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Aliases for MMP19 Gene

Aliases for MMP19 Gene

  • Matrix Metallopeptidase 19 2 3
  • MMP18 3 4 6
  • Matrix Metalloproteinase RASI 3 4
  • Matrix Metalloproteinase-18 3 4
  • Matrix Metalloproteinase-Beta19 3
  • Matrix Metalloproteinase 19 2
  • Matrix Metalloproteinase-19 3
  • EC 3.4.24.- 4
  • RASI-1 3
  • MMP-18 4
  • MMP-19 4
  • RASI 4

External Ids for MMP19 Gene

Previous Symbols for MMP19 Gene

  • MMP18

Summaries for MMP19 Gene

Entrez Gene Summary for MMP19 Gene

  • This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for MMP19 Gene

MMP19 (Matrix Metallopeptidase 19) is a Protein Coding gene. Diseases associated with MMP19 include keloids and arthritis. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP19 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Tocris Summary for MMP19 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP19 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP19 Gene

Genomics for MMP19 Gene

Genomic Location for MMP19 Gene

Start:
55,835,430 bp from pter
End:
55,842,983 bp from pter
Size:
7,554 bases
Orientation:
Minus strand

Genomic View for MMP19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP19 Gene

Regulatory Elements for MMP19 Gene

Proteins for MMP19 Gene

  • Protein details for MMP19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99542-MMP19_HUMAN
    Recommended name:
    Matrix metalloproteinase-19
    Protein Accession:
    Q99542
    Secondary Accessions:
    • B4E030
    • O15278
    • O95606
    • Q99580

    Protein attributes for MMP19 Gene

    Size:
    508 amino acids
    Molecular mass:
    57357 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC99995.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for MMP19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP19 Gene

Proteomics data for MMP19 Gene at MOPED

Post-translational modifications for MMP19 Gene

Other Protein References for MMP19 Gene

No data available for DME Specific Peptides for MMP19 Gene

Domains for MMP19 Gene

UniProtKB/Swiss-Prot:

MMP19_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q99542
Family:
  • Belongs to the peptidase M10A family.:
    • Q99542
Similarity:
  • Contains 4 hemopexin repeats.:
    • Q99542
genes like me logo Genes that share domains with MMP19: view

Function for MMP19 Gene

Molecular function for MMP19 Gene

GENATLAS Biochemistry: matrix metalloproteinase 19,regulator in matrix remodeling,mainly expressed in placenta,lung,pancreas,ovary,spleen and intestine
UniProtKB/Swiss-Prot CatalyticActivity: Cleaves aggrecan at the 360-Ser- -Phe-361 site
UniProtKB/Swiss-Prot EnzymeRegulation: Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient
UniProtKB/Swiss-Prot Function: Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.

Enzyme Numbers (IUBMB) for MMP19 Gene

Gene Ontology (GO) - Molecular Function for MMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP19: view
genes like me logo Genes that share phenotypes with MMP19: view

Animal Models for MMP19 Gene

MGI Knock Outs for MMP19:

miRNA for MMP19 Gene

miRTarBase miRNAs that target MMP19

No data available for Transcription Factor Targeting and HOMER Transcription for MMP19 Gene

Localization for MMP19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP19 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP19 Gene COMPARTMENTS Subcellular localization image for MMP19 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 10809722
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP19: view

Pathways for MMP19 Gene

genes like me logo Genes that share pathways with MMP19: view

Interacting Proteins for MMP19 Gene

Gene Ontology (GO) - Biological Process for MMP19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001541 ovarian follicle development IEA --
GO:0001542 ovulation from ovarian follicle IEA --
GO:0001554 luteolysis IEA --
GO:0006508 proteolysis NAS 9020145
genes like me logo Genes that share ontologies with MMP19: view

Compounds for MMP19 Gene

(5) Tocris Compounds for MMP19 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP19 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MMP19 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor

(2) Novoseek inferred chemical compound relationships for MMP19 Gene

Compound -log(P) Hits PubMed IDs
alpha tocopherol 38.4 1
matrigel 26.5 4
genes like me logo Genes that share compounds with MMP19: view

Transcripts for MMP19 Gene

Unigene Clusters for MMP19 Gene

Matrix metallopeptidase 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7:
SP8: - - - - - - -
SP9:

