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Aliases for MTNR1B Gene

Aliases for MTNR1B Gene

  • Melatonin Receptor 1B 2 3 5
  • Mel1b Receptor 3 4
  • MEL-1B-R 3 4
  • Melatonin Receptor 1B Variant B 3
  • Melatonin Receptor Type 1B 3
  • Melatonin Receptor MEL1B 3
  • FGQTL2 3
  • MT2 3

External Ids for MTNR1B Gene

Previous GeneCards Identifiers for MTNR1B Gene

  • GC11P095033
  • GC11P094210
  • GC11P092887
  • GC11P092390
  • GC11P092342
  • GC11P092705
  • GC11P088793

Summaries for MTNR1B Gene

Entrez Gene Summary for MTNR1B Gene

  • This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin. [provided by RefSeq, Jul 2008]

GeneCards Summary for MTNR1B Gene

MTNR1B (Melatonin Receptor 1B) is a Protein Coding gene. Diseases associated with MTNR1B include Diabetes Mellitus, Noninsulin-Dependent and Idiopathic Scoliosis. Among its related pathways are Eicosanoid ligand-binding receptors and Sweet Taste Signaling. GO annotations related to this gene include G-protein coupled receptor activity and melatonin receptor activity. An important paralog of this gene is MTNR1A.

UniProtKB/Swiss-Prot for MTNR1B Gene

  • High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Tocris Summary for MTNR1B Gene

  • Melatonin receptors are a group of high affinity Gi/G0 protein-coupled receptors, which are split into two subtypes; MT1 and MT2. They are widely distributed with high concentrations found in the brain (especially in the suprachiasmatic nucleus) and in the retina.

Gene Wiki entry for MTNR1B Gene

Additional gene information for MTNR1B Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTNR1B Gene

Genomics for MTNR1B Gene

Regulatory Elements for MTNR1B Gene

Enhancers for MTNR1B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H093234 0.8 ENCODE 10.3 +265.2 265167 0 GTF2F1 CTCF TBL1XR1 ZNF2 RAD21 RFX5 GATAD1 SMC3 ZNF143 RCOR1 ENSG00000254874 MTNR1B TAF1D MED17 ENSG00000255233 ENSG00000233737
GH11H093004 0.6 ENCODE 11.8 +35.9 35872 1 ZNF146 JUND POLR2A USF2 MYC TCF7L2 ENSG00000254874 MTNR1B PIR49183 PIR63007
GH11H093034 0.6 FANTOM5 11.3 +65.2 65194 0 ATF3 HNF4A YY1 MTNR1B ENSG00000254874 GC11P093032 GC11M093266
GH11H093536 1.3 Ensembl ENCODE dbSUPER 4.4 +568.0 567978 3 FOXA2 TAF1 ZNF133 MAX CEBPG RAD21 YY1 FOSL1 IRF9 SCRT2 SMCO4 C11orf54 MTNR1B PIR55384 GC11P093545
GH11H093031 0.5 FANTOM5 ENCODE 11.3 +62.1 62097 1 MTNR1B ENSG00000254874 GC11P093032 GC11M093235
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MTNR1B on UCSC Golden Path with GeneCards custom track

Genomic Location for MTNR1B Gene

Chromosome:
11
Start:
92,969,623 bp from pter
End:
92,986,240 bp from pter
Size:
16,618 bases
Orientation:
Plus strand

Genomic View for MTNR1B Gene

Genes around MTNR1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MTNR1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MTNR1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTNR1B Gene

Proteins for MTNR1B Gene

  • Protein details for MTNR1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49286-MTR1B_HUMAN
    Recommended name:
    Melatonin receptor type 1B
    Protein Accession:
    P49286

    Protein attributes for MTNR1B Gene

    Size:
    362 amino acids
    Molecular mass:
    40188 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTNR1B Gene

Post-translational modifications for MTNR1B Gene

Other Protein References for MTNR1B Gene

Antibody Products

No data available for DME Specific Peptides for MTNR1B Gene

Domains & Families for MTNR1B Gene

Gene Families for MTNR1B Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MTNR1B Gene

Graphical View of Domain Structure for InterPro Entry

P49286

UniProtKB/Swiss-Prot:

