Aliases for MMP7 Gene
External Ids for MMP7 Gene
Previous HGNC Symbols for MMP7 Gene
Previous GeneCards Identifiers for MMP7 Gene
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
GeneCards Summary for MMP7 Gene
MMP7 (Matrix Metallopeptidase 7) is a Protein Coding gene. Diseases associated with MMP7 include light chain deposition disease and brain glioblastoma multiforme. Among its related pathways are GPCR Pathway and Angiogenesis (CST). GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is MMP13.
UniProtKB/Swiss-Prot for MMP7 Gene
Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases and the major proteases in ECM degradation. MMPs are capable of degrading several extracellular molecules and a number of bioactive molecules.