Relevant External Links for MMP19 Gene

GeneLoc Exon Structure for
MMP19
ECgene alternative splicing isoforms for
MMP19

Expression for MMP19 Gene

mRNA expression in normal human tissues for MMP19 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP19 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP19 Gene

SOURCE GeneReport for Unigene cluster for MMP19 Gene Hs.591033

mRNA Expression by UniProt/SwissProt for MMP19 Gene

Q99542-MMP19_HUMAN
Tissue specificity: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients
genes like me logo Genes that share expressions with MMP19: view

Orthologs for MMP19 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP19 36
  • 99.34 (n)
  • 99.01 (a)
MMP19 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP19 36
  • 87.01 (n)
  • 85.92 (a)
MMP19 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP19 36
  • 87.29 (n)
  • 84.58 (a)
MMP19 37
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp19 36
  • 82.31 (n)
  • 79.21 (a)
Mmp19 16
Mmp19 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP19 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP19 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp19 36
  • 83.47 (n)
  • 82.2 (a)
chicken
(Gallus gallus)
Aves MMP19 37
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP19 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp19 36
  • 62.4 (n)
  • 63.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536874 36
  • 58.13 (n)
  • 55.12 (a)
MMP19 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea T21D11.1 37
  • 28 (a)
OneToMany
Species with no ortholog for MMP19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP19 Gene

ENSEMBL:
Gene Tree for MMP19 (if available)
TreeFam:
Gene Tree for MMP19 (if available)

Paralogs for MMP19 Gene

Paralogs for MMP19 Gene

Selected SIMAP similar genes for MMP19 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with MMP19: view

Variants for MMP19 Gene

Sequence variations from dbSNP and Humsavar for MMP19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1056784 - 55,839,529(+) ATCTG(A/G)GTGCA intron-variant, reference, missense, nc-transcript-variant
rs1056785 -- 55,836,942(+) CATTC(A/C)GCTAT utr-variant-3-prime, nc-transcript-variant
rs1056786 -- 55,836,898(+) CCTGC(A/T)ACAGC utr-variant-3-prime, nc-transcript-variant
rs2242295 -- 55,838,392(+) AGAGC(A/G)TGGCA intron-variant
rs2279317 -- 55,836,965(+) TTCTG(C/G)GGGGG utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP19 Gene

Variant ID Type Subtype PubMed ID
nsv832423 CNV Gain 17160897

Relevant External Links for MMP19 Gene

HapMap Linkage Disequilibrium report
MMP19
Human Gene Mutation Database (HGMD)
MMP19

Disorders for MMP19 Gene

UniProtKB/Swiss-Prot

MMP19_HUMAN
  • Note=May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.

(13) Novoseek inferred disease relationships for MMP19 Gene

Disease -log(P) Hits PubMed IDs
squamous cell cancer 53.3 1
skin cancer 32.7 2
invasive cancer 32.2 1
neovascularization 30.4 1
rheumatoid arthritis 27.2 4

Relevant External Links for MMP19

Genetic Association Database (GAD)
MMP19
Human Genome Epidemiology (HuGE) Navigator
MMP19
genes like me logo Genes that share disorders with MMP19: view

Publications for MMP19 Gene

  1. The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient. (PMID: 9232430) Kolb C. … Sedlacek R. (Immunol. Lett. 1997) 2 3 4 23
  2. Matrix metalloproteinase MMP-19 (RASI-1) is expressed on the surface of activated peripheral blood mononuclear cells and is detected as an autoantigen in rheumatoid arthritis. (PMID: 9562866) Sedlacek R. … Krawinkel U. (Immunobiology 1998) 3 4 23
  3. Identification of MMP-18, a putative novel human matrix metalloproteinase. (PMID: 8920941) Cossins J. … Clements J.M. (Biochem. Biophys. Res. Commun. 1996) 3 4 23
  4. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution. (PMID: 9020145) Pendas A.M. … Lopez-Otin C. (J. Biol. Chem. 1997) 3 4 23
  5. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP). (PMID: 10922468) Stracke J.O. … Knaeuper V. (FEBS Lett. 2000) 3 4 23

Products for MMP19 Gene

Sources for MMP19 Gene

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