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Aliases for MT3 Gene

Subcategory (RNA class) for MT3 Gene

lncRNA

Aliases for MT3 Gene

  • Metallothionein 3 2 3
  • Metallothionein 3 (Growth Inhibitory Factor (Neurotrophic)) 2 3
  • Growth Inhibitory Factor 3 4
  • Metallothionein-III 3 4
  • MT-III 3 4
  • GIFB 3 4
  • MT-3 3 4
  • GIF 3 4
  • ZnMT3 3
  • GRIF 3

External Ids for MT3 Gene

ORGUL Members for MT3 Gene

Previous GeneCards Identifiers for MT3 Gene

  • GC16P047006
  • GC16P056674
  • GC16P056357
  • GC16P056398
  • GC16P055180
  • GC16P056623
  • GC16P042492

Summaries for MT3 Gene

GeneCards Summary for MT3 Gene

MT3 (Metallothionein 3) is a Protein Coding gene, and is affiliated with the lncRNA class. Diseases associated with MT3 include intrinsic factor deficiency and alzheimer disease. Among its related pathways are Infectious disease and Metabolism. GO annotations related to this gene include drug binding and antioxidant activity.

UniProtKB/Swiss-Prot for MT3 Gene

  • Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

Gene Wiki entry for MT3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT3 Gene

Genomics for MT3 Gene

Regulatory Elements for MT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MT3 Gene

Chromosome:
16
Start:
56,589,074 bp from pter
End:
56,591,088 bp from pter
Size:
2,015 bases
Orientation:
Plus strand

Genomic View for MT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT3 Gene

Proteins for MT3 Gene

  • Protein details for MT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25713-MT3_HUMAN
    Recommended name:
    Metallothionein-3
    Protein Accession:
    P25713
    Secondary Accessions:
    • Q2V574

    Protein attributes for MT3 Gene

    Size:
    68 amino acids
    Molecular mass:
    6927 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MT3 Gene

neXtProt entry for MT3 Gene

Proteomics data for MT3 Gene at MOPED

Post-translational modifications for MT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MT3 Gene

No data available for DME Specific Peptides for MT3 Gene

Domains & Families for MT3 Gene

Gene Families for MT3 Gene

Suggested Antigen Peptide Sequences for MT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P25713

UniProtKB/Swiss-Prot:

MT3_HUMAN :
  • Belongs to the metallothionein superfamily. Type 1 family.
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT3: view

Function for MT3 Gene

Molecular function for MT3 Gene

GENATLAS Biochemistry:
metallothionein 3,expressed in brain,growth inhibitory factor,neurotrophic
UniProtKB/Swiss-Prot Function:
Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro

Gene Ontology (GO) - Molecular Function for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005507 copper ion binding TAS 8751715
GO:0005515 protein binding IPI 20646067
GO:0008144 drug binding IDA 19536566
GO:0008270 zinc ion binding IDA 17712581
GO:0016209 antioxidant activity NAS 12383939
genes like me logo Genes that share ontologies with MT3: view
genes like me logo Genes that share phenotypes with MT3: view

Animal Models for MT3 Gene

MGI Knock Outs for MT3:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for MT3 Gene

Localization for MT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT3 Gene COMPARTMENTS Subcellular localization image for MT3 gene
Compartment Confidence
cytoskeleton 2
endoplasmic reticulum 2
extracellular 2
mitochondrion 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
GO:0005622 intracellular IDA 21818286
GO:0005737 cytoplasm IDA 10355541
GO:0005741 mitochondrial outer membrane IEA --
GO:0005791 rough endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with MT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT3 Gene

Pathways & Interactions for MT3 Gene

genes like me logo Genes that share pathways with MT3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Alzheimers Disease in human,mouse,rat
    • Drug Metabolism in human,mouse,rat

Interacting Proteins for MT3 Gene

Gene Ontology (GO) - Biological Process for MT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 18554677
GO:0001666 response to hypoxia IDA 12763630
GO:0001934 positive regulation of protein phosphorylation IDA 18295594
GO:0006112 energy reserve metabolic process ISS --
GO:0006707 cholesterol catabolic process ISS --
genes like me logo Genes that share ontologies with MT3: view

No data available for SIGNOR curated interactions for MT3 Gene

Drugs & Compounds for MT3 Gene

(12) Drugs for MT3 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Dopamine Approved Pharma Full agonist, Agonist 2814
Zinc Approved Pharma 1404
Melatonin Approved Nutra Antagonist Melatonin receptors MT inhibitor 215
Vitamin C Approved Nutra 398,398

