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Aliases for MYC Gene

Aliases for MYC Gene

  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 39 3 4
  • Transcription Factor P64 3 4
  • Proto-Oncogene C-Myc 3 4
  • BHLHe39 3 4
  • Myc-Related Translation/Localization Regulatory Factor 3
  • Avian Myelocytomatosis Viral Oncogene Homolog 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 3
  • C-Myc 3
  • MRTL 3
  • MYCC 3

External Ids for MYC Gene

Previous GeneCards Identifiers for MYC Gene

  • GC08P127757
  • GC08P128836
  • GC08P128419
  • GC08P128705
  • GC08P128817
  • GC08P128748
  • GC08P124069

Summaries for MYC Gene

Entrez Gene Summary for MYC Gene

  • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MYC Gene

MYC (V-Myc Avian Myelocytomatosis Viral Oncogene Homolog) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and Myoclonus, Familial Cortical. Among its related pathways are Immune response IL-23 signaling pathway and HTLV-I infection. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYCN.

UniProtKB/Swiss-Prot for MYC Gene

  • Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Gene Wiki entry for MYC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYC Gene

Genomics for MYC Gene

Regulatory Elements for MYC Gene

Enhancers for MYC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MYC on UCSC Golden Path with GeneCards custom track

Promoters for MYC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MYC on UCSC Golden Path with GeneCards custom track

Genomic Location for MYC Gene

127,735,434 bp from pter
127,741,434 bp from pter
6,001 bases
Plus strand

Genomic View for MYC Gene

Genes around MYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYC Gene

Proteins for MYC Gene

  • Protein details for MYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myc proto-oncogene protein
    Protein Accession:
    Secondary Accessions:
    • A8WFE7
    • P01107
    • Q14026

    Protein attributes for MYC Gene

    439 amino acids
    Molecular mass:
    48804 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MYC Gene

    Alternative splice isoforms for MYC Gene


neXtProt entry for MYC Gene

Proteomics data for MYC Gene at MOPED

Post-translational modifications for MYC Gene

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
  • Ubiquitination at Lys 389
  • Glycosylation at Thr 58
  • Modification sites at PhosphoSitePlus

Other Protein References for MYC Gene

No data available for DME Specific Peptides for MYC Gene

Domains & Families for MYC Gene

Gene Families for MYC Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MYC: view

Function for MYC Gene

Molecular function for MYC Gene

GENATLAS Biochemistry:
Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Gene Ontology (GO) - Molecular Function for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10723141
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10723141
genes like me logo Genes that share ontologies with MYC: view

Phenotypes for MYC Gene

MGI mutant phenotypes for MYC:
inferred from 21 alleles
GenomeRNAi human phenotypes for MYC:
genes like me logo Genes that share phenotypes with MYC: view

Human Phenotype Ontology for MYC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYC Gene

MGI Knock Outs for MYC:

Animal Model Products

miRNA for MYC Gene

miRTarBase miRNAs that target MYC

Transcription Factor Targets for MYC Gene

Selected GeneGlobe predicted Target genes for MYC
Targeted motifs for MYC Gene
HOMER Transcription Factor Regulatory Elements motif MYC
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

No data available for Enzyme Numbers (IUBMB) for MYC Gene

Localization for MYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYC Gene

Nucleus, nucleoplasm. Nucleus, nucleolus.

Subcellular locations from

Jensen Localization Image for MYC Gene COMPARTMENTS Subcellular localization image for MYC gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
golgi apparatus 2
mitochondrion 2
peroxisome 2
vacuole 2
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with MYC: view

Pathways & Interactions for MYC Gene

genes like me logo Genes that share pathways with MYC: view

SIGNOR curated interactions for MYC Gene

Gene Ontology (GO) - Biological Process for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002053 positive regulation of mesenchymal cell proliferation ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 10723141
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006879 cellular iron ion homeostasis IDA 9924025
genes like me logo Genes that share ontologies with MYC: view

Drugs & Compounds for MYC Gene

(77) Drugs for MYC Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved Pharma Target, inhibitor 32
10058-F4 Pharma C-Myc-Max dimerization inhibitor, Inhibits c-Myc-Max dimerization 0
Alisertib Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
AVI-4126 Pharma 0

(68) Additional Compounds for MYC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MYC Gene

Compound Action Cas Number
10058-F4 C-Myc-Max dimerization inhibitor 403811-55-2
genes like me logo Genes that share compounds with MYC: view

Transcripts for MYC Gene

Unigene Clusters for MYC Gene

V-myc myelocytomatosis viral oncogene homolog (avian):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3

Relevant External Links for MYC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYC Gene

mRNA expression in normal human tissues for MYC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYC Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.9) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYC Gene

SOURCE GeneReport for Unigene cluster for MYC Gene Hs.202453

genes like me logo Genes that share expression patterns with MYC: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for MYC Gene

Orthologs for MYC Gene

This gene was present in the common ancestor of animals.

