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Aliases for MT-CO2 Gene

Aliases for MT-CO2 Gene

  • Mitochondrially Encoded Cytochrome C Oxidase II 2
  • MTCO2 3 4
  • COII 3 4
  • Cytochrome C Oxidase Polypeptide II 4
  • Cytochrome C Oxidase Subunit II 3
  • Cytochrome C Oxidase II 2
  • EC 63
  • COXII 4
  • COX2 3

External Ids for MT-CO2 Gene

Previous HGNC Symbols for MT-CO2 Gene

  • MTCO2

Summaries for MT-CO2 Gene

GeneCards Summary for MT-CO2 Gene

MT-CO2 (Mitochondrially Encoded Cytochrome C Oxidase II) is a Protein Coding gene. Diseases associated with MT-CO2 include osteoblastoma and cerebral aneurysms. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Metabolism.

UniProtKB/Swiss-Prot for MT-CO2 Gene

  • Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Gene Wiki entry for MT-CO2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT-CO2 Gene

Genomics for MT-CO2 Gene

Genomic Location for MT-CO2 Gene

7,586 bp from pter
8,269 bp from pter
684 bases
Plus strand

Genomic View for MT-CO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:

RefSeq DNA sequence for MT-CO2 Gene

No data available for Regulatory Elements for MT-CO2 Gene

Proteins for MT-CO2 Gene

  • Protein details for MT-CO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cytochrome c oxidase subunit 2
    Protein Accession:
    Secondary Accessions:
    • Q37526

    Protein attributes for MT-CO2 Gene

    227 amino acids
    Molecular mass:
    25565 Da
    Name=Cu cation; Xref=ChEBI:CHEBI:23378; Note=Binds a copper A center.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MT-CO2 Gene

neXtProt entry for MT-CO2 Gene

Proteomics data for MT-CO2 Gene at MOPED

Selected DME Specific Peptides for MT-CO2 Gene

Post-translational modifications for MT-CO2 Gene

  • Ubiquitination at Lys171
  • Modification sites at PhosphoSitePlus

Other Protein References for MT-CO2 Gene

ENSEMBL proteins:
Reactome Protein details:

Domains for MT-CO2 Gene

Gene Families for MT-CO2 Gene

  • comIV :Mitochondrial respiratory chain complex / Complex IV

Suggested Antigen Peptide Sequences for MT-CO2 Gene

Graphical View of Domain Structure for InterPro Entry



  • P00403
  • Belongs to the cytochrome c oxidase subunit 2 family.
genes like me logo Genes that share domains with MT-CO2: view

Function for MT-CO2 Gene

Molecular function for MT-CO2 Gene

UniProtKB/Swiss-Prot Function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Enzyme Numbers (IUBMB) for MT-CO2 Gene

Gene Ontology (GO) - Molecular Function for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004129 cytochrome-c oxidase activity --
GO:0005507 copper ion binding --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with MT-CO2: view

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT-CO2 Gene

Localization for MT-CO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MT-CO2 Gene

Mitochondrion inner membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for MT-CO2 Gene COMPARTMENTS Subcellular localization image for MT-CO2 gene
Compartment Confidence
mitochondrion 5
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
GO:0045277 respiratory chain complex IV --
genes like me logo Genes that share ontologies with MT-CO2: view

Pathways for MT-CO2 Gene

genes like me logo Genes that share pathways with MT-CO2: view

Gene Ontology (GO) - Biological Process for MT-CO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen --
GO:0022900 electron transport chain --
GO:0022904 respiratory electron transport chain --
GO:0044237 cellular metabolic process --
GO:0044281 small molecule metabolic process --
genes like me logo Genes that share ontologies with MT-CO2: view

Compounds for MT-CO2 Gene

(3) HMDB Compounds for MT-CO2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cu
  • Oxygen
  • Dihydrogen oxide

(2) Drugbank Compounds for MT-CO2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cholic Acid
81-25-4 target

(12) Novoseek inferred chemical compound relationships for MT-CO2 Gene

Compound -log(P) Hits PubMed IDs
didanosine 52.1 3
nadh 49.1 7
glyceraldehyde 3-phosphate 32.7 1
rofecoxib 26.6 1
atp 23.5 4
genes like me logo Genes that share compounds with MT-CO2: view

Transcripts for MT-CO2 Gene

mRNA/cDNA for MT-CO2 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for MT-CO2 Gene

No ASD Table

Relevant External Links for MT-CO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MT-CO2 Gene

mRNA expression in normal human tissues for MT-CO2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT-CO2 Gene

genes like me logo Genes that share expressions with MT-CO2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MT-CO2 Gene

