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Aliases for MMP8 Gene

Aliases for MMP8 Gene

  • Matrix Metallopeptidase 8 2 3 5
  • Matrix Metalloproteinase 8 (Neutrophil Collagenase) 2 3
  • Matrix Metalloproteinase-8 3 4
  • PMNL Collagenase 3 4
  • PMNL-CL 3 4
  • MMP-8 3 4
  • CLG1 3 4
  • PMN Leukocyte Collagenase 3
  • Collagenase 2 3
  • EC 3.4.24.34 4
  • EC 3.4.24 63
  • HNC 3

External Ids for MMP8 Gene

Previous HGNC Symbols for MMP8 Gene

  • CLG1

Previous GeneCards Identifiers for MMP8 Gene

  • GC11M104777
  • GC11M103940
  • GC11M102121
  • GC11M102088
  • GC11M098509

Summaries for MMP8 Gene

Entrez Gene Summary for MMP8 Gene

  • This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for MMP8 Gene

MMP8 (Matrix Metallopeptidase 8) is a Protein Coding gene. Diseases associated with MMP8 include preterm premature rupture of the membranes and periodontal disease. Among its related pathways are Degradation of the extracellular matrix and Matrix Metalloproteinases. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP8 Gene

  • Can degrade fibrillar type I, II, and III collagens.

Tocris Summary for MMP8 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP8 Gene

Genomics for MMP8 Gene

Regulatory Elements for MMP8 Gene

Genomic Location for MMP8 Gene

Chromosome:
11
Start:
102,711,795 bp from pter
End:
102,727,050 bp from pter
Size:
15,256 bases
Orientation:
Minus strand

Genomic View for MMP8 Gene

Genes around MMP8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP8 Gene

Proteins for MMP8 Gene

  • Protein details for MMP8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22894-MMP8_HUMAN
    Recommended name:
    Neutrophil collagenase
    Protein Accession:
    P22894
    Secondary Accessions:
    • Q45F99

    Protein attributes for MMP8 Gene

    Size:
    467 amino acids
    Molecular mass:
    53412 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP8 Gene

neXtProt entry for MMP8 Gene

Proteomics data for MMP8 Gene at MOPED

Selected DME Specific Peptides for MMP8 Gene

Post-translational modifications for MMP8 Gene

  • Glycosylation at Asn 54, Asn 73, Asn 112, Asn 204, and Asn 246
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

Assay Products

  • Enzo Life Sciences assays for MMP8

Domains & Families for MMP8 Gene

Gene Families for MMP8 Gene

Suggested Antigen Peptide Sequences for MMP8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22894

UniProtKB/Swiss-Prot:

MMP8_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP8: view

Function for MMP8 Gene

Molecular function for MMP8 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 8,regulator in matrix remodeling,MMP cluster
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.
UniProtKB/Swiss-Prot EnzymeRegulation:
Cannot be activated without removal of the activation peptide.
UniProtKB/Swiss-Prot Function:
Can degrade fibrillar type I, II, and III collagens.

Enzyme Numbers (IUBMB) for MMP8 Gene

Gene Ontology (GO) - Molecular Function for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008270 zinc ion binding IEA,TAS 2164002
genes like me logo Genes that share ontologies with MMP8: view
genes like me logo Genes that share phenotypes with MMP8: view

Animal Models for MMP8 Gene

MGI Knock Outs for MMP8:

Animal Model Products

miRNA for MMP8 Gene

miRTarBase miRNAs that target MMP8

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP8 Gene

Localization for MMP8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP8 Gene

Cytoplasmic granule. Secreted, extracellular space, extracellular matrix. Note=Stored in intracellular granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP8 Gene COMPARTMENTS Subcellular localization image for MMP8 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with MMP8: view

Pathways & Interactions for MMP8 Gene

genes like me logo Genes that share pathways with MMP8: view

Gene Ontology (GO) - Biological Process for MMP8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IDA 2164002
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with MMP8: view

No data available for SIGNOR curated interactions for MMP8 Gene

Drugs & Compounds for MMP8 Gene

(37) Drugs for MMP8 Gene - From: Novoseek, DGIdb, DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, inhibitor MMPs inhibitor,board spectrum, Broad spectrum MMP inhibitor 4
Doxycycline Approved, Investigational Pharma inhibitor 219
Collagenase Approved, Investigational Pharma 0
Batimastat Experimental Pharma Target 0
(1R)-1-{[(4'-METHOXY-1,1'-BIPHENYL-4-YL)SULFONYL]AMINO}-2-METHYLPROPYLPHOSPHONIC ACID Experimental Pharma Target 0

(29) Additional Compounds for MMP8 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ARP 100
704888-90-4
ARP 101
849773-63-3
ONO 4817
223472-31-9
PD 166793
199850-67-4
genes like me logo Genes that share compounds with MMP8: view

Drug Products

Transcripts for MMP8 Gene

Unigene Clusters for MMP8 Gene

Matrix metallopeptidase 8 (neutrophil collagenase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - -
SP3: -
SP4:

Relevant External Links for MMP8 Gene

GeneLoc Exon Structure for
MMP8
ECgene alternative splicing isoforms for
MMP8

Expression for MMP8 Gene

mRNA expression in normal human tissues for MMP8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP8 Gene

This gene is overexpressed in Whole Blood (x48.9).

