Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MTNR1B Gene

Aliases for MTNR1B Gene

  • Melatonin Receptor 1B 2 3 5
  • Mel1b Receptor 3 4
  • MEL-1B-R 3 4
  • Melatonin Receptor 1B Variant B 3
  • Melatonin Receptor MEL1B 3
  • FGQTL2 3
  • MT2 3

External Ids for MTNR1B Gene

Previous GeneCards Identifiers for MTNR1B Gene

  • GC11P095033
  • GC11P094210
  • GC11P092887
  • GC11P092390
  • GC11P092342
  • GC11P092705
  • GC11P088793

Summaries for MTNR1B Gene

Entrez Gene Summary for MTNR1B Gene

  • This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTNR1B Gene

MTNR1B (Melatonin Receptor 1B) is a Protein Coding gene. Diseases associated with MTNR1B include Diabetes Mellitus, Noninsulin-Dependent and Idiopathic Scoliosis. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.

UniProtKB/Swiss-Prot for MTNR1B Gene

  • High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Tocris Summary for MTNR1B Gene

  • Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2. They are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina.

Gene Wiki entry for MTNR1B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTNR1B Gene

Genomics for MTNR1B Gene

Regulatory Elements for MTNR1B Gene

Enhancers for MTNR1B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MTNR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for MTNR1B Gene

Chromosome:
11
Start:
92,969,623 bp from pter
End:
92,986,240 bp from pter
Size:
16,618 bases
Orientation:
Plus strand

Genomic View for MTNR1B Gene

Genes around MTNR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTNR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTNR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTNR1B Gene

Proteins for MTNR1B Gene

  • Protein details for MTNR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49286-MTR1B_HUMAN
    Recommended name:
    Melatonin receptor type 1B
    Protein Accession:
    P49286

    Protein attributes for MTNR1B Gene

    Size:
    362 amino acids
    Molecular mass:
    40188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTNR1B Gene

Proteomics data for MTNR1B Gene at MOPED

Post-translational modifications for MTNR1B Gene

Other Protein References for MTNR1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTNR1B Gene

Domains & Families for MTNR1B Gene

Gene Families for MTNR1B Gene

Protein Domains for MTNR1B Gene

Suggested Antigen Peptide Sequences for MTNR1B Gene

Graphical View of Domain Structure for InterPro Entry

P49286

UniProtKB/Swiss-Prot:

MTR1B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MTNR1B: view

Function for MTNR1B Gene

Molecular function for MTNR1B Gene

GENATLAS Biochemistry:
melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
genes like me logo Genes that share phenotypes with MTNR1B: view

Animal Models for MTNR1B Gene

MGI Knock Outs for MTNR1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTNR1B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MTNR1B Gene

Localization for MTNR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTNR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTNR1B Gene COMPARTMENTS Subcellular localization image for MTNR1B gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MTNR1B: view

Pathways & Interactions for MTNR1B Gene

genes like me logo Genes that share pathways with MTNR1B: view

Pathways by source for MTNR1B Gene

Gene Ontology (GO) - Biological Process for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007623 circadian rhythm IBA --
GO:0042593 glucose homeostasis IMP 20668700
GO:0042753 positive regulation of circadian rhythm IEA --
genes like me logo Genes that share ontologies with MTNR1B: view

No data available for SIGNOR curated interactions for MTNR1B Gene

Drugs & Compounds for MTNR1B Gene

(37) Drugs for MTNR1B Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved Nutra Antagonist, binder, Target, agonist Melatonin receptors MT inhibitor 239
Ramelteon Approved, Investigational Pharma Full agonist, Agonist, agonist, Target, multitarget Agonist of melatonin receptor(M1-M2),highly selective 0
Agomelatine Approved, Investigational Pharma Antagonist, agonist, Target MT1/MT2 / 5-HT2C agonist 0
Tasimelteon Approved Pharma Target, agonist 0
VEC-162 Investigational Pharma Target 0

(6) Additional Compounds for MTNR1B Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Iodomelatonin
93515-00-5
2-Phenylmelatonin
151889-03-1
6-Chloromelatonin
63762-74-3
8-M-PDOT
134865-70-6
N-Acetyltryptamine
1016-47-3

(5) Tocris Compounds for MTNR1B Gene

Compound Action Cas Number
2-Iodomelatonin High affinity melatonin agonist 93515-00-5
2-Phenylmelatonin Potent melatonin agonist 151889-03-1
6-Chloromelatonin Melatonin agonist 63762-74-3
8-M-PDOT Melatonin agonist 134865-70-6
N-Acetyltryptamine Substrate for serotonin N-acetyl transferase 1016-47-3

(2) ApexBio Compounds for MTNR1B Gene

Compound Action Cas Number
Melatonin Melatonin receptors MT inhibitor 73-31-4
Ramelteon Agonist of melatonin receptor(M1-M2),highly selective 196597-26-9
genes like me logo Genes that share compounds with MTNR1B: view

Transcripts for MTNR1B Gene

mRNA/cDNA for MTNR1B Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTNR1B Gene

Melatonin receptor 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTNR1B Gene

No ASD Table

Relevant External Links for MTNR1B Gene

GeneLoc Exon Structure for
MTNR1B
ECgene alternative splicing isoforms for
MTNR1B

Expression for MTNR1B Gene

mRNA expression in normal human tissues for MTNR1B Gene

mRNA differential expression in normal tissues according to GTEx for MTNR1B Gene

This gene is overexpressed in Testis (x15.9), Brain - Nucleus accumbens (basal ganglia) (x12.2), and Brain - Hypothalamus (x4.5).

