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Aliases for MMP17 Gene

Aliases for MMP17 Gene

  • Matrix Metallopeptidase 17 2 3 5
  • Matrix Metalloproteinase 17 (Membrane-Inserted) 2 3
  • Matrix Metallopeptidase 17 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 4 3 4
  • Membrane-Type-4 Matrix Metalloproteinase 3 4
  • MT-MMP 4 3 4
  • MT4-MMP 3 4
  • MMP-17 3 4
  • MT4MMP 3 4
  • MTMMP4 3 4
  • EC 3.4.24.- 4

External Ids for MMP17 Gene

Previous GeneCards Identifiers for MMP17 Gene

  • GC12U990053
  • GC12P131752
  • GC12P132193
  • GC12P130807
  • GC12P130979
  • GC12P130878
  • GC12P132312
  • GC12P129198

Summaries for MMP17 Gene

Entrez Gene Summary for MMP17 Gene

  • This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP17 Gene

MMP17 (Matrix Metallopeptidase 17) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP17 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Tocris Summary for MMP17 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP17 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP17 Gene

Genomics for MMP17 Gene

Regulatory Elements for MMP17 Gene

Genomic Location for MMP17 Gene

Chromosome:
12
Start:
131,828,393 bp from pter
End:
131,851,783 bp from pter
Size:
23,391 bases
Orientation:
Plus strand

Genomic View for MMP17 Gene

Genes around MMP17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP17 Gene

Proteins for MMP17 Gene

  • Protein details for MMP17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULZ9-MMP17_HUMAN
    Recommended name:
    Matrix metalloproteinase-17
    Protein Accession:
    Q9ULZ9
    Secondary Accessions:
    • Q14850

    Protein attributes for MMP17 Gene

    Size:
    603 amino acids
    Molecular mass:
    66653 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MMP17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP17 Gene

Proteomics data for MMP17 Gene at MOPED

Post-translational modifications for MMP17 Gene

Antibody Products

No data available for DME Specific Peptides for MMP17 Gene

Domains & Families for MMP17 Gene

Gene Families for MMP17 Gene

Suggested Antigen Peptide Sequences for MMP17 Gene

Graphical View of Domain Structure for InterPro Entry

Q9ULZ9

UniProtKB/Swiss-Prot:

MMP17_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP17: view

Function for MMP17 Gene

Molecular function for MMP17 Gene

GENATLAS Biochemistry:
membrane type 4-matrix metalloproteinase 17,mainly predominantly expressed in brain and leukocytes,colon,ovary,testis,linked to D12S367,with one minor non expressed transcript and a major alternatively spliced,involved in neurogenesis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleaves pro-TNF-alpha at the 74-Ala- -Gln-75 site.
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also be involved in tumoral process. Not obvious if able to proteolytically activate progelatinase A. Does not hydrolyze collagen types I, II, III, IV and V, gelatin, fibronectin, laminin, decorin nor alpha1-antitrypsin.

Enzyme Numbers (IUBMB) for MMP17 Gene

Gene Ontology (GO) - Molecular Function for MMP17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
genes like me logo Genes that share ontologies with MMP17: view
genes like me logo Genes that share phenotypes with MMP17: view

Animal Models for MMP17 Gene

MGI Knock Outs for MMP17:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP17 Gene

Localization for MMP17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP17 Gene

Isoform Long: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP17 Gene COMPARTMENTS Subcellular localization image for MMP17 gene
Compartment Confidence
extracellular 5
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for MMP17 Gene

Pathways & Interactions for MMP17 Gene

genes like me logo Genes that share pathways with MMP17: view

Pathways by source for MMP17 Gene

1 GeneTex pathway for MMP17 Gene
1 BioSystems pathway for MMP17 Gene

Gene Ontology (GO) - Biological Process for MMP17 Gene

None

No data available for SIGNOR curated interactions for MMP17 Gene

Drugs & Compounds for MMP17 Gene

(2) Drugs for MMP17 Gene - From: HMDB, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
calcium Nutra 0

(4) Additional Compounds for MMP17 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4

(5) Tocris Compounds for MMP17 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
Marimastat Broad spectrum MMP inhibitor 154039-60-8
ONO 4817 Broad spectrum MMP inhibitor 223472-31-9
PD 166793 Broad spectrum MMP inhibitor 199850-67-4
genes like me logo Genes that share compounds with MMP17: view

Transcripts for MMP17 Gene

Unigene Clusters for MMP17 Gene

Matrix metallopeptidase 17 (membrane-inserted):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP17 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5: - -
SP6:

Relevant External Links for MMP17 Gene

GeneLoc Exon Structure for
MMP17
ECgene alternative splicing isoforms for
MMP17

Expression for MMP17 Gene

mRNA expression in normal human tissues for MMP17 Gene

mRNA differential expression in normal tissues according to GTEx for MMP17 Gene

This gene is overexpressed in Brain - Cortex (x4.8) and Brain - Hippocampus (x4.3).

