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Aliases for MAP3K10 Gene

Aliases for MAP3K10 Gene

  • Mitogen-Activated Protein Kinase Kinase Kinase 10 2 3 5
  • Mixed Lineage Kinase 2 2 3 4
  • MKN28 Derived Nonreceptor_type Serine/Threonine Kinase 2 3
  • Protein Kinase MST 3 4
  • MKN28 Kinase 2 3
  • EC 4 63
  • MLK2 3 4
  • MST 3 4
  • EC 2.7.11 63
  • MEKK10 3

External Ids for MAP3K10 Gene

Previous HGNC Symbols for MAP3K10 Gene

  • MLK2

Previous GeneCards Identifiers for MAP3K10 Gene

  • GC19P041337
  • GC19P041089
  • GC19P045373
  • GC19P045389
  • GC19P040697
  • GC19P037132

Summaries for MAP3K10 Gene

Entrez Gene Summary for MAP3K10 Gene

  • The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for MAP3K10 Gene

MAP3K10 (Mitogen-Activated Protein Kinase Kinase Kinase 10) is a Protein Coding gene. Among its related pathways are Development EGFR signaling via small GTPases and ERK Signaling. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot for MAP3K10 Gene

  • Activates the JUN N-terminal pathway.

Gene Wiki entry for MAP3K10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP3K10 Gene

Genomics for MAP3K10 Gene

Regulatory Elements for MAP3K10 Gene

Enhancers for MAP3K10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAP3K10 on UCSC Golden Path with GeneCards custom track

Genomic Location for MAP3K10 Gene

40,191,650 bp from pter
40,215,580 bp from pter
23,931 bases
Plus strand

Genomic View for MAP3K10 Gene

Genes around MAP3K10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAP3K10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAP3K10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP3K10 Gene

Proteins for MAP3K10 Gene

  • Protein details for MAP3K10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Mitogen-activated protein kinase kinase kinase 10
    Protein Accession:
    Secondary Accessions:
    • Q12761
    • Q14871

    Protein attributes for MAP3K10 Gene

    954 amino acids
    Molecular mass:
    103694 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for MAP3K10 Gene

neXtProt entry for MAP3K10 Gene

Proteomics data for MAP3K10 Gene at MOPED

Post-translational modifications for MAP3K10 Gene

  • Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP3K10 Gene

Antibody Products

Domains & Families for MAP3K10 Gene

Suggested Antigen Peptide Sequences for MAP3K10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
  • Contains 1 protein kinase domain.
  • Contains 1 SH3 domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
genes like me logo Genes that share domains with MAP3K10: view

Function for MAP3K10 Gene

Molecular function for MAP3K10 Gene

GENATLAS Biochemistry:
mitogen activated protein (MAP/ERK) kinase kinase kinase 10
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.
UniProtKB/Swiss-Prot Function:
Activates the JUN N-terminal pathway.

Enzyme Numbers (IUBMB) for MAP3K10 Gene

Gene Ontology (GO) - Molecular Function for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004709 MAP kinase kinase kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with MAP3K10: view
genes like me logo Genes that share phenotypes with MAP3K10: view

Animal Models for MAP3K10 Gene

MGI Knock Outs for MAP3K10:

Animal Model Products

CRISPR Products

miRNA for MAP3K10 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MAP3K10 Gene

Localization for MAP3K10 Gene

Subcellular locations from

Jensen Localization Image for MAP3K10 Gene COMPARTMENTS Subcellular localization image for MAP3K10 gene
Compartment Confidence
cytosol 4
cytoskeleton 3
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for MAP3K10 Gene

Pathways & Interactions for MAP3K10 Gene

genes like me logo Genes that share pathways with MAP3K10: view

SIGNOR curated interactions for MAP3K10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for MAP3K10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IEA --
GO:0006468 protein phosphorylation IEA --
GO:0006915 apoptotic process TAS 10801775
GO:0007165 signal transduction TAS 10801775
GO:0007256 activation of JNKK activity ISS --
genes like me logo Genes that share ontologies with MAP3K10: view

Drugs & Compounds for MAP3K10 Gene

(7) Drugs for MAP3K10 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
URMC-099 Pharma 0
Magnesium Nutra 0

(1) Additional Compounds for MAP3K10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0

(1) ApexBio Compounds for MAP3K10 Gene

Compound Action Cas Number
URMC-099 1229582-33-5
genes like me logo Genes that share compounds with MAP3K10: view