MTR1B_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with MTNR1B: view

Function for MTNR1B Gene

Molecular function for MTNR1B Gene

GENATLAS Biochemistry:
melatonin receptor 1B,expressed in retina and brain,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Phenotypes From GWAS Catalog for MTNR1B Gene

Gene Ontology (GO) - Molecular Function for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 7568007
GO:0005515 protein binding IPI 20859254
GO:0008502 melatonin receptor activity IEA --
genes like me logo Genes that share ontologies with MTNR1B: view
genes like me logo Genes that share phenotypes with MTNR1B: view

Animal Models for MTNR1B Gene

MGI Knock Outs for MTNR1B:

Animal Model Products

  • Taconic Biosciences Mouse Models for MTNR1B

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTNR1B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for MTNR1B (Melatonin R1B/MT2/MTNR1B)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for MTNR1B Gene

Localization for MTNR1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTNR1B Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MTNR1B gene
Compartment Confidence
plasma membrane 5
cytosol 1

Gene Ontology (GO) - Cellular Components for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7568007
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MTNR1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for MTNR1B Gene

Pathways & Interactions for MTNR1B Gene

genes like me logo Genes that share pathways with MTNR1B: view

Gene Ontology (GO) - Biological Process for MTNR1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 7568007
GO:0007268 chemical synaptic transmission TAS 7568007
GO:0007623 circadian rhythm IBA --
genes like me logo Genes that share ontologies with MTNR1B: view

No data available for SIGNOR curated interactions for MTNR1B Gene

Drugs & Compounds for MTNR1B Gene

(52) Drugs for MTNR1B Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Melatonin Approved, Vet_approved Nutra Antagonist, binder, Target, agonist Melatonin receptors MT inhibitor 281
Ramelteon Approved, Investigational Pharma Full agonist, Agonist, agonist, Target, multitarget Agonist of melatonin receptor(M1-M2),highly selective 0
Agomelatine Approved, Investigational Pharma Antagonist, agonist, Target MT1/MT2 / 5-HT2C agonist 0
Tasimelteon Approved Pharma Target, agonist 0
Resveratrol Experimental, Investigational Pharma Target Cyclooxygenase inhibitor 123

(1) Additional Compounds for MTNR1B Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Prazosin hydrochloride
19237-84-4

(5) Tocris Compounds for MTNR1B Gene

Compound Action Cas Number
2-Phenylmelatonin Potent melatonin agonist 151889-03-1
4-P-PDOT MT2 antagonist 620170-78-7
GR 135531 High affinity melatonin MT3 ligand 190277-13-5
Luzindole Competitive melatonin MT1/MT2 antagonist 117946-91-5
Prazosin hydrochloride alpha1 and alpha2B antagonist. MT3 antagonist 19237-84-4

(11) ApexBio Compounds for MTNR1B Gene

Compound Action Cas Number
2-Iodomelatonin 93515-00-5
2-Phenylmelatonin 151889-03-1
4-P-PDOT 134865-74-0
6-Chloromelatonin 63762-74-3
8-M-PDOT 134865-70-6
DH 97 220339-00-4
GR 135531 190277-13-5
Luzindole 117946-91-5
Melatonin Melatonin receptors MT inhibitor 73-31-4
N-Acetyltryptamine 1016-47-3
Ramelteon Agonist of melatonin receptor(M1-M2),highly selective 196597-26-9
genes like me logo Genes that share compounds with MTNR1B: view

Drug Products

Transcripts for MTNR1B Gene

mRNA/cDNA for MTNR1B Gene

(3) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MTNR1B Gene

Melatonin receptor 1B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MTNR1B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
  • R&D Systems cDNA Clones for MTNR1B (Melatonin R1B/MT2/MTNR1B)

Alternative Splicing Database (ASD) splice patterns (SP) for MTNR1B Gene

No ASD Table

Relevant External Links for MTNR1B Gene

GeneLoc Exon Structure for
MTNR1B
ECgene alternative splicing isoforms for
MTNR1B

Expression for MTNR1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MTNR1B Gene

mRNA differential expression in normal tissues according to GTEx for MTNR1B Gene

This gene is overexpressed in Testis (x15.9), Brain - Nucleus accumbens (basal ganglia) (x12.2), and Brain - Hypothalamus (x4.5).

