and lower lip cancers. (PMID: 18645122) GAPzA1 A. … Isbir T. (Arch. Otolaryngol. Head Neck Surg. 2008) 3 23
  4. Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas. (PMID: 12707044) Wu R. … Cho K.R. (Am. J. Pathol. 2003) 3 23
  5. MYCL1, FHIT, SPARC, p16(INK4) and TP53 genes associated to lung cancer in idiopathic pulmonary fibrosis. (PMID: 12169206) Demopoulos K. … Spandidos D.A. (J. Cell. Mol. Med. 2002) 3 23

Products for MYCL Gene

Sources for MYCL Gene

Back to Top

Content