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Aliases for MXI1 Gene

Aliases for MXI1 Gene

  • MAX Interactor 1, Dimerization Protein 2 3 5
  • Class C Basic Helix-Loop-Helix Protein 11 3 4
  • BHLHc11 3 4
  • Max-Related Transcription Factor 3
  • MAX Dimerization Protein 2 3
  • MAX Interacting Protein 1 2
  • MAX Interactor 1 2
  • Max Interactor 1 4
  • MAD2 3
  • MXD2 3
  • MXI 3

External Ids for MXI1 Gene

Previous GeneCards Identifiers for MXI1 Gene

  • GC10P110863
  • GC10P111203
  • GC10P112098
  • GC10P111631
  • GC10P111957
  • GC10P105597

Summaries for MXI1 Gene

Entrez Gene Summary for MXI1 Gene

  • Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

GeneCards Summary for MXI1 Gene

MXI1 (MAX Interactor 1, Dimerization Protein) is a Protein Coding gene. Diseases associated with MXI1 include Prostate Cancer. GO annotations related to this gene include protein dimerization activity and transcription corepressor activity. An important paralog of this gene is MXD1.

UniProtKB/Swiss-Prot for MXI1 Gene

  • Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Gene Wiki entry for MXI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXI1 Gene

Genomics for MXI1 Gene

Regulatory Elements for MXI1 Gene

Enhancers for MXI1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MXI1 on UCSC Golden Path with GeneCards custom track

Promoters for MXI1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MXI1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MXI1 Gene

110,207,605 bp from pter
110,287,365 bp from pter
79,761 bases
Plus strand

Genomic View for MXI1 Gene

Genes around MXI1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MXI1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MXI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXI1 Gene

Proteins for MXI1 Gene

  • Protein details for MXI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Max-interacting protein 1
    Protein Accession:
    Secondary Accessions:
    • B1ANN7
    • D3DR25
    • D3DRA9
    • Q15887
    • Q6FHW2
    • Q96E53

    Protein attributes for MXI1 Gene

    228 amino acids
    Molecular mass:
    26062 Da
    Quaternary structure:
    • Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity).

    Alternative splice isoforms for MXI1 Gene


neXtProt entry for MXI1 Gene

Proteomics data for MXI1 Gene at MOPED

Post-translational modifications for MXI1 Gene

  • Ubiquitination at Lys 125
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for MXI1

No data available for DME Specific Peptides for MXI1 Gene

Domains & Families for MXI1 Gene

Protein Domains for MXI1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MXI1: view

Function for MXI1 Gene

Molecular function for MXI1 Gene

GENATLAS Biochemistry:
Max interactor 1,key component of the mitotic checkpoint,induced during terminal differentiation,interacting with Max to bind Myc-Max recognition E box sites through interaction between the N terminus and SIN3 corepressor,antagonizing MYC dependent activation and repressing the c-Myc promoter P2,MYC family (see TSG10A),commonly mutated or deleted in prostate carcinoma
UniProtKB/Swiss-Prot Function:
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.

Gene Ontology (GO) - Molecular Function for MXI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MXI1: view
genes like me logo Genes that share phenotypes with MXI1: view

Animal Models for MXI1 Gene

MGI Knock Outs for MXI1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MXI1 Gene

Localization for MXI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXI1 Gene

Subcellular locations from

Jensen Localization Image for MXI1 Gene COMPARTMENTS Subcellular localization image for MXI1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 2
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MXI1 Gene

Pathways & Interactions for MXI1 Gene

SuperPathways for MXI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MXI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042994 cytoplasmic sequestering of transcription factor TAS 8425219
GO:1903507 negative regulation of nucleic acid-templated transcription TAS 8425219
genes like me logo Genes that share ontologies with MXI1: view

No data available for Pathways by source and SIGNOR curated interactions for MXI1 Gene

Drugs & Compounds for MXI1 Gene

(2) Drugs for MXI1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MXI1: view

Transcripts for MXI1 Gene

Unigene Clusters for MXI1 Gene

MAX interactor 1, dimerization protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MXI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - - - -
SP5: - - - -
SP6: - - -

Relevant External Links for MXI1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MXI1 Gene

mRNA expression in normal human tissues for MXI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MXI1 Gene

