Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MX1 Gene

Aliases for MX1 Gene

  • MX Dynamin-Like GTPase 1 2 3
  • Interferon-Regulated Resistance GTP-Binding Protein MxA 3 4
  • Interferon-Inducible Protein P78 2 3
  • Interferon-Induced Protein P78 3 4
  • Myxoma Resistance Protein 1 3 4
  • IFI-78K 3 4
  • IFI78 3 6
  • MX 3 6
  • Myxovirus (Influenza) Resistance 1, Homolog Of Murine (Interferon-Inducible Protein P78) 2
  • Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 (Mouse) 2
  • Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein P78 3
  • Interferon-Induced GTP-Binding Protein Mx1 3
  • Myxovirus Resistance Protein 1 4
  • MxA 3

External Ids for MX1 Gene

Previous GeneCards Identifiers for MX1 Gene

  • GC21P039372
  • GC21P041713
  • GC21P041718
  • GC21P041720
  • GC21P042792
  • GC21P028262

Summaries for MX1 Gene

Entrez Gene Summary for MX1 Gene

  • This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for MX1 Gene

MX1 (MX Dynamin-Like GTPase 1) is a Protein Coding gene. Diseases associated with MX1 include subacute sclerosing panencephalitis and rift valley fever. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.

UniProtKB/Swiss-Prot for MX1 Gene

  • Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Gene Wiki entry for MX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MX1 Gene

Genomics for MX1 Gene

Regulatory Elements for MX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MX1 Gene

Start:
41,420,304 bp from pter
End:
41,459,214 bp from pter
Size:
38,911 bases
Orientation:
Plus strand

Genomic View for MX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MX1 Gene

Proteins for MX1 Gene

  • Protein details for MX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20591-MX1_HUMAN
    Recommended name:
    Interferon-induced GTP-binding protein Mx1
    Protein Accession:
    P20591
    Secondary Accessions:
    • B2RDA5
    • B3KU10
    • C9IYV7
    • C9J8D6
    • C9JN19
    • C9JN88
    • C9JUL1
    • C9JZS6
    • D3DSI8
    • Q86YP5
    • Q96CI3

    Protein attributes for MX1 Gene

    Size:
    662 amino acids
    Molecular mass:
    75520 Da
    Quaternary structure:
    • Homotetramer. Oligomerizes into multimeric filamentous or ring-like structures by virtue of its stalk domain. Oligomerization is critical for GTPase activity, protein stability, and recognition of viral target structures. Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7. Interacts with HSPA5. Interacts with DDX39A and DDX39B. Interacts with TUBB/TUBB5 (By similarity). The GTP-bound form interacts (via C-terminus) with THOV P5 protein. The GTP-bound form interacts with LACV protein N. Interacts with CCHFV protein N.

    Three dimensional structures from OCA and Proteopedia for MX1 Gene

    Alternative splice isoforms for MX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MX1 Gene

Proteomics data for MX1 Gene at MOPED

Post-translational modifications for MX1 Gene

Antibody Products

No data available for DME Specific Peptides for MX1 Gene

Domains for MX1 Gene

Suggested Antigen Peptide Sequences for MX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20591

UniProtKB/Swiss-Prot:

MX1_HUMAN :
  • P20591
Domain:
  • The C-terminal GTPase effector domain (GED) is involved in oligomerization and viral target recognition.
  • The middle domain mediates self-assembly and oligomerization.
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 GED domain.
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
genes like me logo Genes that share domains with MX1: view

No data available for Gene Families for MX1 Gene

Function for MX1 Gene

Molecular function for MX1 Gene

GENATLAS Biochemistry:
myxovirus (influenza) resistance 1;human murine MX equivalent
UniProtKB/Swiss-Prot Function:
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.
UniProtKB/Swiss-Prot Induction:
By type I and type III interferons. Isoform 2 is induced by HSV-1.

Gene Ontology (GO) - Molecular Function for MX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 15047845
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with MX1: view

Phenotypes for MX1 Gene

genes like me logo Genes that share phenotypes with MX1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MX1 Gene

Localization for MX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MX1 Gene

Cytoplasm. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, perinuclear region. Note=Binds preferentially to negatively charged phospholipids. Colocalizes with CCHFV protein N in the perinuclear region.
Isoform 2: Cytoplasm. Nucleus. Note=Translocates into the nuclei of HSV-1 infected cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MX1 Gene COMPARTMENTS Subcellular localization image for MX1 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
nucleus 5
cytoskeleton 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005737 cytoplasm IDA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MX1: view

Pathways for MX1 Gene

genes like me logo Genes that share pathways with MX1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for MX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006915 apoptotic process TAS 9389754
GO:0006952 defense response TAS 2154602
GO:0007165 signal transduction TAS 9389754
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MX1: view

Compounds for MX1 Gene

(21) Novoseek inferred chemical compound relationships for MX1 Gene

Compound -log(P) Hits PubMed IDs
2,5-oligoadenylate 89.2 28
betaseron 79.2 5
avonex 77.2 5
rebif 74.5 4
ifn-alpha 71.5 18
genes like me logo Genes that share compounds with MX1: view

