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Aliases for MYBL2 Gene

Aliases for MYBL2 Gene

  • V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2 2 3
  • BMYB 3 4 6
  • Myb-Like Protein 2 3 4
  • B-MYB 3 4
  • V-Myb Myeloblastosis Viral Oncogene Homolog-Like 2 3
  • Myb-Related Protein B 3

External Ids for MYBL2 Gene

Summaries for MYBL2 Gene

Entrez Gene Summary for MYBL2 Gene

  • The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for MYBL2 Gene

MYBL2 (V-Myb Avian Myeloblastosis Viral Oncogene Homolog-Like 2) is a Protein Coding gene. Diseases associated with MYBL2 include cerebellar degeneration and neuroblastoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and chromatin binding. An important paralog of this gene is MYBL1.

UniProtKB/Swiss-Prot for MYBL2 Gene

  • Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Gene Wiki entry for MYBL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MYBL2 Gene

Genomics for MYBL2 Gene

Genomic Location for MYBL2 Gene

Start:
43,667,019 bp from pter
End:
43,716,496 bp from pter
Size:
49,478 bases
Orientation:
Plus strand

Genomic View for MYBL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MYBL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MYBL2 Gene

Regulatory Elements for MYBL2 Gene

Proteins for MYBL2 Gene

  • Protein details for MYBL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10244-MYBB_HUMAN
    Recommended name:
    Myb-related protein B
    Protein Accession:
    P10244
    Secondary Accessions:
    • B2RBS5
    • B7Z8D9
    • F8W6N6
    • Q53F07

    Protein attributes for MYBL2 Gene

    Size:
    700 amino acids
    Molecular mass:
    78764 Da
    Quaternary structure:
    • Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.

    Alternative splice isoforms for MYBL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MYBL2 Gene

Proteomics data for MYBL2 Gene at MOPED

Post-translational modifications for MYBL2 Gene

  • Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MYBL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MYBL2 Gene

Domains for MYBL2 Gene

Protein Domains for MYBL2 Gene

Suggested Antigen Peptide Sequences for MYBL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10244

UniProtKB/Swiss-Prot:

MYBB_HUMAN
Domain:
  • Contains 3 HTH myb-type DNA-binding domains.:
    • P10244
genes like me logo Genes that share domains with MYBL2: view

No data available for Gene Families for MYBL2 Gene

Function for MYBL2 Gene

Molecular function for MYBL2 Gene

GENATLAS Biochemistry: avian myeloblastosis viral (v-myb) oncogene homolog-like 2
UniProtKB/Swiss-Prot Function: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.

Gene Ontology (GO) - Molecular Function for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10770937
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 10770937
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 10770937
genes like me logo Genes that share ontologies with MYBL2: view
genes like me logo Genes that share phenotypes with MYBL2: view

Animal Models for MYBL2 Gene

MGI Knock Outs for MYBL2:

miRNA for MYBL2 Gene

Targeting motifs for MYBL2 Gene
HOMER Transcription Factor Regulatory Elements motif MYBL2
  • Consensus sequence: NHAACBGYYV Submotif: canonical Cell Type: Hela GeoId: GSE27030

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for MYBL2 Gene

Localization for MYBL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MYBL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MYBL2 Gene COMPARTMENTS Subcellular localization image for MYBL2 gene
Compartment Confidence
nucleus 5
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0031523 Myb complex IEA --
genes like me logo Genes that share ontologies with MYBL2: view

Pathways for MYBL2 Gene

genes like me logo Genes that share pathways with MYBL2: view

Pathways by source for MYBL2 Gene

1 KEGG pathway for MYBL2 Gene

Gene Ontology (GO) - Biological Process for MYBL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 10770937
GO:0051726 regulation of cell cycle TAS --
genes like me logo Genes that share ontologies with MYBL2: view

Compounds for MYBL2 Gene

(9) Novoseek inferred chemical compound relationships for MYBL2 Gene

Compound -log(P) Hits PubMed IDs
thymidine 22.1 3
dihydrofolate 20.1 1
thymidylate 17.8 1
retinoic acid 13.5 4
chloramphenicol 1.35 3
genes like me logo Genes that share compounds with MYBL2: view

Transcripts for MYBL2 Gene

mRNA/cDNA for MYBL2 Gene

Unigene Clusters for MYBL2 Gene

V-myb myeloblastosis viral oncogene homolog (avian)-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MYBL2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16a ·
SP1: - - - - - - - -
SP2: - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - -
SP7: - - -
SP8: -
SP9: - - -
SP10: -
SP11: - - -
SP12:
SP13:

ExUns: 16b · 16c ^ 17a · 17b
SP1: -
SP2:
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12:
SP13:

