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Aliases for MGST2 Gene

Aliases for MGST2 Gene

  • Microsomal Glutathione S-Transferase 2 2 3 5
  • Microsomal GST-II 3 4
  • Microsomal GST-2 3 4
  • GST2 3 4
  • EC 2.5.1.18 4
  • MGST-II 3

External Ids for MGST2 Gene

Previous GeneCards Identifiers for MGST2 Gene

  • GC04P141492
  • GC04P140886
  • GC04P141053
  • GC04P141164
  • GC04P140944
  • GC04P140586
  • GC04P136315

Summaries for MGST2 Gene

Entrez Gene Summary for MGST2 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for MGST2 Gene

MGST2 (Microsomal Glutathione S-Transferase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include enzyme activator activity and glutathione peroxidase activity. An important paralog of this gene is ALOX5AP.

UniProtKB/Swiss-Prot for MGST2 Gene

  • Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Gene Wiki entry for MGST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST2 Gene

Genomics for MGST2 Gene

Regulatory Elements for MGST2 Gene

Promoters for MGST2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MGST2 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGST2 Gene

Chromosome:
4
Start:
139,665,768 bp from pter
End:
139,740,745 bp from pter
Size:
74,978 bases
Orientation:
Plus strand

Genomic View for MGST2 Gene

Genes around MGST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST2 Gene

Proteins for MGST2 Gene

  • Protein details for MGST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99735-MGST2_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 2
    Protein Accession:
    Q99735
    Secondary Accessions:
    • D6RBB5
    • Q7Z5B8

    Protein attributes for MGST2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16621 Da
    Quaternary structure:
    • Homotrimer.

    Alternative splice isoforms for MGST2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST2 Gene

Proteomics data for MGST2 Gene at MOPED

Post-translational modifications for MGST2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MGST2 Gene

Antibody Products

No data available for DME Specific Peptides for MGST2 Gene

Domains & Families for MGST2 Gene

Gene Families for MGST2 Gene

Suggested Antigen Peptide Sequences for MGST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99735

UniProtKB/Swiss-Prot:

MGST2_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST2: view

Function for MGST2 Gene

Molecular function for MGST2 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 2,expressed in liver,spleen,heart,skeletal muscle,involved in leukotriene biosynthesis,microsomal,GST superfamily
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot Function:
Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4-dinitrobenzene with reduced glutathione.

Enzyme Numbers (IUBMB) for MGST2 Gene

genes like me logo Genes that share phenotypes with MGST2: view

Animal Model Products

miRNA for MGST2 Gene

miRTarBase miRNAs that target MGST2

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST2 Gene

Localization for MGST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Microsome membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGST2 Gene COMPARTMENTS Subcellular localization image for MGST2 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 3
nucleus 2
cytosol 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043231 intracellular membrane-bounded organelle IDA 8703034
genes like me logo Genes that share ontologies with MGST2: view

Pathways & Interactions for MGST2 Gene

genes like me logo Genes that share pathways with MGST2: view

Interacting Proteins for MGST2 Gene

Gene Ontology (GO) - Biological Process for MGST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0098869 cellular oxidant detoxification IEA,IBA --
GO:1901687 glutathione derivative biosynthetic process TAS --
genes like me logo Genes that share ontologies with MGST2: view

No data available for SIGNOR curated interactions for MGST2 Gene

Drugs & Compounds for MGST2 Gene

(4) Drugs for MGST2 Gene - From: HMDB, FDA Approved Drugs, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Busulfan Approved, Investigational Pharma Enzyme, substrate 506
Busulfex Approved February 1999 Pharma 0
Trichloroethylene Pharma 5

(42) Additional Compounds for MGST2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST2: view

Transcripts for MGST2 Gene

Unigene Clusters for MGST2 Gene

Microsomal glutathione S-transferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGST2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - -
SP3: - - -
SP4: - - - -
SP5: - - - - -
SP6: -

Relevant External Links for MGST2 Gene

GeneLoc Exon Structure for
MGST2
ECgene alternative splicing isoforms for
MGST2

Expression for MGST2 Gene

mRNA expression in normal human tissues for MGST2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MGST2 Gene

