Aliases for CD99 Gene
External Ids for CD99 Gene
Previous HGNC Symbols for CD99 Gene
Previous GeneCards Identifiers for CD99 Gene
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. Cyclophilin A binds to CD99 and may act as a signaling regulator of CD99. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2013]
GeneCards Summary for CD99 Gene
CD99 (CD99 Molecule) is a Protein Coding gene. Diseases associated with CD99 include onychomatricoma and testicular fibroma. Among its related pathways are Integrin Pathway and Leukocyte transendothelial migration.
UniProtKB/Swiss-Prot for CD99 Gene
Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).