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Aliases for MMP3 Gene

Aliases for MMP3 Gene

  • Matrix Metallopeptidase 3 2 3
  • STMY1 3 4 6
  • Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase) 2 3
  • Matrix Metalloproteinase-3 3 4
  • EC 3.4.24.17 4 63
  • Transin-1 3 4
  • CHDS6 3 6
  • MMP-3 3 4
  • SL-1 3 4
  • Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) 3
  • Proteoglycanase 3
  • Stromelysin 1 2
  • Stromelysin-1 3
  • EC 3.4.24 63
  • STR1 3
  • STMY 3

External Ids for MMP3 Gene

Previous HGNC Symbols for MMP3 Gene

  • STMY1
  • STMY

Previous GeneCards Identifiers for MMP3 Gene

  • GC11M104900
  • GC11M104063
  • GC11M102695
  • GC11M102199
  • GC11M102200
  • GC11M102211
  • GC11M102706
  • GC11M098634

Summaries for MMP3 Gene

Entrez Gene Summary for MMP3 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP3 Gene

MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include coronary heart disease 6 and conjunctivochalasis. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP3 Gene

  • Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase

Tocris Summary for MMP3 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP3 Gene

Genomics for MMP3 Gene

Regulatory Elements for MMP3 Gene

Genomic Location for MMP3 Gene

Start:
102,835,797 bp from pter
End:
102,843,803 bp from pter
Size:
8,007 bases
Orientation:
Minus strand

Genomic View for MMP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP3 Gene

Proteins for MMP3 Gene

  • Protein details for MMP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08254-MMP3_HUMAN
    Recommended name:
    Stromelysin-1
    Protein Accession:
    P08254
    Secondary Accessions:
    • B2R8B8
    • Q3B7S0
    • Q6GRF8

    Protein attributes for MMP3 Gene

    Size:
    477 amino acids
    Molecular mass:
    53977 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for MMP3 Gene

neXtProt entry for MMP3 Gene

Proteomics data for MMP3 Gene at MOPED

Post-translational modifications for MMP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MMP3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MMP3 (MMP3)

Domains for MMP3 Gene

Suggested Antigen Peptide Sequences for MMP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08254

UniProtKB/Swiss-Prot:

MMP3_HUMAN :
  • P08254
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
Family:
  • Belongs to the peptidase M10A family.
Similarity:
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP3: view

Function for MMP3 Gene

Molecular function for MMP3 Gene

GENATLAS Biochemistry:
matrix metalloproteinase 3,regulator of matrix remodeling,component of MMP cluster,expressed in the developing bone,interacting with ZBP89,playing a role in tumor metastasis
UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage where P1, P2 and P3 are hydrophobic residues
UniProtKB/Swiss-Prot Function:
Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase

Enzyme Numbers (IUBMB) for MMP3 Gene

Gene Ontology (GO) - Molecular Function for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004175 endopeptidase activity IDA 15863497
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008237 metallopeptidase activity --
genes like me logo Genes that share ontologies with MMP3: view
genes like me logo Genes that share phenotypes with MMP3: view

Animal Models for MMP3 Gene

MGI Knock Outs for MMP3:

Animal Model Products

miRNA for MMP3 Gene

miRTarBase miRNAs that target MMP3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MMP3 Gene

Localization for MMP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP3 Gene COMPARTMENTS Subcellular localization image for MMP3 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005615 extracellular space TAS 3360803
GO:0005739 mitochondrion --
GO:0005829 cytosol --
genes like me logo Genes that share ontologies with MMP3: view

Pathways for MMP3 Gene

genes like me logo Genes that share pathways with MMP3: view

PCR Array Products

Gene Ontology (GO) - Biological Process for MMP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IDA 12867428
GO:0010727 negative regulation of hydrogen peroxide metabolic process IDA 20969476
GO:0022617 extracellular matrix disassembly TAS --
GO:0030163 protein catabolic process --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with MMP3: view

Compounds for MMP3 Gene

Compound Products

(5) Tocris Compounds for MMP3 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(3) ApexBio Compounds for MMP3 Gene

Compound Action Cas Number
Batimastat (BB-94) MMP inhibitor [130370-60-4]
Doxycycline HCl Tetracycline antibiotic;MMP inhibitor;cell selection reagent [10592-13-9]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]

(2) HMDB Compounds for MMP3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Simvastatin
  • (+)-Simvastatin
79902-63-9

(120) Novoseek inferred chemical compound relationships for MMP3 Gene

Compound -log(P) Hits PubMed IDs
(4-aminophenyl)mercuric acetate 84.3 12
n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid 76.8 3
ilomastat 68.3 1
hydroxamate 56.2 4
pge2 48 60

(3) PharmGKB related drug/compound annotations for MMP3 Gene

Drug/compound Annotation
chlorthalidone CA
lisinopril CA
pravastatin CA
genes like me logo Genes that share compounds with MMP3: view

Transcripts for MMP3 Gene

mRNA/cDNA for MMP3 Gene

Unigene Clusters for MMP3 Gene

Matrix metallopeptidase 3 (stromelysin 1, progelatinase):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP3 Gene

No ASD Table

Relevant External Links for MMP3 Gene

GeneLoc Exon Structure for
MMP3
ECgene alternative splicing isoforms for
MMP3

Expression for MMP3 Gene

mRNA expression in normal human tissues for MMP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP3 Gene

This gene is overexpressed in Minor Salivary Gland (29.0), Adipose - Subcutaneous (6.7), and Nerve - Tibial (4.1).

