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Aliases for CD99 Gene

Aliases for CD99 Gene

  • CD99 Molecule 2 3
  • Antigen Identified By Monoclonal Antibodies 12E7, F21 And O13 2 3
  • T-Cell Surface Glycoprotein E2 3 4
  • CD99 Antigen 2 4
  • E2 Antigen 3 4
  • MIC2X 3 4
  • MIC2Y 3 4
  • MIC2 3 4
  • Antigen Identified By Monoclonal 12E7, Y Homolog 3
  • MIC2 (Monoclonal Antibody 12E7) 3
  • Surface Antigen MIC2 3
  • Protein MIC2 4
  • HBA71 3
  • MSK5X 3
  • 12E7 4

External Ids for CD99 Gene

Previous HGNC Symbols for CD99 Gene

  • MIC2

Previous GeneCards Identifiers for CD99 Gene

  • GC0XP001778
  • GC0XP002139
  • GC0XP002204
  • GC0YP002602
  • GC0XP002602
  • GC0XP000550

Summaries for CD99 Gene

Entrez Gene Summary for CD99 Gene

  • The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]

GeneCards Summary for CD99 Gene

CD99 (CD99 Molecule) is a Protein Coding gene. Diseases associated with CD99 include onychomatricoma and testicular fibroma. Among its related pathways are Integrin Pathway and Leukocyte transendothelial migration.

UniProtKB/Swiss-Prot for CD99 Gene

  • Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

Gene Wiki entry for CD99 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CD99 Gene

Genomics for CD99 Gene

Regulatory Elements for CD99 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CD99 Gene

Chromosome:
X
Start:
2,691,179 bp from pter
End:
2,741,309 bp from pter
Size:
50,131 bases
Orientation:
Plus strand

Genomic View for CD99 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CD99 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CD99 Gene

Proteins for CD99 Gene

  • Protein details for CD99 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14209-CD99_HUMAN
    Recommended name:
    CD99 antigen
    Protein Accession:
    P14209
    Secondary Accessions:
    • A6NIW1
    • O00518
    • Q6ICV7

    Protein attributes for CD99 Gene

    Size:
    185 amino acids
    Molecular mass:
    18848 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes

    Alternative splice isoforms for CD99 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CD99 Gene

Proteomics data for CD99 Gene at MOPED

Post-translational modifications for CD99 Gene

Antibody Products

No data available for DME Specific Peptides for CD99 Gene

Domains & Families for CD99 Gene

Gene Families for CD99 Gene

Protein Domains for CD99 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CD99 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14209

UniProtKB/Swiss-Prot:

CD99_HUMAN :
  • Belongs to the CD99 family.
Family:
  • Belongs to the CD99 family.
genes like me logo Genes that share domains with CD99: view

Function for CD99 Gene

Molecular function for CD99 Gene

UniProtKB/Swiss-Prot Function:
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).
genes like me logo Genes that share phenotypes with CD99: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for CD99 Gene

Localization for CD99 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CD99 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CD99 Gene COMPARTMENTS Subcellular localization image for CD99 gene
Compartment Confidence
plasma membrane 4
cytoskeleton 3
extracellular 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CD99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2479542
GO:0005886 plasma membrane TAS 2465491
GO:0005887 integral component of plasma membrane TAS 2465491
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with CD99: view

Pathways & Interactions for CD99 Gene

genes like me logo Genes that share pathways with CD99: view

Pathways by source for CD99 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Tight Junctions in human,mouse,rat

Gene Ontology (GO) - Biological Process for CD99 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with CD99: view

No data available for SIGNOR curated interactions for CD99 Gene

Drugs & Compounds for CD99 Gene

(1) Drugs for CD99 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphatidylserine Approved Nutra 0

(2) Additional Compounds for CD99 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Paraffin
VEGF
genes like me logo Genes that share compounds with CD99: view

