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Aliases for MUC2 Gene

Aliases for MUC2 Gene

  • Mucin 2, Oligomeric Mucus/Gel-Forming 2 3 5
  • Mucin 2, Intestinal/Tracheal 2 3
  • Intestinal Mucin-2 3 4
  • MUC-2 3 4
  • SMUC 3 4
  • Mucin-Like Protein 3
  • MLP 3

External Ids for MUC2 Gene

Previous GeneCards Identifiers for MUC2 Gene

  • GC11U990088
  • GC11M000095
  • GC11P001072
  • GC11P001064
  • GC11P000897

Summaries for MUC2 Gene

Entrez Gene Summary for MUC2 Gene

  • This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for MUC2 Gene

MUC2 (Mucin 2, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC2 include pseudomyxoma peritonei and pancreatic ductal carcinoma. Among its related pathways are O-linked glycosylation and Transport to the Golgi and subsequent modification.

UniProtKB/Swiss-Prot for MUC2 Gene

  • Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.

Gene Wiki entry for MUC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MUC2 Gene

Genomics for MUC2 Gene

Regulatory Elements for MUC2 Gene

Genomic Location for MUC2 Gene

1,074,875 bp from pter
1,110,511 bp from pter
35,637 bases
Plus strand

Genomic View for MUC2 Gene

Genes around MUC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MUC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MUC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MUC2 Gene

Proteins for MUC2 Gene

  • Protein details for MUC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q14878

    Protein attributes for MUC2 Gene

    5179 amino acids
    Molecular mass:
    540300 Da
    Quaternary structure:
    • Homotrimer; disulfide-linked. Dimerizes in the endoplasmic reticulum via its C-terminal region and polymerizes via its N-terminal region by disulfide-linked trimerization. Interacts with FCGBP. Interacts with AGR2; disulfide-linked.

neXtProt entry for MUC2 Gene

Proteomics data for MUC2 Gene at MOPED

Post-translational modifications for MUC2 Gene

  • At low pH of 6 and under, undergoes autocatalytic cleavage in vitro in the N-terminal region of the fourth VWD domain. It is likely that this also occurs in vivo and is triggered by the low pH of the late secretory pathway.
  • May undergo proteolytic cleavage in the outer mucus layer of the colon, contributing to the expanded volume and loose nature of this layer which allows for bacterial colonization in contrast to the inner mucus layer which is dense and devoid of bacteria.
  • O-glycosylated.
  • Glycosylation at Asn 163, Asn 423, Asn 670, Asn 770, Asn 894, Asn 1139, Asn 1154, Asn 1215, Asn 1230, Asn 1246, Asn 1787, Asn 1820, Asn 4339, Asn 4351, Asn 4362, Asn 4373, Asn 4422, Asn 4438, Asn 4502, Asn 4616, Asn 4627, Asn 4752, Asn 4787, Asn 4881, Asn 4888, Asn 4955, Asn 4970, Asn 5019, Asn 5038, and Asn 5069
  • Modification sites at PhosphoSitePlus

Other Protein References for MUC2 Gene

REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MUC2 Gene

Domains & Families for MUC2 Gene

Gene Families for MUC2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Contains 1 TIL (trypsin inhibitory-like) domain.
  • Contains 2 VWFC domains.
  • Contains 4 VWFD domains.
genes like me logo Genes that share domains with MUC2: view

Function for MUC2 Gene

Molecular function for MUC2 Gene

GENATLAS Biochemistry:
mucin 2,intestinal,glycoprotein of membrane,belonging to the secreted mucins cluster,involved in epithelial cell differentiation,expressed in epithelial ovarian cancer,in normal urothelium and in bladder cancer
UniProtKB/Swiss-Prot Function:
Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer.
genes like me logo Genes that share phenotypes with MUC2: view

Animal Models for MUC2 Gene

MGI Knock Outs for MUC2:

Animal Model Products

  • Taconic Biosciences Mouse Models for MUC2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MUC2 Gene

Localization for MUC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MUC2 Gene

Secreted. Note=In the intestine, secreted into the inner and outer mucus layers. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for MUC2 Gene COMPARTMENTS Subcellular localization image for MUC2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MUC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070703 outer mucus layer ISS --
genes like me logo Genes that share ontologies with MUC2: view

Pathways & Interactions for MUC2 Gene

genes like me logo Genes that share pathways with MUC2: view

Pathways by source for MUC2 Gene

Interacting Proteins for MUC2 Gene

Selected Interacting proteins: Q02817-MUC2_HUMAN for MUC2 Gene via I2D

Gene Ontology (GO) - Biological Process for MUC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030277 maintenance of gastrointestinal epithelium IMP 17058067
genes like me logo Genes that share ontologies with MUC2: view

No data available for SIGNOR curated interactions for MUC2 Gene

Drugs & Compounds for MUC2 Gene

(16) Drugs for MUC2 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Pranlukast Approved Pharma Antagonist, Target, other/unknown 3

(21) Additional Compounds for MUC2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MUC2: view

Transcripts for MUC2 Gene

mRNA/cDNA for MUC2 Gene

Unigene Clusters for MUC2 Gene

Mucin 2, oligomeric mucus/gel-forming:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MUC2 Gene

No ASD Table

Relevant External Links for MUC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MUC2 Gene

mRNA expression in normal human tissues for MUC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MUC2 Gene

This gene is overexpressed in Colon - Transverse (x31.2) and Small Intestine - Terminal Ileum (x19.0).

