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Aliases for MYC Gene

Aliases for MYC Gene

  • MYC Proto-Oncogene, BHLH Transcription Factor 2 3
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 2 3 5
  • Class E Basic Helix-Loop-Helix Protein 39 3 4
  • Transcription Factor P64 3 4
  • Proto-Oncogene C-Myc 3 4
  • BHLHe39 3 4
  • Myc-Related Translation/Localization Regulatory Factor 3
  • Avian Myelocytomatosis Viral Oncogene Homolog 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 3
  • Myc Proto-Oncogene Protein 3
  • C-Myc 3
  • MRTL 3
  • MYCC 3

External Ids for MYC Gene

Previous GeneCards Identifiers for MYC Gene

  • GC08P127757
  • GC08P128836
  • GC08P128419
  • GC08P128705
  • GC08P128817
  • GC08P128748
  • GC08P124069

Summaries for MYC Gene

Entrez Gene Summary for MYC Gene

  • The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

CIViC summary for MYC Gene

GeneCards Summary for MYC Gene

MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Development IGF-1 receptor signaling and Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYCN.

UniProtKB/Swiss-Prot for MYC Gene

  • Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Gene Wiki entry for MYC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYC Gene

Genomics for MYC Gene

Regulatory Elements for MYC Gene

Enhancers for MYC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G127806 1.9 FANTOM5 Ensembl ENCODE dbSUPER 18 +75.4 75416 8.6 HDGF PKNOX1 SIN3A YBX1 BRCA1 ZBTB7B GLIS2 GATA2 ZNF207 FOS MYC CASC11 TMEM75 MIR1207 RNU1-106P PVT1 MIR1204 ENSG00000278324
GH08G128171 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +441.0 440950 9.3 CREB3L1 YBX1 FEZF1 DMAP1 YY1 ZNF548 NFYC PPARGC1A MEF2D GLIS1 MIR1208 MIR1207 CASC11 MYC RNU4-25P GC08P128172 GC08P128221
GH08G127758 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +24.7 24749 2.8 HDGF PKNOX1 ATF1 ARNT SIN3A BRCA1 ZNF766 JUNB NCOA1 ZNF579 PVT1 MIR1204 MYC CASC11 TMEM75 MIR1207 RNU4-25P GC08P127744
GH08G128181 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +448.6 448602 5.1 HDGF FOXA2 MLX ZFP64 ARID4B YBX1 DMAP1 ZBTB7B SLC30A9 ZNF766 MIR1208 MIR1207 CASC11 MYC RNU1-106P TMEM75 RNU4-25P GC08P128172 GC08P128221
GH08G127863 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 +132.9 132898 10.2 HDGF PKNOX1 ATF1 ZFP64 SIN3A YBX1 ZBTB7B YY1 ETS1 TCF12 SRRM1P1 MIR1204 PVT1 CASC11 MYC TMEM75 RNU4-25P ENSG00000278324
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYC on UCSC Golden Path with GeneCards custom track

Promoters for MYC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000230571 1467 6200 CREB3L1 AGO1 ZFP64 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for MYC Gene

127,735,434 bp from pter
127,741,434 bp from pter
6,001 bases
Plus strand

Genomic View for MYC Gene

Genes around MYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYC Gene

Proteins for MYC Gene

  • Protein details for MYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Myc proto-oncogene protein
    Protein Accession:
    Secondary Accessions:
    • A8WFE7
    • P01107
    • Q14026

    Protein attributes for MYC Gene

    439 amino acids
    Molecular mass:
    48804 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with NO66. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MYC Gene

    Alternative splice isoforms for MYC Gene


neXtProt entry for MYC Gene

Post-translational modifications for MYC Gene

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
  • Ubiquitination at Lys389
  • Glycosylation at Thr58
  • Modification sites at PhosphoSitePlus

Other Protein References for MYC Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYC (Myc)
  • Abcam antibodies for MYC

