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Aliases for OR2B3 Gene

Aliases for OR2B3 Gene

  • Olfactory Receptor Family 2 Subfamily B Member 3 2 3 5
  • Olfactory Receptor OR6-14 3 4
  • Olfactory Receptor 6-4 3 4
  • Hs6M1-1 3 4
  • OR2B3P 3 4
  • OR6-4 3 4
  • Olfactory Receptor, Family 2, Subfamily B, Member 3 Pseudogene 2
  • Olfactory Receptor, Family 2, Subfamily B, Member 3 2
  • Putative Olfactory Receptor 2B3 3
  • OR6-14 3
  • 6M1-1 3

External Ids for OR2B3 Gene

Previous HGNC Symbols for OR2B3 Gene

  • OR2B3P

Previous GeneCards Identifiers for OR2B3 Gene

  • GC06U990213
  • GC06M029167
  • GC06M029054
  • GC06Mo28984
  • GC06M029063

Summaries for OR2B3 Gene

Entrez Gene Summary for OR2B3 Gene

  • Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

GeneCards Summary for OR2B3 Gene

OR2B3 (Olfactory Receptor Family 2 Subfamily B Member 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Olfactory Signaling Pathway. GO annotations related to this gene include G-protein coupled receptor activity and olfactory receptor activity. An important paralog of this gene is OR2B2.

UniProtKB/Swiss-Prot for OR2B3 Gene

  • Odorant receptor.

Gene Wiki entry for OR2B3 Gene

Additional gene information for OR2B3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OR2B3 Gene

Genomics for OR2B3 Gene

Regulatory Elements for OR2B3 Gene

Enhancers for OR2B3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H028141 1.4 ENCODE dbSUPER 14.6 +945.0 945025 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 SP3 ZNF603P ZKSCAN3 ZKSCAN4 ZSCAN12 ZKSCAN8 HNRNPA1P1 ZNF391 ZSCAN23 OR2B2 HIST1H2BPS2
GH06H030065 1.2 ENCODE 14.6 -979.5 -979493 2 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ENSG00000237669 TRIM26 TRIM39 MDC1 PPP1R10 ZNRD1 HLA-A RPL7P4 ETF1P1 ENSG00000233892
GH06H028586 1.1 ENCODE 14.6 +500.1 500148 1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3 ZKSCAN3 ZKSCAN8 ZSCAN12 GPX6 GPX5 ZSCAN9 ZNF311 ZNF603P ZNF90P2 KRT18P1
GH06H028814 0.9 FANTOM5 2.1 +272.9 272936 0 ZSCAN4 ZNF76 KLF17 ZBTB40 ZNF2 ETS1 ZNF366 KLF7 EGR2 ZNF280D ZNF311 ZKSCAN3 ZFP57 ZBED9 ZNF602P OR14J1 GPX6 OR2W1 OR2J3 OR2B3
GH06H029467 0.3 FANTOM5 4.3 -380.4 -380387 0 OR10C1 ZFP57 MAS1L OR11A1 OR14J1 OR2W1 OR2J3 OR2B3 OR12D2 OR5V1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OR2B3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OR2B3 Gene

Chromosome:
6
Start:
29,086,208 bp from pter
End:
29,087,313 bp from pter
Size:
1,106 bases
Orientation:
Minus strand

Genomic View for OR2B3 Gene

Genes around OR2B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OR2B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OR2B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for OR2B3 Gene

  • Protein details for OR2B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O76000-OR2B3_HUMAN
    Recommended name:
    Putative olfactory receptor 2B3
    Protein Accession:
    O76000
    Secondary Accessions:
    • B0UYQ1
    • Q5ST41
    • Q96R13

    Protein attributes for OR2B3 Gene

    Size:
    313 amino acids
    Molecular mass:
    35543 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OR2B3 Gene

Post-translational modifications for OR2B3 Gene

  • Glycosylation at posLast=55
  • Modification sites at PhosphoSitePlus

Other Protein References for OR2B3 Gene

ENSEMBL proteins:
REFSEQ proteins:
HORDE protein sequence:

No data available for DME Specific Peptides for OR2B3 Gene

Domains & Families for OR2B3 Gene

Gene Families for OR2B3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for OR2B3 Gene

Suggested Antigen Peptide Sequences for OR2B3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O76000

UniProtKB/Swiss-Prot:

OR2B3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OR2B3: view

Function for OR2B3 Gene

Molecular function for OR2B3 Gene

GENATLAS Biochemistry:
olfactory receptor,family 2,subfamily B,member 3,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Odorant receptor.

