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Aliases for MN1 Gene

Aliases for MN1 Gene

  • Meningioma (Disrupted In Balanced Translocation) 1 2 3
  • Probable Tumor Suppressor Protein MN1 2
  • Meningioma (Translocation Balanced) 3
  • Meningioma Chromosome Region 1 3
  • Meningioma Chromosome Region 2
  • DJ353E16.2 3
  • MGCR1-PEN 3
  • MGCR1 3
  • MGCR 3

External Ids for MN1 Gene

Previous HGNC Symbols for MN1 Gene

  • MGCR

Previous GeneCards Identifiers for MN1 Gene

  • GC22M024840
  • GC22M026468
  • GC22M028144
  • GC22M011108

Summaries for MN1 Gene

Entrez Gene Summary for MN1 Gene

  • Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MN1 Gene

MN1 (Meningioma (Disrupted In Balanced Translocation) 1) is a Protein Coding gene. Diseases associated with MN1 include mn1 and meningioma, familial.

UniProtKB/Swiss-Prot for MN1 Gene

  • May play a role in tumor suppression

Gene Wiki entry for MN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MN1 Gene

Genomics for MN1 Gene

Regulatory Elements for MN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MN1 Gene

Chromosome:
22
Start:
27,748,277 bp from pter
End:
27,801,498 bp from pter
Size:
53,222 bases
Orientation:
Minus strand

Genomic View for MN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MN1 Gene

Proteins for MN1 Gene

  • Protein details for MN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10571-MN1_HUMAN
    Recommended name:
    Probable tumor suppressor protein MN1
    Protein Accession:
    Q10571
    Secondary Accessions:
    • A9Z1V9

    Protein attributes for MN1 Gene

    Size:
    1320 amino acids
    Molecular mass:
    136001 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MN1 Gene

Proteomics data for MN1 Gene at MOPED

Post-translational modifications for MN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MN1 Gene

Domains & Families for MN1 Gene

Protein Domains for MN1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for MN1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with MN1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for MN1 Gene

Function for MN1 Gene

Molecular function for MN1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in tumor suppression

Gene Ontology (GO) - Molecular Function for MN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with MN1: view
genes like me logo Genes that share phenotypes with MN1: view

Animal Models for MN1 Gene

MGI Knock Outs for MN1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for MN1 Gene

Localization for MN1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MN1 Gene COMPARTMENTS Subcellular localization image for MN1 gene
Compartment Confidence
cytosol 1
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with MN1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MN1 Gene

Pathways & Interactions for MN1 Gene

SuperPathways for MN1 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Interacting Proteins for MN1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304956%0d%0a9606.ENSP00000263253%0d%0a9606.ENSP00000329623%0d%0a
Selected Interacting proteins: ENSP00000304956 Q10571-MN1_HUMAN for MN1 Gene via STRING I2D MINT

SIGNOR curated interactions for MN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001957 intramembranous ossification IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with MN1: view

No data available for Pathways by source for MN1 Gene

Drugs & Compounds for MN1 Gene

(1) Additional Compounds for MN1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
retinoic acid
302-79-4
genes like me logo Genes that share compounds with MN1: view

Transcripts for MN1 Gene

mRNA/cDNA for MN1 Gene

Unigene Clusters for MN1 Gene

Meningioma (disrupted in balanced translocation) 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MN1 Gene

No ASD Table

Relevant External Links for MN1 Gene

GeneLoc Exon Structure for
MN1
ECgene alternative splicing isoforms for
MN1

Expression for MN1 Gene

mRNA expression in normal human tissues for MN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MN1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8) and Artery - Tibial (x4.4).

