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Aliases for MUC6 Gene

Aliases for MUC6 Gene

  • Mucin 6, Oligomeric Mucus/Gel-Forming 2 3
  • Gastric Mucin-6 3 4
  • MUC-6 3 4
  • Mucin 6, Gastric 2
  • Mucin-6 3

External Ids for MUC6 Gene

Summaries for MUC6 Gene

Entrez Gene Summary for MUC6 Gene

  • The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM, Dec 2010]

GeneCards Summary for MUC6 Gene

MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC6 include epstein-barr virus-associated gastric carcinoma and biliary papillomatosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include extracellular matrix structural constituent. An important paralog of this gene is OTOGL.

UniProtKB/Swiss-Prot for MUC6 Gene

  • May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.

Gene Wiki entry for MUC6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC6 Gene

Genomics for MUC6 Gene

Genomic Location for MUC6 Gene

Start:
1,012,821 bp from pter
End:
1,036,706 bp from pter
Size:
23,886 bases
Orientation:
Minus strand

Genomic View for MUC6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MUC6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC6 Gene

Regulatory Elements for MUC6 Gene

Proteins for MUC6 Gene

  • Protein details for MUC6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6W4X9-MUC6_HUMAN
    Recommended name:
    Mucin-6
    Protein Accession:
    Q6W4X9
    Secondary Accessions:
    • O15329
    • Q14394
    • Q2TUQ5
    • Q4L207
    • Q8N8I1
    • Q8NAK1

    Protein attributes for MUC6 Gene

    Size:
    2439 amino acids
    Molecular mass:
    257051 Da
    Quaternary structure:
    • Multimer; disulfide-linked.
    SequenceCaution:
    • Sequence=AK092533; Type=Erroneous termination; Positions=2357; Note=Translated as Glu.; Evidence={ECO:0000305}; Sequence=BAC04860.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for MUC6 Gene

Proteomics data for MUC6 Gene at MOPED

Post-translational modifications for MUC6 Gene

Other Protein References for MUC6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MUC6 Gene

Domains for MUC6 Gene

Gene Families for MUC6 Gene

HGNC:

UniProtKB/Swiss-Prot:

MUC6_HUMAN
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.:
    • Q6W4X9
  • Contains 1 TIL (trypsin inhibitory-like) domain.:
    • Q6W4X9
  • Contains 3 VWFD domains.:
    • Q6W4X9
genes like me logo Genes that share domains with MUC6: view

Function for MUC6 Gene

Molecular function for MUC6 Gene

GENATLAS Biochemistry: mucin 6,gastric,belonging to the secreted mucins cluster,aberrantly expressed in colorectal neoplasia
UniProtKB/Swiss-Prot Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis.
UniProtKB/Swiss-Prot Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors.

Gene Ontology (GO) - Molecular Function for MUC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent NAS 7680650
genes like me logo Genes that share ontologies with MUC6: view

miRNA for MUC6 Gene

miRTarBase miRNAs that target MUC6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MUC6 Gene

Localization for MUC6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC6 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MUC6 Gene COMPARTMENTS Subcellular localization image for MUC6 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 2
cytoskeleton 1
cytosol 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MUC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with MUC6: view

Pathways for MUC6 Gene

genes like me logo Genes that share pathways with MUC6: view

Gene Ontology (GO) - Biological Process for MUC6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006493 protein O-linked glycosylation TAS --
GO:0016266 O-glycan processing TAS --
GO:0030277 maintenance of gastrointestinal epithelium NAS 7680650
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with MUC6: view

Compounds for MUC6 Gene

(8) Novoseek inferred chemical compound relationships for MUC6 Gene

Compound -log(P) Hits PubMed IDs
paraffin 5.55 1
calcium 3.04 2
cholesterol 0 3
oligonucleotide 0 1
progesterone 0 2
genes like me logo Genes that share compounds with MUC6: view

Transcripts for MUC6 Gene

Unigene Clusters for MUC6 Gene

Mucin 6, oligomeric mucus/gel-forming:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC6 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: -

Relevant External Links for MUC6 Gene

GeneLoc Exon Structure for
MUC6
ECgene alternative splicing isoforms for
MUC6

Expression for MUC6 Gene

mRNA expression in normal human tissues for MUC6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC6 Gene

This gene is overexpressed in Stomach (32.7), Pancreas (12.9), and Cervix - Endocervix (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MUC6 Gene

SOURCE GeneReport for Unigene cluster for MUC6 Gene Hs.528432

mRNA Expression by UniProt/SwissProt for MUC6 Gene

Q6W4X9-MUC6_HUMAN
Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunners glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct.
genes like me logo Genes that share expressions with MUC6: view