Orthologs for MYC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MYC 35
  • 90.21 (n)
  • 92.03 (a)
MYC 36
  • 92 (a)
(Canis familiaris)
Mammalia MYC 35
  • 91 (n)
  • 92.7 (a)
MYC 36
  • 94 (a)
(Mus musculus)
Mammalia Myc 35
  • 87.49 (n)
  • 89.62 (a)
Myc 16
Bmyc 36
  • 54 (a)
(Pan troglodytes)
Mammalia MYC 35
  • 99.71 (n)
  • 99.34 (a)
MYC 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Myc 35
  • 86.87 (n)
  • 89.6 (a)
(Monodelphis domestica)
Mammalia MYC 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia MYC 36
  • 86 (a)
(Gallus gallus)
Aves MYC 35
  • 75.9 (n)
  • 72.54 (a)
MYC 36
  • 68 (a)
(Anolis carolinensis)
Reptilia MYC 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76254 35
MGC76254 35
  • 70.94 (n)
  • 72.25 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52595 35
(Danio rerio)
Actinopterygii -- 35
mycb 35
  • 65.08 (n)
  • 65.08 (a)
myca 36
  • 58 (a)
mycb 36
  • 59 (a)
mych 36
  • 33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11908 35
fruit fly
(Drosophila melanogaster)
Insecta dm 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
Species with no ortholog for MYC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYC Gene

Gene Tree for MYC (if available)
Gene Tree for MYC (if available)

Paralogs for MYC Gene

Paralogs for MYC Gene

genes like me logo Genes that share paralogs with MYC: view

Variants for MYC Gene

Sequence variations from dbSNP and Humsavar for MYC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs4645959 - 127,738,294(+) CAGGA(A/C/G)CTATG reference, missense
rs4645960 - 127,738,740(+) ACAGC(A/C/G/T)GCAGC reference, missense
rs4645961 - 127,738,770(+) ACAGC(A/G)TCTGC reference, missense
rs4645968 - 127,740,603(+) TGCTG(C/T)CAAGA reference, missense
VAR_063384 A Burkitt lymphoma symple

Structural Variations from Database of Genomic Variants (DGV) for MYC Gene

Variant ID Type Subtype PubMed ID
nsv7419 OTHER Inversion 18451855
nsv499795 OTHER Inversion 21111241
esv2752208 CNV Gain 17911159
nsv831458 CNV Loss 17160897
nsv516713 CNV Gain+Loss 19592680

Variation tolerance for MYC Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYC Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYC Gene

Disorders for MYC Gene

MalaCards: The human disease database

(101) MalaCards diseases for MYC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • burkitt's lymphoma
myoclonus, familial cortical
  • familial cortical myoclonus
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
diffuse large b-cell lymphoma
  • large b cell diffuse lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards
Search MYC in MalaCards View complete list of genes associated with diseases


  • Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269 PubMed:2166998, ECO:0000269 PubMed:8220424}. Note=The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
  • Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. {ECO:0000269 PubMed:2069907}.

Genatlas disease for MYC Gene

Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

Relevant External Links for MYC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYC: view

Publications for MYC Gene

  1. Genetic variation in chromosomal translocation breakpoint and immune function genes and risk of non-Hodgkin lymphoma. (PMID: 20087644) Fernberg P. … EkstrAPm Smedby K. (Cancer Causes Control 2010) 3 48 67
  2. c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma. (PMID: 19881537) Scheller H. … Jungnickel B. (Oncogene 2010) 3 23
  3. Overexpression of c-myc induces epithelial mesenchymal transition in mammary epithelial cells. (PMID: 20144848) Cho K.B. … Kang K.W. (Cancer Lett. 2010) 3 23
  4. p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication. (PMID: 20212154) Cannell I.G. … Bushell M. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  5. [Influence of gemcitabine on expression of C-myc gene and its apoptosis-inducing effect on HL-60 cells]. (PMID: 20416159) Gong H.T. … Han X.F. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 23

Products for MYC Gene

Sources for MYC Gene