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Aliases for MGST3 Gene

Aliases for MGST3 Gene

  • Microsomal Glutathione S-Transferase 3 2 3 5
  • Microsomal GST-III 2 3 4
  • Microsomal GST-3 2 3 4
  • Microsomal Glutathione S-Transferase III 2 3
  • EC 2.5.1.18 4
  • GST-III 3

External Ids for MGST3 Gene

Previous GeneCards Identifiers for MGST3 Gene

  • GC01P163234
  • GC01P161251
  • GC01P162296
  • GC01P162787
  • GC01P162332
  • GC01P163866
  • GC01P136847

Summaries for MGST3 Gene

Entrez Gene Summary for MGST3 Gene

  • This gene encodes a member of the MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) protein family. Members of this family are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[provided by RefSeq, May 2011]

GeneCards Summary for MGST3 Gene

MGST3 (Microsomal Glutathione S-Transferase 3) is a Protein Coding gene. Diseases associated with MGST3 include Choline Deficiency Disease. Among its related pathways are Glutathione metabolism and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include glutathione transferase activity and glutathione peroxidase activity.

UniProtKB/Swiss-Prot for MGST3 Gene

  • Also functions as a glutathione peroxidase.

Gene Wiki entry for MGST3 Gene

Additional gene information for MGST3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST3 Gene

Genomics for MGST3 Gene

GeneHancer (GH) Regulatory Elements for MGST3 Gene

Promoters and enhancers for MGST3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I165629 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 593.9 +1.3 1264 4.6 HDGF SMAD1 MLX ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF213 MGST3 LOC284685 LRRC52 ALDH9A1 ENSG00000206990 GC01M165662
GH01I165695 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.9 +66.6 66554 3.7 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ALDH9A1 LOC440700 LOC284685 MGST3 UCK2 GC01M165672
GH01I165636 Enhancer 1.1 Ensembl ENCODE dbSUPER 21.8 +6.6 6576 2.5 FOXA2 RXRA MAX CEBPB CEBPG REST RAD21 FOXA1 NR2F2 YY1 MGST3 GC01M165662 ENSG00000206990
GH01I165644 Enhancer 1 Ensembl ENCODE 21 +15.5 15495 3.2 FOXA2 RAD21 RARA YY1 ZNF121 TCF12 ZNF766 RXRA CEBPB REST MGST3 GC01M165662 ENSG00000206990
GH01I165601 Enhancer 0.9 Ensembl ENCODE 17.5 -29.0 -28978 0.2 ELF3 CTCF RAD21 RFX5 YY1 ZNF335 CC2D1A ZNF766 DIDO1 ZNF366 MGST3 RXRG ENSG00000236206
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around MGST3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the MGST3 gene promoter:

Genomic Locations for MGST3 Gene

Genomic Locations for MGST3 Gene
chr1:165,630,861-165,661,796
(GRCh38/hg38)
Size:
30,936 bases
Orientation:
Plus strand
chr1:165,600,098-165,631,033
(GRCh37/hg19)

Genomic View for MGST3 Gene

Genes around MGST3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST3 Gene

Proteins for MGST3 Gene

  • Protein details for MGST3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14880-MGST3_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 3
    Protein Accession:
    O14880
    Secondary Accessions:
    • B2R592
    • Q6ICN4

    Protein attributes for MGST3 Gene

    Size:
    152 amino acids
    Molecular mass:
    16516 Da
    Quaternary structure:
    No Data Available

neXtProt entry for MGST3 Gene

Post-translational modifications for MGST3 Gene

Other Protein References for MGST3 Gene

No data available for DME Specific Peptides for MGST3 Gene

Domains & Families for MGST3 Gene

Gene Families for MGST3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for MGST3 Gene

Graphical View of Domain Structure for InterPro Entry

O14880

UniProtKB/Swiss-Prot:

MGST3_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST3: view

Function for MGST3 Gene

Molecular function for MGST3 Gene

GENATLAS Biochemistry:
glutathione-S-transferase 3,microsomal,16.5kDa,widely distributed,predominantly expressed in heart,skeletal muscle,adrenal cortex,microsomal GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Also functions as a glutathione peroxidase.

Enzyme Numbers (IUBMB) for MGST3 Gene

Phenotypes From GWAS Catalog for MGST3 Gene

Gene Ontology (GO) - Molecular Function for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity TAS --
GO:0004464 leukotriene-C4 synthase activity IDA 9278457
GO:0004602 glutathione peroxidase activity IDA 9278457
GO:0005515 protein binding IPI 25416956
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with MGST3: view
genes like me logo Genes that share phenotypes with MGST3: view

Animal Models for MGST3 Gene

MGI Knock Outs for MGST3:

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MGST3 Gene

Localization for MGST3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein. Microsome membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MGST3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
nucleus 3
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope IBA --
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IEA,IDA 9278457
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with MGST3: view

