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Aliases for MXI1 Gene

Aliases for MXI1 Gene

  • MAX Interactor 1, Dimerization Protein 2 3
  • Class C Basic Helix-Loop-Helix Protein 11 3 4
  • BHLHc11 3 4
  • Max-Related Transcription Factor 3
  • MAX Dimerization Protein 2 3
  • MAX Interacting Protein 1 2
  • Max-Interacting Protein 1 3
  • MAX Interactor 1 2
  • Max Interactor 1 4
  • MAD2 3
  • MXD2 3
  • MXI 3

External Ids for MXI1 Gene

Summaries for MXI1 Gene

Entrez Gene Summary for MXI1 Gene

  • Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

GeneCards Summary for MXI1 Gene

MXI1 (MAX Interactor 1, Dimerization Protein) is a Protein Coding gene. Diseases associated with MXI1 include prostate cancer and neurofibrosarcoma. GO annotations related to this gene include transcription corepressor activity and protein dimerization activity. An important paralog of this gene is MXD1.

UniProtKB/Swiss-Prot for MXI1 Gene

  • Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX

Gene Wiki entry for MXI1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MXI1 Gene

Genomics for MXI1 Gene

Genomic Location for MXI1 Gene

Start:
110,207,605 bp from pter
End:
110,287,365 bp from pter
Size:
79,761 bases
Orientation:
Plus strand

Genomic View for MXI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MXI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MXI1 Gene

Regulatory Elements for MXI1 Gene

Proteins for MXI1 Gene

  • Protein details for MXI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50539-MXI1_HUMAN
    Recommended name:
    Max-interacting protein 1
    Protein Accession:
    P50539
    Secondary Accessions:
    • B1ANN7
    • D3DR25
    • D3DRA9
    • Q15887
    • Q6FHW2
    • Q96E53

    Protein attributes for MXI1 Gene

    Size:
    228 amino acids
    Molecular mass:
    26062 Da
    Quaternary structure:
    • Interacts with SMC3 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with RNF17 (By similarity).

    Alternative splice isoforms for MXI1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MXI1 Gene

Proteomics data for MXI1 Gene at MOPED

Post-translational modifications for MXI1 Gene

No data available for DME Specific Peptides for MXI1 Gene

Domains for MXI1 Gene

Gene Families for MXI1 Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins
  • MXD :MAX dimerization proteins

Protein Domains for MXI1 Gene

Graphical View of Domain Structure for InterPro Entry

P50539

UniProtKB/Swiss-Prot:

MXI1_HUMAN
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.:
    • P50539
genes like me logo Genes that share domains with MXI1: view

Function for MXI1 Gene

Molecular function for MXI1 Gene

GENATLAS Biochemistry: Max interactor 1,key component of the mitotic checkpoint,induced during terminal differentiation,interacting with Max to bind Myc-Max recognition E box sites through interaction between the N terminus and SIN3 corepressor,antagonizing MYC dependent activation and repressing the c-Myc promoter P2,MYC family (see TSG10A),commonly mutated or deleted in prostate carcinoma
UniProtKB/Swiss-Prot Function: Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX

Gene Ontology (GO) - Molecular Function for MXI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity TAS 8425219
GO:0005515 protein binding IPI 16189514
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with MXI1: view
genes like me logo Genes that share phenotypes with MXI1: view

Animal Models for MXI1 Gene

MGI Knock Outs for MXI1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MXI1 Gene

Localization for MXI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MXI1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MXI1 Gene COMPARTMENTS Subcellular localization image for MXI1 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MXI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MXI1: view

Pathways for MXI1 Gene

SuperPathways for MXI1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MXI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0008285 negative regulation of cell proliferation TAS 9624006
GO:0042994 cytoplasmic sequestering of transcription factor TAS 8425219
genes like me logo Genes that share ontologies with MXI1: view

No data available for Pathways by source for MXI1 Gene

Compounds for MXI1 Gene

(2) Novoseek inferred chemical compound relationships for MXI1 Gene

Compound -log(P) Hits PubMed IDs
leucine 41.3 5
ornithine 16.9 1
genes like me logo Genes that share compounds with MXI1: view

Transcripts for MXI1 Gene

Unigene Clusters for MXI1 Gene

MAX interactor 1, dimerization protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MXI1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c
SP1: - -
SP2: -
SP3: - - - -
SP4:
SP5: - - - -
SP6: - - -

