Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MNDA Gene

Aliases for MNDA Gene

  • Myeloid Cell Nuclear Differentiation Antigen 2 3 5
  • PYHIN3 3

External Ids for MNDA Gene

Previous GeneCards Identifiers for MNDA Gene

  • GC01P156593
  • GC01P154533
  • GC01P155579
  • GC01P156017
  • GC01P155614
  • GC01P157067
  • GC01P130158

Summaries for MNDA Gene

Entrez Gene Summary for MNDA Gene

  • The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNDA Gene

MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. Diseases associated with MNDA include diffuse scleroderma and limited scleroderma. An important paralog of this gene is IFI16.

UniProtKB/Swiss-Prot for MNDA Gene

  • May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Gene Wiki entry for MNDA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNDA Gene

Genomics for MNDA Gene

Regulatory Elements for MNDA Gene

Promoters for MNDA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MNDA on UCSC Golden Path with GeneCards custom track

Genomic Location for MNDA Gene

Chromosome:
1
Start:
158,831,317 bp from pter
End:
158,849,506 bp from pter
Size:
18,190 bases
Orientation:
Plus strand

Genomic View for MNDA Gene

Genes around MNDA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MNDA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MNDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNDA Gene

Proteins for MNDA Gene

  • Protein details for MNDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41218-MNDA_HUMAN
    Recommended name:
    Myeloid cell nuclear differentiation antigen
    Protein Accession:
    P41218

    Protein attributes for MNDA Gene

    Size:
    407 amino acids
    Molecular mass:
    45836 Da
    Quaternary structure:
    • Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

    Three dimensional structures from OCA and Proteopedia for MNDA Gene

neXtProt entry for MNDA Gene

Proteomics data for MNDA Gene at MOPED

Post-translational modifications for MNDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNDA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MNDA (MNDA)

No data available for DME Specific Peptides for MNDA Gene

Domains & Families for MNDA Gene

Protein Domains for MNDA Gene

Graphical View of Domain Structure for InterPro Entry

P41218

UniProtKB/Swiss-Prot:

MNDA_HUMAN :
  • Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
Domain:
  • Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.
  • Contains 1 HIN-200 domain.
  • Contains 1 pyrin domain.
genes like me logo Genes that share domains with MNDA: view

Function for MNDA Gene

Molecular function for MNDA Gene

GENATLAS Biochemistry:
myeloid nuclear differentiation antigen,interferon alpha-inducible protein
UniProtKB/Swiss-Prot Function:
May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.
UniProtKB/Swiss-Prot Induction:
Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.

Phenotypes for MNDA Gene

genes like me logo Genes that share phenotypes with MNDA: view

Animal Model Products

miRNA for MNDA Gene

miRTarBase miRNAs that target MNDA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MNDA Gene

Localization for MNDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNDA Gene

Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNDA Gene COMPARTMENTS Subcellular localization image for MNDA gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with MNDA: view

Pathways & Interactions for MNDA Gene

SuperPathways for MNDA Gene

No Data Available

Gene Ontology (GO) - Biological Process for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 17875758
GO:0030889 negative regulation of B cell proliferation IMP 17875758
GO:0050853 B cell receptor signaling pathway IMP 17875758
genes like me logo Genes that share ontologies with MNDA: view

No data available for Pathways by source and SIGNOR curated interactions for MNDA Gene

Drugs & Compounds for MNDA Gene

(1) Drugs for MNDA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for MNDA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with MNDA: view

Transcripts for MNDA Gene

mRNA/cDNA for MNDA Gene

Unigene Clusters for MNDA Gene

Myeloid cell nuclear differentiation antigen:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MNDA Gene

No ASD Table

Relevant External Links for MNDA Gene

GeneLoc Exon Structure for
MNDA
ECgene alternative splicing isoforms for
MNDA

Expression for MNDA Gene

mRNA expression in normal human tissues for MNDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNDA Gene

This gene is overexpressed in Whole Blood (x47.0).

Protein differential expression in normal tissues from HIPED for MNDA Gene

This gene is overexpressed in Neutrophil (23.2), Monocytes (10.0), Peripheral blood mononuclear cells (9.5), and Lavage (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MNDA Gene



SOURCE GeneReport for Unigene cluster for MNDA Gene Hs.153837

mRNA Expression by UniProt/SwissProt for MNDA Gene

P41218-MNDA_HUMAN
Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
genes like me logo Genes that share expression patterns with MNDA: view

Protein tissue co-expression partners for MNDA Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for MNDA Gene

This gene was present in the common ancestor of mammals.

Orthologs for MNDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNDA 35
  • 99.34 (n)
  • 99.51 (a)
MNDA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 33 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MNDA 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifi204 36
  • 30 (a)
OneToMany
Ifi205 36
  • 44 (a)
OneToMany
Mnda 36
  • 42 (a)
OneToMany
Mndal 36
  • 35 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for MNDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MNDA Gene

ENSEMBL:
Gene Tree for MNDA (if available)
TreeFam:
Gene Tree for MNDA (if available)

Paralogs for MNDA Gene

Paralogs for MNDA Gene

(3) SIMAP similar genes for MNDA Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MNDA Gene

genes like me logo Genes that share paralogs with MNDA: view

Variants for MNDA Gene

Sequence variations from dbSNP and Humsavar for MNDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1056771 - 158,845,872(+) CATCT(A/C/G)TGTCT reference, missense
rs2276403 - 158,847,809(+) AATGG(C/T)ACAAT reference, missense
rs35417083 - 158,844,020(-) GGCTT(A/T)CTCTG reference, missense
rs703151 -- 158,844,592(+) ACACA(A/G)TCGAG intron-variant
rs857795 -- 158,829,601(-) gggaa(A/C/T)gtttg upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MNDA Gene

Variant ID Type Subtype PubMed ID
esv2669506 CNV Deletion 23128226

Variation tolerance for MNDA Gene

Residual Variation Intolerance Score: 60% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.87; 48.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MNDA Gene

HapMap Linkage Disequilibrium report
MNDA
Human Gene Mutation Database (HGMD)
MNDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNDA Gene

Disorders for MNDA Gene

MalaCards: The human disease database

(4) MalaCards diseases for MNDA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
diffuse scleroderma
  • diffuse systemic sclerosis
limited scleroderma
  • limited cutaneous systemic sclerosis
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
follicular lymphoma
  • lymphoma, follicular
- elite association - COSMIC cancer census association via MalaCards
Search MNDA in MalaCards View complete list of genes associated with diseases

Relevant External Links for MNDA

Genetic Association Database (GAD)
MNDA
Human Genome Epidemiology (HuGE) Navigator
MNDA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MNDA
genes like me logo Genes that share disorders with MNDA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MNDA Gene

Publications for MNDA Gene

  1. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (PMID: 1644857) Briggs J.A. … Briggs R.C. (J. Cell. Biochem. 1992) 2 3 4 23 67
  2. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. (PMID: 7512843) Briggs R.C. … Dessypris E.N. (Blood 1994) 2 3 23
  3. Identification of MNDA as a new marker for nodal marginal zone lymphoma. (PMID: 19474799) Kanellis G. … Piris M.A. (Leukemia 2009) 3 23
  4. ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. (PMID: 17875758) Joshi A.D. … Joshi S.S. (Clin. Cancer Res. 2007) 3 23
  5. Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis. (PMID: 16651415) Briggs R.C. … Head D.R. (Cancer Res. 2006) 3 23

Products for MNDA Gene

Sources for MNDA Gene

Back to Top

Content