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Aliases for MYC Gene

Aliases for MYC Gene

  • MYC Proto-Oncogene, BHLH Transcription Factor 2 3 5
  • V-Myc Avian Myelocytomatosis Viral Oncogene Homolog 2 3
  • Class E Basic Helix-Loop-Helix Protein 39 3 4
  • Transcription Factor P64 3 4
  • Proto-Oncogene C-Myc 3 4
  • BHLHe39 3 4
  • Myc-Related Translation/Localization Regulatory Factor 3
  • Avian Myelocytomatosis Viral Oncogene Homolog 3
  • V-Myc Myelocytomatosis Viral Oncogene Homolog 3
  • Myc Proto-Oncogene Protein 3
  • C-Myc 3
  • MRTL 3
  • MYCC 3

External Ids for MYC Gene

Previous GeneCards Identifiers for MYC Gene

  • GC08P127757
  • GC08P128836
  • GC08P128419
  • GC08P128705
  • GC08P128817
  • GC08P128748
  • GC08P124069

Summaries for MYC Gene

Entrez Gene Summary for MYC Gene

  • This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

CIViC summary for MYC Gene

GeneCards Summary for MYC Gene

MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphoma and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and IL-2 Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYCN.

UniProtKB/Swiss-Prot for MYC Gene

  • Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Gene Wiki entry for MYC Gene

Additional gene information for MYC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYC Gene

Genomics for MYC Gene

Regulatory Elements for MYC Gene

Enhancers for MYC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H128181 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.4 +448.6 448602 5 HDGF FOXA2 ATF1 MLX ZFP64 ARID4B YBX1 DMAP1 ZBTB7B TCF12 MYC MIR1208 MIR1207 CASC11 RNU1-106P TMEM75 RNU4-25P GC08P128172 GC08P128221
GH08H127806 1.8 FANTOM5 Ensembl ENCODE dbSUPER 18 +75.4 75416 8 HDGF PKNOX1 SIN3A YBX1 BRCA1 ZBTB7B GLIS2 ZNF207 FOS REST MYC SRRM1P1 CASC11 TMEM75 MIR1207 RNU1-106P PVT1 MIR1204 ENSG00000278324
GH08H127895 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.2 +163.4 163354 5 HNRNPUL1 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF766 CBX5 ZNF207 SRRM1P1 RNU1-106P MYC ENSG00000278324 TMEM75
GH08H128171 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +441.0 440950 9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A YBX1 FEZF1 DMAP1 ZBTB7B MIR1208 MIR1207 CASC11 MYC RNU4-25P GC08P128172 GC08P128221
GH08H127758 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +24.7 24749 2 HDAC1 TBP HDGF PKNOX1 ATF1 NFIB ARNT SIN3A ZBTB40 BRCA1 PVT1 MIR1204 MYC CASC11 TMEM75 MIR1207 RNU4-25P GC08P127744
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MYC on UCSC Golden Path with GeneCards custom track

Promoters for MYC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000230571 1467 6200 HNRNPUL1 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B

Genomic Location for MYC Gene

Chromosome:
8
Start:
127,735,434 bp from pter
End:
127,741,434 bp from pter
Size:
6,001 bases
Orientation:
Plus strand

Genomic View for MYC Gene

Genes around MYC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MYC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MYC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYC Gene

Proteins for MYC Gene

  • Protein details for MYC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01106-MYC_HUMAN
    Recommended name:
    Myc proto-oncogene protein
    Protein Accession:
    P01106
    Secondary Accessions:
    • A8WFE7
    • P01107
    • Q14026

    Protein attributes for MYC Gene

    Size:
    439 amino acids
    Molecular mass:
    48804 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B. Interacts (when phosphorylated at Thr-58 and Ser-62) with FBXW7. Interacts with PIM2. Interacts with RIOX1. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity. Interacts with TRIM6 (By similarity). Interacts with NPM1; the binary complex is recruited to the promoter of MYC target genes and enhances their transcription (PubMed:25956029).

    Three dimensional structures from OCA and Proteopedia for MYC Gene

    Alternative splice isoforms for MYC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYC Gene

Post-translational modifications for MYC Gene

  • Phosphorylated by PRKDC. Phosphorylation at Ser-329 by PIM2 leads to the stabilization of MYC (By similarity). Phosphorylation at Ser-62 by CDK2 prevents Ras-induced senescence. Phosphorylated at Ser-62 by DYRK2; this primes the protein for subsequent phosphorylation by GSK3B at Thr-58. Phosphorylation at Thr-58 and Ser-62 by GSK3 is required for ubiquitination and degradation by the proteasome.
  • Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degradation. In the nucleolus, however, ubiquitination is not counteracted by USP28, due to the lack of interaction between isoform 4 of FBXW7 (FBW7gamma) and USP28, explaining the selective MYC degradation in the nucleolus. Also polyubiquitinated by the DCX(TRUSS) complex. Ubiquitinated by TRIM6 in a phosphorylation-independent manner (By similarity).
  • Ubiquitination at Lys389
  • Glycosylation at posLast=5858
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MYC (Myc)
  • Abcam antibodies for MYC