Orthologs for MT-CO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MT-CO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia COX2 35
  • 90.46 (n)
  • 96.92 (a)
MT-CO2 36
  • 98 (a)
(Bos Taurus)
Mammalia COX2 35
  • 71.21 (n)
  • 74.55 (a)
MT-CO2 36
  • 73 (a)
(Canis familiaris)
Mammalia COX2 35
  • 71.52 (n)
  • 75.45 (a)
COX2 36
  • 73 (a)
(Mus musculus)
Mammalia COX2 35
  • 72.58 (n)
  • 74.55 (a)
mt-Co2 16
mt-Co2 36
  • 71 (a)
(Monodelphis domestica)
Mammalia COII 36
  • 69 (a)
(Ornithorhynchus anatinus)
Mammalia MT-CO2 36
  • 70 (a)
(Rattus norvegicus)
Mammalia COX2 35
  • 72.27 (n)
  • 74.09 (a)
(Gallus gallus)
Aves COX2 35
  • 69.41 (n)
  • 68.04 (a)
gga-mir-3527 36
  • 66 (a)
(Anolis carolinensis)
Reptilia COX2 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia COX2 35
  • 68.94 (n)
  • 69.55 (a)
Str.8896 35
(Danio rerio)
Actinopterygii COX2 35
  • 68.48 (n)
  • 68.64 (a)
mt-co2 36
  • 65 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta COX2 35
  • 59.67 (n)
  • 59.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta COX2 35
  • 57.69 (n)
  • 57.99 (a)
mt:CoII 36
  • 56 (a)
(Caenorhabditis elegans)
Secernentea COX2 35
  • 51.22 (n)
  • 50 (a)
MTCE.31 36
  • 39 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AMI001W 35
  • 50.55 (n)
  • 45.97 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COX2 35
  • 48.5 (n)
  • 44.55 (a)
COX2 36
  • 38 (a)
COX2 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes COX2 35
  • 51.5 (n)
  • 46.92 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons cox2 35
  • 55.82 (n)
  • 51.89 (a)
(Oryza sativa)
Liliopsida cox2 35
  • 54.21 (n)
  • 49.07 (a)
Os.23374 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cox2 35
  • 50.39 (n)
  • 44.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
Species with no ortholog for MT-CO2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MT-CO2 Gene

Gene Tree for MT-CO2 (if available)
Gene Tree for MT-CO2 (if available)

Paralogs for MT-CO2 Gene

Selected SIMAP similar genes for MT-CO2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MT-CO2: view

No data available for Paralogs for MT-CO2 Gene

Variants for MT-CO2 Gene

Sequence variations from dbSNP and Humsavar for MT-CO2 Gene

SNP ID Clin Chr MT pos Sequence Context AA Info Type MAF
VAR_008390 Colorectal cancer
VAR_008571 -
VAR_008572 -
VAR_008863 -
VAR_011344 -

Relevant External Links for MT-CO2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT-CO2 Gene

Disorders for MT-CO2 Gene


  • Mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]: A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, exercise intolerance, developmental delay, delayed motor development and mental retardation. Some affected individuals manifest a fatal hypertrophic cardiomyopathy resulting in neonatal death. A subset of patients manifest Leigh syndrome. {ECO:0000269 PubMed:10486321}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for MT-CO2 Gene

(6) Novoseek inferred disease relationships for MT-CO2 Gene

Disease -log(P) Hits PubMed IDs
mitochondrial encephalomyopathies 40.3 1
carcinoma squamous cell 0 2
osteosarcoma 0 1
tumors 0 3
carcinoma 0 2

Relevant External Links for MT-CO2

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with MT-CO2: view

Publications for MT-CO2 Gene

  1. Investigation on mitochondrial tRNA(Leu/Lys), NDI and ATPase 6/8 in Iranian multiple sclerosis patients. (PMID: 17619138) Ahari S.E. … Bahar M.A. (Cell. Mol. Neurobiol. 2007) 3 23 48
  2. Differential modulation of mitochondrial OXPHOS system during HIV-1 induced T-cell apoptosis: up regulation of Complex-IV subunit COX-II and its possible implications. (PMID: 19771519) Tripathy M.K. … Mitra D. (Apoptosis 2010) 3 23
  3. Sequence and organization of the human mitochondrial genome. (PMID: 7219534) Anderson S. … Young I.G. (Nature 1981) 3 4
  4. A study to survey susceptible genetic factors responsible for troglitazone-associated hepatotoxicity in Japanese patients with type 2 diabetes mellitus. (PMID: 12732844) Watanabe I. … Koga T. (Clin. Pharmacol. Ther. 2003) 3 48
  5. Increased incidence of mitochondrial cytochrome c-oxidase gene mutations in patients with myelodysplastic syndromes. (PMID: 11849212) Reddy P.L. … Raza A. (Br. J. Haematol. 2002) 3 48

Products for MT-CO2 Gene

Sources for MT-CO2 Gene

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