Protein differential expression in normal tissues from HIPED for MMP17 Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP17 Gene



SOURCE GeneReport for Unigene cluster for MMP17 Gene Hs.709245

mRNA Expression by UniProt/SwissProt for MMP17 Gene

Q9ULZ9-MMP17_HUMAN
Tissue specificity: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.
genes like me logo Genes that share expression patterns with MMP17: view

Protein tissue co-expression partners for MMP17 Gene

Primer Products

In Situ Assay Products

Orthologs for MMP17 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP17 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP17 35
  • 85.78 (n)
  • 85.84 (a)
MMP17 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP17 35
  • 84.22 (n)
  • 85.45 (a)
MMP17 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp17 35
  • 83.66 (n)
  • 89.22 (a)
Mmp17 16
Mmp17 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP17 35
  • 98.87 (n)
  • 98.98 (a)
MMP17 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp17 35
  • 83.4 (n)
  • 89.41 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP17 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP17 35
  • 76.72 (n)
  • 81.82 (a)
MMP17 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP17 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp17 35
  • 66.92 (n)
  • 73.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp17a 35
  • 69.28 (n)
  • 72.08 (a)
mmp17a 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 33 (a)
Mmp2 37
  • 40 (a)
Mmp2 35
  • 51.39 (n)
  • 41.54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011870 35
  • 54.44 (n)
  • 40.62 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 38 (a)
zmp-1 35
  • 40.98 (n)
  • 30.5 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToMany
Species with no ortholog for MMP17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP17 Gene

ENSEMBL:
Gene Tree for MMP17 (if available)
TreeFam:
Gene Tree for MMP17 (if available)

Paralogs for MMP17 Gene

genes like me logo Genes that share paralogs with MMP17: view

Variants for MMP17 Gene

Sequence variations from dbSNP and Humsavar for MMP17 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs3087864 -- 131,846,828(-) GAAAC(A/G)GGGTC intron-variant
rs7134215 -- 131,833,196(+) GCAGG(G/T)ACCAC intron-variant, upstream-variant-2KB
rs7134349 -- 131,833,284(+) TGTTA(C/G)GATCG intron-variant, upstream-variant-2KB
rs6598161 -- 131,827,943(+) CCAGC(A/C)CCCCC upstream-variant-2KB
rs6598163 -- 131,840,694(+) GCAGC(A/G/T)CCGCC nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP17 Gene

Variant ID Type Subtype PubMed ID
nsv899685 CNV Loss 21882294
nsv899699 CNV Gain 21882294
nsv455803 CNV Gain 19166990
nsv832555 CNV Loss 17160897
esv2751042 CNV Gain 17911159
dgv1516n71 CNV Loss 21882294
nsv826561 CNV Gain 20364138
nsv455804 CNV Loss 19166990
esv2746901 CNV Deletion 23290073
esv2746902 CNV Deletion 23290073

Variation tolerance for MMP17 Gene

Residual Variation Intolerance Score: 53.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.50; 88.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP17 Gene

HapMap Linkage Disequilibrium report
MMP17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP17 Gene

Disorders for MMP17 Gene

Relevant External Links for MMP17

Genetic Association Database (GAD)
MMP17
Human Genome Epidemiology (HuGE) Navigator
MMP17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP17

No disorders were found for MMP17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MMP17 Gene

Publications for MMP17 Gene

  1. Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase. (PMID: 10567400) Itoh Y. … Seiki M. (J. Biol. Chem. 1999) 3 4 23 67
  2. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. (PMID: 9878265) Puente X.S. … LA^pez-OtA-n C. (Genomics 1998) 2 3 23
  3. Membrane-type 4 matrix metalloproteinase (MT4-MMP) induces lung metastasis by alteration of primary breast tumour vascular architecture. (PMID: 19426156) Chabottaux V. … Noel A. (J. Cell. Mol. Med. 2009) 3 23
  4. Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis. (PMID: 20019845) Huang C.H. … Yang M.H. (Neoplasia 2009) 3 23
  5. MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells. (PMID: 16686598) Atkinson S.J. … Murphy G. (Biochem. J. 2006) 3 23

Products for MMP17 Gene

Sources for MMP17 Gene

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