Protein differential expression in normal tissues from HIPED for MUC2 Gene

This gene is overexpressed in Colon (26.3), Rectum (22.8), and Fetal gut (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MUC2 Gene

SOURCE GeneReport for Unigene cluster for MUC2 Gene Hs.315

mRNA Expression by UniProt/SwissProt for MUC2 Gene

Tissue specificity: Colon, small intestine, colonic tumors, bronchus, cervix and gall bladder.
genes like me logo Genes that share expression patterns with MUC2: view

Protein tissue co-expression partners for MUC2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MUC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MUC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC102154704 35
  • 83.47 (n)
  • 81.2 (a)
MUC2 36
  • 83 (a)
(Mus musculus)
Mammalia Muc2 35
  • 78.7 (n)
  • 76.19 (a)
Muc2 16
(Monodelphis domestica)
Mammalia MUC2 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia MUC2 36
  • 60 (a)
(Pan troglodytes)
Mammalia MUC2 36
  • 96 (a)
(Anolis carolinensis)
Reptilia MUC2 36
  • 66 (a)
(Danio rerio)
Actinopterygii MUC2 (1 of 2) 36
  • 46 (a)
MUC2 (2 of 2) 36
  • 44 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hml 37
  • 28 (a)
Hml 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for MUC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MUC2 Gene

Gene Tree for MUC2 (if available)
Gene Tree for MUC2 (if available)

Paralogs for MUC2 Gene

(6) SIMAP similar genes for MUC2 Gene using alignment to 8 proteins: Pseudogenes for MUC2 Gene

genes like me logo Genes that share paralogs with MUC2: view

No data available for Paralogs for MUC2 Gene

Variants for MUC2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MUC2 Gene

The number of repeats is highly polymorphic and varies among different alleles.

Sequence variations from dbSNP and Humsavar for MUC2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_056582 -
VAR_056583 -
VAR_056584 -
VAR_059531 -
VAR_059532 -

Structural Variations from Database of Genomic Variants (DGV) for MUC2 Gene

Variant ID Type Subtype PubMed ID
nsv469923 CNV Loss 18288195
esv2743878 CNV Deletion 23290073
esv2669189 CNV Deletion 23128226
essv22587 CNV CNV 17122850
nsv896643 CNV Loss 21882294
nsv896644 CNV Loss 21882294
nsv832045 CNV Gain+Loss 17160897
dgv959n71 CNV Loss 21882294
nsv896651 CNV Loss 21882294
dgv960n71 CNV Loss 21882294
nsv60 CNV Insertion 15895083
nsv7638 CNV Insertion 18451855
nsv896653 CNV Gain+Loss 21882294
dgv961n71 CNV Loss 21882294
dgv962n71 CNV Loss 21882294
dgv963n71 CNV Loss 21882294
nsv518205 CNV Loss 19592680
esv2743888 CNV Deletion 23290073
esv2743889 CNV Deletion 23290073
esv1678011 CNV Insertion 17803354
nsv511482 CNV Loss 21212237
esv1010440 CNV Insertion 20482838
nsv512200 CNV Loss 21212237
dgv145e201 CNV Deletion 23290073
dgv184e199 CNV Deletion 23128226
nsv39410 CNV Loss 16902084
esv22815 CNV Gain+Loss 19812545
esv2743891 CNV Deletion 23290073
esv992502 CNV Deletion 20482838
esv2743893 CNV Deletion 23290073
esv2743894 CNV Deletion 23290073
dgv146e201 CNV Deletion 23290073
nsv511471 CNV Loss 21212237
nsv825690 CNV Loss 20364138
esv1217413 CNV Deletion 17803354
esv1343845 CNV Insertion 17803354

Variation tolerance for MUC2 Gene

Gene Damage Index Score: 24.78; 99.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MUC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for MUC2 Gene

MalaCards: The human disease database

(56) MalaCards diseases for MUC2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pseudomyxoma peritonei
  • mucinous ascites
pancreatic ductal carcinoma
  • malignant neoplasm of duct of wirsung
biliary tract neoplasm
  • extrahepatic bile duct neoplasm
signet ring cell adenocarcinoma
  • signet ring carcinoma nos
bile duct carcinoma
  • carcinoma of extrahepatic bile duct
- elite association - COSMIC cancer census association via MalaCards
Search MUC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MUC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MUC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MUC2 Gene

Publications for MUC2 Gene

  1. Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5. (PMID: 1550588) Xu G. … Forstner J. (Biochem. Biophys. Res. Commun. 1992) 3 4 23 67
  2. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. (PMID: 20198339) Lee H.Y. … Kim Y.S. (Int. J. Oncol. 2010) 3 23
  3. MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. (PMID: 20198318) Okudaira K. … Deng G. (Int. J. Oncol. 2010) 3 23
  4. Small intestinal MUC2 synthesis in human preterm infants. (PMID: 19246635) Schaart M.W. … van Goudoever J.B. (Am. J. Physiol. Gastrointest. Liver Physiol. 2009) 3 23
  5. Pseudomyxoma peritonei: is disease progression related to microbial agents? A study of bacteria, MUC2 AND MUC5AC expression in disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis. (PMID: 18299935) Semino-Mora C. … Dubois A. (Ann. Surg. Oncol. 2008) 3 23

Products for MUC2 Gene

Sources for MUC2 Gene

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