Transcripts for CD99 Gene

Unigene Clusters for CD99 Gene

CD99 molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CD99 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - -
SP3: -
SP4: - -
SP5: - - - -
SP6: -
SP7: -
SP8:

Relevant External Links for CD99 Gene

GeneLoc Exon Structure for
CD99
ECgene alternative splicing isoforms for
CD99

Expression for CD99 Gene

mRNA expression in normal human tissues for CD99 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CD99 Gene

This gene is overexpressed in Adrenal (18.0) and Urine (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CD99 Gene



SOURCE GeneReport for Unigene cluster for CD99 Gene Hs.653349

genes like me logo Genes that share expression patterns with CD99: view

Protein tissue co-expression partners for CD99 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CD99 Gene

Orthologs for CD99 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CD99 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CD99 35
  • 70.7 (n)
  • 66.94 (a)
CD99 36
  • 59 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CD99 35
  • 68.64 (n)
  • 65.68 (a)
CD99 36
  • 60 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100615666 35
  • 99.28 (n)
  • 98.38 (a)
CD99 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia MGI:1913728 16
oppossum
(Monodelphis domestica)
Mammalia CD99 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CD99 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves CD99 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CD99 36
  • 46 (a)
OneToOne
Species with no ortholog for CD99:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CD99 Gene

ENSEMBL:
Gene Tree for CD99 (if available)
TreeFam:
Gene Tree for CD99 (if available)

Paralogs for CD99 Gene

(1) SIMAP similar genes for CD99 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for CD99 Gene

genes like me logo Genes that share paralogs with CD99: view

No data available for Paralogs for CD99 Gene

Variants for CD99 Gene

Sequence variations from dbSNP and Humsavar for CD99 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
VAR_014733 -
VAR_014734 -

Structural Variations from Database of Genomic Variants (DGV) for CD99 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
dgv2432e1 CNV Complex 17122850
esv2752318 CNV Gain 17911159
esv29994 CNV Gain 17803354
esv34985 CNV Gain 17911159

Variation tolerance for CD99 Gene

Residual Variation Intolerance Score: 72.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CD99 Gene

HapMap Linkage Disequilibrium report
CD99

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CD99 Gene

Disorders for CD99 Gene

MalaCards: The human disease database

(68) MalaCards diseases for CD99 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
onychomatricoma
testicular fibroma
extraosseous ewing's sarcoma
  • extraosseous ewings sarcoma-primitive neuroepithelial tumor
epithelioid neurofibroma
bone ewing's sarcoma
  • bone localized ewing's sarcoma
- elite association
Search CD99 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CD99

Genetic Association Database (GAD)
CD99
Human Genome Epidemiology (HuGE) Navigator
CD99
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CD99
genes like me logo Genes that share disorders with CD99: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CD99 Gene

Publications for CD99 Gene

  1. Onychomatricoma: new clinical and histological features. A review of 19 tumors. (PMID: 20098079) Perrin C. … Michiels J.F. (Am J Dermatopathol 2010) 23 67
  2. Comparative proteomics of human embryonic stem cells and embryonal carcinoma cells. (PMID: 20104618) Chaerkady R. … Pandey A. (Proteomics 2010) 23 67
  3. Angiomatoid fibrous histiocytoma including cases with pleomorphic features analysed by fluorescence in situ hybridisation. (PMID: 20154033) Matsumura T. … Hasegawa T. (J. Clin. Pathol. 2010) 23 67
  4. [Construction of mic2/CD99 gene vector and its transfection in Hodgkin lymphoma L428 cell line]. (PMID: 20034888) Huang Z.P. … Zhao T. (Nan Fang Yi Ke Da Xue Xue Bao 2009) 23 67
  5. Adenoma of the non-pigmented ciliary epithelium: a rare intraocular tumor with unusual immunohistochemical findings. (PMID: 19346082) Pecorella I. … Appolloni R. (Pathol. Res. Pract. 2009) 23 67

Products for CD99 Gene

Sources for CD99 Gene

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