No data available for DME Specific Peptides for MYC Gene

Domains & Families for MYC Gene

Gene Families for MYC Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MYC: view

No data available for UniProtKB/Swiss-Prot for MYC Gene

Function for MYC Gene

Molecular function for MYC Gene

GENATLAS Biochemistry:
Avian myelocytomatosis viral (v-myc). Oncogene homolog,erythropoietin early response gene,interacting with various cellular factors including MAX,YY1,AMPHL, for binding E box recognition sites,stimulating genes required for proliferation,also inducing apoptosis in sensitive cells,involved in lymphomagenesis (diffuse large B cell lymphoma)
UniProtKB/Swiss-Prot Function:
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5-CAC[GA]TG-3. Activates the transcription of growth-related genes.

Phenotypes From GWAS Catalog for MYC Gene

Gene Ontology (GO) - Molecular Function for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10723141
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP 25956029
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 10723141
GO:0003677 DNA binding TAS 10597290
GO:0003700 transcription factor activity, sequence-specific DNA binding IDA 9924025
genes like me logo Genes that share ontologies with MYC: view

Phenotypes for MYC Gene

MGI mutant phenotypes for MYC:
inferred from 21 alleles
GenomeRNAi human phenotypes for MYC:
genes like me logo Genes that share phenotypes with MYC: view

Human Phenotype Ontology for MYC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MYC Gene

MGI Knock Outs for MYC:

Animal Model Products

CRISPR Products

miRNA for MYC Gene

miRTarBase miRNAs that target MYC

Transcription Factor Targets for MYC Gene

Selected GeneGlobe predicted Target genes for MYC
Targeted motifs for MYC Gene
HOMER Transcription Factor Regulatory Elements motif MYC
  • Consensus sequence: GNCCACGTGG Submotif: canonical Cell Type: mES GEO ID: GSE11431

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYC
  • Applied Biological Materials Clones for MYC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) for MYC Gene

Localization for MYC Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYC Gene

Nucleus, nucleoplasm. Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MYC gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
golgi apparatus 2
endosome 2
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IMP 12837246
GO:0005634 nucleus IDA,TAS 11793365
GO:0005635 nuclear envelope IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA,IEA 17558397
genes like me logo Genes that share ontologies with MYC: view

Pathways & Interactions for MYC Gene

genes like me logo Genes that share pathways with MYC: view

Pathways by source for MYC Gene

SIGNOR curated interactions for MYC Gene

Gene Ontology (GO) - Biological Process for MYC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9924025
GO:0000165 MAPK cascade IMP 17873522
GO:0001658 branching involved in ureteric bud morphogenesis ISS --
GO:0002053 positive regulation of mesenchymal cell proliferation ISS --
genes like me logo Genes that share ontologies with MYC: view

Drugs & Compounds for MYC Gene

(78) Drugs for MYC Gene - From: DrugBank, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nadroparin Approved Pharma Target, inhibitor 35
Alisertib Investigational Pharma inhibitor, Biomarker Aurora A kinase inhibitor, AURKA Inhibitors, Kinase Inhibitors 0
Dinaciclib Investigational Pharma inhibitor, Biomarker CDK inhibitor, CDK2 Inhibitors, Kinase Inhibitors 0
10058-F4 Pharma C-Myc-Max dimerization inhibitor 0
AMG900 Pharma Biomarker, inhibitor AURKA Inhibitors, Kinase Inhibitors, Inhibitors of mitosis Aurora kinase inhibitors 0

(67) Additional Compounds for MYC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for MYC Gene

Compound Action Cas Number
10058-F4 C-Myc-Max dimerization inhibitor 403811-55-2
genes like me logo Genes that share compounds with MYC: view

Drug Products

Transcripts for MYC Gene

Unigene Clusters for MYC Gene

V-myc myelocytomatosis viral oncogene homolog (avian):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for MYC
  • Applied Biological Materials Clones for MYC
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MYC Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3
SP1:
SP2:

Relevant External Links for MYC Gene

GeneLoc Exon Structure for
MYC
ECgene alternative splicing isoforms for
MYC

Expression for MYC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MYC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYC Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x4.9) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MYC Gene



NURSA nuclear receptor signaling pathways regulating expression of MYC Gene:

MYC

SOURCE GeneReport for Unigene cluster for MYC Gene:

Hs.202453

Evidence on tissue expression from TISSUES for MYC Gene

  • Nervous system(4.2)
  • Intestine(3.8)
  • Blood(3.7)
  • Liver(3.5)
  • Bone marrow(3.2)
  • Muscle(3.2)
  • Lymph node(3.1)
  • Skin(3.1)
  • Lung(3)
  • Stomach(2.9)
  • Kidney(2.8)
  • Pancreas(2.8)
  • Heart(2.7)
  • Spleen(2.7)
  • Adrenal gland(2.4)
  • Thyroid gland(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for MYC Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • digestive
  • immune
  • lymphatic
  • nervous
  • reproductive
  • skeleton
Organs:
Head and neck:
  • brain
  • head
  • jaw
  • mandible
  • skull
Abdomen:
  • intestine
Pelvis:
  • ovary
  • pelvis
  • testicle
General:
  • blood
  • bone marrow
  • lymph node
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MYC: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for MYC Gene

Orthologs for MYC Gene

This gene was present in the common ancestor of animals.

