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Aliases for MNT Gene

Aliases for MNT Gene

  • MAX Network Transcriptional Repressor 2 3 5
  • Class D Basic Helix-Loop-Helix Protein 3 3 4
  • MNT, MAX Dimerization Protein 2 3
  • Max-Interacting Protein 2 3
  • MAX Binding Protein 2 3
  • Myc Antagonist MNT 3 4
  • BHLHd3 3 4
  • ROX 3 4
  • Max-Binding Protein MNT 3
  • Myc Antagonist 2
  • Protein ROX 4
  • MAD6 3
  • MXD6 3

External Ids for MNT Gene

Previous GeneCards Identifiers for MNT Gene

  • GC17M002594
  • GC17M002238
  • GC17M002493
  • GC17M002234
  • GC17M002183
  • GC17M002287

Summaries for MNT Gene

Entrez Gene Summary for MNT Gene

  • The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNT Gene

MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include Tetanus Neonatorum and Retinitis Pigmentosa, Y-Linked. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for MNT Gene

  • Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.

Gene Wiki entry for MNT Gene

Additional gene information for MNT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNT Gene

Genomics for MNT Gene

Regulatory Elements for MNT Gene

Enhancers for MNT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H002390 1.9 FANTOM5 ENCODE dbSUPER 28.3 +2.1 2107 18 MLX FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC SSRP1 ZNF610 ZNF585B METTL16 PRPF8 SMYD4 HNRNPA1P16 SMG6 MNT TSR1 ENSG00000263345 SGSM2 RPA1
GH17H002261 1.8 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +136.0 136029 7 PKNOX1 FEZF1 ZNF2 ZNF207 FOS ATF7 RUNX3 ZNF491 ZNF592 ZNF624 SRR HNRNPA1P16 SMG6 METTL16 DPH1 ENSG00000263345 TSR1 ENSG00000263050 MNT LOC105371592
GH17H002357 1.4 Ensembl ENCODE dbSUPER 16.8 +41.9 41862 2 TBP PKNOX1 INSM2 ZNF76 KLF17 GLIS2 ZNF366 SCRT2 ATF7 FOS SGSM2 MNT TSR1 SNORD91A SNORD91B SMG6 SRR HIC1 OVCA2 METTL16
GH17H001712 1.8 FANTOM5 ENCODE dbSUPER 11.6 +685.3 685344 7 MLX DMAP1 YBX1 YY1 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 SMYD4 PRPF8 GEMIN4 RPA1 SERPINF2 METTL16 WDR81 TSR1 TLCD2 MNT
GH17H001624 1.7 FANTOM5 ENCODE dbSUPER 9.8 +773.6 773642 6 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B ZNF143 ZNF207 PITPNA SLC43A2 ENSG00000263050 SMG6 ENSG00000262869 SAMD11P1 EIF4A1P9 HNRNPA1P16 ENSG00000263345 SCARF1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MNT on UCSC Golden Path with GeneCards custom track

Promoters for MNT Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090234 518 3601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for MNT Gene

Chromosome:
17
Start:
2,384,060 bp from pter
End:
2,401,118 bp from pter
Size:
17,059 bases
Orientation:
Minus strand

Genomic View for MNT Gene

Genes around MNT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNT Gene

Proteins for MNT Gene

  • Protein details for MNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99583-MNT_HUMAN
    Recommended name:
    Max-binding protein MNT
    Protein Accession:
    Q99583
    Secondary Accessions:
    • A8K6D1
    • D3DTI7
    • Q1ED38

    Protein attributes for MNT Gene

    Size:
    582 amino acids
    Molecular mass:
    62300 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

neXtProt entry for MNT Gene

Post-translational modifications for MNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNT Gene

No data available for DME Specific Peptides for MNT Gene

Domains & Families for MNT Gene

Gene Families for MNT Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for MNT Gene

Suggested Antigen Peptide Sequences for MNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MNT: view

No data available for UniProtKB/Swiss-Prot for MNT Gene

Function for MNT Gene

Molecular function for MNT Gene

GENATLAS Biochemistry:
Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer
UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3.

