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Aliases for MMP16 Gene

Aliases for MMP16 Gene

  • Matrix Metallopeptidase 16 (Membrane-Inserted) 2 3
  • Membrane-Type Matrix Metalloproteinase 3 3 4
  • Membrane-Type-3 Matrix Metalloproteinase 3 4
  • MT-MMP 3 3 4
  • MT3-MMP 3 4
  • MMP-16 3 4
  • MMP-X2 3 4
  • MT3MMP 3 4
  • MTMMP3 3 4
  • Matrix Metalloproteinase 16 (Membrane-Inserted) 2
  • Putative Transmembrane Protein C8orf57 3
  • Chromosome 8 Open Reading Frame 57 2
  • EC 3.4.24.80 63
  • EC 3.4.24.- 4
  • EC 3.4.24 63
  • MT-MMP2 3
  • MT-MMP3 3
  • C8orf57 3
  • MMPX2 4

External Ids for MMP16 Gene

Previous HGNC Symbols for MMP16 Gene

  • C8orf57

Previous GeneCards Identifiers for MMP16 Gene

  • GC08M087480
  • GC08M088781
  • GC08M089009
  • GC08M088999
  • GC08M089118
  • GC08M084259
  • GC08M089044

Summaries for MMP16 Gene

Entrez Gene Summary for MMP16 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein activates MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16. [provided by RefSeq, Oct 2010]

GeneCards Summary for MMP16 Gene

MMP16 (Matrix Metallopeptidase 16 (Membrane-Inserted)) is a Protein Coding gene. Diseases associated with MMP16 include osteochondrosis and seminoma. Among its related pathways are MicroRNAs in cancer and Degradation of the extracellular matrix. GO annotations related to this gene include calcium ion binding and metallopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP16 Gene

  • Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Tocris Summary for MMP16 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP16 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP16 Gene

Genomics for MMP16 Gene

Regulatory Elements for MMP16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP16 Gene

Chromosome:
8
Start:
88,003,095 bp from pter
End:
88,328,025 bp from pter
Size:
324,931 bases
Orientation:
Minus strand

Genomic View for MMP16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP16 Gene

Proteins for MMP16 Gene

  • Protein details for MMP16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51512-MMP16_HUMAN
    Recommended name:
    Matrix metalloproteinase-16
    Protein Accession:
    P51512
    Secondary Accessions:
    • B2RAN7
    • Q14824
    • Q52H48

    Protein attributes for MMP16 Gene

    Size:
    607 amino acids
    Molecular mass:
    69521 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    • Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan.

    Three dimensional structures from OCA and Proteopedia for MMP16 Gene

    Alternative splice isoforms for MMP16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MMP16 Gene

Proteomics data for MMP16 Gene at MOPED

Selected DME Specific Peptides for MMP16 Gene

Post-translational modifications for MMP16 Gene

Other Protein References for MMP16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP16 (MMP-16/MT3-MMP)

Domains & Families for MMP16 Gene

Gene Families for MMP16 Gene

Suggested Antigen Peptide Sequences for MMP16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51512

UniProtKB/Swiss-Prot:

MMP16_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP16: view

Function for MMP16 Gene

Molecular function for MMP16 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 16,membrane-type,activator of MMP2,possessing a proteolytic activity against extracellular matrix molecules,expressed in placenta,brain and lung
UniProtKB/Swiss-Prot EnzymeRegulation:
TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform
UniProtKB/Swiss-Prot Function:
Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

Enzyme Numbers (IUBMB) for MMP16 Gene

Gene Ontology (GO) - Molecular Function for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008047 enzyme activator activity TAS 7559440
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP16: view
genes like me logo Genes that share phenotypes with MMP16: view

Animal Models for MMP16 Gene

MGI Knock Outs for MMP16:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP16

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MMP16 Gene

Localization for MMP16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP16 Gene

Isoform Long: Cell membrane; Single-pass type I membrane protein; Extracellular side. Note=Localized at the cell surface of melanoma cells.
Isoform Short: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP16 Gene COMPARTMENTS Subcellular localization image for MMP16 gene
Compartment Confidence
extracellular 5
golgi apparatus 4
plasma membrane 4
cytosol 2

Gene Ontology (GO) - Cellular Components for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005796 Golgi lumen TAS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7559440
GO:0009986 cell surface IEA --
genes like me logo Genes that share ontologies with MMP16: view

Pathways & Interactions for MMP16 Gene

genes like me logo Genes that share pathways with MMP16: view

Pathways by source for MMP16 Gene

1 KEGG pathway for MMP16 Gene
1 GeneGo (Thomson Reuters) pathway for MMP16 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Extracellular Matrix & Adhesion Molecules in human,mouse,rat

Gene Ontology (GO) - Biological Process for MMP16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001503 ossification --
GO:0001958 endochondral ossification IEA --
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with MMP16: view

No data available for SIGNOR curated interactions for MMP16 Gene

Drugs & Compounds for MMP16 Gene

(5) Drugs for MMP16 Gene - From: DrugBank, NovoSeek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum 4
Losartan Approved Pharma Antagonist 265
Batimastat Experimental Pharma Target 0
Calcium Nutra 0
tyrosine Nutra 547

(8) Additional Compounds for MMP16 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
Minocycline hydrochloride
13614-98-7
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP16: view

