Aliases for MUC4 Gene
External Ids for MUC4 Gene
Previous GeneCards Identifiers for MUC4 Gene
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]
GeneCards Summary for MUC4 Gene
MUC4 (Mucin 4, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC4 include intrahepatic cholangiocarcinoma and cholangiocarcinoma. Among its related pathways are Diseases associated with O-glycosylation of proteins and Defective GALNT12 causes colorectal cancer 1 (CRCS1). GO annotations related to this gene include ErbB-2 class receptor binding and extracellular matrix constituent, lubricant activity. An important paralog of this gene is SUSD2.
UniProtKB/Swiss-Prot for MUC4 Gene
May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 Tyr-1248. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.