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Aliases for MUC7 Gene

Aliases for MUC7 Gene

  • Mucin 7, Secreted 2 3 5
  • Mucin 7, Salivary 2 3
  • Salivary Mucin-7 3 4
  • Apo-MG2 3 4
  • MUC-7 3 4
  • MG2 3 4

External Ids for MUC7 Gene

Previous GeneCards Identifiers for MUC7 Gene

  • GC04U990038
  • GC04P071587
  • GC04P071653
  • GC04P071518
  • GC04P071372
  • GC04P067098

Summaries for MUC7 Gene

Entrez Gene Summary for MUC7 Gene

  • This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014]

GeneCards Summary for MUC7 Gene

MUC7 (Mucin 7, Secreted) is a Protein Coding gene. Diseases associated with MUC7 include asthma and oral candidiasis. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for MUC7 Gene

  • May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.

Gene Wiki entry for MUC7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC7 Gene

Genomics for MUC7 Gene

Genomic Location for MUC7 Gene

Chromosome:
4
Start:
70,430,492 bp from pter
End:
70,482,997 bp from pter
Size:
52,506 bases
Orientation:
Plus strand

Genomic View for MUC7 Gene

Genes around MUC7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC7 Gene

No data available for Regulatory Elements for MUC7 Gene

Proteins for MUC7 Gene

  • Protein details for MUC7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAX7-MUC7_HUMAN
    Recommended name:
    Mucin-7
    Protein Accession:
    Q8TAX7
    Secondary Accessions:
    • Q9UCD7
    • Q9UCD8

    Protein attributes for MUC7 Gene

    Size:
    377 amino acids
    Molecular mass:
    39159 Da
    Quaternary structure:
    • Monomer.

neXtProt entry for MUC7 Gene

Proteomics data for MUC7 Gene at MOPED

Post-translational modifications for MUC7 Gene

  • N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.
  • Glycosylation at Asn 97, Asn 128, Asn 135, and Asn 146

Other Protein References for MUC7 Gene

Antibody Products

No data available for DME Specific Peptides for MUC7 Gene

Domains & Families for MUC7 Gene

Gene Families for MUC7 Gene

HGNC:

Protein Domains for MUC7 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MUC7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MUC7: view

No data available for UniProtKB/Swiss-Prot for MUC7 Gene

Function for MUC7 Gene

Molecular function for MUC7 Gene

GENATLAS Biochemistry:
mucin 7,salivary,expressed only in bladder cancer during the malignant transformation of bladder urothelium
UniProtKB/Swiss-Prot Function:
May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
genes like me logo Genes that share phenotypes with MUC7: view

Animal Model Products

miRNA for MUC7 Gene

miRTarBase miRNAs that target MUC7

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MUC7 Gene

Localization for MUC7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC7 Gene COMPARTMENTS Subcellular localization image for MUC7 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MUC7 Gene

Pathways & Interactions for MUC7 Gene

genes like me logo Genes that share pathways with MUC7: view

Pathways by source for MUC7 Gene

Gene Ontology (GO) - Biological Process for MUC7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016266 O-glycan processing TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with MUC7: view

No data available for SIGNOR curated interactions for MUC7 Gene

Drugs & Compounds for MUC7 Gene

(6) Drugs for MUC7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for MUC7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC7: view

Transcripts for MUC7 Gene

Unigene Clusters for MUC7 Gene

Mucin 7, secreted:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c
SP1: -
SP2:
SP3:
SP4: - -
SP5: -

Relevant External Links for MUC7 Gene

GeneLoc Exon Structure for
MUC7
ECgene alternative splicing isoforms for
MUC7

Expression for MUC7 Gene

mRNA expression in normal human tissues for MUC7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC7 Gene

This gene is overexpressed in Minor Salivary Gland (x52.9).