Transcripts for MMP16 Gene

Unigene Clusters for MMP16 Gene

Matrix metallopeptidase 16 (membrane-inserted):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP16 Gene

No ASD Table

Relevant External Links for MMP16 Gene

GeneLoc Exon Structure for
MMP16
ECgene alternative splicing isoforms for
MMP16

Expression for MMP16 Gene

mRNA expression in normal human tissues for MMP16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MMP16 Gene

This gene is overexpressed in Plasma (22.2), Milk (9.6), and Cervix (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP16 Gene



SOURCE GeneReport for Unigene cluster for MMP16 Gene Hs.546267

mRNA Expression by UniProt/SwissProt for MMP16 Gene

P51512-MMP16_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary
genes like me logo Genes that share expression patterns with MMP16: view

Protein tissue co-expression partners for MMP16 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MMP16 Gene

Orthologs for MMP16 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP16 35
  • 93.19 (n)
  • 98.02 (a)
MMP-16 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP16 35
  • 94.45 (n)
  • 99.34 (a)
MMP16 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp16 35
  • 93.19 (n)
  • 98.02 (a)
Mmp16 16
Mmp16 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP16 35
  • 99.67 (n)
  • 100 (a)
MMP16 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp16 35
  • 92 (n)
  • 97.8 (a)
oppossum
(Monodelphis domestica)
Mammalia MMP16 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP16 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP16 35
  • 87.07 (n)
  • 92.57 (a)
MMP16 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP16 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp16 35
  • 80.61 (n)
  • 87.44 (a)
zebrafish
(Danio rerio)
Actinopterygii mmp16b 35
  • 70.11 (n)
  • 74 (a)
CABZ01029422.1 36
  • 74 (a)
OneToMany
mmp16a 36
  • 76 (a)
OneToMany
mmp16b 36
  • 70 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2106 35
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 36 (a)
Mmp2 37
  • 46 (a)
Mmp2 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 41 (a)
H19M22.3a 37
  • 33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
Species with no ortholog for MMP16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP16 Gene

ENSEMBL:
Gene Tree for MMP16 (if available)
TreeFam:
Gene Tree for MMP16 (if available)

Paralogs for MMP16 Gene

(17) SIMAP similar genes for MMP16 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP16: view

Variants for MMP16 Gene

Sequence variations from dbSNP and Humsavar for MMP16 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs874346 -- 88,040,990(+) AAACT(C/T)TTTTT utr-variant-3-prime, intron-variant
rs922389 -- 88,125,049(+) AACCT(A/G)TGAAT intron-variant
rs939277 -- 88,206,480(-) ggatc(A/C)tttag intron-variant
rs939278 -- 88,205,482(-) TTATA(C/T)CCAGA intron-variant
rs939279 -- 88,313,903(-) tctca(C/T)gagat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP16 Gene

Variant ID Type Subtype PubMed ID
essv19267 CNV CNV 17122850
esv2669999 CNV Deletion 23128226
esv23361 CNV Loss 19812545
nsv396473 CNV Loss 16902084
nsv831386 CNV Gain 17160897
nsv527243 CNV Loss 19592680
esv2737272 CNV Deletion 23290073
esv1991117 CNV Deletion 18987734
esv2737273 CNV Deletion 23290073
esv2737275 CNV Deletion 23290073
nsv891170 CNV Loss 21882294
esv2737276 CNV Deletion 23290073
esv3247 CNV Deletion 18987735
esv2188156 CNV Deletion 18987734
esv2671281 CNV Deletion 23128226

Variation tolerance for MMP16 Gene

Residual Variation Intolerance Score: 12.08% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.02; 21.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP16 Gene

HapMap Linkage Disequilibrium report
MMP16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP16 Gene

Disorders for MMP16 Gene

MalaCards: The human disease database

(2) MalaCards diseases for MMP16 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
osteochondrosis
  • juvenile osteochondrosis of tibial tubercle
seminoma
  • seminoma, pure
- elite association
Search MMP16 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP16

Genetic Association Database (GAD)
MMP16
Human Genome Epidemiology (HuGE) Navigator
MMP16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP16
genes like me logo Genes that share disorders with MMP16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP16 Gene

Publications for MMP16 Gene

  1. Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family. (PMID: 7559440) Takino T. … Seiki M. (J. Biol. Chem. 1995) 2 23 67
  2. Malignant fibrous histiocytoma--pleomorphic sarcoma, NOS gene expression, histology, and clinical course. A pilot study. (PMID: 19159951) Daigeler A. … Marcus L. (Langenbecks Arch Surg 2010) 23 67
  3. Many new down- and up-regulatory signaling pathways, from known cancer progression suppressors to matrix metalloproteinases, differ widely in cells of various cancers. (PMID: 20432456) Delassus G.S. … Eliceiri G.L. (J. Cell. Physiol. 2010) 23 67
  4. Effects of IL-2 on MMP expression in freshly isolated human NK cells and the IL-2-independent NK cell line YT. (PMID: 20463600) Edsparr K. … Albertsson P. (J. Immunother. 2010) 23 67
  5. Age-associated changes of extracellular matrix collagen impair lung cancer cell migration. (PMID: 19109409) Bartling B. … Simm A. (FASEB J. 2009) 23 67

Products for MMP16 Gene

Sources for MMP16 Gene

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