Relevant External Links for MYBL2 Gene

GeneLoc Exon Structure for
MYBL2
ECgene alternative splicing isoforms for
MYBL2

Expression for MYBL2 Gene

mRNA expression in normal human tissues for MYBL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MYBL2 Gene

This gene is overexpressed in Spleen (6.2), Testis (4.4), and Whole Blood (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MYBL2 Gene

SOURCE GeneReport for Unigene cluster for MYBL2 Gene Hs.179718

genes like me logo Genes that share expressions with MYBL2: view

No data available for mRNA Expression by UniProt/SwissProt for MYBL2 Gene

Orthologs for MYBL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MYBL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MYBL2 35
  • 96.71 (n)
  • 96 (a)
MYBL2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MYBL2 35
  • 87.48 (n)
  • 88.63 (a)
MYBL2 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MYBL2 35
  • 88.59 (n)
  • 90.97 (a)
MYBL2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mybl2 35
  • 84.24 (n)
  • 85.82 (a)
Mybl2 16
Mybl2 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MYBL2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Mybl2 35
  • 85.1 (n)
  • 88.54 (a)
chicken
(Gallus gallus)
Aves MYBL2 35
  • 72.57 (n)
  • 74.34 (a)
MYBL2 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MYBL2 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia myb1 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mybl2 35
  • 63.11 (n)
  • 63.31 (a)
Str.10235 35
zebrafish
(Danio rerio)
Actinopterygii mybl2 35
  • 74.96 (n)
  • 73.02 (a)
mybl2 36
  • 55 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Myb 36
  • 28 (a)
OneToMany
Myb 37
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BAS1 36
  • 15 (a)
OneToMany
Species with no ortholog for MYBL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MYBL2 Gene

ENSEMBL:
Gene Tree for MYBL2 (if available)
TreeFam:
Gene Tree for MYBL2 (if available)

Paralogs for MYBL2 Gene

Paralogs for MYBL2 Gene

Selected SIMAP similar genes for MYBL2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for MYBL2 Gene

genes like me logo Genes that share paralogs with MYBL2: view

Variants for MYBL2 Gene

Sequence variations from dbSNP and Humsavar for MYBL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs7660 - 43,713,065(+) AGGAT(A/G)TGAAG missense, reference
rs166941 -- 43,714,387(+) CAAAG(C/G)CAACG intron-variant
rs166942 -- 43,690,876(+) ACCGC(A/G)CCTGA intron-variant
rs169551 -- 43,714,730(+) GGTTC(A/G)CACCA intron-variant
rs184032 -- 43,698,240(+) gtttt(A/G)tagag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MYBL2 Gene

Variant ID Type Subtype PubMed ID
nsv3385 CNV Loss 18451855
esv2606313 CNV Insertion 19546169
esv259941 OTHER Complex 20981092
nsv180297 CNV Loss 16902084

Relevant External Links for MYBL2 Gene

HapMap Linkage Disequilibrium report
MYBL2
Human Gene Mutation Database (HGMD)
MYBL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MYBL2 Gene

Disorders for MYBL2 Gene

(1) University of Copenhagen DISEASES for MYBL2 Gene

(8) Novoseek inferred disease relationships for MYBL2 Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 51.5 8
tumors 9.53 15
cervical carcinoma 9.21 1
osteosarcoma 1 1
leukemia 0 1

Relevant External Links for MYBL2

Genetic Association Database (GAD)
MYBL2
Human Genome Epidemiology (HuGE) Navigator
MYBL2
genes like me logo Genes that share disorders with MYBL2: view

No data available for UniProtKB/Swiss-Prot for MYBL2 Gene

Publications for MYBL2 Gene

  1. Mybl2 (Bmyb) maps to mouse chromosome 2 and human chromosome 20q 13.1. (PMID: 8812502) Noben-Trauth K. … Klempnauer K.H. (Genomics 1996) 2 3 23
  2. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. (PMID: 10095772) Bartsch O. … Ferrari S. (Eur. J. Biochem. 1999) 3 4 23
  3. The cell-cycle regulated transcription factor B-Myb is phosphorylated by cyclin A/Cdk2 at sites that enhance its transactivation properties. (PMID: 9840932) Saville M.K. … Watson R.J. (Oncogene 1998) 3 4 23
  4. Phosphorylation of B-Myb regulates its transactivation potential and DNA binding. (PMID: 10593981) Johnson T.K. … Lewis R.E. (J. Biol. Chem. 1999) 3 23
  5. Regulation of B-Myb activity by cyclin D1. (PMID: 10645009) Horstmann S. … Klempnauer K.H. (Oncogene 2000) 3 23

Products for MYBL2 Gene

  • Addgene plasmids for MYBL2

Sources for MYBL2 Gene

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