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Aliases for MTF1 Gene

Aliases for MTF1 Gene

  • Metal-Regulatory Transcription Factor 1 2 3
  • MRE-Binding Transcription Factor 3 4
  • Transcription Factor MTF-1 3 4
  • Metal Regulatory Transcription Factor 1 3
  • Metal-Responsive Transcription Factor 1 3
  • MRE-Binding Transcription Factor-1 3
  • Zinc Regulatory Factor 3
  • MTF-1 3
  • ZRF 3

External Ids for MTF1 Gene

Previous GeneCards Identifiers for MTF1 Gene

  • GC01M038114
  • GC01M037334
  • GC01M037706
  • GC01M9V0006
  • GC01M037948
  • GC01M038047
  • GC01M038275
  • GC01M036393

Summaries for MTF1 Gene

Entrez Gene Summary for MTF1 Gene

  • This gene encodes a transcription factor that induces expression of metallothioneins and other genes involved in metal homeostasis in response to heavy metals such as cadmium, zinc, copper, and silver. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). [provided by RefSeq, Jul 2008]

GeneCards Summary for MTF1 Gene

MTF1 (Metal-Regulatory Transcription Factor 1) is a Protein Coding gene. Diseases associated with MTF1 include enamel erosion and dentine erosion. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is ZIC4.

UniProtKB/Swiss-Prot for MTF1 Gene

  • Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Gene Wiki entry for MTF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MTF1 Gene

Genomics for MTF1 Gene

Genomic Location for MTF1 Gene

Start:
37,809,567 bp from pter
End:
37,859,620 bp from pter
Size:
50,054 bases
Orientation:
Minus strand

Genomic View for MTF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MTF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MTF1 Gene

Proteins for MTF1 Gene

  • Protein details for MTF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14872-MTF1_HUMAN
    Recommended name:
    Metal regulatory transcription factor 1
    Protein Accession:
    Q14872
    Secondary Accessions:
    • B2RAK6
    • Q96CB1

    Protein attributes for MTF1 Gene

    Size:
    753 amino acids
    Molecular mass:
    80957 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MTF1 Gene

Proteomics data for MTF1 Gene at MOPED

Post-translational modifications for MTF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MTF1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MTF1 Gene

Domains for MTF1 Gene

Protein Domains for MTF1 Gene

Suggested Antigen Peptide Sequences for MTF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14872

UniProtKB/Swiss-Prot:

MTF1_HUMAN :
  • Q14872
Similarity:
  • Contains 6 C2H2-type zinc fingers.
genes like me logo Genes that share domains with MTF1: view

No data available for Gene Families for MTF1 Gene

Function for MTF1 Gene

Molecular function for MTF1 Gene

GENATLAS Biochemistry: metal-regulatory transcription factor MTF-1
UniProtKB/Swiss-Prot Function: Activates the metallothionein I promoter. Binds to the metal responsive element (MRE).

Gene Ontology (GO) - Molecular Function for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9582278
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0001047 core promoter binding IDA 15735762
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 9582278
GO:0003677 DNA binding TAS 8065932
genes like me logo Genes that share ontologies with MTF1: view
genes like me logo Genes that share phenotypes with MTF1: view

Animal Models for MTF1 Gene

MGI Knock Outs for MTF1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MTF1 Gene

Localization for MTF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MTF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MTF1 Gene COMPARTMENTS Subcellular localization image for MTF1 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 3208749
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MTF1: view

Pathways for MTF1 Gene

SuperPathways for MTF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MTF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 3208749
GO:0006979 response to oxidative stress IEA --
GO:0010038 response to metal ion TAS 8065932
GO:0045893 positive regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with MTF1: view

No data available for Pathways by source for MTF1 Gene

Compounds for MTF1 Gene

(13) Novoseek inferred chemical compound relationships for MTF1 Gene

Compound -log(P) Hits PubMed IDs
zinc 77.5 77
cadmium 67.5 12
gamma-glutamylcysteine 58 3
copper 57 14
mercury 33.2 2
genes like me logo Genes that share compounds with MTF1: view

Transcripts for MTF1 Gene

Unigene Clusters for MTF1 Gene

Metal-regulatory transcription factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MTF1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:
SP4: -
SP5:

Relevant External Links for MTF1 Gene

GeneLoc Exon Structure for
MTF1
ECgene alternative splicing isoforms for
MTF1

Expression for MTF1 Gene

mRNA expression in normal human tissues for MTF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MTF1 Gene