Assay Products

  • Cloud-Clone Corp Assay Kits for MYC
  • Abcam assays for MYC

No data available for DME Specific Peptides for MYC Gene

Domains & Families for MYC Gene

No data available for UniProtKB/Swiss-Prot for MYC Gene

Function for MYC Gene

Molecular function for MYC Gene

GENATLAS Biochemistry:
Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Gene Ontology (GO) - Molecular Function for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10723141
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10723141
GO:0003677 DNA binding TAS 10597290
GO:0003690 double-stranded DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA,IEA 9924025
genes like me logo Genes that share ontologies with MYC: view

Phenotypes for MYC Gene

MGI mutant phenotypes for MYC:
inferred from 21 alleles
GenomeRNAi human phenotypes for MYC:
genes like me logo Genes that share phenotypes with MYC: view

Human Phenotype Ontology for MYC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYC Gene

MGI Knock Outs for MYC:

Animal Model Products

miRNA for MYC Gene

miRTarBase miRNAs that target MYC

Transcription Factor Targets for MYC Gene

Selected GeneGlobe predicted Target genes for MYC
Targeted motifs for MYC Gene
HOMER Transcription Factor Regulatory Elements motif MYC
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYC

No data available for Enzyme Numbers (IUBMB) for MYC Gene

Localization for MYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYC Gene

Nucleus, nucleoplasm. Nucleus, nucleolus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYC gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
golgi apparatus 2
endosome 2
lysosome 1

Gene Ontology (GO) - Cellular Components for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 11793365
GO:0005654 nucleoplasm IDA,TAS --
GO:0005730 nucleolus IDA,IEA 17558397
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MYC: view

Pathways & Interactions for MYC Gene

genes like me logo Genes that share pathways with MYC: view

Pathways by source for MYC Gene

SIGNOR curated interactions for MYC Gene

Gene Ontology (GO) - Biological Process for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9924025
GO:0000165 MAPK cascade IMP 17873522
GO:0000320 re-entry into mitotic cell cycle IEA --
GO:0001541 ovarian follicle development IEA --
genes like me logo Genes that share ontologies with MYC: view

Drugs & Compounds for MYC Gene

(78) Drugs for MYC Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved Pharma Target, inhibitor 35
10058-F4 Pharma C-Myc-Max dimerization inhibitor 0
Alisertib Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0
AVI-4126 Pharma 0

(67) Additional Compounds for MYC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MYC Gene

Compound Action Cas Number
10058-F4 C-Myc-Max dimerization inhibitor 403811-55-2
genes like me logo Genes that share compounds with MYC: view

Drug Products

Transcripts for MYC Gene

Unigene Clusters for MYC Gene

V-myc myelocytomatosis viral oncogene homolog (avian):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYC

Alternative Splicing Database (ASD) splice patterns (SP) for MYC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3

Relevant External Links for MYC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYC Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.9) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYC Gene

NURSA nuclear receptor signaling pathways regulating expression of MYC Gene:


SOURCE GeneReport for Unigene cluster for MYC Gene:


Evidence on tissue expression from TISSUES for MYC Gene

  • Nervous system(4.2)
  • Intestine(3.8)
  • Blood(3.7)
  • Liver(3.4)
  • Bone marrow(3.2)
  • Muscle(3.2)
  • Lymph node(3.1)
  • Skin(3.1)
  • Lung(3)
  • Stomach(2.9)
  • Kidney(2.8)
  • Pancreas(2.8)
  • Spleen(2.7)
  • Heart(2.6)
  • Adrenal gland(2.4)
  • Thyroid gland(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MYC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • digestive
  • immune
  • lymphatic
  • nervous
  • reproductive
  • skeleton
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • skull
  • intestine
  • ovary
  • pelvis
  • testicle
  • blood
  • bone marrow
  • lymph node
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MYC: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYC Gene

Orthologs for MYC Gene

This gene was present in the common ancestor of animals.

