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Aliases for ASMT Gene

Aliases for ASMT Gene

  • Acetylserotonin O-Methyltransferase 2 3
  • Hydroxyindole O-Methyltransferase 3 4
  • HIOMT 3 4
  • Acetylserotonin Methyltransferase (Y Chromosome) 3
  • Acetylserotonin N-Methyltransferase 3
  • EC 4
  • HIOMTY 3
  • ASMTY 3

External Ids for ASMT Gene

Summaries for ASMT Gene

Entrez Gene Summary for ASMT Gene

  • This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]

GeneCards Summary for ASMT Gene

ASMT (Acetylserotonin O-Methyltransferase) is a Protein Coding gene. Diseases associated with ASMT include pineocytoma and pineoblastoma. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and O-methyltransferase activity. An important paralog of this gene is ASMTL.

UniProtKB/Swiss-Prot for ASMT Gene

  • Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.

Gene Wiki entry for ASMT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ASMT Gene

Genomics for ASMT Gene

Genomic Location for ASMT Gene

1,595,455 bp from pter
1,643,081 bp from pter
47,627 bases
Plus strand

Genomic View for ASMT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ASMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ASMT Gene

Regulatory Elements for ASMT Gene

Proteins for ASMT Gene

  • Protein details for ASMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Acetylserotonin O-methyltransferase
    Protein Accession:
    Secondary Accessions:
    • B2RC33
    • Q16598
    • Q5JQ72
    • Q5JQ73

    Protein attributes for ASMT Gene

    345 amino acids
    Molecular mass:
    38453 Da
    Quaternary structure:
    • Homodimer.
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes

    Three dimensional structures from OCA and Proteopedia for ASMT Gene

    Alternative splice isoforms for ASMT Gene


neXtProt entry for ASMT Gene

Proteomics data for ASMT Gene at MOPED

Post-translational modifications for ASMT Gene

No Post-translational modifications

Other Protein References for ASMT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ASMT Gene

Domains for ASMT Gene

Gene Families for ASMT Gene

  • PAR1 :Pseudoautosomal regions / PAR1

Protein Domains for ASMT Gene


  • Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.:
    • P46597
genes like me logo Genes that share domains with ASMT: view

Function for ASMT Gene

Molecular function for ASMT Gene

GENATLAS Biochemistry: methyltransferase,hydroxyindole-O,catalyzing the final step of melatonin synthesis,expressed in the pineal gland
UniProtKB/Swiss-Prot CatalyticActivity: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
UniProtKB/Swiss-Prot Function: Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity.
UniProtKB/Swiss-Prot Induction: By all-trans-, 9-cis- and 13-cis-retinoic acid and by serum treatment, following starvation, in the retinoblastoma cell line Y79.

Enzyme Numbers (IUBMB) for ASMT Gene

Gene Ontology (GO) - Molecular Function for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008171 O-methyltransferase activity TAS 8397829
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity --
GO:0017096 acetylserotonin O-methyltransferase activity IDA 22775292
GO:0042802 identical protein binding IPI 22775292
genes like me logo Genes that share ontologies with ASMT: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ASMT Gene

Localization for ASMT Gene

Subcellular locations from

Jensen Localization Image for ASMT Gene COMPARTMENTS Subcellular localization image for ASMT gene
Compartment Confidence
cytosol 4
mitochondrion 2
cytoskeleton 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ASMT: view

Pathways for ASMT Gene

genes like me logo Genes that share pathways with ASMT: view

UniProtKB/Swiss-Prot P46597-ASMT_HUMAN

  • Pathway: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2

Gene Ontology (GO) - Biological Process for ASMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 8397829
GO:0030187 melatonin biosynthetic process IEA --
GO:0032259 methylation IEA --
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ASMT: view

Compounds for ASMT Gene

(6) HMDB Compounds for ASMT Gene

Compound Synonyms Cas Number PubMed IDs
5-Hydroxyindoleacetic acid
  • 5-Hydroxy-1H-indole-3-acetate
  • 5-Methoxyindol-3-ylacetate
  • 5-Methoxy-N-acetyltryptamine
  • 5-Hydroxy-N-acetyltryptamine
  • (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine

(2) Drugbank Compounds for ASMT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
  • MEL
73-31-4 target
  • MEL
73-31-4 enzyme substrate

(7) Novoseek inferred chemical compound relationships for ASMT Gene

Compound -log(P) Hits PubMed IDs
arylalkylamine 90.6 8
melatonin 84.2 43
dbc-amp 43 5
cyclic amp 38.2 2
butyrate 31.9 6
genes like me logo Genes that share compounds with ASMT: view

Transcripts for ASMT Gene

Unigene Clusters for ASMT Gene

Acetylserotonin O-methyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ASMT Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9
SP1: - - -
SP2: - - - - -
SP3: - - -

Relevant External Links for ASMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ASMT Gene

mRNA expression in normal human tissues for ASMT Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ASMT Gene

SOURCE GeneReport for Unigene cluster for ASMT Gene Hs.522572

mRNA Expression by UniProt/SwissProt for ASMT Gene

Tissue specificity: Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683).
genes like me logo Genes that share expressions with ASMT: view