This gene is overexpressed in Nasal epithelium (15.3), Liver (7.2), and Pancreas (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGST2 Gene



SOURCE GeneReport for Unigene cluster for MGST2 Gene Hs.81874

mRNA Expression by UniProt/SwissProt for MGST2 Gene

Q99735-MGST2_HUMAN
Tissue specificity: Liver, spleen, skeletal muscle, heart, adrenals, pancreas, prostate, testis, fetal liver, and fetal spleen. Very low expression in lung, brain, placenta and bone marrow.
genes like me logo Genes that share expression patterns with MGST2: view

Protein tissue co-expression partners for MGST2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MGST2 Gene

Orthologs for MGST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGST2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGST2 35
  • 88.28 (n)
  • 86.9 (a)
MGST2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGST2 35
  • 86.58 (n)
  • 90.91 (a)
MGST2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgst2 35
  • 80.27 (n)
  • 74.83 (a)
Mgst2 16
Mgst2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGST2 35
  • 99.55 (n)
  • 99.32 (a)
MGST2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgst2 35
  • 81.63 (n)
  • 78.91 (a)
oppossum
(Monodelphis domestica)
Mammalia MGST2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MGST2 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST2 35
  • 67.35 (n)
  • 63.95 (a)
MGST2 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731146 35
  • 59.54 (n)
  • 59.31 (a)
zebrafish
(Danio rerio)
Actinopterygii mgst2 35
  • 56.15 (n)
  • 53.08 (a)
mgst2 36
  • 51 (a)
OneToOne
Species with no ortholog for MGST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST2 Gene

ENSEMBL:
Gene Tree for MGST2 (if available)
TreeFam:
Gene Tree for MGST2 (if available)

Paralogs for MGST2 Gene

Paralogs for MGST2 Gene

(3) SIMAP similar genes for MGST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MGST2: view

Variants for MGST2 Gene

Sequence variations from dbSNP and Humsavar for MGST2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs8192111 - 139,703,527(+) AGCTG(C/T)TAAAA reference, synonymous-codon, missense
rs345972 -- 139,711,392(+) gaatg(C/G)ctact intron-variant
rs345973 -- 139,711,704(+) tgact(C/T)agaat intron-variant
rs345974 -- 139,711,915(+) tatga(A/G)ggtct intron-variant
rs345975 -- 139,712,852(+) aaaat(A/G)accca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGST2 Gene

Variant ID Type Subtype PubMed ID
nsv830086 CNV Gain 17160897
nsv880162 CNV Loss 21882294
dgv5766n71 CNV Loss 21882294
nsv525242 CNV Loss 19592680

Variation tolerance for MGST2 Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MGST2 Gene

HapMap Linkage Disequilibrium report
MGST2
Human Gene Mutation Database (HGMD)
MGST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST2 Gene

Disorders for MGST2 Gene

Relevant External Links for MGST2

Genetic Association Database (GAD)
MGST2
Human Genome Epidemiology (HuGE) Navigator
MGST2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGST2

No disorders were found for MGST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MGST2 Gene

Publications for MGST2 Gene

  1. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. (PMID: 8703034) Jakobsson P.-J. … Ford-Hutchinson A.W. (J. Biol. Chem. 1996) 2 3 4 67
  2. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. (PMID: 17632548) Ago H. … Miyano M. (Nature 2007) 25 26
  3. A novel MGST2 non-synonymous mutation in a Chinese pedigree with psoriasis vulgaris. (PMID: 16498398) Yan K.L. … Liu J.J. (J. Invest. Dermatol. 2006) 3 23
  4. Systematic evaluation of association between the microsomal glutathione S-transferase 2 common variation and psoriasis vulgaris in Chinese population. (PMID: 16773312) Yang S. … Liu J.J. (Arch. Dermatol. Res. 2006) 3 23
  5. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. (PMID: 11322876) SjAPstrAPm M. … HaeggstrAPm J.Z. (Eur. J. Biochem. 2001) 3 23

Products for MGST2 Gene

Sources for MGST2 Gene

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