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Aliases for MMP19 Gene

Aliases for MMP19 Gene

  • Matrix Metallopeptidase 19 2 3 5
  • Matrix Metalloproteinase RASI 3 4
  • Matrix Metalloproteinase-18 3 4
  • MMP18 3 4
  • Matrix Metalloproteinase-Beta19 3
  • Matrix Metalloproteinase 19 2
  • EC 3.4.24.- 4
  • RASI-1 3
  • MMP-18 4
  • MMP-19 4
  • CODA 3
  • RASI 4

External Ids for MMP19 Gene

Previous HGNC Symbols for MMP19 Gene

  • MMP18

Previous GeneCards Identifiers for MMP19 Gene

  • GC12M056347
  • GC12M056451
  • GC12M055945
  • GC12M054515
  • GC12M056230
  • GC12M053267

Summaries for MMP19 Gene

Entrez Gene Summary for MMP19 Gene

  • This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for MMP19 Gene

MMP19 (Matrix Metallopeptidase 19) is a Protein Coding gene. Diseases associated with MMP19 include cavitary optic disc anomalies and anthracosis. Among its related pathways are Matrix Metalloproteinases and GPCR Pathway. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP19 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Tocris Summary for MMP19 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP19 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP19 Gene

Genomics for MMP19 Gene

Regulatory Elements for MMP19 Gene

Enhancers for MMP19 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MMP19 on UCSC Golden Path with GeneCards custom track

Promoters for MMP19 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MMP19 on UCSC Golden Path with GeneCards custom track

Genomic Location for MMP19 Gene

Chromosome:
12
Start:
55,835,430 bp from pter
End:
55,842,983 bp from pter
Size:
7,554 bases
Orientation:
Minus strand

Genomic View for MMP19 Gene

Genes around MMP19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP19 Gene

Proteins for MMP19 Gene

  • Protein details for MMP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99542-MMP19_HUMAN
    Recommended name:
    Matrix metalloproteinase-19
    Protein Accession:
    Q99542
    Secondary Accessions:
    • B4E030
    • O15278
    • O95606
    • Q99580

    Protein attributes for MMP19 Gene

    Size:
    508 amino acids
    Molecular mass:
    57357 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Autoantigen anti-MMP19 are frequent in RA patients.
    SequenceCaution:
    • Sequence=AAC99995.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MMP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP19 Gene

Proteomics data for MMP19 Gene at MOPED

Post-translational modifications for MMP19 Gene

Other Protein References for MMP19 Gene

Antibody Products

No data available for DME Specific Peptides for MMP19 Gene

Domains & Families for MMP19 Gene

Gene Families for MMP19 Gene

Graphical View of Domain Structure for InterPro Entry

Q99542

UniProtKB/Swiss-Prot:

MMP19_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP19: view

Function for MMP19 Gene

Molecular function for MMP19 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 19,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and intestine
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves aggrecan at the 360-Ser- -Phe-361 site.
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Enzyme Numbers (IUBMB) for MMP19 Gene

Gene Ontology (GO) - Molecular Function for MMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP19: view
genes like me logo Genes that share phenotypes with MMP19: view

Animal Models for MMP19 Gene

MGI Knock Outs for MMP19:

Animal Model Products

  • Taconic Biosciences Mouse Models for MMP19

miRNA for MMP19 Gene

miRTarBase miRNAs that target MMP19

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP19 Gene

Localization for MMP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP19 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP19 Gene COMPARTMENTS Subcellular localization image for MMP19 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for MMP19 Gene

Pathways & Interactions for MMP19 Gene

genes like me logo Genes that share pathways with MMP19: view

Interacting Proteins for MMP19 Gene

Gene Ontology (GO) - Biological Process for MMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001541 ovarian follicle development IEA --
GO:0001542 ovulation from ovarian follicle IEA --
GO:0006508 proteolysis IEA,NAS 9020145
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with MMP19: view

No data available for SIGNOR curated interactions for MMP19 Gene

Drugs & Compounds for MMP19 Gene

(2) Drugs for MMP19 Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
calcium Nutra 0

(6) Additional Compounds for MMP19 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP19 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP19: view

Transcripts for MMP19 Gene

Unigene Clusters for MMP19 Gene

Matrix metallopeptidase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - - -
SP9:

Relevant External Links for MMP19 Gene

GeneLoc Exon Structure for
MMP19
ECgene alternative splicing isoforms for
MMP19

Expression for MMP19 Gene

mRNA expression in normal human tissues for MMP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP19 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x6.5).