This gene is overexpressed in Whole Blood (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MTF1 Gene

SOURCE GeneReport for Unigene cluster for MTF1 Gene Hs.471991

genes like me logo Genes that share expressions with MTF1: view

No data available for mRNA Expression by UniProt/SwissProt for MTF1 Gene

Orthologs for MTF1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MTF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MTF1 35
  • 99.73 (n)
  • 99.73 (a)
MTF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MTF1 35
  • 91.83 (n)
  • 91.34 (a)
MTF1 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MTF1 35
  • 93.83 (n)
  • 95.3 (a)
MTF1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mtf1 35
  • 91.23 (n)
  • 92.72 (a)
Mtf1 16
Mtf1 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MTF1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MTF1 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mtf1 35
  • 91.73 (n)
  • 93.16 (a)
chicken
(Gallus gallus)
Aves MTF1 35
  • 78.44 (n)
  • 80.33 (a)
MTF1 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MTF1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mtf1 35
  • 64.77 (n)
  • 64.01 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.308 35
zebrafish
(Danio rerio)
Actinopterygii mtf1 35
  • 63.07 (n)
  • 62.43 (a)
mtf1 36
  • 56 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta MTF-1 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToOne
Species with no ortholog for MTF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MTF1 Gene

ENSEMBL:
Gene Tree for MTF1 (if available)
TreeFam:
Gene Tree for MTF1 (if available)

Paralogs for MTF1 Gene

Paralogs for MTF1 Gene

genes like me logo Genes that share paralogs with MTF1: view

Variants for MTF1 Gene

Sequence variations from dbSNP and Humsavar for MTF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs473186 -- 37,810,709(-) CAGAA(A/G)GATTT utr-variant-3-prime
rs766588 -- 37,833,168(-) CCAAG(A/G)TTTAT intron-variant
rs900679 -- 37,825,816(-) aaaaa(A/T)aaaat intron-variant
rs2361033 -- 37,842,266(+) TAATA(A/C)CAATA intron-variant
rs3748682 -- 37,814,315(+) AGCGA(C/T)GTTCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MTF1 Gene

Variant ID Type Subtype PubMed ID
nsv871810 CNV Loss 21882294
nsv870730 CNV Gain 21882294
nsv510 CNV Insertion 18451855
nsv506927 CNV Insertion 20534489

Relevant External Links for MTF1 Gene

HapMap Linkage Disequilibrium report
MTF1
Human Gene Mutation Database (HGMD)
MTF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MTF1 Gene

Disorders for MTF1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for MTF1 Gene including...

Search for MTF1 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MTF1 Gene

(3) Novoseek inferred disease relationships for MTF1 Gene

Disease -log(P) Hits PubMed IDs
shock 15.6 4
tumors 0 2
lymphoma 0 3

Relevant External Links for MTF1

Genetic Association Database (GAD)
MTF1
Human Genome Epidemiology (HuGE) Navigator
MTF1
genes like me logo Genes that share disorders with MTF1: view

No data available for UniProtKB/Swiss-Prot for MTF1 Gene

Publications for MTF1 Gene

  1. Cloning, chromosomal mapping and characterization of the human metal- regulatory transcription factor MTF-1. (PMID: 8065932) Brugnera E. … Schaffner W. (Nucleic Acids Res. 1994) 2 3 4 23
  2. Genetic susceptibility to environmental toxicants in ALS. (PMID: 17503480) Morahan J.M. … Pamphlett R. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007) 3 23 48
  3. Metal transcription factor-1 is involved in hypoxia-dependent regulation of placenta growth factor in trophoblast-derived cells. (PMID: 19022893) Nishimoto F. … Kimura T. (Endocrinology 2009) 3 23
  4. Loss of liver-intestine cadherin in human intrahepatic cholangiocarcinoma promotes angiogenesis by up-regulating metal-responsive transcription factor-1 and placental growth factor. (PMID: 19956853) Takamura M. … Aoyagi Y. (Int. J. Oncol. 2010) 3 23
  5. Divalent metal-dependent regulation of hepcidin expression by MTF-1. (PMID: 20026331) Balesaria S. … Srai S.K. (FEBS Lett. 2010) 3 23

Products for MTF1 Gene

Sources for MTF1 Gene

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