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Aliases for MMP17 Gene

Aliases for MMP17 Gene

  • Matrix Metallopeptidase 17 (Membrane-Inserted) 2 3
  • Matrix Metalloproteinase 17 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 4 3 4
  • Membrane-Type-4 Matrix Metalloproteinase 3 4
  • MT-MMP 4 3 4
  • MT4-MMP 3 4
  • MMP-17 3 4
  • MT4MMP 3 4
  • MTMMP4 3 4
  • Matrix Metalloproteinase-17 3
  • EC 3.4.24.- 4

External Ids for MMP17 Gene

Previous GeneCards Identifiers for MMP17 Gene

  • GC12U990053
  • GC12P131752
  • GC12P132193
  • GC12P130807
  • GC12P130979
  • GC12P130878
  • GC12P132312
  • GC12P129198

Summaries for MMP17 Gene

Entrez Gene Summary for MMP17 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMP's in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP17 Gene

MMP17 (Matrix Metallopeptidase 17 (Membrane-Inserted)) is a Protein Coding gene. Diseases associated with MMP17 include arthritis. Among its related pathways are Degradation of the extracellular matrix and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and enzyme activator activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP17 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin

Tocris Summary for MMP17 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP17 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP17 Gene

Genomics for MMP17 Gene

Regulatory Elements for MMP17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP17 Gene

Start:
131,828,393 bp from pter
End:
131,851,783 bp from pter
Size:
23,391 bases
Orientation:
Plus strand

Genomic View for MMP17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP17 Gene

Proteins for MMP17 Gene

  • Protein details for MMP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULZ9-MMP17_HUMAN
    Recommended name:
    Matrix metalloproteinase-17
    Protein Accession:
    Q9ULZ9
    Secondary Accessions:
    • Q14850

    Protein attributes for MMP17 Gene

    Size:
    603 amino acids
    Molecular mass:
    66653 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP17 Gene

Proteomics data for MMP17 Gene at MOPED

Post-translational modifications for MMP17 Gene

Other Protein References for MMP17 Gene

No data available for DME Specific Peptides for MMP17 Gene

Domains for MMP17 Gene

Suggested Antigen Peptide Sequences for MMP17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULZ9

UniProtKB/Swiss-Prot:

MMP17_HUMAN :
  • Q9ULZ9
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP17: view

Function for MMP17 Gene

Molecular function for MMP17 Gene

GENATLAS Biochemistry: membrane type 4-matrix metalloproteinase 17,mainly predominantly expressed in brain and leukocytes,colon,ovary,testis,linked to D12S367,with one minor non expressed transcript and a major alternatively spliced,involved in neurogenesis
UniProtKB/Swiss-Prot CatalyticActivity: Cleaves pro-TNF-alpha at the 74-Ala- -Gln-75 site
UniProtKB/Swiss-Prot Function: Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin

Enzyme Numbers (IUBMB) for MMP17 Gene

Gene Ontology (GO) - Molecular Function for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008047 enzyme activator activity TAS 8640782
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP17: view
genes like me logo Genes that share phenotypes with MMP17: view

Animal Model Products

CRISPR Products

miRNA for MMP17 Gene

miRTarBase miRNAs that target MMP17

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP17

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MMP17 Gene

Localization for MMP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP17 Gene

Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP17 Gene COMPARTMENTS Subcellular localization image for MMP17 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005887 integral component of plasma membrane TAS 8640782
GO:0031012 extracellular matrix --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with MMP17: view

Pathways for MMP17 Gene

genes like me logo Genes that share pathways with MMP17: view

Pathways by source for MMP17 Gene

Gene Ontology (GO) - Biological Process for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0043085 positive regulation of catalytic activity TAS 8640782
genes like me logo Genes that share ontologies with MMP17: view

Compounds for MMP17 Gene

(5) Tocris Compounds for MMP17 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP17 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MMP17 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor
genes like me logo Genes that share compounds with MMP17: view

Transcripts for MMP17 Gene

Unigene Clusters for MMP17 Gene

Matrix metallopeptidase 17 (membrane-inserted):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP17

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for MMP17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MMP17 Gene

GeneLoc Exon Structure for
MMP17
ECgene alternative splicing isoforms for
MMP17

Expression for MMP17 Gene

mRNA expression in normal human tissues for MMP17 Gene

mRNA differential expression in normal tissues according to GTEx for MMP17 Gene

This gene is overexpressed in Brain - Cortex (4.8) and Brain - Hippocampus (4.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MMP17 Gene

