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Aliases for MNT Gene

Aliases for MNT Gene

  • MAX Network Transcriptional Repressor 2 3
  • Class D Basic Helix-Loop-Helix Protein 3 3 4
  • MNT, MAX Dimerization Protein 2 3
  • Max-Interacting Protein 2 3
  • MAX Binding Protein 2 3
  • Myc Antagonist MNT 3 4
  • BHLHd3 3 4
  • ROX 3 4
  • Myc Antagonist 2
  • Protein ROX 4
  • MAD6 3
  • MXD6 3

External Ids for MNT Gene

Previous GeneCards Identifiers for MNT Gene

  • GC17M002594
  • GC17M002238
  • GC17M002493
  • GC17M002234
  • GC17M002183
  • GC17M002287

Summaries for MNT Gene

Entrez Gene Summary for MNT Gene

  • The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNT Gene

MNT (MAX Network Transcriptional Repressor) is a Protein Coding gene. Diseases associated with MNT include tetanus neonatorum. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for MNT Gene

  • Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3

Gene Wiki entry for MNT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNT Gene

Genomics for MNT Gene

Regulatory Elements for MNT Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MNT Gene

Chromosome:
17
Start:
2,384,060 bp from pter
End:
2,401,118 bp from pter
Size:
17,059 bases
Orientation:
Minus strand

Genomic View for MNT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MNT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNT Gene

Proteins for MNT Gene

  • Protein details for MNT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99583-MNT_HUMAN
    Recommended name:
    Max-binding protein MNT
    Protein Accession:
    Q99583
    Secondary Accessions:
    • A8K6D1
    • D3DTI7
    • Q1ED38

    Protein attributes for MNT Gene

    Size:
    582 amino acids
    Molecular mass:
    62300 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX

neXtProt entry for MNT Gene

Proteomics data for MNT Gene at MOPED

Post-translational modifications for MNT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MNT Gene

Domains & Families for MNT Gene

Protein Domains for MNT Gene

Suggested Antigen Peptide Sequences for MNT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99583

UniProtKB/Swiss-Prot:

MNT_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with MNT: view

Function for MNT Gene

Molecular function for MNT Gene

GENATLAS Biochemistry:
Max interactor 2 (interacting with Max to bind Myc-Max recognition sites),MYC family acting as a transcriptional repressor in an E.box driver reporter gene repression system through interaction between the N-terminus and SIN3 corepressor,potentially involved in proliferation and differentiation,not involved in lung cancer
UniProtKB/Swiss-Prot Function:
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5-CACGTG-3 and, with higher affinity, to 5-CACGCG-3

Gene Ontology (GO) - Molecular Function for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 9184233
GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA 9184233
GO:0003677 DNA binding --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9184233
genes like me logo Genes that share ontologies with MNT: view
genes like me logo Genes that share phenotypes with MNT: view

Animal Models for MNT Gene

MGI Knock Outs for MNT:

Animal Model Products

miRNA for MNT Gene

miRTarBase miRNAs that target MNT

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MNT

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MNT Gene

Localization for MNT Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNT Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNT Gene COMPARTMENTS Subcellular localization image for MNT gene
Compartment Confidence
nucleus 5
endosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with MNT: view

Pathways & Interactions for MNT Gene

SuperPathways for MNT Gene

No Data Available

Gene Ontology (GO) - Biological Process for MNT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 9184233
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 9184233
GO:0007275 multicellular organismal development TAS 9184233
GO:0007569 cell aging IEA --
genes like me logo Genes that share ontologies with MNT: view

No data available for Pathways by source and SIGNOR curated interactions for MNT Gene

Drugs & Compounds for MNT Gene

(1) Drugs for MNT Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
leucine Nutra 93
genes like me logo Genes that share compounds with MNT: view

Transcripts for MNT Gene

Unigene Clusters for MNT Gene

MNT, MAX dimerization protein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MNT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNT Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - - - -
SP2: - -
SP3: - -
SP4:
SP5: - - - - - - - - - - -
SP6: -
SP7:

Relevant External Links for MNT Gene

GeneLoc Exon Structure for
MNT
ECgene alternative splicing isoforms for
MNT

Expression for MNT Gene

mRNA expression in normal human tissues for MNT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MNT Gene

This gene is overexpressed in Esophagus (41.8) and Lymph node (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MNT Gene



SOURCE GeneReport for Unigene cluster for MNT Gene Hs.632239

genes like me logo Genes that share expression patterns with MNT: view

Protein tissue co-expression partners for MNT Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MNT Gene

Orthologs for MNT Gene

This gene was present in the common ancestor of animals.