Protein differential expression in normal tissues from HIPED for MMP8 Gene

This gene is overexpressed in Neutrophil (47.7) and Blymphocyte (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP8 Gene



SOURCE GeneReport for Unigene cluster for MMP8 Gene Hs.161839

mRNA Expression by UniProt/SwissProt for MMP8 Gene

P22894-MMP8_HUMAN
Tissue specificity: Neutrophils.
genes like me logo Genes that share expression patterns with MMP8: view

Protein tissue co-expression partners for MMP8 Gene

- Elite partner

In Situ Assay Products

Orthologs for MMP8 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP8 36
  • 99 (a)
OneToOne
MMP8 35
  • 99.07 (n)
  • 98.5 (a)
cow
(Bos Taurus)
Mammalia MMP8 35
  • 83.19 (n)
  • 76.61 (a)
MMP8 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP8 36
  • 77 (a)
OneToOne
MMP8 35
  • 83.11 (n)
  • 79.69 (a)
mouse
(Mus musculus)
Mammalia Mmp8 16
Mmp8 35
  • 80.01 (n)
  • 74.24 (a)
Mmp8 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP8 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP8 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp8 35
  • 79.81 (n)
  • 73.72 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii mmp13a 35
  • 57.16 (n)
  • 48.42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 39 (a)
Species with no ortholog for MMP8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMP8 Gene

ENSEMBL:
Gene Tree for MMP8 (if available)
TreeFam:
Gene Tree for MMP8 (if available)

Paralogs for MMP8 Gene

(16) SIMAP similar genes for MMP8 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for MMP8 Gene

genes like me logo Genes that share paralogs with MMP8: view

Variants for MMP8 Gene

Sequence variations from dbSNP and Humsavar for MMP8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1320632 -- 102,725,332(+) ACTTA(C/T)CCTCC upstream-variant-2KB
rs1939012 -- 102,724,404(+) TATAG(C/T)AACTT intron-variant
rs1939017 -- 102,712,302(+) TTGGC(A/T)GCTGT utr-variant-3-prime
rs1939018 -- 102,713,292(+) AATGC(A/T)TGCTG utr-variant-3-prime
rs1939019 -- 102,713,509(+) TCAGA(C/T)GTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP8 Gene

Variant ID Type Subtype PubMed ID
nsv832252 CNV Gain 17160897

Variation tolerance for MMP8 Gene

Residual Variation Intolerance Score: 94% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.01; 60.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MMP8 Gene

HapMap Linkage Disequilibrium report
MMP8
Human Gene Mutation Database (HGMD)
MMP8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP8 Gene

Disorders for MMP8 Gene

MalaCards: The human disease database

(28) MalaCards diseases for MMP8 Gene - From: ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
preterm premature rupture of the membranes
  • preterm premature rupture of the membranes, susceptibility to
periodontal disease
  • disease of supporting structures of teeth, nos
gingivitis
  • acute gingivitis
gum cancer
  • malignant gingival tumor
periodontitis
  • chronic pericementitis
- elite association - COSMIC cancer census association via MalaCards
Search MMP8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MMP8

Genetic Association Database (GAD)
MMP8
Human Genome Epidemiology (HuGE) Navigator
MMP8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MMP8
genes like me logo Genes that share disorders with MMP8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP8 Gene

Publications for MMP8 Gene

  1. Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase. (PMID: 2176876) Mallya S.K. … van Wart H.E. (Biochemistry 1990) 3 4 23 67
  2. High plasma levels of matrix metalloproteinase-8 in patients with unstable angina. (PMID: 19674746) Momiyama Y. … Ohsuzu F. (Atherosclerosis 2010) 3 23
  3. Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: a role for MMP-8. (PMID: 20442866) Schubert-Unkmeir A. … Frosch M. (PLoS Pathog. 2010) 3 23
  4. Prevotella intermedia upregulates MMP-1 and MMP-8 expression in human periodontal ligament cells. (PMID: 19708869) Guan S.M. … Wu J.Z. (FEMS Microbiol. Lett. 2009) 3 23
  5. A role of matrix metalloproteinase-8 in atherosclerosis. (PMID: 19745165) Laxton R.C. … Ye S. (Circ. Res. 2009) 3 23

Products for MMP8 Gene

Sources for MMP8 Gene

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