Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MT-TS1 Gene

Subcategory (RNA class) for MT-TS1 Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for MT-TS1 Gene

  • Mitochondrially Encoded TRNA Serine 1 (UCN) 2 5
  • TRNA Serine 1 (UCN) 2
  • TRNS1 3
  • MTTS1 3
  • TRNA 3

External Ids for MT-TS1 Gene

Previous HGNC Symbols for MT-TS1 Gene

  • MTTS1

Previous GeneCards Identifiers for MT-TS1 Gene

  • GC00U921612

Summaries for MT-TS1 Gene

GeneCards Summary for MT-TS1 Gene

MT-TS1 (Mitochondrially Encoded TRNA Serine 1 (UCN)) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with MT-TS1 include Keratoderma, Palmoplantar, With Deafness and Merrf/Melas Overlap Syndrome. Among its related pathways are tRNA Aminoacylation.

Additional gene information for MT-TS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-TS1 Gene

Genomics for MT-TS1 Gene

Genomic Location for MT-TS1 Gene

Chromosome:
MT
Start:
7,446 bp from pter
End:
7,514 bp from pter
Size:
69 bases
Orientation:
Minus strand

Genomic View for MT-TS1 Gene

Genes around MT-TS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for MT-TS1 Gene

No data available for Regulatory Elements for MT-TS1 Gene

Proteins for MT-TS1 Gene

Post-translational modifications for MT-TS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for MT-TS1 Gene

Domains & Families for MT-TS1 Gene

Gene Families for MT-TS1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MT-TS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for MT-TS1 Gene

Function for MT-TS1 Gene

Human Phenotype Ontology for MT-TS1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MT-TS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for MT-TS1 Gene

Localization for MT-TS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MT-TS1 gene
Compartment Confidence
mitochondrion 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for MT-TS1 Gene

Pathways & Interactions for MT-TS1 Gene

SuperPathways for MT-TS1 Gene

SuperPathway Contained pathways
1 tRNA Aminoacylation
genes like me logo Genes that share pathways with MT-TS1: view

Pathways by source for MT-TS1 Gene

1 KEGG pathway for MT-TS1 Gene

Interacting Proteins for MT-TS1 Gene

Gene Ontology (GO) - Biological Process for MT-TS1 Gene

None

No data available for SIGNOR curated interactions for MT-TS1 Gene

Drugs & Compounds for MT-TS1 Gene

No Compound Related Data Available

Transcripts for MT-TS1 Gene

mRNA/cDNA for MT-TS1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for MT-TS1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MT-TS1 Gene

No ASD Table

Relevant External Links for MT-TS1 Gene

GeneLoc Exon Structure for
MT-TS1
ECgene alternative splicing isoforms for
MT-TS1

Expression for MT-TS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MT-TS1 Gene

Phenotype-based relationships between genes and organs from Gene ORGANizer for MT-TS1 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • nervous
  • respiratory
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • inner ear
  • middle ear
  • outer ear
Thorax:
  • diaphragm
  • esophagus
  • heart
  • heart valve
  • lung
Abdomen:
  • kidney
  • pancreas
  • stomach
Limb:
  • foot
  • forearm
  • hand
  • lower limb
  • upper limb
General:
  • blood
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with MT-TS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for MT-TS1 Gene

Orthologs for MT-TS1 Gene

Evolution for MT-TS1 Gene

ENSEMBL:
Gene Tree for MT-TS1 (if available)
TreeFam:
Gene Tree for MT-TS1 (if available)

No data available for Orthologs for MT-TS1 Gene

Paralogs for MT-TS1 Gene

No data available for Paralogs for MT-TS1 Gene

Variants for MT-TS1 Gene

Relevant External Links for MT-TS1 Gene

Human Gene Mutation Database (HGMD)
MT-TS1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MT-TS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for MT-TS1 Gene

Disorders for MT-TS1 Gene

MalaCards: The human disease database

(13) MalaCards diseases for MT-TS1 Gene - From: HGMD, ClinVar, GeneTests, Orphanet, and DISEASES

Disorder Aliases PubMed IDs
keratoderma, palmoplantar, with deafness
  • keratoderma palmoplantar deafness
merrf/melas overlap syndrome
maternally-inherited progressive external ophthalmoplegia
  • maternally-inherited cpeo
mitochondrial non-syndromic sensorineural deafness
  • isolated mitochondrial neurosensory deafness
nonsyndromic hearing loss and deafness, mitochondrial
  • nonsyndromic deafness and hearing loss, maternally-inherited
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MT-TS1

Genetic Association Database (GAD)
MT-TS1
genes like me logo Genes that share disorders with MT-TS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT-TS1 Gene

Publications for MT-TS1 Gene

  1. Prevalence of the A1555G (12S rRNA) and tRNASer(UCN) mitochondrial mutations in hearing-impaired Brazilian patients. (PMID: 16470309) Abreu-Silva RS … Mingroni-Netto RC (Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2006) 3 45 60
  2. Mutational analysis of the mitochondrial 12S rRNA and tRNASer(UCN) genes in Tunisian patients with nonsyndromic hearing loss. (PMID: 16406239) Mkaouar-Rebai E … Fakhfakh F (Biochemical and biophysical research communications 2006) 3 45 60
  3. Sequence variations of mitochondrial DNA and individual sensitivity to the ototoxic effect of cisplatin. (PMID: 12820379) Peters U … Lamprecht-Dinnesen A (Anticancer research 2003) 3 45 60
  4. Mutation in PCDH15 may modify the phenotypic expression of the 7511T>C mutation in MT-TS1 in a Chinese Han family with maternally inherited nonsyndromic hearing loss. (PMID: 26279247) Chen DY … Wu H (International journal of pediatric otorhinolaryngology 2015) 3 60
  5. Mitochondrial COI/tRNASer(UCN) G7444A mutation may be associated with aminoglycoside-induced and non-syndromic hearing impairment. (PMID: 26497601) Liu Q … Yang GC (Molecular medicine reports 2015) 3 60

Products for MT-TS1 Gene

Sources for MT-TS1 Gene

Content
Loading form....