(11) Additional Compounds for MT3 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
cadmium
  • Cadmium atom
  • Cadmium elemental
  • Cadmium metallicum
  • Cd
  • Colloidal cadmium
7440-43-9
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
DTNB
Endotoxin
glutamate
genes like me logo Genes that share compounds with MT3: view

Transcripts for MT3 Gene

Unigene Clusters for MT3 Gene

Metallothionein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b
SP1: - -
SP2: -
SP3:

Relevant External Links for MT3 Gene

GeneLoc Exon Structure for
MT3
ECgene alternative splicing isoforms for
MT3

Expression for MT3 Gene

mRNA expression in normal human tissues for MT3 Gene

mRNA differential expression in normal tissues according to GTEx for MT3 Gene

This gene is overexpressed in Brain - Amygdala (x6.2), Brain - Putamen (basal ganglia) (x5.6), Brain - Caudate (basal ganglia) (x5.4), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Hippocampus (x5.0), and Brain - Substantia nigra (x4.8).

Protein differential expression in normal tissues from HIPED for MT3 Gene

This gene is overexpressed in Brain (36.6), Fetal Brain (19.0), and Frontal cortex (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for MT3 Gene



SOURCE GeneReport for Unigene cluster for MT3 Gene Hs.73133

mRNA Expression by UniProt/SwissProt for MT3 Gene

P25713-MT3_HUMAN
Tissue specificity: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain
genes like me logo Genes that share expression patterns with MT3: view

Protein tissue co-expression partners for MT3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MT3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT3 35
  • 99.02 (n)
  • 100 (a)
MT3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mt3 16
Mt3 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MT3 36
  • 93 (a)
OneToOne
Species with no ortholog for MT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT3 Gene

ENSEMBL:
Gene Tree for MT3 (if available)
TreeFam:
Gene Tree for MT3 (if available)

Paralogs for MT3 Gene

(6) SIMAP similar genes for MT3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MT3: view

No data available for Paralogs for MT3 Gene

Variants for MT3 Gene

Sequence variations from dbSNP and Humsavar for MT3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1048970 -- 56,591,026(+) AGTGT(G/T)GCTGG utr-variant-3-prime
rs1048972 -- 56,591,027(+) GTGTG(A/C/G)CTGGT utr-variant-3-prime
rs1048973 -- 56,591,035(+) GGTGT(A/C/T)CCCTT utr-variant-3-prime
rs2066841 -- 56,590,999(+) GCTCA(G/T)TGCCA utr-variant-3-prime
rs3764334 -- 56,588,459(+) ATCCA(C/G)ATAAT upstream-variant-2KB

Variation tolerance for MT3 Gene

Residual Variation Intolerance Score: 65.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.46; 9.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MT3 Gene

HapMap Linkage Disequilibrium report
MT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for MT3 Gene

Disorders for MT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MT3 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
intrinsic factor deficiency
  • congenital pernicious anemia due to defect of intrinsic factor
alzheimer disease
  • alzheimer disease, late-onset
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
- elite association
Search MT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MT3

Genetic Association Database (GAD)
MT3
Human Genome Epidemiology (HuGE) Navigator
MT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MT3
genes like me logo Genes that share disorders with MT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MT3 Gene

Publications for MT3 Gene

  1. MT-III, a brain-specific member of the metallothionein gene family. (PMID: 1631128) Palmiter R.D. … Durnam D.M. (Proc. Natl. Acad. Sci. U.S.A. 1992) 2 23 67
  2. Induction of metallothionein in mouse cerebellum and cerebrum with low-dose thimerosal injection. (PMID: 19357975) Minami T. … Ichida S. (Cell Biol. Toxicol. 2010) 23 67
  3. Zinc protects human peripheral blood lymphocytes from Cr(III)(phenanthroline)3-induced apoptosis. (PMID: 20043934) Sankaramanivel S. … Rajaram R. (Toxicol. Appl. Pharmacol. 2010) 23 67
  4. Reaction of human metallothionein-3 with cisplatin and transplatin. (PMID: 19536566) Karotki A.V. … VasA!k M. (J. Biol. Inorg. Chem. 2009) 23 67
  5. Important roles of the conserved linker-KKS in human neuronal growth inhibitory factor. (PMID: 19306065) Ding Z.C. … Huang Z.X. (Biometals 2009) 23 67

Products for MT3 Gene

Sources for MT3 Gene

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