Orthologs for MYC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYC 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia MYC 33 34
  • 91 (n)
cow
(Bos Taurus)
Mammalia MYC 33 34
  • 90.21 (n)
mouse
(Mus musculus)
Mammalia Myc 33 16
  • 87.49 (n)
Bmyc 34
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myc 33
  • 86.87 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MYC 34
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYC 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves MYC 33 34
  • 75.9 (n)
lizard
(Anolis carolinensis)
Reptilia MYC 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76254 33 33
  • 70.94 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC52595 33
zebrafish
(Danio rerio)
Actinopterygii mycb 33 34
  • 65.08 (n)
myca 34
  • 58 (a)
OneToMany
mych 34
  • 33 (a)
OneToMany
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11908 33
fruit fly
(Drosophila melanogaster)
Insecta dm 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 11 (a)
OneToMany
Species where no ortholog for MYC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYC Gene

ENSEMBL:
Gene Tree for MYC (if available)
TreeFam:
Gene Tree for MYC (if available)

Paralogs for MYC Gene

Paralogs for MYC Gene

genes like me logo Genes that share paralogs with MYC: view

Variants for MYC Gene

Sequence variations from dbSNP and Humsavar for MYC Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs121918683 Pathogenic, A Burkitt lymphoma sample 127,738,519(+) AGACA(A/C)CGACG reference, missense
rs121918684 Pathogenic, A Burkitt lymphoma symple 127,738,379(+) AGCGA(C/G)CTGCA reference, missense
rs121918685 Pathogenic, A Burkitt lymphoma sample 127,738,437(+) CCACC(C/G)CGCCC reference, missense
rs28933407 Pathogenic, A Burkitt lymphoma sample 127,738,431(+) TGCTG(C/T)CCACC reference, missense
rs1000054901 -- 127,739,330(+) TTTTA(A/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYC Gene

Variant ID Type Subtype PubMed ID
esv2752208 CNV gain 17911159
esv3618781 CNV gain 21293372
nsv499795 OTHER inversion 21111241
nsv516713 CNV gain+loss 19592680
nsv7419 OTHER inversion 18451855
nsv831458 CNV loss 17160897

Variation tolerance for MYC Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.26; 52.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MYC Gene

Human Gene Mutation Database (HGMD)
MYC
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MYC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYC Gene

Disorders for MYC Gene

MalaCards: The human disease database

(107) MalaCards diseases for MYC Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
burkitt lymphoma
  • burkitt's lymphoma
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
lymphoma
  • lymphoid cancer
childhood medulloblastoma
  • pediatric medulloblastoma
diffuse large b-cell lymphoma
  • dlbcl
- elite association - COSMIC cancer census association via MalaCards
Search MYC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MYC_HUMAN
  • Burkitt lymphoma (BL) [MIM:113970]: A form of undifferentiated malignant lymphoma commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. {ECO:0000269 PubMed:2166998, ECO:0000269 PubMed:8220424}. Note=The gene represented in this entry is involved in disease pathogenesis. Chromosomal aberrations involving MYC are usually found in Burkitt lymphoma. Translocations t(8;14), t(8;22) or t(2;8) which juxtapose MYC to one of the heavy or light chain immunoglobulin gene loci.
  • Note=A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1. {ECO:0000269 PubMed:2069907}.

Genatlas disease for MYC Gene

Burkitt lymphoma/acute lymphoblastic leukemia,B cell,with translocations t(8;14)(q24;q32),t(2;8)(p12;q24),t(8;22)(q24;q11); (see also BVR1,PVT1)

Relevant External Links for MYC

Genetic Association Database (GAD)
MYC
Human Genome Epidemiology (HuGE) Navigator
MYC
Tumor Gene Database (TGDB):
MYC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MYC
genes like me logo Genes that share disorders with MYC: view

Publications for MYC Gene

  1. DNA-activated protein kinase in Raji Burkitt's lymphoma cells. Phosphorylation of c-Myc oncoprotein. (PMID: 1597196) Iijima S … Tsukada K (European journal of biochemistry 1992) 3 4 22 60
  2. The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis. (PMID: 25956029) Kim JY … Park JH (The American journal of pathology 2015) 3 4 60
  3. DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells. (PMID: 22307329) Taira N … Yoshida K (The Journal of clinical investigation 2012) 3 4 60
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 45 60
  5. A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24. (PMID: 20852632) Goode EL … Ovarian Cancer Association Consortium (OCAC) (Nature genetics 2010) 3 45 60

Products for MYC Gene

  • Addgene plasmids for MYC