SOURCE GeneReport for Unigene cluster for MTNR1B Gene Hs.569039

mRNA Expression by UniProt/SwissProt for MTNR1B Gene

P49286-MTR1B_HUMAN
Tissue specificity: Expressed in retina and less in brain and hippocampus.
genes like me logo Genes that share expression patterns with MTNR1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for MTNR1B Gene

Orthologs for MTNR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MTNR1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MTNR1B 35
  • 83.06 (n)
  • 76.24 (a)
dog
(Canis familiaris)
Mammalia MTNR1B 35
  • 85.52 (n)
  • 80.97 (a)
MTNR1B 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtnr1b 35
  • 81.2 (n)
  • 80.91 (a)
Mtnr1b 16
Mtnr1b 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MTNR1B 35
  • 98.53 (n)
  • 98.34 (a)
MTNR1B 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtnr1b 35
  • 80.15 (n)
  • 80.34 (a)
oppossum
(Monodelphis domestica)
Mammalia MTNR1B 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTNR1B 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MTNR1B 35
  • 67.6 (n)
  • 69.36 (a)
MEL1B 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTNR1B 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493509 35
  • 68.24 (n)
  • 70.55 (a)
zebrafish
(Danio rerio)
Actinopterygii mel1c 35
mtnr1bb 35
  • 70.4 (n)
  • 69.16 (a)
mtnr1ba 36
  • 57 (a)
OneToMany
mtnr1bb 36
  • 65 (a)
OneToMany
mtnr1bb 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30340 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-35 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
CSA.5131 36
  • 20 (a)
ManyToMany
Species with no ortholog for MTNR1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTNR1B Gene

ENSEMBL:
Gene Tree for MTNR1B (if available)
TreeFam:
Gene Tree for MTNR1B (if available)

Paralogs for MTNR1B Gene

Paralogs for MTNR1B Gene

(2) SIMAP similar genes for MTNR1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTNR1B: view

Variants for MTNR1B Gene

Sequence variations from dbSNP and Humsavar for MTNR1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs8192552 - 92,969,796(+) GTCGG(A/G)GGCTG reference, missense
VAR_009263 -
rs8192553 - 92,981,915(+) GGCCC(A/G/T)CAGGA reference, missense
rs1374646 -- 92,972,662(+) TGGCA(C/T)CTCAC intron-variant
rs1447350 -- 92,984,961(+) GGGAA(C/G)CCTGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTNR1B Gene

Variant ID Type Subtype PubMed ID
nsv898173 CNV Loss 21882294
esv28204 CNV Gain 19812545
nsv442239 CNV CNV 18776908
esv2744911 CNV Deletion 23290073

Variation tolerance for MTNR1B Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTNR1B Gene

Human Gene Mutation Database (HGMD)
MTNR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTNR1B Gene

Disorders for MTNR1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTNR1B Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes mellitus, noninsulin-dependent, 2
idiopathic scoliosis
  • scoliosis idiopathic
adolescent idiopathic scoliosis
  • ais
scoliosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MTNR1B

Genetic Association Database (GAD)
MTNR1B
Human Genome Epidemiology (HuGE) Navigator
MTNR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTNR1B
genes like me logo Genes that share disorders with MTNR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTNR1B Gene

Publications for MTNR1B Gene

  1. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. (PMID: 20200315) Andersson E.A. … Hansen T. (Diabetes 2010) 3 23 48 67
  2. MT1 melatonin receptors mediate somatic, behavioral, and reproductive neuroendocrine responses to photoperiod and melatonin in Siberian hamsters (Phodopus sungorus). (PMID: 19966183) Prendergast B.J. (Endocrinology 2010) 25 26
  3. Design, synthesis, and pharmacological effects of structurally simple ligands for MT(1) and MT(2) melatonin receptors. (PMID: 20674373) Carocci A. … Franchini C. (Bioorg. Med. Chem. 2010) 25 26
  4. Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs. (PMID: 20827520) Srinivasan V. … Cardinali D.P. (Adv Ther 2010) 25 26
  5. Variants in MTNR1B influence fasting glucose levels. (PMID: 19060907) Prokopenko I. … Abecasis G.R. (Nat. Genet. 2009) 3 23

Products for MTNR1B Gene

Sources for MTNR1B Gene

Content