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Aliases for MMP12 Gene

Aliases for MMP12 Gene

  • Matrix Metallopeptidase 12 2 3
  • Matrix Metalloproteinase 12 (Macrophage Elastase) 2 3
  • Macrophage Elastase 2 4
  • EC 3.4.24.65 4 63
  • MMP-12 3 4
  • HME 3 4
  • MME 3 4
  • ME 3 4
  • Matrix Metallopeptidase 12 (Macrophage Elastase) 3
  • Matrix Metalloproteinase-12 4
  • Macrophage Metalloelastase 3
  • EC 3.4.24 63

External Ids for MMP12 Gene

Summaries for MMP12 Gene

Entrez Gene Summary for MMP12 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP12 Gene

MMP12 (Matrix Metallopeptidase 12) is a Protein Coding gene. Diseases associated with MMP12 include gastric cardia adenocarcinoma and coronary artery aneurysm. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and endopeptidase activity.

UniProtKB/Swiss-Prot for MMP12 Gene

  • May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1 site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3

Tocris Summary for MMP12 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP12 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP12 Gene

Genomics for MMP12 Gene

Genomic Location for MMP12 Gene

Start:
102,862,733 bp from pter
End:
102,875,034 bp from pter
Size:
12,302 bases
Orientation:
Minus strand

Genomic View for MMP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP12 Gene

Regulatory Elements for MMP12 Gene

Proteins for MMP12 Gene

  • Protein details for MMP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P39900-MMP12_HUMAN
    Recommended name:
    Macrophage metalloelastase
    Protein Accession:
    P39900
    Secondary Accessions:
    • B2R9X8
    • B7ZLF6
    • Q2M1L9

    Protein attributes for MMP12 Gene

    Size:
    470 amino acids
    Molecular mass:
    54002 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP12 Gene

neXtProt entry for MMP12 Gene

Proteomics data for MMP12 Gene at MOPED

Selected DME Specific Peptides for MMP12 Gene

Post-translational modifications for MMP12 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn20 and Asn285

Other Protein References for MMP12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MMP12 Gene

Suggested Antigen Peptide Sequences for MMP12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P39900

UniProtKB/Swiss-Prot:

MMP12_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • P39900
Family:
  • Belongs to the peptidase M10A family.:
    • P39900
Similarity:
  • Contains 4 hemopexin repeats.:
    • P39900
genes like me logo Genes that share domains with MMP12: view

Function for MMP12 Gene

Molecular function for MMP12 Gene

GENATLAS Biochemistry: matrix metalloproteinase 12,regulator in matrix remodeling in the MMP cluster,expressed in alveolar macrophage and placental cells,mRNA upregulated in rheumatoid arthritis
UniProtKB/Swiss-Prot CatalyticActivity: Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in the B chain of insulin
UniProtKB/Swiss-Prot Function: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1 site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3
UniProtKB/Swiss-Prot Induction: By exposure to bacterial lipopolysaccharides (LPS). Inhibited by dexamethasone

Enzyme Numbers (IUBMB) for MMP12 Gene

Gene Ontology (GO) - Molecular Function for MMP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity TAS 8226919
GO:0004222 metalloendopeptidase activity TAS 8226919
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP12: view
genes like me logo Genes that share phenotypes with MMP12: view

Animal Models for MMP12 Gene

MGI Knock Outs for MMP12:

miRNA for MMP12 Gene

miRTarBase miRNAs that target MMP12

No data available for Transcription Factor Targeting and HOMER Transcription for MMP12 Gene

Localization for MMP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP12 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP12 Gene COMPARTMENTS Subcellular localization image for MMP12 gene
Compartment Confidence
extracellular 4
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP12: view

Pathways for MMP12 Gene

genes like me logo Genes that share pathways with MMP12: view

Interacting Proteins for MMP12 Gene

Selected Interacting proteins: P39900-MMP12_HUMAN for MMP12 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for MMP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030198 extracellular matrix organization TAS --
GO:0030574 collagen catabolic process TAS --
GO:0035313 wound healing, spreading of epidermal cells IDA 15802269
genes like me logo Genes that share ontologies with MMP12: view

Compounds for MMP12 Gene

(15) ApexBio Compounds for MMP12 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2. [704888-90-4]
ARP 101 Selective inhibitor of MMP-2. [849773-63-3]
Batimastat (BB-94) potent and synthetic inhibitor of a broad spectrum of MMPs [130370-60-4]
CL 82198 hydrochloride Selective inhibitor of MMP-13. [307002-71-7]
CP 471474 Broad spectrum MMP inhibitor. [210755-45-6]
CTS-1027 potent small molecule inhibitor of MMPs. [193022-04-7]
GM 6001 Broad-spectrum MMP inhibitor. [142880-36-2]
Marimastat Broad spectrum inhibitor of MMPs. [154039-60-8]
NSC 405020 novel small molecule inhibitor of MT1-MMP [7497-7-6]
ONO 4817 Broad spectrum MMP inhibitor. [223472-31-9]
PD 166793 Broad spectrum MMP inhibitor. [199850-67-4]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor. [190648-49-8]
UK 356618 Potent and selective inhibitor of MMP-3. [230961-08-7]
UK 370106 Highly selective MMP-3 and MMP-12 inhibitor. [230961-21-4]
WAY 170523 Potent and selective inhibitor of MMP-13. [307002-73-9]