This gene is overexpressed in Fetal gut (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MXI1 Gene

SOURCE GeneReport for Unigene cluster for MXI1 Gene Hs.728542

mRNA Expression by UniProt/SwissProt for MXI1 Gene

Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
genes like me logo Genes that share expression patterns with MXI1: view

Protein tissue co-expression partners for MXI1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for MXI1 Gene

Orthologs for MXI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MXI1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MXI1 35
  • 95.76 (n)
  • 95.53 (a)
MXI1 36
  • 98 (a)
(Canis familiaris)
Mammalia MXI1 35
  • 94.85 (n)
  • 94.85 (a)
MXI1 36
  • 97 (a)
(Mus musculus)
Mammalia Mxi1 35
  • 92.43 (n)
  • 95.25 (a)
Mxi1 16
Mxi1 36
  • 95 (a)
(Pan troglodytes)
Mammalia MXI1 35
  • 96.95 (n)
  • 95.8 (a)
MXI1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Mxi1 35
  • 91.4 (n)
  • 96.38 (a)
(Monodelphis domestica)
Mammalia MXI1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia MXI1 36
  • 80 (a)
(Gallus gallus)
Aves MXI1 35
  • 82.32 (n)
  • 85.23 (a)
MXI1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia MXI1 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mxi1 35
  • 67.12 (n)
  • 70.4 (a)
Str.6117 35
(Danio rerio)
Actinopterygii mxi1 35
  • 67.52 (n)
  • 70.51 (a)
mxi1 36
  • 61 (a)
(Caenorhabditis elegans)
Secernentea mdl-1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 36
  • 37 (a)
Species with no ortholog for MXI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MXI1 Gene

Gene Tree for MXI1 (if available)
Gene Tree for MXI1 (if available)

Paralogs for MXI1 Gene

Paralogs for MXI1 Gene

(4) SIMAP similar genes for MXI1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MXI1: view

Variants for MXI1 Gene

Sequence variations from dbSNP and Humsavar for MXI1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
VAR_004499 Prostate cancer (PC)
rs1475502 -- 110,207,797(-) GCGGG(A/G)GTCCG utr-variant-5-prime
rs14401 -- 110,285,413(+) CTATT(C/T)GAATG utr-variant-3-prime
rs16410 -- 110,285,272(+) TTGAG(-/TTGA)TTGAG utr-variant-3-prime
rs16448 -- 110,285,085(+) TCTTT(-/AAAAC)AAAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MXI1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2673748 CNV Deletion 23128226
nsv896001 CNV Loss 21882294
esv2740795 CNV Deletion 23290073
esv2740807 CNV Deletion 23290073
esv275343 CNV Loss 21479260
nsv524405 CNV Loss 19592680
esv2673572 CNV Deletion 23128226

Variation tolerance for MXI1 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.96; 36.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MXI1 Gene

Disorders for MXI1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MXI1 Gene - From: OMIM, ClinVar, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
- elite association - COSMIC cancer census association via MalaCards
Search MXI1 in MalaCards View complete list of genes associated with diseases


  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:7773287}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MXI1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Tumor Gene Database (TGDB):
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MXI1: view

No data available for Genatlas for MXI1 Gene

Publications for MXI1 Gene

  1. Genomic organization of human MXI1, a putative tumor suppressor gene. (PMID: 8838813) Wechsler D.S. … Dang C.V. (Genomics 1996) 3 4 23 67
  2. HIF-1alpha induces MXI1 by alternate promoter usage in human neuroblastoma cells. (PMID: 19254710) LAPfstedt T. … Axelson H. (Exp. Cell Res. 2009) 3 23
  3. Inhibition of Mxi1 suppresses HIF-2alpha-dependent renal cancer tumorigenesis. (PMID: 19018165) Tsao C.C. … Corn P.G. (Cancer Biol. Ther. 2008) 3 23
  4. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. (PMID: 17452451) Delpuech O. … Schulze A. (Mol. Cell. Biol. 2007) 3 23
  5. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo X.L. … Ohno R. (Leuk. Lymphoma 2007) 3 23

Products for MXI1 Gene

Sources for MXI1 Gene