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Aliases for MT-CYB Gene

Aliases for MT-CYB Gene

  • Mitochondrially Encoded Cytochrome B 2
  • Cytochrome B 2 3
  • MTCYB 3 4
  • CYTB 3 4
  • Ubiquinol-Cytochrome-C Reductase Complex Cytochrome B Subunit 4
  • Cytochrome B-C1 Complex Subunit 3 4
  • Complex III Subunit III 4
  • Complex III Subunit 3 4
  • COB 4

External Ids for MT-CYB Gene

Previous Symbols for MT-CYB Gene

  • MTCYB

Summaries for MT-CYB Gene

GeneCards Summary for MT-CYB Gene

MT-CYB (Mitochondrially Encoded Cytochrome B) is a Protein Coding gene. Diseases associated with MT-CYB include infantile histiocytoid cardiomyopathy and mt-cyb-related recurrent myoglobinuria. Among its related pathways are Metabolism and Metabolism.

UniProtKB/Swiss-Prot for MT-CYB Gene

  • Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Wiki entry for MT-CYB Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-CYB Gene

Genomics for MT-CYB Gene

Genomic Location for MT-CYB Gene

Start:
14,747 bp from pter
End:
15,887 bp from pter
Size:
1,141 bases
Orientation:
Plus strand

Genomic View for MT-CYB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for MT-CYB Gene

No data available for Regulatory Elements for MT-CYB Gene

Proteins for MT-CYB Gene

  • Protein details for MT-CYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00156-CYB_HUMAN
    Recommended name:
    Cytochrome b
    Protein Accession:
    P00156
    Secondary Accessions:
    • Q34786
    • Q8HBR6
    • Q8HNQ0
    • Q8HNQ1
    • Q8HNQ9
    • Q8HNR4
    • Q8HNR7
    • Q8W7V8
    • Q8WCV9
    • Q8WCY2
    • Q8WCY7
    • Q8WCY8
    • Q9B1A6
    • Q9B1B6
    • Q9B1B8
    • Q9B1D4
    • Q9B1X6
    • Q9B2V0
    • Q9B2V8
    • Q9B2W0
    • Q9B2W3
    • Q9B2W8
    • Q9B2X1
    • Q9B2X7
    • Q9B2X9
    • Q9B2Y3
    • Q9B2Z0
    • Q9B2Z4
    • Q9T6H6
    • Q9T9Y0
    • Q9TEH4

    Protein attributes for MT-CYB Gene

    Size:
    380 amino acids
    Molecular mass:
    42718 Da
    Cofactor:
    Name=heme; Xref=ChEBI:CHEBI:30413; Note=Binds 2 heme groups non-covalently.;
    Quaternary structure:
    • The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1)
    Miscellaneous:
    • Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.

neXtProt entry for MT-CYB Gene

Proteomics data for MT-CYB Gene at MOPED

Post-translational modifications for MT-CYB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT-CYB Gene

ENSEMBL proteins:
Reactome Protein details:

No data available for DME Specific Peptides for MT-CYB Gene

Domains for MT-CYB Gene

Gene Families for MT-CYB Gene

HGNC:
  • comIII :Mitochondrial respiratory chain complex / Complex III
  • CYB :Cytochrome b genes

Protein Domains for MT-CYB Gene

Suggested Antigen Peptide Sequences for MT-CYB Gene

Graphical View of Domain Structure for InterPro Entry

P00156

UniProtKB/Swiss-Prot:

CYB_HUMAN
Family:
  • Belongs to the cytochrome b family.:
    • P00156
genes like me logo Genes that share domains with MT-CYB: view

Function for MT-CYB Gene

Molecular function for MT-CYB Gene

UniProtKB/Swiss-Prot Function: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Ontology (GO) - Molecular Function for MT-CYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008121 ubiquinol-cytochrome-c reductase activity --
GO:0009055 electron carrier activity --
GO:0016491 oxidoreductase activity --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with MT-CYB: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT-CYB Gene

