Aliases for MYBL2 Gene
External Ids for MYBL2 Gene
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for MYBL2 Gene
MYBL2 (V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2) is a Protein Coding gene. Diseases associated with MYBL2 include cerebellar degeneration and neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MYBL1.
UniProtKB/Swiss-Prot for MYBL2 Gene
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.