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Aliases for MPO Gene

Aliases for MPO Gene

  • Myeloperoxidase 2 3
  • EC 1.11.1.7 64
  • EC 1.11.2.2 4
  • EC 1.11.1 64

External Ids for MPO Gene

Summaries for MPO Gene

Entrez Gene Summary for MPO Gene

  • Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]

GeneCards Summary for MPO Gene

MPO (Myeloperoxidase) is a Protein Coding gene. Diseases associated with MPO include myeloperoxidase deficiency and idiopathic edema. Among its related pathways are amb2 Integrin signaling and Transcriptional misregulation in cancer. GO annotations related to this gene include chromatin binding and heme binding. An important paralog of this gene is EPX.

UniProtKB/Swiss-Prot for MPO Gene

  • Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

Gene Wiki entry for MPO Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MPO Gene

Genomics for MPO Gene

Genomic Location for MPO Gene

Start:
58,269,856 bp from pter
End:
58,280,935 bp from pter
Size:
11,080 bases
Orientation:
Minus strand

Genomic View for MPO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MPO Gene

Regulatory Elements for MPO Gene

Proteins for MPO Gene

  • Protein details for MPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05164-PERM_HUMAN
    Recommended name:
    Myeloperoxidase
    Protein Accession:
    P05164
    Secondary Accessions:
    • A1L4B8
    • Q14862
    • Q4PJH5
    • Q9UCL7

    Protein attributes for MPO Gene

    Size:
    745 amino acids
    Molecular mass:
    83869 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 1 Ca(2+) ion per monomer.;
    Cofactor:
    Name=heme b; Xref=ChEBI:CHEBI:60344; Note=Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per monomer.;
    Quaternary structure:
    • Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.

    Three dimensional structures from OCA and Proteopedia for MPO Gene

    Alternative splice isoforms for MPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MPO Gene

Proteomics data for MPO Gene at MOPED

Selected DME Specific Peptides for MPO Gene

Post-translational modifications for MPO Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn139, Asn323, Asn355, Asn391, Asn483, and Asn729

Other Protein References for MPO Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MPO Gene

Protein Domains for MPO Gene

UniProtKB/Swiss-Prot:

PERM_HUMAN
Family:
  • Belongs to the peroxidase family. XPO subfamily.:
    • P05164
genes like me logo Genes that share domains with MPO: view

No data available for Gene Families for MPO Gene

Function for MPO Gene

Molecular function for MPO Gene

GENATLAS Biochemistry: myeloperoxidase,formed by dimerization of hemi-MPO,78kDa,cleaved in an alpha large (59kDa) iron binding subunit and two smaller beta subunits (13kDa),expressed in azurophilic granules of neutrophils and primary liposomes of monocytes,involved in oxygen dependent mechanism of phagocytosis
UniProtKB/Swiss-Prot CatalyticActivity: Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O
UniProtKB/Swiss-Prot CatalyticActivity: Cl(-) + H(2)O(2) = HOCl + 2 H(2)O
UniProtKB/Swiss-Prot Function: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity

Enzyme Numbers (IUBMB) for MPO Gene

Gene Ontology (GO) - Molecular Function for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 2829220
GO:0004601 peroxidase activity IDA 10772654
GO:0008201 heparin binding IDA 11907569
GO:0020037 heme binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with MPO: view
genes like me logo Genes that share phenotypes with MPO: view

Animal Models for MPO Gene

MGI Knock Outs for MPO:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MPO Gene

Localization for MPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for MPO Gene

Lysosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MPO Gene COMPARTMENTS Subcellular localization image for MPO gene
Compartment Confidence
lysosome 5
vacuole 5
extracellular 4
nucleus 4
cytoskeleton 2
endoplasmic reticulum 2
golgi apparatus 2
mitochondrion 2
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 10772654
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome TAS 8621627
GO:0030141 secretory granule IDA 11907569
genes like me logo Genes that share ontologies with MPO: view

Pathways for MPO Gene

genes like me logo Genes that share pathways with MPO: view

Interacting Proteins for MPO Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000225275%0d%0a9606.ENSP00000264613%0d%0a9606.ENSP00000321345%0d%0a9606.ENSP00000371067%0d%0a9606.ENSP00000403103%0d%0a9606.ENSP00000228534%0d%0a
Selected Interacting proteins: P05164-PERM_HUMAN ENSP00000225275 for MPO Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for MPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001878 response to yeast IEA --
GO:0002149 hypochlorous acid biosynthetic process IEA --
GO:0002679 respiratory burst involved in defense response IEA --
GO:0006952 defense response TAS 8621627
GO:0006979 response to oxidative stress TAS 2903767
genes like me logo Genes that share ontologies with MPO: view

Compounds for MPO Gene

(14) HMDB Compounds for MPO Gene

Compound Synonyms Cas Number PubMed IDs
2-Phenylacetamide
  • Benzeneacetamide
103-81-1
4-Coumaryl alcohol
  • 3-(4-Hydroxyphenyl)-1-propane
1076-38-6
Calcium
  • Ca
7440-70-2
Carnosine
  • Beta-Alanyl-L-histidine
305-84-0
Cyanosulfurous acid anion
  • CNSu
Not Available

(23) Drugbank Compounds for MPO Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Aminosalicylic Acid
  • 4-aminosalicylic acid
65-49-6 enzyme inhibitor
Bivalirudin
128270-60-0 enzyme inhibitor
Calcipotriol
112965-21-6 enzyme inhibitor
Carboplatin
  • CBDCA
41575-94-4 enzyme substrate
Cefaclor
  • CCL
53994-73-3 enzyme inducer