Orthologs for MNT Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MNT 35
  • 89.06 (n)
  • 94.47 (a)
MNT 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MNT 35
  • 89.24 (n)
  • 92.53 (a)
MNT 36
  • 70 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mnt 35
  • 89.86 (n)
  • 94.33 (a)
Mnt 16
Mnt 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MNT 35
  • 98.91 (n)
  • 98.45 (a)
MNT 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNT 36
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MNT 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MNT 35
  • 69.16 (n)
  • 70.83 (a)
MNT 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MNT 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mnt 35
  • 64.42 (n)
  • 65.61 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10853 35
zebrafish
(Danio rerio)
Actinopterygii mntb 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mnt 36
  • 16 (a)
OneToOne
Species with no ortholog for MNT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNT Gene

ENSEMBL:
Gene Tree for MNT (if available)
TreeFam:
Gene Tree for MNT (if available)

Paralogs for MNT Gene

No data available for Paralogs for MNT Gene

Variants for MNT Gene

Sequence variations from dbSNP and Humsavar for MNT Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs898751 -- 2,388,569(-) CTAGG(A/G)GGTCG intron-variant
rs1381247 -- 2,399,093(-) GCTTC(A/C/G)ATGAT intron-variant, upstream-variant-2KB
rs1540582 -- 2,386,405(-) GCGGA(C/T)TGGGG utr-variant-3-prime
rs1540583 -- 2,386,318(-) GGGCC(C/T)CAGCC utr-variant-3-prime
rs1545717 -- 2,392,111(-) GGACC(A/G)GGCGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MNT Gene

Variant ID Type Subtype PubMed ID
nsv833336 CNV Loss 17160897
nsv469765 CNV Complex 16826518
nsv907529 CNV Gain 21882294
nsv517489 CNV Loss 19592680
nsv907530 CNV Loss 21882294
dgv3036n71 CNV Loss 21882294
nsv907532 CNV Loss 21882294
nsv470569 CNV Loss 18288195
nsv833338 CNV Loss 17160897
nsv907537 CNV Loss 21882294

Variation tolerance for MNT Gene

Residual Variation Intolerance Score: 9.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MNT Gene

HapMap Linkage Disequilibrium report
MNT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNT Gene

Disorders for MNT Gene

MalaCards: The human disease database

(1) MalaCards diseases for MNT Gene - From: DISEASES

Disorder Aliases PubMed IDs
tetanus neonatorum
  • neonatal tetanus
- elite association
Search MNT in MalaCards View complete list of genes associated with diseases

Relevant External Links for MNT

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MNT
genes like me logo Genes that share disorders with MNT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MNT Gene

Publications for MNT Gene

  1. Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes. (PMID: 19086036) Yang H. … Lu S.C. (Hepatology 2009) 23 67
  2. roX RNAs: non-coding regulators of the male X chromosome in flies. (PMID: 19229132) Ilik I. … Akhtar A. (RNA Biol 2009) 23 67
  3. Transcription rate of noncoding roX1 RNA controls local spreading of the Drosophila MSL chromatin remodeling complex. (PMID: 18793722) Kelley R.L. … Shim Y.K. (Mech. Dev. 2008) 23 67
  4. Mnt takes control as key regulator of the myc/max/mxd network. (PMID: 17419941) WahlstrAPm T. … Henriksson M. (Adv. Cancer Res. 2007) 23 67
  5. Expression and mutation analysis of genes that encode the Myc antagonists Mad1, Mxi1 and Rox in acute leukaemia. (PMID: 17577784) Guo X.L. … Ohno R. (Leuk. Lymphoma 2007) 23 67

Products for MNT Gene

Sources for MNT Gene

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