SOURCE GeneReport for Unigene cluster for MMP17 Gene Hs.709245

mRNA Expression by UniProt/SwissProt for MMP17 Gene

Q9ULZ9-MMP17_HUMAN
Tissue specificity: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types
genes like me logo Genes that share expressions with MMP17: view

In Situ Assay Products

Orthologs for MMP17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP17 35
  • 98.87 (n)
  • 98.98 (a)
MMP17 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP17 35
  • 85.78 (n)
  • 85.84 (a)
MMP17 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP17 35
  • 84.22 (n)
  • 85.45 (a)
MMP17 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp17 35
  • 83.66 (n)
  • 89.22 (a)
Mmp17 16
Mmp17 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP17 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp17 35
  • 83.4 (n)
  • 89.41 (a)
chicken
(Gallus gallus)
Aves MMP17 35
  • 76.72 (n)
  • 81.82 (a)
MMP17 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP17 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp17 35
  • 66.92 (n)
  • 73.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp17a 35
  • 69.28 (n)
  • 72.08 (a)
mmp17a 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011870 35
  • 54.44 (n)
  • 40.62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 51.39 (n)
  • 41.54 (a)
Mmp2 37
  • 40 (a)
Mmp1 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea zmp-1 35
  • 40.98 (n)
  • 30.5 (a)
C31B8.8 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MMP17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP17 Gene

ENSEMBL:
Gene Tree for MMP17 (if available)
TreeFam:
Gene Tree for MMP17 (if available)

Paralogs for MMP17 Gene

genes like me logo Genes that share paralogs with MMP17: view

Variants for MMP17 Gene

Sequence variations from dbSNP and Humsavar for MMP17 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3087864 -- 131,846,828(-) GAAAC(A/G)GGGTC intron-variant
rs3087865 -- 131,846,986(-) TCTGT(A/T)CCCTT intron-variant
rs4964883 -- 131,838,705(+) TCCAG(C/G)CCCCA reference, missense
rs4964884 -- 131,838,749(+) GGGTG(C/T)GTGGC intron-variant
rs4964924 -- 131,829,398(+) CGCAG(C/T)CGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP17 Gene

Variant ID Type Subtype PubMed ID
nsv899685 CNV Loss 21882294
nsv899699 CNV Gain 21882294
nsv455803 CNV Gain 19166990
nsv832555 CNV Loss 17160897
esv2751042 CNV Gain 17911159
dgv1516n71 CNV Loss 21882294
nsv826561 CNV Gain 20364138
nsv455804 CNV Loss 19166990
esv2746901 CNV Deletion 23290073
esv2746902 CNV Deletion 23290073

Relevant External Links for MMP17 Gene

HapMap Linkage Disequilibrium report
MMP17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP17 Gene

Disorders for MMP17 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MMP17 Gene including...

Search for MMP17 Gene in MalaCards »

(7) Novoseek inferred disease relationships for MMP17 Gene

Disease -log(P) Hits PubMed IDs
breast carcinoma 34.3 2
metastasis 17.2 10
arthritis 13.6 1
breast cancer 4.36 3
necrosis 0.788 2

Relevant External Links for MMP17

Genetic Association Database (GAD)
MMP17
Human Genome Epidemiology (HuGE) Navigator
MMP17
genes like me logo Genes that share disorders with MMP17: view

No data available for UniProtKB/Swiss-Prot for MMP17 Gene

Publications for MMP17 Gene

  1. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. (PMID: 9878265) Puente X.S. … LA^pez-OtA-n C. (Genomics 1998) 2 3 23
  2. Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript: isolation of complementary DNA clones for human and mouse mt4-mmp transcripts. (PMID: 10471807) Kajita M. … Seiki M. (FEBS Lett. 1999) 3 4 23
  3. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. (PMID: 10567400) Itoh Y. … Seiki M. (J. Biol. Chem. 1999) 3 4 23
  4. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. (PMID: 8640782) Puente X.S. … Lopez-Otin C. (Cancer Res. 1996) 3 4 23
  5. The low density lipoprotein receptor-related protein LRP is regulated by membrane type-1 matrix metalloproteinase (MT1-MMP) proteolysis in malignant cells. (PMID: 14645246) Rozanov D.V. … Strongin A.Y. (J. Biol. Chem. 2004) 3 23

Products for MMP17 Gene

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