(154) Novoseek inferred chemical compound relationships for MPO Gene

Compound -log(P) Hits PubMed IDs
hocl 94.8 209
3-chlorotyrosine 86.4 36
4-aminobenzoic acid hydrazide 82.9 19
hobr 82.3 21
h2o2 79.9 221
genes like me logo Genes that share compounds with MPO: view

Transcripts for MPO Gene

Unigene Clusters for MPO Gene

Myeloperoxidase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MPO Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5:

Relevant External Links for MPO Gene

GeneLoc Exon Structure for
MPO
ECgene alternative splicing isoforms for
MPO

Expression for MPO Gene

mRNA expression in normal human tissues for MPO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MPO Gene

This gene is overexpressed in Whole Blood (38.6) and Spleen (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MPO Gene

SOURCE GeneReport for Unigene cluster for MPO Gene Hs.458272

genes like me logo Genes that share expressions with MPO: view

Orthologs for MPO Gene

This gene was present in the common ancestor of animals.

Orthologs for MPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MPO 36
  • 99.46 (n)
  • 99.33 (a)
MPO 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MPO 36
  • 87.14 (n)
  • 86.43 (a)
MPO 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MPO 36
  • 87.53 (n)
  • 88.19 (a)
MPO 37
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mpo 36
  • 85.02 (n)
  • 86.45 (a)
Mpo 16
Mpo 37
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MPO 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MPO 37
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 37
  • 60 (a)
OneToMany
MPO 36
  • 64.96 (n)
  • 63.05 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 59 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia mpo-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496213 36
  • 60.9 (n)
  • 61.73 (a)
Str.11704 36
zebrafish
(Danio rerio)
Actinopterygii mpx 37
  • 39 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pxd 37
  • 28 (a)
ManyToMany
CG6879 38
  • 32 (a)
CG6969 38
  • 33 (a)
CG10211 38
  • 33 (a)
CG4009 38
  • 29 (a)
CG5873 38
  • 34 (a)
pxt 38
  • 29 (a)
worm
(Caenorhabditis elegans)
Secernentea mlt-7 37
  • 30 (a)
ManyToMany
F09F3.5 38
  • 32 (a)
K10B4.1 38
  • 30 (a)
R08F11.7 38
  • 31 (a)
ZK430.8 38
  • 35 (a)
C46A5.4 38
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
ManyToMany
Species with no ortholog for MPO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MPO Gene

ENSEMBL:
Gene Tree for MPO (if available)
TreeFam:
Gene Tree for MPO (if available)

Paralogs for MPO Gene

Paralogs for MPO Gene

Selected SIMAP similar genes for MPO Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MPO: view

Variants for MPO Gene

Sequence variations from dbSNP and Humsavar for MPO Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2759 - 58,270,745(-) ACAAC(A/G)TCTTC reference, missense
rs916114 -- 58,269,727(-) GAGTT(C/T)TCCTT downstream-variant-500B
rs916115 -- 58,276,701(-) GATCC(A/T)GGACG intron-variant
rs916116 -- 58,276,698(-) CCTGG(A/T)CGGAC intron-variant
rs2071409 -- 58,270,869(-) TCCCC(A/C)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MPO Gene

Variant ID Type Subtype PubMed ID
nsv517229 CNV Gain+Loss 19592680
nsv509663 CNV Insertion 20534489
nsv2109 CNV Loss 18451855

Relevant External Links for MPO Gene

HapMap Linkage Disequilibrium report
MPO
Human Gene Mutation Database (HGMD)
MPO
Locus Specific Mutation Databases (LSDB)
MPO

Disorders for MPO Gene

(2) OMIM Diseases for MPO Gene (606989)

UniProtKB/Swiss-Prot

PERM_HUMAN
  • Myeloperoxidase deficiency (MPOD) [MIM:254600]: A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis. {ECO:0000269 PubMed:7904599, ECO:0000269 PubMed:8142659, ECO:0000269 PubMed:9354683, ECO:0000269 PubMed:9637725}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(92) Novoseek inferred disease relationships for MPO Gene

Disease -log(P) Hits PubMed IDs
mpo deficiency 93.3 157
vasculitis 86.5 142
wegeners granulomatosis 83.7 44
inflammation 79 130
glomerulonephritis 77.8 95

Genatlas disease for MPO Gene

infections,recurrent,with disseminated candidiasis

Relevant External Links for MPO

Genetic Association Database (GAD)
MPO
Human Genome Epidemiology (HuGE) Navigator
MPO
genes like me logo Genes that share disorders with MPO: view

Publications for MPO Gene

  1. Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan. (PMID: 7904599) Nauseef W.M. … Cogley M. (J. Biol. Chem. 1994) 3 4 23
  2. Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1. (PMID: 8383257) Hosokawa Y. … Yamaguchi K. (Leukemia 1993) 3 4 23
  3. Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency. (PMID: 8142659) Kizaki M. … Koeffler H.P. (Blood 1994) 3 4 23
  4. Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase. (PMID: 8621627) Nauseef W. … McCormick S. (J. Biol. Chem. 1996) 3 4 23
  5. Biochemical and molecular characterization of hereditary myeloperoxidase deficiency. (PMID: 9354683) Romano M. … Baralle F.E. (Blood 1997) 3 4 23

Products for MPO Gene

Sources for MPO Gene

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