Transcripts for MX1 Gene

Unigene Clusters for MX1 Gene

Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MX1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a ·
SP1: - -
SP2:
SP3: - -
SP4:
SP5: -
SP6: - - - - - -
SP7:
SP8:
SP9:
SP10: -
SP11:
SP12: -
SP13:

ExUns: 15b ^ 16 ^ 17 ^ 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for MX1 Gene

GeneLoc Exon Structure for
MX1
ECgene alternative splicing isoforms for
MX1

Expression for MX1 Gene

mRNA expression in normal human tissues for MX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MX1 Gene

This gene is overexpressed in Nasal epithelium (14.7), Lymph node (12.6), and Stomach (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MX1 Gene

SOURCE GeneReport for Unigene cluster for MX1 Gene Hs.517307

genes like me logo Genes that share expressions with MX1: view

Expression partners for MX1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MX1 Gene

Orthologs for MX1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MX1 35
  • 80.2 (n)
  • 76.54 (a)
MX1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MX1 35
  • 80.11 (n)
  • 77.63 (a)
MX1 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MX1 35
  • 98.89 (n)
  • 98.79 (a)
MX1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mx2 35
  • 76.94 (n)
  • 75.27 (a)
mouse
(Mus musculus)
Mammalia Mx2 16
Mx1 36
  • 69 (a)
OneToMany
Mx2 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 60 (a)
ManyToMany
chicken
(Gallus gallus)
Aves MX 36
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 55 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia mx2 35
  • 64.2 (n)
  • 63.97 (a)
zebrafish
(Danio rerio)
Actinopterygii mxa 35
  • 58.39 (n)
  • 55.23 (a)
mxa 36
  • 52 (a)
ManyToMany
mxb 36
  • 52 (a)
ManyToMany
mxb 36
  • 50 (a)
ManyToMany
mxc 36
  • 50 (a)
ManyToMany
mxd 36
  • 43 (a)
ManyToMany
mxe 36
  • 53 (a)
ManyToMany
mxf 36
  • 41 (a)
ManyToMany
mxg 36
  • 44 (a)
ManyToMany
si:dkeyp-110c12.3 36
  • 42 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11791 35
fruit fly
(Drosophila melanogaster)
Insecta shi 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea dyn-1 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS1 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons DRP4C 35
  • 44.52 (n)
  • 33.11 (a)
rice
(Oryza sativa)
Liliopsida Os04g0129900 35
  • 47.85 (n)
  • 37.47 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for MX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MX1 Gene

ENSEMBL:
Gene Tree for MX1 (if available)
TreeFam:
Gene Tree for MX1 (if available)

Paralogs for MX1 Gene

Paralogs for MX1 Gene

Selected SIMAP similar genes for MX1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with MX1: view

Variants for MX1 Gene

Sequence variations from dbSNP and Humsavar for MX1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs13920 -- 41,458,553(+) CAGCC(A/G)CATCC reference, missense, synonymous-codon
rs148214 -- 41,442,291(+) ATGAT(A/G)AATGC intron-variant
rs363882 -- 41,446,346(+) aggga(C/T)gaaca intron-variant
rs363976 -- 41,449,719(+) atagt(A/G)ggggc intron-variant
rs363981 -- 41,434,482(+) atctt(G/T)ctatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MX1 Gene

Variant ID Type Subtype PubMed ID
nsv834102 CNV Loss 17160897
esv1009381 CNV Deletion 20482838
nsv459261 CNV Loss 19166990

Relevant External Links for MX1 Gene

HapMap Linkage Disequilibrium report
MX1
Human Gene Mutation Database (HGMD)
MX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MX1 Gene

Disorders for MX1 Gene

(4) University of Copenhagen DISEASES for MX1 Gene

(58) Novoseek inferred disease relationships for MX1 Gene

Disease -log(P) Hits PubMed IDs
vesicular stomatitis 80.7 18
influenza 70.4 97
multiple sclerosis 70.2 22
virus infection 69.1 67
rna virus infections 65.1 1

Relevant External Links for MX1

Genetic Association Database (GAD)
MX1
Human Genome Epidemiology (HuGE) Navigator
MX1
genes like me logo Genes that share disorders with MX1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MX1 Gene

Publications for MX1 Gene

  1. Cloning and sequence analyses of cDNAs for interferon- and virus- induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter. (PMID: 2154602) Horisberger M.A. … Content J. (J. Virol. 1990) 3 4 23
  2. Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. (PMID: 2161946) Pavlovic J. … Staeheli P. (J. Virol. 1990) 3 4 23
  3. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. (PMID: 8411374) Pitossi F. … Staeheli P. (J. Virol. 1993) 3 4 23
  4. Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity. (PMID: 9060610) Ponten A. … Kochs G. (J. Virol. 1997) 3 4 23
  5. Structure and polymorphism of the human gene for the interferon- induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region. (PMID: 10942113) Tazi-Ahnini R. … Cork M.J. (Hum. Genet. 2000) 3 4 23

Products for MX1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Antiviral Response in human,mouse,rat
    • Apoptosis 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MX1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MX1
    • Block miRNA regulation of MX1 using miScript Target Protectors

    Sources for MX1 Gene

    Back to Top

    Content