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Aliases for MTTP Gene

Aliases for MTTP Gene

  • Microsomal Triglyceride Transfer Protein 2 3
  • Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kDa) 2 3
  • MTP 3 4
  • Microsomal Triglyceride Transfer Protein (Large Polypeptide, 88kD) 2
  • ABL 3

External Ids for MTTP Gene

Previous HGNC Symbols for MTTP Gene

  • MTP

Previous GeneCards Identifiers for MTTP Gene

  • GCMTU990051
  • GC04P100854
  • GC04P100715
  • GC04P100485
  • GC04P096223

Summaries for MTTP Gene

Entrez Gene Summary for MTTP Gene

  • MTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a central role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTTP Gene

MTTP (Microsomal Triglyceride Transfer Protein) is a Protein Coding gene. Diseases associated with MTTP include abetalipoproteinemia and abdominal obesity-metabolic syndrome 1. Among its related pathways are Metabolism and Fat digestion and absorption. GO annotations related to this gene include protein heterodimerization activity and lipid transporter activity.

UniProtKB/Swiss-Prot for MTTP Gene

  • Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B

Gene Wiki entry for MTTP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTTP Gene

Genomics for MTTP Gene

Regulatory Elements for MTTP Gene

Genomic Location for MTTP Gene

Chromosome:
4
Start:
99,563,761 bp from pter
End:
99,623,999 bp from pter
Size:
60,239 bases
Orientation:
Plus strand

Genomic View for MTTP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTTP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTTP Gene

Proteins for MTTP Gene

  • Protein details for MTTP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55157-MTP_HUMAN
    Recommended name:
    Microsomal triglyceride transfer protein large subunit
    Protein Accession:
    P55157
    Secondary Accessions:
    • A8K428
    • Q08AM4
    • Q6P5T3

    Protein attributes for MTTP Gene

    Size:
    894 amino acids
    Molecular mass:
    99351 Da
    Quaternary structure:
    • Heterodimer composed of MTTP and of protein disulfide isomerase (P4HB/PDI).

    Alternative splice isoforms for MTTP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MTTP Gene

Proteomics data for MTTP Gene at MOPED

Post-translational modifications for MTTP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MTTP Gene

Domains & Families for MTTP Gene

Graphical View of Domain Structure for InterPro Entry

P55157

UniProtKB/Swiss-Prot:

MTP_HUMAN :
  • Contains 1 vitellogenin domain.
Domain:
  • Contains 1 vitellogenin domain.
genes like me logo Genes that share domains with MTTP: view

No data available for Gene Families for MTTP Gene

Function for MTTP Gene

Molecular function for MTTP Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B
UniProtKB/Swiss-Prot Induction:
Positively regulated by cholesterol and negatively regulated by insulin.

Gene Ontology (GO) - Molecular Function for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity TAS --
GO:0005515 protein binding IPI 23475612
GO:0005548 phospholipid transporter activity IDA 23475612
GO:0008289 lipid binding IEA --
GO:0034185 apolipoprotein binding --
genes like me logo Genes that share ontologies with MTTP: view
genes like me logo Genes that share phenotypes with MTTP: view

Animal Model Products

miRNA for MTTP Gene

miRTarBase miRNAs that target MTTP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MTTP Gene

Localization for MTTP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTTP Gene

Endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTTP Gene COMPARTMENTS Subcellular localization image for MTTP gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 2
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 22236406
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005791 rough endoplasmic reticulum --
GO:0005794 Golgi apparatus --
GO:0016323 basolateral plasma membrane --
genes like me logo Genes that share ontologies with MTTP: view

Pathways & Interactions for MTTP Gene

genes like me logo Genes that share pathways with MTTP: view

Pathways by source for MTTP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MTTP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006497 protein lipidation --
GO:0006629 lipid metabolic process TAS 1439810
GO:0006641 triglyceride metabolic process --
GO:0006869 lipid transport --
GO:0007623 circadian rhythm --
genes like me logo Genes that share ontologies with MTTP: view

No data available for SIGNOR curated interactions for MTTP Gene

Drugs & Compounds for MTTP Gene

(27) Drugs for MTTP Gene - From: NovoSeek, DGIdb, PharmGKB, DrugBank, HMDB, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lomitapide Approved Pharma Target, antagonist 0
Hesperetin Approved Pharma Target, antagonist 0
Atorvastatin Approved Pharma Competitive, Inhibitor 690
Pravastatin Approved Pharma 142
Ethanol Approved Pharma 1708

(29) Additional Compounds for MTTP Gene - From: NovoSeek and HMDB