Localization for MT-CYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-CYB Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT-CYB Gene COMPARTMENTS Subcellular localization image for MT-CYB gene
Compartment Confidence
mitochondrion 5
nucleus 3
plasma membrane 3
chloroplast 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MT-CYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0005750 mitochondrial respiratory chain complex III --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with MT-CYB: view

Pathways for MT-CYB Gene

genes like me logo Genes that share pathways with MT-CYB: view

Gene Ontology (GO) - Biological Process for MT-CYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c --
GO:0022904 respiratory electron transport chain --
GO:0044237 cellular metabolic process --
GO:0044281 small molecule metabolic process --
GO:1902600 hydrogen ion transmembrane transport --
genes like me logo Genes that share ontologies with MT-CYB: view

Compounds for MT-CYB Gene

(1) HMDB Compounds for MT-CYB Gene

Compound Synonyms Cas Number PubMed IDs
Heme
  • (protoporphyrinato)iron
14875-96-8

(1) Drugbank Compounds for MT-CYB Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Atovaquone
95233-18-4 target inhibitor

(72) Novoseek inferred chemical compound relationships for MT-CYB Gene

Compound -log(P) Hits PubMed IDs
ubiquinol 79.5 13
iron-sulfur 77.8 23
atovaquone 76 15
antimycin a 74.9 14
myxothiazol 73.1 3
genes like me logo Genes that share compounds with MT-CYB: view

Transcripts for MT-CYB Gene

mRNA/cDNA for MT-CYB Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-CYB Gene

No ASD Table

Relevant External Links for MT-CYB Gene

GeneLoc Exon Structure for
MT-CYB
ECgene alternative splicing isoforms for
MT-CYB

Expression for MT-CYB Gene

mRNA expression in normal human tissues for MT-CYB Gene

mRNA differential expression in normal tissues according to GTEx for MT-CYB Gene

This gene is overexpressed in Heart - Left Ventricle (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MT-CYB Gene

genes like me logo Genes that share expressions with MT-CYB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for MT-CYB Gene

Orthologs for MT-CYB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CYTB 35
  • 88.42 (n)
  • 92.11 (a)
MT-CYB 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CYTB 35
  • 73 (n)
  • 78.1 (a)
MT-CYB 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CYTB 35
  • 74.76 (n)
  • 82.06 (a)
MT-CYB 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia CYTB 35
  • 74.87 (n)
  • 78.57 (a)
mt-Cytb 16
mt-Cytb 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CYTB 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CYTB 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia CYTB 35
  • 75.99 (n)
  • 77.84 (a)
chicken
(Gallus gallus)
Aves CYTB 35
  • 73.4 (n)
  • 73.14 (a)
MT-CYB 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CYTB 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24968 35
tropical clawed frog
(Silurana tropicalis)
Amphibia CYTB 35
  • 71.77 (n)
  • 73.09 (a)
Str.8624 35
zebrafish
(Danio rerio)
Actinopterygii CYTB 35
  • 69.04 (n)
  • 69.47 (a)
Dr.29626 35
mt-cyb 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta CYTB 35
  • 59.66 (n)
  • 62.77 (a)
fruit fly
(Drosophila melanogaster)
Insecta CYTB 35
  • 60.04 (n)
  • 61.88 (a)
mt:Cyt-b 36
  • 60 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ctb-1 36
  • 43 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AMI008W 35
  • 53.96 (n)
  • 51.89 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BI4 36
  • 24 (a)
OneToMany
COB 35
  • 52.15 (n)
  • 49.73 (a)
COB 36
  • 42 (a)
OneToMany
COB 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes CYTB 35
  • 53.53 (n)
  • 51.21 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons cob 35
  • 52.03 (n)
  • 49.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cob 35
  • 52.1 (n)
  • 49.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for MT-CYB:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MT-CYB Gene