NURSA nuclear receptor signaling pathways regulating expression of MTNR1B Gene:

MTNR1B

SOURCE GeneReport for Unigene cluster for MTNR1B Gene:

Hs.569039

mRNA Expression by UniProt/SwissProt for MTNR1B Gene:

P49286-MTR1B_HUMAN
Tissue specificity: Expressed in retina and less in brain and hippocampus.

Evidence on tissue expression from TISSUES for MTNR1B Gene

  • Eye(4)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with MTNR1B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for MTNR1B Gene

Orthologs for MTNR1B Gene

This gene was present in the common ancestor of animals.

Orthologs for MTNR1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTNR1B 33 34
  • 98.53 (n)
dog
(Canis familiaris)
Mammalia MTNR1B 33 34
  • 85.52 (n)
cow
(Bos Taurus)
Mammalia MTNR1B 33
  • 83.06 (n)
mouse
(Mus musculus)
Mammalia Mtnr1b 33 16 34
  • 81.2 (n)
rat
(Rattus norvegicus)
Mammalia Mtnr1b 33
  • 80.15 (n)
oppossum
(Monodelphis domestica)
Mammalia MTNR1B 34
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTNR1B 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MEL1B 34
  • 68 (a)
OneToOne
MTNR1B 33
  • 67.6 (n)
lizard
(Anolis carolinensis)
Reptilia MTNR1B 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493509 33
  • 68.24 (n)
zebrafish
(Danio rerio)
Actinopterygii mtnr1bb 33 34 34
  • 70.4 (n)
mtnr1ba 34
  • 57 (a)
OneToMany
mel1c 33
fruit fly
(Drosophila melanogaster)
Insecta CG30340 34
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-35 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
ManyToMany
CSA.5131 34
  • 20 (a)
ManyToMany
Species where no ortholog for MTNR1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MTNR1B Gene

ENSEMBL:
Gene Tree for MTNR1B (if available)
TreeFam:
Gene Tree for MTNR1B (if available)

Paralogs for MTNR1B Gene

Paralogs for MTNR1B Gene

(2) SIMAP similar genes for MTNR1B Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MTNR1B: view

Variants for MTNR1B Gene

Sequence variations from dbSNP and Humsavar for MTNR1B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs141804752 other 92,969,904(+) CCTCC(A/G/T)GGTGA reference, missense
rs182349376 other 92,981,507(+) CTACC(C/T)GCTAA reference, missense
rs184917682 other 92,982,146(+) TGTCT(A/C/G)TGGGC reference, missense
rs387906779 other 92,969,849(+) CTCCA(C/G)CGCTG reference, missense
rs1000054341 -- 92,983,988(+) TGTGG(A/C)GCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MTNR1B Gene

Variant ID Type Subtype PubMed ID
dgv2094n54 CNV loss 21841781
esv2744911 CNV deletion 23290073
esv2760202 CNV gain 21179565
esv28204 CNV gain 19812545
nsv442239 CNV gain 18776908

Variation tolerance for MTNR1B Gene

Residual Variation Intolerance Score: 70% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MTNR1B Gene

Human Gene Mutation Database (HGMD)
MTNR1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MTNR1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTNR1B Gene

Disorders for MTNR1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for MTNR1B Gene - From: HGMD, OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, noninsulin-dependent
  • diabetes, type 2
idiopathic scoliosis
  • scoliosis idiopathic
adolescent idiopathic scoliosis
  • idiopathic adolescent scoliosis
scoliosis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for MTNR1B

Genetic Association Database (GAD)
MTNR1B
Human Genome Epidemiology (HuGE) Navigator
MTNR1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MTNR1B
genes like me logo Genes that share disorders with MTNR1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MTNR1B Gene

Publications for MTNR1B Gene

  1. MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans. (PMID: 20200315) Andersson EA … Hansen T (Diabetes 2010) 3 22 45 60
  2. Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. (PMID: 19533084) Reiling E … 't Hart LM (Diabetologia 2009) 3 22 45 60
  3. A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals. (PMID: 19241057) Rönn T … Ling C (Diabetologia 2009) 3 22 45 60
  4. Variants in MTNR1B influence fasting glucose levels. (PMID: 19060907) Prokopenko I … Abecasis GR (Nature genetics 2009) 3 22 45 60
  5. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. (PMID: 19060908) Lyssenko V … Groop L (Nature genetics 2009) 3 22 45 60

Products for MTNR1B Gene

Sources for MTNR1B Gene

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