Phenotypes From GWAS Catalog for MNT Gene

Gene Ontology (GO) - Molecular Function for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 9184233
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 9184233
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA,TAS 9184233
genes like me logo Genes that share ontologies with MNT: view
genes like me logo Genes that share phenotypes with MNT: view

Animal Models for MNT Gene

MGI Knock Outs for MNT:

Animal Model Products

CRISPR Products

miRNA for MNT Gene

miRTarBase miRNAs that target MNT

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MNT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MNT Gene

Localization for MNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MNT gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MNT: view

Pathways & Interactions for MNT Gene

No Data Available

Gene Ontology (GO) - Biological Process for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9184233
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9184233
GO:0007275 multicellular organism development TAS 9184233
genes like me logo Genes that share ontologies with MNT: view

No data available for Pathways by source and SIGNOR curated interactions for MNT Gene

Drugs & Compounds for MNT Gene

(1) Drugs for MNT Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with MNT: view

Transcripts for MNT Gene

Unigene Clusters for MNT Gene

MNT, MAX dimerization protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for MNT
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for MNT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - -
SP3: - -
SP4:
SP5: - - - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MNT Gene

GeneLoc Exon Structure for
MNT
ECgene alternative splicing isoforms for
MNT

Expression for MNT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MNT Gene

This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MNT Gene



Protein tissue co-expression partners for MNT Gene

NURSA nuclear receptor signaling pathways regulating expression of MNT Gene:

MNT

SOURCE GeneReport for Unigene cluster for MNT Gene:

Hs.632239

Evidence on tissue expression from TISSUES for MNT Gene

  • Nervous system(4.6)
  • Pancreas(4.1)
  • Blood(2.2)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with MNT: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MNT Gene

Orthologs for MNT Gene

This gene was present in the common ancestor of animals.

Orthologs for MNT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNT 33 34
  • 98.91 (n)
mouse
(Mus musculus)
Mammalia Mnt 16 34 33
  • 89.86 (n)
dog
(Canis familiaris)
Mammalia MNT 33 34
  • 89.24 (n)
cow
(Bos Taurus)
Mammalia MNT 33 34
  • 89.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MNT 34
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNT 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNT 34 33
  • 69.16 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MNT 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mnt 33
  • 64.42 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10853 33
zebrafish
(Danio rerio)
Actinopterygii mntb 34
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mnt 34
  • 16 (a)
OneToOne
Species where no ortholog for MNT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNT Gene

ENSEMBL:
Gene Tree for MNT (if available)
TreeFam:
Gene Tree for MNT (if available)

Paralogs for MNT Gene

No data available for Paralogs for MNT Gene

Variants for MNT Gene

Sequence variations from dbSNP and Humsavar for MNT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000120213 -- 2,401,705(+) GGCCG(C/G)GAGCC upstream-variant-2KB
rs1000171535 -- 2,390,744(+) CAGCT(G/T)CCCAC intron-variant, utr-variant-5-prime
rs1000213502 -- 2,393,245(+) GCGCG(C/G)AAGCC intron-variant, upstream-variant-2KB
rs1000214954 -- 2,383,834(+) AGATG(A/T)AACAA downstream-variant-500B
rs1000234548 -- 2,389,023(+) AGCCC(A/G)CCTTG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MNT Gene

Variant ID Type Subtype PubMed ID
dgv3083n100 CNV gain 25217958
nsv1055225 CNV loss 25217958
nsv1063109 CNV gain 25217958
nsv1066475 CNV loss 25217958
nsv1070377 CNV deletion 25765185
nsv1160443 CNV deletion 26073780
nsv1160444 CNV deletion 26073780
nsv1160445 CNV duplication 26073780
nsv469765 CNV loss 16826518
nsv470569 CNV loss 18288195
nsv517489 CNV loss 19592680
nsv574224 CNV gain 21841781
nsv833336 CNV loss 17160897
nsv833338 CNV loss 17160897
nsv952104 CNV deletion 24416366

Variation tolerance for MNT Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MNT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene

Disorders for MNT Gene

MalaCards: The human disease database

(3) MalaCards diseases for MNT Gene - From: DISEASES

Disorder Aliases PubMed IDs
tetanus neonatorum
  • neonatal tetanus
retinitis pigmentosa, y-linked
  • retinitis pigmentosa y-linked
wolfram syndrome 2
  • wfs2
- elite association - COSMIC cancer census association via MalaCards
Search MNT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MNT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MNT
genes like me logo Genes that share disorders with MNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MNT Gene

Publications for MNT Gene

  1. The human ROX gene: genomic structure and mutation analysis in human breast tumors. (PMID: 9598315) Lo Nigro C … Carrozzo R (Genomics 1998) 2 3 4 60
  2. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H … Lu SC (Hepatology (Baltimore, Md.) 2009) 3 22 60
  3. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo XL … Ohno R (Leukemia & lymphoma 2007) 3 22 60
  4. Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) Wahlström T … Henriksson M (Advances in cancer research 2007) 3 22 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60

Products for MNT Gene

Sources for MNT Gene

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