External Ids for GLRA4 Gene
Previous GeneCards Identifiers for GLRA4 Gene
This gene encodes a protein which has a neurotransmitter-gated ion-channel ligand binding domain. The encoded protein is very similar to a mouse protein which is a subunit of the retinal glycine receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
GeneCards Summary for GLRA4 Gene
GLRA4 (Glycine Receptor Alpha 4) is a Protein Coding gene. Diseases associated with GLRA4 include Pelizaeus-Merzbacher Disease. Among its related pathways are DAG and IP3 signaling and Ligand-gated ion channel transport. Gene Ontology (GO) annotations related to this gene include chloride channel activity and glycine binding. An important paralog of this gene is GLRA2.
UniProtKB/Swiss-Prot for GLRA4 Gene
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.
Glycine receptors (GlyR) are members of the cys-loop family of ligand-gated ion channels, responsible for mediating the inhibitory effects of glycine. They are widely distributed throughout the CNS, particularly within the hippocampus, spinal cord and brain stem.