Pathways & Interactions for MGST3 Gene

genes like me logo Genes that share pathways with MGST3: view

Gene Ontology (GO) - Biological Process for MGST3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IDA 9278457
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0019370 leukotriene biosynthetic process IDA 9278457
GO:0098869 cellular oxidant detoxification IEA --
genes like me logo Genes that share ontologies with MGST3: view

No data available for SIGNOR curated interactions for MGST3 Gene

Drugs & Compounds for MGST3 Gene

(4) Drugs for MGST3 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved, Investigational Nutra Target 0
Water Approved Pharma 0
Ezatiostat hydrochloride Pharma GST inhibitor 0
Trichloroethylene Pharma 5

(40) Additional Compounds for MGST3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide

(1) ApexBio Compounds for MGST3 Gene

Compound Action Cas Number
Ezatiostat hydrochloride GST inhibitor 286942-97-0
genes like me logo Genes that share compounds with MGST3: view

Drug Products

Transcripts for MGST3 Gene

Unigene Clusters for MGST3 Gene

Microsomal glutathione S-transferase 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - - - - -
SP8: - - - - - -
SP9: -
SP10:
SP11: - - - -
SP12: - -

Relevant External Links for MGST3 Gene

GeneLoc Exon Structure for
MGST3
ECgene alternative splicing isoforms for
MGST3

Expression for MGST3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MGST3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST3 Gene

This gene is overexpressed in Nasal epithelium (22.3), Heart (8.0), and Fetal heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MGST3 Gene



Protein tissue co-expression partners for MGST3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MGST3 Gene:

MGST3

SOURCE GeneReport for Unigene cluster for MGST3 Gene:

Hs.191734

mRNA Expression by UniProt/SwissProt for MGST3 Gene:

O14880-MGST3_HUMAN
Tissue specificity: Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for MGST3 Gene

  • Nervous system(4.9)
  • Lung(4.7)
  • Kidney(4.5)
  • Liver(4.5)
  • Heart(2.9)
  • Muscle(2.9)
  • Eye(2.3)
  • Skin(2.3)
  • Intestine(2.2)
  • Adrenal gland(2)
  • Stomach(2)
  • Thyroid gland(2)
genes like me logo Genes that share expression patterns with MGST3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for MGST3 Gene

Orthologs for MGST3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MGST3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST3 33 34
  • 99.78 (n)
dog
(Canis familiaris)
Mammalia MGST3 33 34 34
  • 91.01 (n)
cow
(Bos Taurus)
Mammalia MGST3 33 34
  • 89.04 (n)
rat
(Rattus norvegicus)
Mammalia Mgst3 33
  • 84.65 (n)
mouse
(Mus musculus)
Mammalia Mgst3 33 16 34
  • 83.77 (n)
oppossum
(Monodelphis domestica)
Mammalia MGST3 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGST3 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST3 33 34
  • 74.29 (n)
lizard
(Anolis carolinensis)
Reptilia MGST3 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst3 33
  • 71.43 (n)
Str.10366 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11525 33
zebrafish
(Danio rerio)
Actinopterygii mgst3 33 34
  • 60.43 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13985 33
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G65820 33
  • 53.02 (n)
rice
(Oryza sativa)
Liliopsida Os03g0709000 33
  • 53.12 (n)
Species where no ortholog for MGST3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST3 Gene

ENSEMBL:
Gene Tree for MGST3 (if available)
TreeFam:
Gene Tree for MGST3 (if available)

Paralogs for MGST3 Gene

(1) SIMAP similar genes for MGST3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MGST3: view

No data available for Paralogs for MGST3 Gene

Variants for MGST3 Gene

Sequence variations from dbSNP and Humsavar for MGST3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000006321 -- 165,643,683(+) T/G intron_variant
rs1000032957 -- 165,655,466(+) A/G coding_sequence_variant, missense_variant
rs1000059631 -- 165,649,270(+) T/C intron_variant
rs1000091665 -- 165,649,042(+) A/C intron_variant
rs1000105771 -- 165,637,083(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for MGST3 Gene

Variant ID Type Subtype PubMed ID
dgv611n54 CNV loss 21841781
dgv612n54 CNV loss 21841781
esv28160 CNV loss 19812545
nsv548090 CNV loss 21841781
nsv548096 CNV loss 21841781

Variation tolerance for MGST3 Gene

Residual Variation Intolerance Score: 50.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for MGST3 Gene

Human Gene Mutation Database (HGMD)
MGST3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
MGST3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST3 Gene

Disorders for MGST3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGST3 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
choline deficiency disease
  • choline deficiency
- elite association - COSMIC cancer census association via MalaCards
Search MGST3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for MGST3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with MGST3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST3 Gene

Publications for MGST3 Gene

  1. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. (PMID: 9278457) Jakobsson PJ … Ford-Hutchinson AW (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians. (PMID: 12898215) Thameem F … Prochazka M (Human genetics 2003) 3 22 44 58
  3. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney SJ … AddNeuroMed Consortium (Molecular psychiatry 2011) 3 44 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung CL … Kung AW (Human molecular genetics 2009) 3 44 58

Products for MGST3 Gene

Sources for MGST3 Gene

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