Transcripts for MAP3K10 Gene

Unigene Clusters for MAP3K10 Gene

Mitogen-activated protein kinase kinase kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAP3K10 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9
SP1: -
SP2: - -
SP3: - - - - -
SP4: - -

Relevant External Links for MAP3K10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP3K10 Gene

mRNA expression in normal human tissues for MAP3K10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAP3K10 Gene

This gene is overexpressed in Brain - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for MAP3K10 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for MAP3K10 Gene

SOURCE GeneReport for Unigene cluster for MAP3K10 Gene Hs.466743

mRNA Expression by UniProt/SwissProt for MAP3K10 Gene

Tissue specificity: Expressed in brain and skeletal muscle.
genes like me logo Genes that share expression patterns with MAP3K10: view

Protein tissue co-expression partners for MAP3K10 Gene

- Elite partner

Primer Products

Orthologs for MAP3K10 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAP3K10 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MAP3K10 35
  • 90.85 (n)
  • 92.57 (a)
MAP3K10 36
  • 83 (a)
(Mus musculus)
Mammalia Map3k10 35
  • 87.54 (n)
  • 92.46 (a)
Map3k10 16
Map3k10 36
  • 94 (a)
(Rattus norvegicus)
Mammalia Map3k10 35
  • 87.69 (n)
  • 92.99 (a)
(Bos Taurus)
Mammalia MAP3K10 36
  • 73 (a)
(Monodelphis domestica)
Mammalia MAP3K10 36
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia MAP3K10 36
  • 64 (a)
(Pan troglodytes)
Mammalia MAP3K10 36
  • 100 (a)
(Anolis carolinensis)
Reptilia MAP3K10 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia map3k10 35
  • 62.75 (n)
  • 68.44 (a)
Str.11205 35
African clawed frog
(Xenopus laevis)
Amphibia mlk2 35
(Danio rerio)
Actinopterygii map3k10 35
  • 66.59 (n)
  • 68.27 (a)
map3k10 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta slpr 37
  • 50 (a)
(Caenorhabditis elegans)
Secernentea K11D12.10b 37
  • 31 (a)
mlk-1 36
  • 19 (a)
Species with no ortholog for MAP3K10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAP3K10 Gene

Gene Tree for MAP3K10 (if available)
Gene Tree for MAP3K10 (if available)

Paralogs for MAP3K10 Gene

(15) SIMAP similar genes for MAP3K10 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with MAP3K10: view

Variants for MAP3K10 Gene

Sequence variations from dbSNP and Humsavar for MAP3K10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_040702 A metastatic melanoma sample
rs36102209 - 40,192,534(+) CCCCC(A/C)ACACC reference, missense
rs7257636 -- 40,208,371(+) ttttg(G/T)atttt intron-variant
rs7258548 -- 40,196,646(+) CTCAA(A/G)TAGCT intron-variant, upstream-variant-2KB
rs7259191 -- 40,211,992(+) agtgc(G/T)gggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP3K10 Gene

Variant ID Type Subtype PubMed ID
nsv911697 CNV Gain 21882294
dgv1083e1 CNV Complex 17122850
dgv3865n71 CNV Loss 21882294
nsv911699 CNV Loss 21882294
dgv3866n71 CNV Loss 21882294
nsv9727 CNV Gain 18304495
nsv9728 CNV Loss 18304495

Variation tolerance for MAP3K10 Gene

Residual Variation Intolerance Score: 10% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MAP3K10 Gene

Disorders for MAP3K10 Gene

Relevant External Links for MAP3K10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for MAP3K10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MAP3K10 Gene

Publications for MAP3K10 Gene

  1. Cloning and characterization of MST, a novel (putative) serine/threonine kinase with SH3 domain. (PMID: 7731697) Katoh M. … Terada M. (Oncogene 1995) 2 3 4 23 67
  2. Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2. (PMID: 8536694) Dorow D.S. … Simpson R.J. (Eur. J. Biochem. 1995) 2 3 23
  3. Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease. (PMID: 19332348) Nagao M. … Hayashi H. (J. Neurol. Sci. 2009) 3 23
  4. Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways. (PMID: 19801649) Pedraza N. … Gallego C. (J. Biol. Chem. 2009) 3 23
  5. Dissection of a signaling pathway by which pathogen-associated molecular patterns recruit the JNK and p38 MAPKs and trigger cytokine release. (PMID: 17584736) Zhong J. … Kyriakis J.M. (J. Biol. Chem. 2007) 3 23

Products for MAP3K10 Gene

Sources for MAP3K10 Gene