Aliases for MYBL2 Gene
External Ids for MYBL2 Gene
Previous GeneCards Identifiers for MYBL2 Gene
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for MYBL2 Gene
MYBL2 (V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2) is a Protein Coding gene. Diseases associated with MYBL2 include paraneoplastic cerebellar degeneration. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is MYBL1.
UniProtKB/Swiss-Prot for MYBL2 Gene
Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.