Gene Ontology (GO) - Molecular Function for OR2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0004984 olfactory receptor activity IBA --
genes like me logo Genes that share ontologies with OR2B3: view
genes like me logo Genes that share phenotypes with OR2B3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2B3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OR2B3 Gene

Localization for OR2B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OR2B3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OR2B3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OR2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA --
genes like me logo Genes that share ontologies with OR2B3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OR2B3 Gene

Pathways & Interactions for OR2B3 Gene

genes like me logo Genes that share pathways with OR2B3: view

Pathways by source for OR2B3 Gene

1 KEGG pathway for OR2B3 Gene

Interacting Proteins for OR2B3 Gene

Gene Ontology (GO) - Biological Process for OR2B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007608 sensory perception of smell IBA --
GO:0050896 response to stimulus IEA --
GO:0050911 detection of chemical stimulus involved in sensory perception of smell IEA --
genes like me logo Genes that share ontologies with OR2B3: view

No data available for SIGNOR curated interactions for OR2B3 Gene

Drugs & Compounds for OR2B3 Gene

No Compound Related Data Available

Transcripts for OR2B3 Gene

mRNA/cDNA for OR2B3 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for OR2B3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for OR2B3 Gene

No ASD Table

Relevant External Links for OR2B3 Gene

GeneLoc Exon Structure for
OR2B3
ECgene alternative splicing isoforms for
OR2B3

Expression for OR2B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OR2B3 Gene

Protein differential expression in normal tissues from HIPED for OR2B3 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OR2B3 Gene



Protein tissue co-expression partners for OR2B3 Gene

NURSA nuclear receptor signaling pathways regulating expression of OR2B3 Gene:

OR2B3

SOURCE GeneReport for Unigene cluster for OR2B3 Gene:

Hs.553835
genes like me logo Genes that share expression patterns with OR2B3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OR2B3 Gene

Orthologs for OR2B3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for OR2B3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC471929 33
  • 99.15 (n)
OR2B3 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
LOC515704 33
  • 87.75 (n)
mouse
(Mus musculus)
Mammalia Olfr1359 34
  • 74 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 71 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia OPOR61 34
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 54 (a)
ManyToMany
Species where no ortholog for OR2B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OR2B3 Gene

ENSEMBL:
Gene Tree for OR2B3 (if available)
TreeFam:
Gene Tree for OR2B3 (if available)

Paralogs for OR2B3 Gene

Paralogs for OR2B3 Gene

(437) SIMAP similar genes for OR2B3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OR2B3: view

Variants for OR2B3 Gene

Sequence variations from dbSNP and Humsavar for OR2B3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1001484535 -- 29,088,050(+) CACTC(A/T)TTATT upstream-variant-2KB
rs1001808171 -- 29,089,122(+) CTCTG(A/G)AGCCA upstream-variant-2KB
rs1002082419 -- 29,086,580(+) ACTGC(G/T)TGAGC reference, missense
rs1002516844 -- 29,087,052(+) TGGAG(A/G)GATTA reference, missense
rs1003991701 -- 29,085,703(+) TACCC(C/T)GAAGT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OR2B3 Gene

Variant ID Type Subtype PubMed ID
dgv10338n54 CNV gain 21841781
esv2763545 CNV loss 21179565
nsv1015796 CNV gain 25217958
nsv1032468 CNV loss 25217958
nsv1074388 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1145096 CNV deletion 24896259
nsv601216 CNV gain 21841781
nsv830623 CNV gain 17160897

Variation tolerance for OR2B3 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OR2B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OR2B3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OR2B3 Gene

Disorders for OR2B3 Gene

Relevant External Links for OR2B3

Genetic Association Database (GAD)
OR2B3
Human Genome Epidemiology (HuGE) Navigator
OR2B3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OR2B3

No disorders were found for OR2B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OR2B3 Gene

Publications for OR2B3 Gene

  1. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 45 60
  2. The human olfactory receptor gene family. (PMID: 14983052) Malnic B … Buck LB (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. DEFOG: a practical scheme for deciphering families of genes. (PMID: 12213199) Fuchs T … Shamir R (Genomics 2002) 3 4 60
  5. Common variation contributes to the genetic architecture of social communication traits. (PMID: 24047820) St Pourcain B … Smith GD (Molecular autism 2013) 3 60

Products for OR2B3 Gene

Sources for OR2B3 Gene

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