(5) Tocris Compounds for MMP12 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP12 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(21) Novoseek inferred chemical compound relationships for MMP12 Gene

Compound -log(P) Hits PubMed IDs
marimastat 66 1
acetohydroxamic acid 63 2
batimastat 52.7 2
hydroxamate 51.2 4
zinc 26.9 5
genes like me logo Genes that share compounds with MMP12: view

Transcripts for MMP12 Gene

mRNA/cDNA for MMP12 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(67) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP12 Gene

Matrix metallopeptidase 12 (macrophage elastase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP12 Gene

No ASD Table

Relevant External Links for MMP12 Gene

GeneLoc Exon Structure for
MMP12
ECgene alternative splicing isoforms for
MMP12

Expression for MMP12 Gene

mRNA expression in normal human tissues for MMP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP12 Gene

This gene is overexpressed in Minor Salivary Gland (10.9), Small Intestine - Terminal Ileum (8.3), Spleen (7.8), Colon - Transverse (7.1), and Bladder (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MMP12 Gene

SOURCE GeneReport for Unigene cluster for MMP12 Gene Hs.1695

mRNA Expression by UniProt/SwissProt for MMP12 Gene

P39900-MMP12_HUMAN
Tissue specificity: Found in alveolar macrophages but not in peripheral blood monocytes
genes like me logo Genes that share expressions with MMP12: view

Orthologs for MMP12 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP12 35
  • 99.43 (n)
  • 99.15 (a)
cow
(Bos Taurus)
Mammalia MMP12 35
  • 78.75 (n)
  • 68.02 (a)
dog
(Canis familiaris)
Mammalia MMP12 35
  • 79.89 (n)
  • 70.58 (a)
mouse
(Mus musculus)
Mammalia Mmp12 35
  • 75.7 (n)
  • 63.34 (a)
Mmp12 16
rat
(Rattus norvegicus)
Mammalia Mmp12 35
  • 75.42 (n)
  • 64.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 35 (a)
Species with no ortholog for MMP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP12 Gene

ENSEMBL:
Gene Tree for MMP12 (if available)
TreeFam:
Gene Tree for MMP12 (if available)

Paralogs for MMP12 Gene

Selected SIMAP similar genes for MMP12 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for MMP12 Gene

genes like me logo Genes that share paralogs with MMP12: view

No data available for Paralogs for MMP12 Gene

Variants for MMP12 Gene

Sequence variations from dbSNP and Humsavar for MMP12 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473286 -- 102,871,264(-) AAGGT(A/T)AAAGC intron-variant
rs476185 -- 102,864,372(+) ATGAA(A/G/T)AAAAC intron-variant
rs476391 -- 102,864,299(-) GTCAG(C/G)AAAGC intron-variant
rs495914 -- 102,873,959(-) ctccg(C/T)ctcct intron-variant
rs505770 -- 102,863,479(-) TCAAC(A/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP12 Gene

Variant ID Type Subtype PubMed ID
nsv898335 CNV Loss 21882294

Relevant External Links for MMP12 Gene

HapMap Linkage Disequilibrium report
MMP12
Human Gene Mutation Database (HGMD)
MMP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP12 Gene

Disorders for MMP12 Gene

(48) Novoseek inferred disease relationships for MMP12 Gene

Disease -log(P) Hits PubMed IDs
pulmonary disease chronic obstructive 63.9 9
pulmonary emphysema 63.7 2
solar elastosis 59.4 1
inflammation 44.3 18
aortic aneurysm abdominal 43.8 5

Relevant External Links for MMP12

Genetic Association Database (GAD)
MMP12
Human Genome Epidemiology (HuGE) Navigator
MMP12
genes like me logo Genes that share disorders with MMP12: view

No data available for UniProtKB/Swiss-Prot for MMP12 Gene

Publications for MMP12 Gene

  1. Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase. (PMID: 9115292) Gronski T.J. Jr. … Shapiro S.D. (J. Biol. Chem. 1997) 3 4 23
  2. Substrate specificity determinants of human macrophage elastase (MMP- 12) based on the 1.1 A crystal structure. (PMID: 11575928) Lang R. … Maskos K. (J. Mol. Biol. 2001) 3 4 23
  3. Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. (PMID: 11575929) Nar H. … Jung B. (J. Mol. Biol. 2001) 3 4 23
  4. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. (PMID: 11875051) Joos L. … Sandford A.J. (Hum. Mol. Genet. 2002) 3 23 48
  5. Genotype-phenotype relationships in an investigation of the role of proteases in abdominal aortic aneurysm expansion. (PMID: 16082623) Eriksson P. … Powell J.T. (Br J Surg 2005) 3 23 48

Products for MMP12 Gene

Sources for MMP12 Gene

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