Aliases for MXI1 Gene
External Ids for MXI1 Gene
Previous GeneCards Identifiers for MXI1 Gene
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]
GeneCards Summary for MXI1 Gene
MXI1 (MAX Interactor 1, Dimerization Protein) is a Protein Coding gene. Diseases associated with MXI1 include Prostate Cancer and Neurofibrosarcoma. Among its related pathways are Hematopoietic Stem Cell Differentiation. Gene Ontology (GO) annotations related to this gene include protein dimerization activity and transcription corepressor activity. An important paralog of this gene is MXD1.
UniProtKB/Swiss-Prot for MXI1 Gene
Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5-CAC[GA]TG-3. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.