ENSEMBL:
Gene Tree for MT-CYB (if available)
TreeFam:
Gene Tree for MT-CYB (if available)

Paralogs for MT-CYB Gene

Selected SIMAP similar genes for MT-CYB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-CYB: view

No data available for Paralogs for MT-CYB Gene

Variants for MT-CYB Gene

Sequence variations from dbSNP and Humsavar for MT-CYB Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type MAF
VAR_002197 Leber hereditary optic neuropathy (LHON)
VAR_002198 -
VAR_002199 Leber hereditary optic neuropathy (LHON)
VAR_008388 Colorectal cancer
VAR_008389 Colorectal cancer

Relevant External Links for MT-CYB Gene

HapMap Linkage Disequilibrium report
MT-CYB
Human Gene Mutation Database (HGMD)
MT-CYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT-CYB Gene

Disorders for MT-CYB Gene

UniProtKB/Swiss-Prot

CYB_HUMAN
  • Note=Defects in MT-CYB are a rare cause of mitochondrial dysfunction underlying different myopathies. They include mitochondrial encephalomyopathy, hypertrophic cardiomyopathy (HCM), and sporadic mitochondrial myopathy (MM). In mitochondrial myopathy, exercise intolerance is the predominant symptom. Additional features include lactic acidosis, muscle weakness and/or myoglobinuria. Defects in MTCYB are also found in cases of exercise intolerance accompanied by deafness, mental retardation, retinitis pigmentosa, cataract, growth retardation, epilepsy (multisystem disorder). {ECO:0000269 PubMed:11047755, ECO:0000269 PubMed:11601507}.
  • Cardiomyopathy, infantile histiocytoid (CMIH) [MIM:500000]: A heart disease characterized by the presence of pale granular foamy histiocyte-like cells within the myocardium. It usually affects children younger than 2 years of age, with a clear predominance of females over males. Infants present with dysrhythmia or cardiac arrest. The clinical course is usually fulminant, sometimes simulating sudden infant death syndrome. {ECO:0000269 PubMed:10960495}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Leber hereditary optic neuropathy (LHON) [MIM:535000]: A maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. {ECO:0000269 PubMed:1732158}. Note=The disease is caused by mutations affecting distinct genetic loci, including the gene represented in this entry.

(19) Novoseek inferred disease relationships for MT-CYB Gene

Disease -log(P) Hits PubMed IDs
granulomatous disease chronic 75.9 17
malaria avian 67.1 2
lebers hereditary optic neuropathy 48.5 1
iron deficiency 26 2
malaria 22.2 5

Relevant External Links for MT-CYB

GeneTests
MT-CYB
GeneReviews
MT-CYB
Genetic Association Database (GAD)
MT-CYB
genes like me logo Genes that share disorders with MT-CYB: view

Publications for MT-CYB Gene

  1. The mtDNA 15497 G/A polymorphism in cytochrome b in severe obese subjects from Southern Italy. (PMID: 17015183) Liguori R. … Sacchetti L. (Nutr Metab Cardiovasc Dis 2006) 3 23 48
  2. Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease. (PMID: 12391595) Tanaka M. … Yagi K. (J. Neurosci. Res. 2002) 3 23 48
  3. Forced cytochrome B gene mutation expression induces mitochondrial proliferation and prevents apoptosis in human uroepithelial SV-HUC-1 cells. (PMID: 19569044) Dasgupta S. … Sidransky D. (Int. J. Cancer 2009) 3 23
  4. Sequence and organization of the human mitochondrial genome. (PMID: 7219534) Anderson S. … Young I.G. (Nature 1981) 3 4
  5. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. (PMID: 10508508) Andrews R.M. … Howell N. (Nat. Genet. 1999) 3 4

Products for MT-CYB Gene

  • antibodies-online peptides for MT-CYB
  • antibodies-online antibodies for MT-CYB
  • antibodies-online kits for MT-CYB

Sources for MT-CYB Gene

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