Orthologs for MUC6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MUC6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MUC6 36
  • 94.65 (n)
  • 92.96 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 57 (a)
OneToMany
-- 37
  • 77 (a)
OneToMany
LOC100856444 36
  • 80.87 (n)
  • 76.62 (a)
mouse
(Mus musculus)
Mammalia Muc6 36
  • 75.09 (n)
  • 70.97 (a)
Muc6 16
Muc6 37
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MUC6 37
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MUC6 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Muc6 36
  • 68.8 (n)
  • 62.29 (a)
chicken
(Gallus gallus)
Aves MUC6 37
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MUC6 37
  • 56 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 31 (a)
OneToOne
Species with no ortholog for MUC6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MUC6 Gene

ENSEMBL:
Gene Tree for MUC6 (if available)
TreeFam:
Gene Tree for MUC6 (if available)

Paralogs for MUC6 Gene

Paralogs for MUC6 Gene

genes like me logo Genes that share paralogs with MUC6: view

Variants for MUC6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC6 Gene

Q6W4X9-MUC6_HUMAN
The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical

Sequence variations from dbSNP and Humsavar for MUC6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs3208810 -- 1,016,724(-) CATCA(C/T)CACTA missense, reference
rs4076950 -- 1,015,021(+) GTTGT(C/T)GCCTG intron-variant
rs4077531 -- 1,013,167(-) CCCAC(C/T)GTCCA utr-variant-3-prime
rs6597946 -- 1,037,888(-) TGGGA(C/T)GGGGG upstream-variant-2KB
rs6597947 -- 1,037,029(-) GGCGT(G/T)TGGCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MUC6 Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
essv11734 CNV CNV 17122850
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
dgv332e1 CNV Complex 17122850
nsv428244 CNV Loss 18775914
essv22587 CNV CNV 17122850
nsv896640 CNV Loss 21882294
dgv957n71 CNV Loss 21882294
nsv896643 CNV Loss 21882294
nsv896644 CNV Loss 21882294
nsv832045 CNV Gain+Loss 17160897
dgv958n71 CNV Loss 21882294
nsv7637 CNV Insertion 18451855
nsv482155 CNV Gain 20164927
esv988598 CNV Insertion 20482838
nsv511474 CNV Loss 21212237
nsv59 CNV Insertion 15895083
esv23591 CNV Loss 19812545
nsv825684 CNV Gain 20364138
nsv820593 CNV Duplication 20802225
dgv187n67 CNV Gain 20364138
dgv10n47 CNV Gain 21111241
esv2743883 CNV Deletion 23290073
esv3523 CNV Complex 18987735
nsv825688 CNV Gain 20364138
esv2743884 CNV Deletion 23290073
esv7984 CNV Loss 19470904
esv3671 CNV Complex 18987735
esv1474704 CNV Insertion 17803354
nsv896648 CNV Loss 21882294
dgv959n71 CNV Loss 21882294

Relevant External Links for MUC6 Gene

HapMap Linkage Disequilibrium report
MUC6
Human Gene Mutation Database (HGMD)
MUC6

Disorders for MUC6 Gene

(5) University of Copenhagen DISEASES for MUC6 Gene

(38) Novoseek inferred disease relationships for MUC6 Gene

Disease -log(P) Hits PubMed IDs
gastric carcinoma 73.9 34
metaplasia 72.7 16
carcinoma mucinous 72.5 6
adenocarcinoma 61.2 24
carcinoma 57.3 16

Relevant External Links for MUC6

Genetic Association Database (GAD)
MUC6
Human Genome Epidemiology (HuGE) Navigator
MUC6
genes like me logo Genes that share disorders with MUC6: view

No data available for UniProtKB/Swiss-Prot for MUC6 Gene

Publications for MUC6 Gene

  1. The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence. (PMID: 9195947) Toribara N.W. … Kim Y.S. (J. Biol. Chem. 1997) 3 4 23
  2. Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution. (PMID: 11988092) Nordman H. … Carlstedt I. (Biochem. J. 2002) 3 4 23
  3. The complete genomic organization of the human MUC6 and MUC2 mucin genes. (PMID: 15081123) Rousseau K. … Toribara N.W. (Genomics 2004) 3 4 23
  4. Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. (PMID: 15280409) Xia H.H.-X. … Wong B.C.-Y. (J. Clin. Pathol. 2004) 3 4 23
  5. Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors. (PMID: 15979574) Sakai H. … Yuasa Y. (Biochem. Biophys. Res. Commun. 2005) 3 4 23

Products for MUC6 Gene

Sources for MUC6 Gene

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