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Aliases for MMP7 Gene

Aliases for MMP7 Gene

  • Matrix Metallopeptidase 7 2 3 5
  • Matrix Metalloproteinase 7 (Matrilysin, Uterine) 2 3
  • Matrix Metalloproteinase-7 3 4
  • Uterine Metalloproteinase 3 4
  • Pump-1 Protease 3 4
  • Matrilysin 2 3
  • Matrin 3 4
  • MPSL1 3 4
  • MMP-7 3 4
  • Matrix Metallopeptidase 7 (Matrilysin, Uterine) 3
  • Uterine Matrilysin 3
  • EC 3.4.24.23 4
  • EC 3.4.24 56
  • PUMP-1 3
  • PUMP1 4

External Ids for MMP7 Gene

Previous HGNC Symbols for MMP7 Gene

  • MPSL1

Previous GeneCards Identifiers for MMP7 Gene

  • GC11M104584
  • GC11M103748
  • GC11M101928
  • GC11M101896
  • GC11M098318

Summaries for MMP7 Gene

Entrez Gene Summary for MMP7 Gene

  • This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016]

GeneCards Summary for MMP7 Gene

MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include Brain Glioblastoma Multiforme and Light Chain Deposition Disease. Among its related pathways are Matrix Metalloproteinases and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP3.

UniProtKB/Swiss-Prot for MMP7 Gene

  • Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Tocris Summary for MMP7 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.

Gene Wiki entry for MMP7 Gene

Additional gene information for MMP7 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP7 Gene

Genomics for MMP7 Gene

GeneHancer (GH) Regulatory Elements for MMP7 Gene

Promoters and enhancers for MMP7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I102530 Promoter/Enhancer 1.2 EPDnew Ensembl ENCODE 561.5 -0.2 -167 1 SMARCA5 ZNF335 JUN ZBTB33 ATF7 ELF1 MLLT1 MMP7 ENSG00000256916
GH11I102445 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10 +79.2 79197 11.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 TMEM123 LOC101928424 BIRC2 MMP7 ENSG00000256916 MMP20 BIRC3 GC11P102396
GH11I102558 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.3 -29.8 -29831 3.4 HDGF PKNOX1 SMAD1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 CBFB JUNB MMP7 MMP20 ENSG00000256916 BIRC2 MMP10 ANGPTL5 BIRC3
GH11I102311 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +213.1 213091 13.2 HDGF PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 IRF4 YY1 ZNF207 ZNF143 BIRC3 BIRC2 ENSG00000256916 MMP20 MMP7 TMEM123 RNU6-952P
GH11I102563 Enhancer 1.1 Ensembl ENCODE dbSUPER 17.6 -33.6 -33620 2 JUN BACH1 BATF FOSL1 ZNF316 STAT2 ATF7 FOSL2 NFE2 FOS MMP7 ENSG00000256916 MMP20 ANGPTL5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MMP7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MMP7 gene promoter:

Genomic Locations for MMP7 Gene

Genomic Locations for MMP7 Gene
chr11:102,520,508-102,530,753
(GRCh38/hg38)
Size:
10,246 bases
Orientation:
Minus strand
chr11:102,391,239-102,401,484
(GRCh37/hg19)

Genomic View for MMP7 Gene

Genes around MMP7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MMP7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MMP7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP7 Gene

Proteins for MMP7 Gene

  • Protein details for MMP7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09237-MMP7_HUMAN
    Recommended name:
    Matrilysin
    Protein Accession:
    P09237
    Secondary Accessions:
    • Q9BTK9

    Protein attributes for MMP7 Gene

    Size:
    267 amino acids
    Molecular mass:
    29677 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP7 Gene

neXtProt entry for MMP7 Gene

Selected DME Specific Peptides for MMP7 Gene

P09237:
  • PRCGVPD
  • LAHAFAPG
  • MQKFFGL

Post-translational modifications for MMP7 Gene

No Post-translational modifications

Other Protein References for MMP7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for MMP7 Gene

Gene Families for MMP7 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for MMP7 Gene

Graphical View of Domain Structure for InterPro Entry

P09237

UniProtKB/Swiss-Prot:

MMP7_HUMAN :
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Belongs to the peptidase M10A family.
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
Family:
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP7: view

Function for MMP7 Gene

Molecular function for MMP7 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 7,regulator of matrix remodeling,component of MMP cluster,matrilysin,stromelysin subclass of MMP,expressed in uterus,also expressed in Paneth cells (in mice),colocalizing and regulating DEFA5,generating angiostatin fragments by hydrolyzing plasminogen,overexpressed in 82% of colorectal,regulating by beta catenin/CF4 and important factor in early tumor growth progression and metastasis
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of 14-Ala- -Leu-15 and 16-Tyr- -Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
UniProtKB/Swiss-Prot Function:
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.

Enzyme Numbers (IUBMB) for MMP7 Gene

Phenotypes From GWAS Catalog for MMP7 Gene

Gene Ontology (GO) - Molecular Function for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity TAS --
GO:0004252 serine-type endopeptidase activity TAS --
GO:0005515 protein binding IPI 20812334
GO:0008201 heparin binding IEA --
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with MMP7: view
genes like me logo Genes that share phenotypes with MMP7: view

Animal Models for MMP7 Gene

MGI Knock Outs for MMP7:

Clone Products

  • Addgene plasmids for MMP7

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MMP7 Gene

Localization for MMP7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP7 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MMP7 gene
Compartment Confidence
extracellular 5
plasma membrane 4
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space IEA,TAS 1497627
GO:0009986 cell surface IEA --
GO:0031012 extracellular matrix IEA --
genes like me logo Genes that share ontologies with MMP7: view

Pathways & Interactions for MMP7 Gene

genes like me logo Genes that share pathways with MMP7: view

Gene Ontology (GO) - Biological Process for MMP7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA,TAS 15297466
GO:0007568 aging IEA --
GO:0022617 extracellular matrix disassembly TAS --
GO:0030574 collagen catabolic process IEA,TAS --
GO:0031667 response to nutrient levels IEA --
genes like me logo Genes that share ontologies with MMP7: view

No data available for SIGNOR curated interactions for MMP7 Gene

Drugs & Compounds for MMP7 Gene

(24) Drugs for MMP7 Gene - From: DrugBank, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Marimastat Approved, Investigational Pharma Target, antagonist MMPs inhibitor,board spectrum 4
calcium Approved Nutra 0
(1R)-N,6-DIHYDROXY-7-METHOXY-2-[(4-METHOXYPHENYL)SULFONYL]-1,2,3,4-TETRAHYDROISOQUINOLINE-1-CARBOXAMIDE Experimental Pharma Target 0
5-METHYL-3-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YLCARBAMOYL)-HEXANOIC ACID Experimental Pharma Target 0
N4-HYDROXY-2-ISOBUTYL-N1-(9-OXO-1,8-DIAZA-TRICYCLO[10.6.1.013,18]NONADECA-12(19),13,15,17-TETRAEN-10-YL)-SUCCINAMIDE Experimental Pharma Target 0

(21) Additional Compounds for MMP7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(3) Tocris Compounds for MMP7 Gene

Compound Action Cas Number
ARP 100 Selective inhibitor of MMP-2 704888-90-4
ARP 101 Inhibitor of MMP-2 849773-63-3
PD 166793 Broad spectrum MMP inhibitor 199850-67-4

(4) ApexBio Compounds for MMP7 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor 130370-60-4
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent 10592-13-9
Marimastat MMPs inhibitor,board spectrum 154039-60-8
Triptolide IL-2/MMP-3/MMP7/MMP19 inhibitor 38748-32-2
genes like me logo Genes that share compounds with MMP7: view

Drug Products

Transcripts for MMP7 Gene

mRNA/cDNA for MMP7 Gene

Unigene Clusters for MMP7 Gene

Matrix metallopeptidase 7 (matrilysin, uterine):
Representative Sequences:

Clone Products

  • Addgene plasmids for MMP7

Alternative Splicing Database (ASD) splice patterns (SP) for MMP7 Gene

No ASD Table

Relevant External Links for MMP7 Gene

GeneLoc Exon Structure for
MMP7
ECgene alternative splicing isoforms for
MMP7

Expression for MMP7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MMP7 Gene

mRNA differential expression in normal tissues according to GTEx for MMP7 Gene

This gene is overexpressed in Minor Salivary Gland (x18.0), Kidney - Cortex (x8.1), Pancreas (x5.7), and Breast - Mammary Tissue (x4.4).

