Aliases for MX1 Gene
External Ids for MX1 Gene
Previous GeneCards Identifiers for MX1 Gene
This gene encodes a guanosine triphosphate (GTP)-metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for MX1 Gene
MX1 (MX Dynamin-Like GTPase 1) is a Protein Coding gene. Diseases associated with MX1 include influenza and subacute sclerosing panencephalitis. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is DNM1.
UniProtKB/Swiss-Prot for MX1 Gene
Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.