Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MT1X Gene

Aliases for MT1X Gene

  • Metallothionein 1X 2 3
  • Metallothionein-IX 3 4
  • MT-1X 3 4
  • MT-IX 3 4
  • Metallothionein-1X 3
  • MT-1L 3
  • MT1 3

External Ids for MT1X Gene

Previous HGNC Symbols for MT1X Gene

  • MT1

Previous GeneCards Identifiers for MT1X Gene

  • GC16U990045
  • GC16P056428
  • GC16P056486
  • GC16P056487
  • GC16P055267
  • GC16P055273
  • GC16P056711
  • GC16P042585

Summaries for MT1X Gene

GeneCards Summary for MT1X Gene

MT1X (Metallothionein 1X) is a Protein Coding gene. Diseases associated with MT1X include prostate cancer. Among its related pathways are Mineral absorption and Oxidative Stress. An important paralog of this gene is MT1B.

UniProtKB/Swiss-Prot for MT1X Gene

  • Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1X Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MT1X Gene

Genomics for MT1X Gene

Regulatory Elements for MT1X Gene

Genomic Location for MT1X Gene

Start:
56,682,424 bp from pter
End:
56,684,196 bp from pter
Size:
1,773 bases
Orientation:
Plus strand

Genomic View for MT1X Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MT1X Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MT1X Gene

Proteins for MT1X Gene

  • Protein details for MT1X Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80297-MT1X_HUMAN
    Recommended name:
    Metallothionein-1X
    Protein Accession:
    P80297
    Secondary Accessions:
    • A8MUC7

    Protein attributes for MT1X Gene

    Size:
    61 amino acids
    Molecular mass:
    6068 Da
    Quaternary structure:
    • Monomer

neXtProt entry for MT1X Gene

Proteomics data for MT1X Gene at MOPED

Post-translational modifications for MT1X Gene

  • Ubiquitination at Lys43 and Lys51
  • Modification sites at PhosphoSitePlus

Other Protein References for MT1X Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MT1X Gene

Domains for MT1X Gene

Gene Families for MT1X Gene

HGNC:
  • MT :Metallothioneins

Suggested Antigen Peptide Sequences for MT1X Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P80297

UniProtKB/Swiss-Prot:

MT1X_HUMAN :
  • P80297
Domain:
  • Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
Family:
  • Belongs to the metallothionein superfamily. Type 1 family.
genes like me logo Genes that share domains with MT1X: view

Function for MT1X Gene

Molecular function for MT1X Gene

GENATLAS Biochemistry:
metallothionein 1X cluster
UniProtKB/Swiss-Prot Function:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids

Gene Ontology (GO) - Molecular Function for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding ISS --
GO:0046872 metal ion binding TAS 9074634
genes like me logo Genes that share ontologies with MT1X: view

miRNA for MT1X Gene

miRTarBase miRNAs that target MT1X

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1X

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MT1X Gene

Localization for MT1X Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MT1X Gene COMPARTMENTS Subcellular localization image for MT1X gene
Compartment Confidence
nucleus 5
extracellular 3
cytosol 1

Gene Ontology (GO) - Cellular Components for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 8619255
GO:0005737 cytoplasm IDA 8619255
GO:0048471 perinuclear region of cytoplasm ISS --
genes like me logo Genes that share ontologies with MT1X: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MT1X Gene

Pathways for MT1X Gene

SuperPathways for MT1X Gene

genes like me logo Genes that share pathways with MT1X: view

Pathways by source for MT1X Gene

1 BioSystems pathway for MT1X Gene
1 KEGG pathway for MT1X Gene

Interacting Proteins for MT1X Gene

Gene Ontology (GO) - Biological Process for MT1X Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006882 cellular zinc ion homeostasis IEA --
GO:0007263 nitric oxide mediated signal transduction IEA --
GO:0010038 response to metal ion TAS 9074634
GO:0010273 detoxification of copper ion IEA --
GO:0036018 cellular response to erythropoietin IEP 11168427
genes like me logo Genes that share ontologies with MT1X: view

