Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MNDA Gene

Aliases for MNDA Gene

  • Myeloid Cell Nuclear Differentiation Antigen 2 3
  • PYHIN3 3

External Ids for MNDA Gene

Summaries for MNDA Gene

Entrez Gene Summary for MNDA Gene

  • The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons. [provided by RefSeq, Jul 2008]

GeneCards Summary for MNDA Gene

MNDA (Myeloid Cell Nuclear Differentiation Antigen) is a Protein Coding gene. Diseases associated with MNDA include chronic lymphocytic leukemia. Among its related pathways are Apoptosis and Autophagy and Lymphocyte Signaling. An important paralog of this gene is IFI16.

UniProtKB/Swiss-Prot for MNDA Gene

  • May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1

Gene Wiki entry for MNDA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNDA Gene

Genomics for MNDA Gene

Genomic Location for MNDA Gene

Start:
158,831,317 bp from pter
End:
158,849,506 bp from pter
Size:
18,190 bases
Orientation:
Plus strand

Genomic View for MNDA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MNDA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNDA Gene

Regulatory Elements for MNDA Gene

Proteins for MNDA Gene

  • Protein details for MNDA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41218-MNDA_HUMAN
    Recommended name:
    Myeloid cell nuclear differentiation antigen
    Protein Accession:
    P41218
    Secondary Accessions:

    Protein attributes for MNDA Gene

    Size:
    407 amino acids
    Molecular mass:
    45836 Da
    Quaternary structure:
    • Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23

    Three dimensional structures from OCA and Proteopedia for MNDA Gene

neXtProt entry for MNDA Gene

Proteomics data for MNDA Gene at MOPED

Post-translational modifications for MNDA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MNDA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MNDA Gene

Domains for MNDA Gene

Protein Domains for MNDA Gene

Graphical View of Domain Structure for InterPro Entry

P41218

UniProtKB/Swiss-Prot:

MNDA_HUMAN
Domain:
  • Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1:
    • P41218
  • Contains 1 DAPIN domain.:
    • P41218
  • Contains 1 HIN-200 domain.:
    • P41218
genes like me logo Genes that share domains with MNDA: view

No data available for Gene Families for MNDA Gene

Function for MNDA Gene

Molecular function for MNDA Gene

GENATLAS Biochemistry: myeloid nuclear differentiation antigen,interferon alpha-inducible protein
UniProtKB/Swiss-Prot Function: May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1
UniProtKB/Swiss-Prot Induction: Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.

Gene Ontology (GO) - Molecular Function for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23455924
genes like me logo Genes that share ontologies with MNDA: view

Phenotypes for MNDA Gene

GenomeRNAi human phenotypes for MNDA:
genes like me logo Genes that share phenotypes with MNDA: view

miRNA for MNDA Gene

miRTarBase miRNAs that target MNDA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MNDA Gene

Localization for MNDA Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNDA Gene

Nucleus. Cytoplasm. Note=Uniformly distributed throughout the interphase cell nucleus. Associates with chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNDA Gene COMPARTMENTS Subcellular localization image for MNDA gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with MNDA: view

Pathways for MNDA Gene

genes like me logo Genes that share pathways with MNDA: view

Pathways by source for MNDA Gene

2 Cell Signaling Technology pathways for MNDA Gene

Gene Ontology (GO) - Biological Process for MNDA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006968 cellular defense response TAS 1644857
GO:0006974 cellular response to DNA damage stimulus IMP 17875758
GO:0030889 negative regulation of B cell proliferation IMP 17875758
genes like me logo Genes that share ontologies with MNDA: view

Compounds for MNDA Gene

(5) Novoseek inferred chemical compound relationships for MNDA Gene

Compound -log(P) Hits PubMed IDs
mnda 99.6 153
p202 93.9 2
physostigmine 70 3
endotoxin 13.2 2
lipid 0 1
genes like me logo Genes that share compounds with MNDA: view

Transcripts for MNDA Gene

mRNA/cDNA for MNDA Gene

Unigene Clusters for MNDA Gene

Myeloid cell nuclear differentiation antigen:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MNDA Gene