Protein differential expression in normal tissues from HIPED for MN1 Gene

This gene is overexpressed in Monocytes (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MN1 Gene



SOURCE GeneReport for Unigene cluster for MN1 Gene Hs.268515

mRNA Expression by UniProt/SwissProt for MN1 Gene

Q10571-MN1_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in skeletal muscle
genes like me logo Genes that share expression patterns with MN1: view

Protein tissue co-expression partners for MN1 Gene

Primer Products

In Situ Assay Products

Orthologs for MN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MN1 35
  • 89.06 (n)
  • 91.93 (a)
MN1 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MN1 35
  • 90.24 (n)
  • 93.31 (a)
MN1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mn1 35
  • 85.3 (n)
  • 90.52 (a)
Mn1 16
Mn1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MN1 35
  • 98.78 (n)
  • 98.68 (a)
rat
(Rattus norvegicus)
Mammalia Mn1 35
  • 85.13 (n)
  • 90.25 (a)
oppossum
(Monodelphis domestica)
Mammalia MN1 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves MN1 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mn1.1 35
  • 63.35 (n)
  • 66.47 (a)
zebrafish
(Danio rerio)
Actinopterygii mn1b 35
  • 61.16 (n)
  • 58.26 (a)
mn1a 36
  • 44 (a)
OneToMany
mn1b 36
  • 56 (a)
OneToMany
Species with no ortholog for MN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MN1 Gene

ENSEMBL:
Gene Tree for MN1 (if available)
TreeFam:
Gene Tree for MN1 (if available)

Paralogs for MN1 Gene

No data available for Paralogs for MN1 Gene

Variants for MN1 Gene

Sequence variations from dbSNP and Humsavar for MN1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs372418 -- 27,773,511(+) CTCGC(C/T)GCACT intron-variant
rs376840 -- 27,789,294(+) AAGGG(G/T)TCTCC intron-variant
rs382819 -- 27,785,448(+) AACTT(A/C)AAAAT intron-variant
rs384770 -- 27,774,735(+) CTGCC(A/T)TCATC intron-variant
rs385505 -- 27,789,499(+) AGTTG(A/G)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MN1 Gene

Variant ID Type Subtype PubMed ID
esv2056669 CNV Deletion 18987734
esv2724116 CNV Deletion 23290073
nsv829144 CNV Gain 20364138
esv2675305 CNV Deletion 23128226
nsv518700 CNV Gain 19592680
esv2210205 CNV Deletion 18987734
nsv829145 CNV Gain 20364138
nsv829146 CNV Gain 20364138

Variation tolerance for MN1 Gene

Residual Variation Intolerance Score: 3.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.00; 74.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MN1 Gene

HapMap Linkage Disequilibrium report
MN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MN1 Gene

Disorders for MN1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for MN1 Gene - From: OMIM, GeneTests, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
mn1
  • meningioma 1 gene
meningioma, familial
  • meningioma
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association
Search MN1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MN1_HUMAN
  • Note=A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL.
  • Note=Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.

Relevant External Links for MN1

Genetic Association Database (GAD)
MN1
Human Genome Epidemiology (HuGE) Navigator
MN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MN1
genes like me logo Genes that share disorders with MN1: view

No data available for Genatlas for MN1 Gene

Publications for MN1 Gene

  1. Cloning and characterization of MN1, a gene from chromosome 22q11, which is disrupted by a balanced translocation in a meningioma. (PMID: 7731706) Deprez R.H.L. … Zwarthoff E.C. (Oncogene 1995) 2 23 67
  2. MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. (PMID: 18632758) Meester-Smoor M.A. … Zwarthoff E.C. (Carcinogenesis 2008) 23 67
  3. [Cytogenetic alterations in meningioma tumors and their impact on disease outcome]. (PMID: 17335728) SayaguAcs J.M. … MaA-llo A. (Med Clin (Barc) 2007) 23 67
  4. Minimally differentiated acute myeloid leukemia with t(12;22)(p13;q11) translocation showing primary multidrug resistance and expressing multiple multidrug-resistant proteins. (PMID: 17476096) Chen S. … Pan J. (Acta Haematol. 2007) 23 67
  5. The MN1 oncoprotein activates transcription of the IGFBP5 promoter through a CACCC-rich consensus sequence. (PMID: 17242174) Meester-Smoor M.A. … Zwarthoff E.C. (J. Mol. Endocrinol. 2007) 23 67

Products for MN1 Gene

Sources for MN1 Gene

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