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Aliases for MNAT1 Gene

Aliases for MNAT1 Gene

  • MNAT CDK-Activating Kinase Assembly Factor 1 2 3
  • MAT1 3 4 6
  • Menage A Trois 1 (CAK Assembly Factor) 2 3
  • Cyclin-G1-Interacting Protein 3 4
  • CDK7/Cyclin-H Assembly Factor 3 4
  • RING Finger Protein MAT1 3 4
  • RING Finger Protein 66 3 4
  • CAP35 3 4
  • RNF66 3 4
  • Menage A Trois Homolog 1, Cyclin H Assembly Factor (Xenopus Laevis) 2
  • Menage A Trois Homolog 1, Cyclin H Assembly Factor 3
  • CDK-Activating Kinase Assembly Factor MAT1 3
  • CDK-Activating Kinase Assembly Factor 2
  • Cyclin G1 Interacting Protein 3
  • Menage A Trois 4
  • TFB3 3
  • P35 4
  • P36 4

External Ids for MNAT1 Gene

Previous GeneCards Identifiers for MNAT1 Gene

  • GC14P058527
  • GC14P054995
  • GC14P059191
  • GC14P060271
  • GC14P061201
  • GC14P041364

Summaries for MNAT1 Gene

Entrez Gene Summary for MNAT1 Gene

  • The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for MNAT1 Gene

MNAT1 (MNAT CDK-Activating Kinase Assembly Factor 1) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include protein N-terminus binding and RNA polymerase II carboxy-terminal domain kinase activity.

UniProtKB/Swiss-Prot for MNAT1 Gene

  • Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Gene Wiki entry for MNAT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNAT1 Gene

Genomics for MNAT1 Gene

Regulatory Elements for MNAT1 Gene

Genomic Location for MNAT1 Gene

Start:
60,734,741 bp from pter
End:
60,969,953 bp from pter
Size:
235,213 bases
Orientation:
Plus strand

Genomic View for MNAT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MNAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNAT1 Gene

Proteins for MNAT1 Gene

  • Protein details for MNAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51948-MAT1_HUMAN
    Recommended name:
    CDK-activating kinase assembly factor MAT1
    Protein Accession:
    P51948
    Secondary Accessions:
    • G3V1U8
    • Q15817
    • Q6ICQ7

    Protein attributes for MNAT1 Gene

    Size:
    309 amino acids
    Molecular mass:
    35823 Da
    Quaternary structure:
    • Associates primarily with CDK7 and cyclin H to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.

    Three dimensional structures from OCA and Proteopedia for MNAT1 Gene

    Alternative splice isoforms for MNAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MNAT1 Gene

Proteomics data for MNAT1 Gene at MOPED

Post-translational modifications for MNAT1 Gene

  • Ubiquitination at Lys167, Lys180, and Lys202
  • Modification sites at PhosphoSitePlus

Other Protein References for MNAT1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MNAT1 Gene

Domains for MNAT1 Gene

Gene Families for MNAT1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TFIIH :General transcription factor IIH complex subunits

Suggested Antigen Peptide Sequences for MNAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51948

UniProtKB/Swiss-Prot:

MAT1_HUMAN :
  • P51948
Domain:
  • Contains 1 UIM (ubiquitin-interacting motif) domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with MNAT1: view

Function for MNAT1 Gene

Molecular function for MNAT1 Gene

GENATLAS Biochemistry: CDK activating kinase (CAK1) assembly factor MAT1 (menage a trois),36kDa,forming a ternary complex with CDK7 and CCNH (see symbols),associating in the multisubunit complex TFIIH (GTF2H),putatively involved in cell cycle control,transcription,DNA repair
UniProtKB/Swiss-Prot Function: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.

Gene Ontology (GO) - Molecular Function for MNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10801852
GO:0008094 contributes_to DNA-dependent ATPase activity IDA 9852112
GO:0008270 zinc ion binding IEA --
GO:0008353 contributes_to RNA polymerase II carboxy-terminal domain kinase activity IDA 9852112
GO:0047485 protein N-terminus binding IPI 11445587
genes like me logo Genes that share ontologies with MNAT1: view
genes like me logo Genes that share phenotypes with MNAT1: view

Animal Models for MNAT1 Gene

MGI Knock Outs for MNAT1:

Animal Model Products

CRISPR Products

miRNA for MNAT1 Gene

miRTarBase miRNAs that target MNAT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MNAT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MNAT1 Gene

Localization for MNAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNAT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNAT1 Gene COMPARTMENTS Subcellular localization image for MNAT1 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for MNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005675 holo TFIIH complex IDA 9852112
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with MNAT1: view

Pathways for MNAT1 Gene

SuperPathways for MNAT1 Gene

Superpath Contained pathways
1 Formation of RNA Pol II elongation complex
2 DNA Repair
3 Global Genomic NER (GG-NER)
4 RNA Polymerase I Promoter Opening
5 HIV Life Cycle
genes like me logo Genes that share pathways with MNAT1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MNAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity TAS 8521818
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0000718 nucleotide-excision repair, DNA damage removal TAS --
genes like me logo Genes that share ontologies with MNAT1: view

Compounds for MNAT1 Gene

(1) Novoseek inferred chemical compound relationships for MNAT1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 36.5 10
genes like me logo Genes that share compounds with MNAT1: view