Orthologs for ASMT Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ASMT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ASMT 37
  • 61 (a)
(Canis familiaris)
Mammalia ASMT 36
  • 76.81 (n)
  • 71.01 (a)
  • 70 (a)
(Mus musculus)
Mammalia Asmt 37
  • 45 (a)
(Monodelphis domestica)
Mammalia ASMT 37
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia ASMT 37
  • 53 (a)
(Rattus norvegicus)
Mammalia Asmt 36
  • 60.2 (n)
  • 52.84 (a)
(Gallus gallus)
Aves ASMT 36
  • 62.51 (n)
  • 57.1 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 37
  • 44 (a)
-- 37
  • 47 (a)
-- 37
  • 43 (a)
-- 37
  • 55 (a)
-- 37
  • 43 (a)
-- 37
  • 44 (a)
-- 37
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia asmt 36
  • 59.62 (n)
  • 51.7 (a)
Str.8492 36
(Danio rerio)
Actinopterygii asmt 36
  • 61.11 (n)
  • 51.82 (a)
asmt 37
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9515 37
  • 16 (a)
(Caenorhabditis elegans)
Secernentea dod-18 37
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 15 (a)
Species with no ortholog for ASMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ASMT Gene

Gene Tree for ASMT (if available)
Gene Tree for ASMT (if available)

Paralogs for ASMT Gene

Paralogs for ASMT Gene

Selected SIMAP similar genes for ASMT Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ASMT: view

Variants for ASMT Gene

Sequence variations from dbSNP and Humsavar for ASMT Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_045991 -
VAR_069111 -
VAR_069112 -
VAR_069113 -
VAR_069114 -

Structural Variations from Database of Genomic Variants (DGV) for ASMT Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
nsv510811 CNV Loss 20534489
esv2657890 CNV Deletion 23128226
esv2314773 CNV Deletion 18987734
esv2739741 CNV Deletion 23290073
esv2739742 CNV Deletion 23290073
esv2739743 CNV Deletion 23290073
dgv1391e199 CNV Deletion 23128226
esv2677663 CNV Deletion 23128226
esv2662274 CNV Deletion 23128226
esv2739744 CNV Deletion 23290073
esv2739745 CNV Deletion 23290073
esv2739746 CNV Deletion 23290073
esv1988316 CNV Deletion 18987734
esv2739747 CNV Deletion 23290073
esv2665745 CNV Deletion 23128226
esv21704 CNV Gain+Loss 19812545
esv2739748 CNV Deletion 23290073
esv2739749 CNV Deletion 23290073
esv2739750 CNV Deletion 23290073
esv2666469 CNV Deletion 23128226
esv2661143 CNV Deletion 23128226
esv2739752 CNV Deletion 23290073
dgv1364e201 CNV Deletion 23290073
esv2669510 CNV Deletion 23128226
esv2739754 CNV Deletion 23290073
esv24971 CNV Gain+Loss 19812545
nsv821241 CNV Deletion 20802225
esv2381959 CNV Deletion 18987734
dgv1365e201 CNV Deletion 23290073
esv2739756 CNV Deletion 23290073
dgv1366e201 CNV Deletion 23290073
esv2739759 CNV Deletion 23290073
esv2662510 CNV Deletion 23128226
esv2658498 CNV Deletion 23128226
esv2739764 CNV Deletion 23290073
esv2739765 CNV Deletion 23290073
esv2739766 CNV Deletion 23290073
esv2739767 CNV Deletion 23290073
nsv510871 CNV Loss 20534489

Relevant External Links for ASMT Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

Disorders for ASMT Gene

(2) MalaCards Diseases for ASMT Gene

Search for ASMT Gene in MalaCards »

(1) University of Copenhagen DISEASES for ASMT Gene

(5) Novoseek inferred disease relationships for ASMT Gene

Disease -log(P) Hits PubMed IDs
pineocytoma 82.4 5
pineal tumors 79.6 1
pineoblastoma 79.2 5
retinoblastoma 58.6 5
tumors 0 3

Relevant External Links for ASMT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ASMT: view

No data available for UniProtKB/Swiss-Prot for ASMT Gene

Publications for ASMT Gene

  1. Structural analysis of the human hydroxyindole-O-methyltransferase gene. Presence of two distinct promoters. (PMID: 7989373) Rodriguez I.R. … Chader G.J. (J. Biol. Chem. 1994) 2 3 4 23
  2. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. (PMID: 8397829) Donohue S.J. … Klein D.C. (DNA Cell Biol. 1993) 2 3 4 23
  3. Single-nucleotide polymorphisms and mRNA expression for melatonin synthesis rate-limiting enzyme in recurrent depressive disorder. (PMID: 20433639) GaA8ecki P. … Karbownik-LewiA8ska M. (J. Pineal Res. 2010) 3 23 49
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for ASMT Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ASMT
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ASMT
    • Block miRNA regulation of ASMT using miScript Target Protectors

    Sources for ASMT Gene

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