Orthologs for MYC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MYC 34 35
  • 99.71 (n)
(Canis familiaris)
Mammalia MYC 34 35
  • 91 (n)
(Bos Taurus)
Mammalia MYC 34 35
  • 90.21 (n)
(Mus musculus)
Mammalia Myc 34 16
  • 87.49 (n)
Bmyc 35
  • 54 (a)
(Rattus norvegicus)
Mammalia Myc 34
  • 86.87 (n)
(Ornithorhynchus anatinus)
Mammalia MYC 35
  • 86 (a)
(Monodelphis domestica)
Mammalia MYC 35
  • 71 (a)
(Gallus gallus)
Aves MYC 34 35
  • 75.9 (n)
(Anolis carolinensis)
Reptilia MYC 35
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76254 34 34
  • 70.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52595 34
(Danio rerio)
Actinopterygii mycb 34 35
  • 65.08 (n)
myca 35
  • 58 (a)
mych 35
  • 33 (a)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11908 34
fruit fly
(Drosophila melanogaster)
Insecta dm 35
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 11 (a)
Species where no ortholog for MYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYC Gene

Gene Tree for MYC (if available)
Gene Tree for MYC (if available)

Paralogs for MYC Gene

Paralogs for MYC Gene

genes like me logo Genes that share paralogs with MYC: view

Variants for MYC Gene

Sequence variations from dbSNP and Humsavar for MYC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs121918683 Pathogenic, A Burkitt lymphoma sample 127,738,519(+) AGACA(A/C)CGACG reference, missense
rs121918684 Pathogenic, A Burkitt lymphoma symple 127,738,379(+) AGCGA(C/G)CTGCA reference, missense
rs121918685 Pathogenic, A Burkitt lymphoma sample 127,738,437(+) CCACC(C/G)CGCCC reference, missense
rs28933407 Pathogenic, A Burkitt lymphoma sample 127,738,431(+) TGCTG(C/T)CCACC reference, missense
rs1000054901 -- 127,739,330(+) TTTTA(A/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYC Gene

Variant ID Type Subtype PubMed ID
esv2752208 CNV gain 17911159
esv3618781 CNV gain 21293372
nsv499795 OTHER inversion 21111241
nsv516713 CNV gain+loss 19592680
nsv7419 OTHER inversion 18451855
nsv831458 CNV loss 17160897

Variation tolerance for MYC Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYC Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYC Gene

Disorders for MYC Gene

MalaCards: The human disease database

(107) MalaCards diseases for MYC Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • burkitt's lymphoma
precursor t-cell acute lymphoblastic leukemia
  • t-all
diffuse large b-cell lymphoma
  • dlbcl
childhood medulloblastoma
  • pediatric medulloblastoma
primary effusion lymphoma
  • aids-related lymphoma
- elite association - COSMIC cancer census association via MalaCards
Search MYC in MalaCards View complete list of genes associated with diseases


  • Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269 PubMed:2166998, ECO:0000269 PubMed:8220424}. Note=The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
  • Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. {ECO:0000269 PubMed:2069907}.

Genatlas disease for MYC Gene

Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

Relevant External Links for MYC

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MYC: view

Publications for MYC Gene

  1. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. (PMID: 1597196) Iijima S. … Tsukada K. (Eur. J. Biochem. 1992) 3 4 22 64
  2. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N. … Yoshida K. (J. Clin. Invest. 2012) 3 4 64
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  4. Genetic heterogeneity in colorectal cancer associations between African and European americans. (PMID: 20659471) Kupfer S.S. … Ellis N.A. (Gastroenterology 2010) 3 46 64
  5. c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma. (PMID: 19881537) Scheller H. … Jungnickel B. (Oncogene 2010) 3 22 64

Products for MYC Gene

  • Addgene plasmids for MYC

Sources for MYC Gene