No ASD Table

Relevant External Links for MNDA Gene

GeneLoc Exon Structure for
MNDA
ECgene alternative splicing isoforms for
MNDA

Expression for MNDA Gene

mRNA expression in normal human tissues for MNDA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNDA Gene

This gene is overexpressed in Whole Blood (47.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MNDA Gene

SOURCE GeneReport for Unigene cluster for MNDA Gene Hs.153837

mRNA Expression by UniProt/SwissProt for MNDA Gene

P41218-MNDA_HUMAN
Tissue specificity: Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appear in myeloblast cells in some cases of acute myeloid Leukemia.
genes like me logo Genes that share expressions with MNDA: view

Orthologs for MNDA Gene

This gene was present in the common ancestor of mammals.

Orthologs for MNDA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNDA 35
  • 99.34 (n)
  • 99.51 (a)
MNDA 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 33 (a)
OneToMany
dog
(Canis familiaris)
Mammalia MNDA 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifi204 36
  • 30 (a)
OneToMany
Ifi205 36
  • 44 (a)
OneToMany
Mnda 36
  • 42 (a)
OneToMany
Mndal 36
  • 35 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
OneToMany
Species with no ortholog for MNDA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MNDA Gene

ENSEMBL:
Gene Tree for MNDA (if available)
TreeFam:
Gene Tree for MNDA (if available)

Paralogs for MNDA Gene

Paralogs for MNDA Gene

Selected SIMAP similar genes for MNDA Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for MNDA Gene

genes like me logo Genes that share paralogs with MNDA: view

Variants for MNDA Gene

Sequence variations from dbSNP and Humsavar for MNDA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs703151 -- 158,844,592(+) ACACA(A/G)TCGAG intron-variant
rs714877 -- 158,831,183(+) GCGAA(C/G)AAGAG upstream-variant-2KB
rs714878 -- 158,831,220(+) TGACT(C/G)AGATT upstream-variant-2KB
rs857795 -- 158,829,601(-) gggaa(A/C/T)gtttg upstream-variant-2KB
rs857796 -- 158,831,776(+) CAGCA(A/G)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MNDA Gene

Variant ID Type Subtype PubMed ID
esv2669506 CNV Deletion 23128226

Relevant External Links for MNDA Gene

HapMap Linkage Disequilibrium report
MNDA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNDA Gene

Disorders for MNDA Gene

(10) Novoseek inferred disease relationships for MNDA Gene

Disease -log(P) Hits PubMed IDs
myeloid leukemia 37 2
myelodysplastic syndromes 36.1 3
burkitt lymphoma 34.7 1
myeloid leukemia chronic 32.8 3
melanoma 26.2 3

Relevant External Links for MNDA

Genetic Association Database (GAD)
MNDA
Human Genome Epidemiology (HuGE) Navigator
MNDA
genes like me logo Genes that share disorders with MNDA: view

No data available for UniProtKB/Swiss-Prot for MNDA Gene

Publications for MNDA Gene

  1. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (PMID: 1644857) Briggs J.A. … Briggs R.C. (J. Cell. Biochem. 1992) 2 3 4 23
  2. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located on chromosome 1q that are expressed specifically in hematopoietic cells. (PMID: 7512843) Briggs R.C. … Dessypris E.N. (Blood 1994) 2 3 4 23
  3. The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression. (PMID: 7806273) Dawson M.J. … Baker E. (Immunogenetics 1995) 3 4 23
  4. Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. (PMID: 8175894) Briggs R. … Lian J. (J. Cell. Biochem. 1994) 3 4 23
  5. Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding. (PMID: 9712147) Xie J. … Briggs R.C. (J. Cell. Biochem. 1998) 3 4 23

Products for MNDA Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Interferons & Receptors in human,mouse,rat
    • Type I Interferon Response in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate MNDA
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for MNDA
    • Block miRNA regulation of MNDA using miScript Target Protectors

    Sources for MNDA Gene

    Back to Top

    Content