Protein differential expression in normal tissues for MMP3 Gene

This gene is overexpressed in Synovial fluid (55.5) and Monocytes (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MMP3 Gene

SOURCE GeneReport for Unigene cluster for MMP3 Gene Hs.375129

genes like me logo Genes that share expressions with MMP3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for MMP3 Gene

Orthologs for MMP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MMP3 35
  • 84 (n)
  • 83.02 (a)
MMP3 36
  • 50 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP3 35
  • 84.56 (n)
  • 80.92 (a)
MMP3 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp3 35
  • 81.9 (n)
  • 77.15 (a)
Mmp3 16
Mmp3 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MMP3 35
  • 98.67 (n)
  • 98.74 (a)
MMP3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp3 35
  • 81.4 (n)
  • 75.79 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC428086 35
  • 62.37 (n)
  • 53.7 (a)
-- 36
  • 53 (a)
ManyToMany
MMP10 36
  • 52 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489571 35
  • 59.64 (n)
  • 54.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 44 (a)
Species with no ortholog for MMP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for MMP3 Gene

ENSEMBL:
Gene Tree for MMP3 (if available)
TreeFam:
Gene Tree for MMP3 (if available)

Paralogs for MMP3 Gene

Selected SIMAP similar genes for MMP3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MMP3: view

Variants for MMP3 Gene

Sequence variations from dbSNP and Humsavar for MMP3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs476762 -- 102,839,976(+) CCAGA(A/T)CTAAA intron-variant
rs494963 -- 102,845,095(-) CTTGA(G/T)CCCAG upstream-variant-2KB
rs496045 -- 102,844,998(-) TCTAA(A/G)AATGA upstream-variant-2KB
rs520540 -- 102,838,694(+) CTGAT(A/G)GCCCA synonymous-codon, reference
rs522616 -- 102,844,317(-) TTTCA(A/G)TTCTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MMP3 Gene

Variant ID Type Subtype PubMed ID
nsv898335 CNV Loss 21882294
esv2663139 CNV Deletion 23128226
nsv898336 CNV Loss 21882294

Relevant External Links for MMP3 Gene

HapMap Linkage Disequilibrium report
MMP3
Human Gene Mutation Database (HGMD)
MMP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP3 Gene

Disorders for MMP3 Gene

(1) OMIM Diseases for MMP3 Gene (185250)

UniProtKB/Swiss-Prot

MMP3_HUMAN
  • Coronary heart disease 6 (CHDS6) [MIM:614466]: A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. {ECO:0000269 PubMed:12477941, ECO:0000269 PubMed:8662692}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions.

(5) University of Copenhagen DISEASES for MMP3 Gene

(97) Novoseek inferred disease relationships for MMP3 Gene

Disease -log(P) Hits PubMed IDs
rheumatoid arthritis 79.1 111
osteoarthritis 78.1 42
arthritis 65.7 39
necrosis 60.9 83
tumors 56 126

Relevant External Links for MMP3

Genetic Association Database (GAD)
MMP3
Human Genome Epidemiology (HuGE) Navigator
MMP3
genes like me logo Genes that share disorders with MMP3: view

No data available for Genatlas for MMP3 Gene

Publications for MMP3 Gene

  1. The NMR structure of the inhibited catalytic domain of human stromelysin-1. (PMID: 7656014) Gooley P.R. … Johnson B.A. (Nat. Struct. Biol. 1994) 3 4 23
  2. Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression. (PMID: 8662692) Ye S. … Henney A.M. (J. Biol. Chem. 1996) 3 4 23
  3. Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4- aminophenyl)mercuric acetate. (PMID: 2383557) Nagase H. … Salvesen G. (Biochemistry 1990) 3 4 23
  4. Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1. (PMID: 9288970) Gomis-Rueth F.-X. … Bode W. (Nature 1997) 3 4 23
  5. Stromelysin-1 and interleukin-6 gene promoter polymorphisms are determinants of asymptomatic carotid artery atherosclerosis. (PMID: 11116068) Rauramaa R. … Humphries S.E. (Arterioscler. Thromb. Vasc. Biol. 2000) 3 23 48

Products for MMP3 Gene

Sources for MMP3 Gene

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