Relevant External Links for MXI1 Gene

GeneLoc Exon Structure for
MXI1
ECgene alternative splicing isoforms for
MXI1

Expression for MXI1 Gene

mRNA expression in normal human tissues for MXI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MXI1 Gene

SOURCE GeneReport for Unigene cluster for MXI1 Gene Hs.728542

mRNA Expression by UniProt/SwissProt for MXI1 Gene

P50539-MXI1_HUMAN
Tissue specificity: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle
genes like me logo Genes that share expressions with MXI1: view

No data available for mRNA differential expression in normal tissues for MXI1 Gene

Orthologs for MXI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MXI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MXI1 35
  • 96.95 (n)
  • 95.8 (a)
MXI1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MXI1 35
  • 95.76 (n)
  • 95.53 (a)
MXI1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MXI1 35
  • 94.85 (n)
  • 94.85 (a)
MXI1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mxi1 35
  • 92.43 (n)
  • 95.25 (a)
Mxi1 16
Mxi1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MXI1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MXI1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mxi1 35
  • 91.4 (n)
  • 96.38 (a)
chicken
(Gallus gallus)
Aves MXI1 35
  • 82.32 (n)
  • 85.23 (a)
MXI1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MXI1 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mxi1 35
  • 67.12 (n)
  • 70.4 (a)
Str.6117 35
zebrafish
(Danio rerio)
Actinopterygii mxi1 35
  • 67.52 (n)
  • 70.51 (a)
mxi1 36
  • 61 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea mdl-1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2549 36
  • 37 (a)
OneToMany
Species with no ortholog for MXI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MXI1 Gene

ENSEMBL:
Gene Tree for MXI1 (if available)
TreeFam:
Gene Tree for MXI1 (if available)

Paralogs for MXI1 Gene

Paralogs for MXI1 Gene

Selected SIMAP similar genes for MXI1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MXI1: view

Variants for MXI1 Gene

Sequence variations from dbSNP and Humsavar for MXI1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs14401 -- 110,285,413(+) CTATT(C/T)GAATG utr-variant-3-prime
rs16410 -- 110,285,272(+) TTGAG(-/TTGA)TTGAG utr-variant-3-prime
rs16448 -- 110,285,085(+) TCTTT(-/AAAAC)AAAAC utr-variant-3-prime
rs17658 -- 110,286,392(-) CCACA(A/G)GGGAA utr-variant-3-prime
rs716594 -- 110,246,553(+) ACAGT(A/G)CTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MXI1 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
esv2673748 CNV Deletion 23128226
nsv896001 CNV Loss 21882294
esv2740795 CNV Deletion 23290073
esv2740807 CNV Deletion 23290073
esv275343 CNV Loss 21479260
nsv524405 CNV Loss 19592680
esv2673572 CNV Deletion 23128226

Relevant External Links for MXI1 Gene

HapMap Linkage Disequilibrium report
MXI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MXI1 Gene

Disorders for MXI1 Gene

(1) OMIM Diseases for MXI1 Gene (600020)

UniProtKB/Swiss-Prot

MXI1_HUMAN
  • Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269 PubMed:7773287}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(14) Novoseek inferred disease relationships for MXI1 Gene

Disease -log(P) Hits PubMed IDs
prostatic hyperplasia 52.5 2
allelic loss 50.5 7
glioblastoma 50.2 8
myeloid leukemia 39.6 2
tumors 38.6 59

Relevant External Links for MXI1

Genetic Association Database (GAD)
MXI1
Human Genome Epidemiology (HuGE) Navigator
MXI1
Tumor Gene Database (TGDB):
MXI1
genes like me logo Genes that share disorders with MXI1: view

Publications for MXI1 Gene

  1. Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas. (PMID: 7789959) Albarosa R. … Finocchiaro G. (Hum. Genet. 1995) 3 4 23
  2. Genomic organization of human MXI1, a putative tumor suppressor gene. (PMID: 8838813) Wechsler D.S. … Dang C.V. (Genomics 1996) 3 4 23
  3. Expression, regulation and polymorphism of the mxi1 genes. (PMID: 8918230) Shimizu E. … Shimizu B. (Gene 1996) 3 4 23
  4. Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites. (PMID: 8425219) Zervos A.S. … Brent R. (Cell 1993) 3 4 23
  5. Commonly occurring loss and mutation of the MXI1 gene in prostate cancer. (PMID: 9669667) Prochownik E.V. … Brothman A.R. (Genes Chromosomes Cancer 1998) 3 23

Products for MXI1 Gene

Sources for MXI1 Gene

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