Transcripts for MNAT1 Gene

Unigene Clusters for MNAT1 Gene

Menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MNAT1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNAT1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1:
SP2: -

Relevant External Links for MNAT1 Gene

GeneLoc Exon Structure for
MNAT1
ECgene alternative splicing isoforms for
MNAT1

Expression for MNAT1 Gene

mRNA expression in normal human tissues for MNAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MNAT1 Gene

SOURCE GeneReport for Unigene cluster for MNAT1 Gene Hs.509523

mRNA Expression by UniProt/SwissProt for MNAT1 Gene

P51948-MAT1_HUMAN
Tissue specificity: Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes
genes like me logo Genes that share expressions with MNAT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MNAT1 Gene

Orthologs for MNAT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MNAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNAT1 35
  • 99.78 (n)
  • 100 (a)
MNAT1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MNAT1 35
  • 94.17 (n)
  • 97.73 (a)
MNAT1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MNAT1 35
  • 94.5 (n)
  • 97.41 (a)
MNAT1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mnat1 35
  • 87.01 (n)
  • 95.78 (a)
Mnat1 16
Mnat1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNAT1 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MNAT1 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mnat1 35
  • 88.2 (n)
  • 96.43 (a)
chicken
(Gallus gallus)
Aves MNAT1 35
  • 81.12 (n)
  • 90.61 (a)
MNAT1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MNAT1 36
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia mnat1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mnat1 35
  • 74.24 (n)
  • 81.49 (a)
Str.6295 35
zebrafish
(Danio rerio)
Actinopterygii mnat1 35
  • 66.99 (n)
  • 75.41 (a)
mnat1 36
  • 75 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008991 35
  • 53.51 (n)
  • 53.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mat1 35
  • 54.93 (n)
  • 55.26 (a)
Mat1 36
  • 52 (a)
OneToOne
Mat1 37
  • 52 (a)
worm
(Caenorhabditis elegans)
Secernentea mnat-1 35
  • 47.32 (n)
  • 34.56 (a)
mnat-1 36
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR202C 35
  • 45.41 (n)
  • 34.15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TFB3 35
  • 47.87 (n)
  • 33.69 (a)
TFB3 36
  • 28 (a)
OneToOne
TFB3 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C14872g 35
  • 56.74 (n)
  • 43.51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02587 35
  • 41.58 (n)
  • 30.1 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pmh1 35
  • 46.3 (n)
  • 34.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10583 36
  • 39 (a)
OneToOne
Species with no ortholog for MNAT1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MNAT1 Gene

ENSEMBL:
Gene Tree for MNAT1 (if available)
TreeFam:
Gene Tree for MNAT1 (if available)

Paralogs for MNAT1 Gene

No data available for Paralogs for MNAT1 Gene

Variants for MNAT1 Gene

Sequence variations from dbSNP and Humsavar for MNAT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs14852 -- 60,968,589(+) TGATG(A/G)AAGAG utr-variant-3-prime
rs752571 -- 60,905,626(-) TCAGG(A/C)CTTCA intron-variant
rs753014 -- 60,904,862(+) GTATC(A/G)TGGTA intron-variant
rs913482 -- 60,906,942(-) gatga(C/T)tgtaa intron-variant
rs913483 -- 60,904,541(-) AGAAG(A/C)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MNAT1 Gene

Variant ID Type Subtype PubMed ID
nsv902001 CNV Loss 21882294
esv2482420 CNV Deletion 19546169
esv2540729 CNV Deletion 19546169
esv2748755 CNV Deletion 23290073
nsv510637 CNV Loss 20534489
nsv507754 CNV Insertion 20534489
esv268846 CNV Insertion 20981092

Relevant External Links for MNAT1 Gene

HapMap Linkage Disequilibrium report
MNAT1
Human Gene Mutation Database (HGMD)
MNAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNAT1 Gene

Disorders for MNAT1 Gene

(4) Novoseek inferred disease relationships for MNAT1 Gene

Disease -log(P) Hits PubMed IDs
paratuberculosis 53.8 4
ovarian carcinoma 22.2 2
retinoblastoma 20.4 1
tumors 0 2

Relevant External Links for MNAT1

Genetic Association Database (GAD)
MNAT1
Human Genome Epidemiology (HuGE) Navigator
MNAT1
genes like me logo Genes that share disorders with MNAT1: view

No data available for UniProtKB/Swiss-Prot for MNAT1 Gene

Publications for MNAT1 Gene

  1. Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor. (PMID: 8521393) Yee A. … Xiong Y. (Cancer Res. 1995) 3 4 23
  2. In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein. (PMID: 8521818) Tassan J.-P. … Nigg E.A. (EMBO J. 1995) 3 4 23
  3. Mapping of the human genes encoding cyclin H (CCNH) and the CDK-activating kinase (CAK) assembly factor MAT1 (MNAT1) to chromosome bands 5q13.3-q14 and 14q23, respectively. (PMID: 9465303) Eki T. … Hanaoka F. (Genomics 1998) 2 3 23
  4. Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family. (PMID: 11056162) Gervais V. … Kieffer B. (J. Biol. Chem. 2001) 3 4 23
  5. Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population. (PMID: 17707548) Li Y. … Lu D. (Lung Cancer 2007) 3 23 48

Products for MNAT1 Gene

Sources for MNAT1 Gene

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