Compounds for MT1X Gene

(1) HMDB Compounds for MT1X Gene

Compound Synonyms Cas Number PubMed IDs
Cadmium
  • Cd
7440-43-9

(5) Novoseek inferred chemical compound relationships for MT1X Gene

Compound -log(P) Hits PubMed IDs
cadmium 65.7 5
glyceraldehyde 3-phosphate 46.8 2
zinc 26.4 3
estrogen 21.1 2
copper 8.54 1
genes like me logo Genes that share compounds with MT1X: view

Transcripts for MT1X Gene

mRNA/cDNA for MT1X Gene

Unigene Clusters for MT1X Gene

Metallothionein 1X:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MT1X

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MT1X Gene

No ASD Table

Relevant External Links for MT1X Gene

GeneLoc Exon Structure for
MT1X
ECgene alternative splicing isoforms for
MT1X

Expression for MT1X Gene

mRNA expression in normal human tissues for MT1X Gene

mRNA differential expression in normal tissues according to GTEx for MT1X Gene

This gene is overexpressed in Muscle - Skeletal (8.1) and Liver (6.5).

Protein differential expression in normal tissues for MT1X Gene

This gene is overexpressed in Fetal Liver (60.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MT1X Gene

SOURCE GeneReport for Unigene cluster for MT1X Gene Hs.374950

genes like me logo Genes that share expressions with MT1X: view

Expression partners for MT1X Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for MT1X Gene

Orthologs for MT1X Gene

This gene was present in the common ancestor of mammals.

Orthologs for MT1X Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MT1X 35
  • 100 (n)
  • 100 (a)
MT1X 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MT1E 36
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 80 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Mt1 36
  • 79 (a)
ManyToMany
Species with no ortholog for MT1X:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MT1X Gene

ENSEMBL:
Gene Tree for MT1X (if available)
TreeFam:
Gene Tree for MT1X (if available)

Paralogs for MT1X Gene

Paralogs for MT1X Gene

Selected SIMAP similar genes for MT1X Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MT1X: view

Variants for MT1X Gene

Sequence variations from dbSNP and Humsavar for MT1X Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1140745 -- 56,684,114(+) TTTTT(C/T)TTTTT utr-variant-3-prime
rs1140746 -- 56,684,151(+) ACATC(C/T)TTTTT utr-variant-3-prime
rs1599933 -- 56,681,950(-) CACAG(G/T)GCTCT upstream-variant-2KB
rs1827206 -- 56,680,835(-) TGGGT(C/T)CTCAC upstream-variant-2KB
rs2301232 -- 56,682,885(+) TGCCT(C/T)TTCGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MT1X Gene

Variant ID Type Subtype PubMed ID
nsv906720 CNV Loss 21882294
nsv833244 CNV Gain 17160897

Relevant External Links for MT1X Gene

HapMap Linkage Disequilibrium report
MT1X

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MT1X Gene

Disorders for MT1X Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MT1X Gene in MalaCards »

(1) Diseases for MT1X Gene including...

(4) Novoseek inferred disease relationships for MT1X Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 34.2 4
breast cancer 22.6 3
bladder cancer 21.5 4
tumors 3.27 2

Relevant External Links for MT1X

Genetic Association Database (GAD)
MT1X
Human Genome Epidemiology (HuGE) Navigator
MT1X
genes like me logo Genes that share disorders with MT1X: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MT1X Gene

Publications for MT1X Gene

  1. Characterisation of six additional human metallothionein genes. (PMID: 8049263) Stennard F.A. … West A.K. (Biochim. Biophys. Acta 1994) 2 3 4 23
  2. Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney. (PMID: 8619255) Mididoddi S. … Sens D.A. (Toxicol. Lett. 1996) 3 23
  3. Metallothionein isogene transcription in red blood cell precursors from human cord blood. (PMID: 11168427) Rahman M.T. … De Ley M. (Eur. J. Biochem. 2001) 3 23
  4. Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals. (PMID: 9831543) Garrett S.H. … Sens D.A. (Environ. Health Perspect. 1998) 3 23
  5. Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. (PMID: 10754528) Garrett S.H. … Sens D.A. (Prostate 2000) 3 23

Products for MT1X Gene

Sources for MT1X Gene

Back to Top

Content