Protein differential expression in normal tissues from HIPED for MUC7 Gene

This gene is overexpressed in Salivary gland (24.9), Saliva (24.3), Nasal epithelium (9.4), and Skin (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MUC7 Gene



SOURCE GeneReport for Unigene cluster for MUC7 Gene Hs.631946

mRNA Expression by UniProt/SwissProt for MUC7 Gene

Q8TAX7-MUC7_HUMAN
Tissue specificity: Expressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
genes like me logo Genes that share expression patterns with MUC7: view

Protein tissue co-expression partners for MUC7 Gene

Primer Products

In Situ Assay Products

Orthologs for MUC7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MUC7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC7 35
  • 99.06 (n)
  • 98.31 (a)
MUC7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MUC7 35
  • 66.84 (n)
  • 51.3 (a)
dog
(Canis familiaris)
Mammalia LOC102153116 35
  • 63.46 (n)
  • 46.52 (a)
MUC7 36
  • 44 (a)
OneToOne
Species with no ortholog for MUC7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC7 Gene

ENSEMBL:
Gene Tree for MUC7 (if available)
TreeFam:
Gene Tree for MUC7 (if available)

Paralogs for MUC7 Gene

No data available for Paralogs for MUC7 Gene

Variants for MUC7 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC7 Gene

Q8TAX7-MUC7_HUMAN
The most common allele, MUC7*6, contains a tandem repeat domain comprising 6 repeats (shown here) each composed of 23 amino acids. These repeats are very similar but not identical. In a large cohort of 375 individuals from a variety of ethnic backgrounds, three different alleles were detected, MUC7*6 being the most common, in all populations studied, followed by MUC7*5 (5 repeats), with frequency varying from 0.05 in Africans to 0.22 in East Asians. The MUC7*5 allele is less prevalent in patients with asthma than in controls, and seems to have a protective role in respiratory function. MUC7*8 (8 repeats), a novel rare allele, was identified in 1 Northern European individual.

Sequence variations from dbSNP and Humsavar for MUC7 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs6826961 - 70,480,984(+) AATAA(C/G)CCCCC reference, missense
rs1387962 -- 70,480,160(-) CATGA(A/G)TCATC intron-variant
rs998210 -- 70,480,619(+) CTCTC(C/T)AGTAG intron-variant
rs1109501 -- 70,463,773(+) ctccc(A/G)ctatg intron-variant
rs881730 -- 70,463,704(+) TTGGC(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MUC7 Gene

Variant ID Type Subtype PubMed ID
nsv829964 CNV Gain 17160897
dgv1642e1 CNV Complex 17122850
nsv518183 CNV Loss 19592680
esv2727789 CNV Deletion 23290073
esv2727790 CNV Deletion 23290073

Variation tolerance for MUC7 Gene

Residual Variation Intolerance Score: 94.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.71; 86.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC7 Gene

HapMap Linkage Disequilibrium report
MUC7
Human Gene Mutation Database (HGMD)
MUC7

Disorders for MUC7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for MUC7 Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
asthma
  • asthma, protection against
oral candidiasis
  • candidiasis of mouth
chronic ethmoiditis
  • chronic ethmoid sinusitis
ethmoid sinusitis
  • ethmoidal sinusitis
dental caries
  • dental caries extending into pulp
- elite association - COSMIC cancer census association via MalaCards
Search MUC7 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MUC7_HUMAN
  • Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269 PubMed:11378823}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for MUC7

Genetic Association Database (GAD)
MUC7
Human Genome Epidemiology (HuGE) Navigator
MUC7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MUC7
genes like me logo Genes that share disorders with MUC7: view

No data available for Genatlas for MUC7 Gene

Publications for MUC7 Gene

  1. Genetic polymorphism of MUC7: allele frequencies and association with asthma. (PMID: 11378823) Kirkbride H.J. … Swallow D.M. (Eur. J. Hum. Genet. 2001) 3 4 48 67
  2. Structure and chromosomal localization of the human salivary mucin gene, MUC7. (PMID: 8838308) Bobek L.A. … Levine M.J. (Genomics 1996) 2 3 23
  3. MUC7 haplotype analysis: results from a longitudinal birth cohort support protective effect of the MUC7*5 allele on respiratory function. (PMID: 16759176) Rousseau K. … Swallow D.M. (Ann. Hum. Genet. 2006) 3 23
  4. Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells. (PMID: 16778149) Li S. … Bobek L.A. (Am. J. Respir. Cell Mol. Biol. 2006) 3 23
  5. Modulation of MUC7 mucin expression by exogenous factors in airway cells in vitro and in vivo. (PMID: 16514118) Li S. … Bobek L.A. (Am. J. Respir. Cell Mol. Biol. 2006) 3 23

Products for MUC7 Gene

Sources for MUC7 Gene

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