Aliases for MUTYH Gene
External Ids for MUTYH Gene
Previous GeneCards Identifiers for MUTYH Gene
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for MUTYH Gene
MUTYH (MutY Homolog) is a Protein Coding gene. Diseases associated with MUTYH include adenomas, multiple colorectal and mutyh-associated polyposis. Among its related pathways are Cell Cycle / Checkpoint Control and Cell Cycle / Checkpoint Control. GO annotations related to this gene include 4 iron, 4 sulfur cluster binding and MutSalpha complex binding.
UniProtKB/Swiss-Prot for MUTYH Gene
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.