Protein differential expression in normal tissues from HIPED for MMP7 Gene

This gene is overexpressed in Cervix (29.4), Stomach (13.7), and Islet of Langerhans (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MMP7 Gene



NURSA nuclear receptor signaling pathways regulating expression of MMP7 Gene:

MMP7

SOURCE GeneReport for Unigene cluster for MMP7 Gene:

Hs.2256

Evidence on tissue expression from TISSUES for MMP7 Gene

  • Kidney(4.6)
  • Intestine(4.5)
  • Lung(2.7)
  • Blood(2.5)
  • Gall bladder(2.5)
  • Lymph node(2.1)
  • Pancreas(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with MMP7: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MMP7 Gene

Orthologs for MMP7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MMP7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP7 33 34
  • 98.75 (n)
dog
(Canis familiaris)
Mammalia MMP7 33 34
  • 81.12 (n)
cow
(Bos Taurus)
Mammalia MMP7 33 34
  • 80.52 (n)
mouse
(Mus musculus)
Mammalia Mmp7 33 16 34
  • 74.4 (n)
rat
(Rattus norvegicus)
Mammalia Mmp7 33
  • 73.89 (n)
oppossum
(Monodelphis domestica)
Mammalia MMP7 34
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP7 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves MMP7 33 34
  • 59.62 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 45 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii mmp30 34
  • 24 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 35
  • 53 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G16640 33
  • 49.42 (n)
rice
(Oryza sativa)
Liliopsida Os10g0557900 33
  • 44.66 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
OneToMany
Species where no ortholog for MMP7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MMP7 Gene

ENSEMBL:
Gene Tree for MMP7 (if available)
TreeFam:
Gene Tree for MMP7 (if available)

Paralogs for MMP7 Gene

(18) SIMAP similar genes for MMP7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP7: view

Variants for MMP7 Gene

Sequence variations from dbSNP and Humsavar for MMP7 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000079990 -- 102,529,973(-) C/A/T intron_variant
rs1000302078 -- 102,520,285(-) G/T downstream_transcript_variant
rs1000381022 -- 102,531,716(-) T/C upstream_transcript_variant
rs1000909777 -- 102,528,823(-) C/T intron_variant
rs1000962032 -- 102,522,937(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MMP7 Gene

Variant ID Type Subtype PubMed ID
dgv2136n54 CNV gain 21841781
nsv468854 CNV gain 19166990
nsv469990 CNV gain 18288195
nsv972953 CNV duplication 23825009

Variation tolerance for MMP7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.16; 69.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MMP7 Gene

Human Gene Mutation Database (HGMD)
MMP7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MMP7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP7 Gene

Disorders for MMP7 Gene

MalaCards: The human disease database

(29) MalaCards diseases for MMP7 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
brain glioblastoma multiforme
  • brain glioblastoma
light chain deposition disease
  • lcdd
spastic entropion
focal myositis
  • focal nodular myositis
biliary atresia
  • atresia of bile duct
- elite association - COSMIC cancer census association via MalaCards
Search MMP7 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MMP7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MMP7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MMP7 Gene

Publications for MMP7 Gene

  1. Common MMP-7 polymorphisms and breast cancer susceptibility: a multistage study of association and functionality. (PMID: 18648013) Beeghly-Fadiel A … Zheng W (Cancer research 2008) 3 22 44 58
  2. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. (PMID: 20452482) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58
  3. Interferon gamma receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection. (PMID: 20587546) Nalpas B … Abel L (Gut 2010) 3 44 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). (PMID: 20673868) Romero R … Menon R (American journal of obstetrics and gynecology 2010) 3 44 58

Products for MMP7 Gene

  • Addgene plasmids for MMP7

Sources for MMP7 Gene

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