Protein differential expression in normal tissues from HIPED for MMP19 Gene

This gene is overexpressed in Liver, secretome (23.8), Heart (19.5), Placenta (11.5), and Fetal heart (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP19 Gene



SOURCE GeneReport for Unigene cluster for MMP19 Gene Hs.591033

mRNA Expression by UniProt/SwissProt for MMP19 Gene

Q99542-MMP19_HUMAN
Tissue specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941).
genes like me logo Genes that share expression patterns with MMP19: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for MMP19 Gene

Orthologs for MMP19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP19 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP19 35
  • 87.01 (n)
  • 85.92 (a)
MMP19 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP19 35
  • 87.29 (n)
  • 84.58 (a)
MMP19 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp19 35
  • 82.31 (n)
  • 79.21 (a)
Mmp19 16
Mmp19 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP19 35
  • 99.34 (n)
  • 99.01 (a)
MMP19 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp19 35
  • 83.47 (n)
  • 82.2 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP19 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP19 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP19 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP19 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp19 35
  • 62.4 (n)
  • 63.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536874 35
  • 58.13 (n)
  • 55.12 (a)
MMP19 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea T21D11.1 36
  • 28 (a)
OneToMany
Species with no ortholog for MMP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP19 Gene

ENSEMBL:
Gene Tree for MMP19 (if available)
TreeFam:
Gene Tree for MMP19 (if available)

Paralogs for MMP19 Gene

Paralogs for MMP19 Gene

(9) SIMAP similar genes for MMP19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MMP19: view

Variants for MMP19 Gene

Sequence variations from dbSNP and Humsavar for MMP19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17844794 - 55,840,880(-) TAGGC(A/C/T)GCTGG intron-variant, nc-transcript-variant, reference, missense
rs17118042 - 55,837,101(+) TGAGG(G/T)AGTGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs17844806 - 55,837,091(-) AGGTA(C/T)GGGCA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs1056784 - 55,839,529(+) ATCTG(A/G)GTGCA intron-variant, nc-transcript-variant, reference, missense
rs7294345 -- 55,842,747(+) ACCAC(A/G)GGCGC nc-transcript-variant, reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MMP19 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897

Variation tolerance for MMP19 Gene

Residual Variation Intolerance Score: 90.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP19 Gene

HapMap Linkage Disequilibrium report
MMP19
Human Gene Mutation Database (HGMD)
MMP19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP19 Gene

Disorders for MMP19 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MMP19 Gene - From: OMIM, ClinVar, and DISEASES

Disorder Aliases PubMed IDs
cavitary optic disc anomalies
  • coda
anthracosis
  • pneumoconiosis
- elite association - COSMIC cancer census association via MalaCards
Search MMP19 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP19

Genetic Association Database (GAD)
MMP19
Human Genome Epidemiology (HuGE) Navigator
MMP19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP19
genes like me logo Genes that share disorders with MMP19: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP19 Gene

Publications for MMP19 Gene

  1. The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient. (PMID: 9232430) Kolb C. … Sedlacek R. (Immunol. Lett. 1997) 2 3 4 23 67
  2. Matrix metalloproteinase-19 is highly expressed in astroglial tumors and promotes invasion of glioma cells. (PMID: 20142769) Lettau I. … Mentlein R. (J. Neuropathol. Exp. Neurol. 2010) 3 23
  3. Regulation of matrix metalloproteinases and their inhibitors by interferon-beta: a longitudinal study in multiple sclerosis patients. (PMID: 19383643) Bernal F. … Kieseier B.C. (Mult. Scler. 2009) 3 23
  4. Expression of matrix metalloproteinases MMP-1, MMP-11 and MMP-19 is correlated with the WHO-grading of human malignant gliomas. (PMID: 17980449) Stojic J. … Vince G.H. (Neurosci. Res. 2008) 3 23
  5. Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation. (PMID: 17195013) Beck I.M. … Sedlacek R. (J. Invest. Dermatol. 2007) 3 23

Products for MMP19 Gene

Sources for MMP19 Gene

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