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Aliases for MGST1 Gene

Aliases for MGST1 Gene

  • Microsomal Glutathione S-Transferase 1 2 3 5
  • Microsomal GST-1 3 4
  • Microsomal GST-I 3 4
  • EC 2.5.1.18 4 63
  • GST12 3 4
  • MGST 3 4
  • Glutathione S-Transferase 12 3
  • MGST-I 3

External Ids for MGST1 Gene

Previous HGNC Symbols for MGST1 Gene

  • GST12

Previous GeneCards Identifiers for MGST1 Gene

  • GC12P016240
  • GC12P016644
  • GC12P016400
  • GC12P016391
  • GC12P016500

Summaries for MGST1 Gene

Entrez Gene Summary for MGST1 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MGST1 Gene

MGST1 (Microsomal Glutathione S-Transferase 1) is a Protein Coding gene. Diseases associated with MGST1 include Megalencephalic Leukoencephalopathy With Subcortical Cysts. Among its related pathways are Aflatoxin activation and detoxification and Phase II conjugation. GO annotations related to this gene include protein homodimerization activity and glutathione transferase activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot for MGST1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Gene Wiki entry for MGST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST1 Gene

Genomics for MGST1 Gene

Regulatory Elements for MGST1 Gene

Enhancers for MGST1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MGST1 on UCSC Golden Path with GeneCards custom track

Genomic Location for MGST1 Gene

Chromosome:
12
Start:
16,347,142 bp from pter
End:
16,609,259 bp from pter
Size:
262,118 bases
Orientation:
Plus strand

Genomic View for MGST1 Gene

Genes around MGST1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MGST1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MGST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST1 Gene

Proteins for MGST1 Gene

  • Protein details for MGST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10620-MGST1_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 1
    Protein Accession:
    P10620
    Secondary Accessions:
    • A8K533
    • G5EA53

    Protein attributes for MGST1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17599 Da
    Quaternary structure:
    • Homotrimer; The trimer binds only one molecule of glutathione.

    Alternative splice isoforms for MGST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST1 Gene

Proteomics data for MGST1 Gene at MOPED

Selected DME Specific Peptides for MGST1 Gene

Post-translational modifications for MGST1 Gene

  • Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for MGST1 Gene

Gene Families for MGST1 Gene

Suggested Antigen Peptide Sequences for MGST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10620

UniProtKB/Swiss-Prot:

MGST1_HUMAN :
  • Belongs to the MAPEG family.
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST1: view

Function for MGST1 Gene

Molecular function for MGST1 Gene

GENATLAS Biochemistry:
microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues
UniProtKB/Swiss-Prot CatalyticActivity:
RX + glutathione = HX + R-S-glutathione.
UniProtKB/Swiss-Prot EnzymeRegulation:
Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity).
UniProtKB/Swiss-Prot Function:
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Enzyme Numbers (IUBMB) for MGST1 Gene

Gene Ontology (GO) - Molecular Function for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20195357
GO:0043295 glutathione binding IEA --
genes like me logo Genes that share ontologies with MGST1: view
genes like me logo Genes that share phenotypes with MGST1: view

Animal Model Products

miRNA for MGST1 Gene

miRTarBase miRNAs that target MGST1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for MGST1 Gene

Localization for MGST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST1 Gene

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGST1 Gene COMPARTMENTS Subcellular localization image for MGST1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 5
cytosol 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
genes like me logo Genes that share ontologies with MGST1: view

Pathways & Interactions for MGST1 Gene

genes like me logo Genes that share pathways with MGST1: view

Gene Ontology (GO) - Biological Process for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0042493 response to drug IEA --
GO:0071449 cellular response to lipid hydroperoxide IDA 20727966
GO:0098869 cellular oxidant detoxification IDA 20727966
genes like me logo Genes that share ontologies with MGST1: view

No data available for SIGNOR curated interactions for MGST1 Gene

Drugs & Compounds for MGST1 Gene

(8) Drugs for MGST1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glutathione Approved Nutra Target 0
Trichloroethylene Pharma 5

(47) Additional Compounds for MGST1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(1R)-Glutathionyl-(2R)-hydroxy-1,2-dihydronaphthalene
(1R)-Hydroxy-(2R)-glutathionyl-1,2-dihydronaphthalene
(1S)-Hydroxy-(2S)-glutathionyl-1,2-dihydronaphthalene
(1S,2R)-Naphthalene 1,2-oxide
1,1-Dichloroethylene epoxide
genes like me logo Genes that share compounds with MGST1: view

Transcripts for MGST1 Gene

Unigene Clusters for MGST1 Gene

Microsomal glutathione S-transferase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for MGST1 Gene

GeneLoc Exon Structure for
MGST1
ECgene alternative splicing isoforms for
MGST1

Expression for MGST1 Gene

mRNA expression in normal human tissues for MGST1 Gene

mRNA differential expression in normal tissues according to GTEx for MGST1 Gene

This gene is overexpressed in Liver (x9.0), Adrenal Gland (x6.8), and Adipose - Visceral (Omentum) (x4.5).

Protein differential expression in normal tissues from HIPED for MGST1 Gene

This gene is overexpressed in Nasal epithelium (17.6) and Liver (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGST1 Gene



SOURCE GeneReport for Unigene cluster for MGST1 Gene Hs.389700

mRNA Expression by UniProt/SwissProt for MGST1 Gene

P10620-MGST1_HUMAN
Tissue specificity: Highly expressed in liver.
genes like me logo Genes that share expression patterns with MGST1: view

Protein tissue co-expression partners for MGST1 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for MGST1 Gene

Orthologs for MGST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGST1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MGST1 35
  • 87.31 (n)
  • 88.39 (a)
MGST1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGST1 35
  • 88.6 (n)
  • 89.68 (a)
MGST1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgst1 35
  • 79.35 (n)
  • 82.58 (a)
Mgst1 16
Mgst1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MGST1 35
  • 99.57 (n)
  • 99.35 (a)
MGST1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgst1 35
  • 77.85 (n)
  • 83.23 (a)
oppossum
(Monodelphis domestica)
Mammalia MGST1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves MGST1 35
  • 72.47 (n)
  • 67.74 (a)
MGST1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGST1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst1 35
  • 59.35 (n)
  • 58.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mgst1.1 35
  • 57.36 (n)
  • 57.14 (a)
mgst1.1 36
  • 56 (a)
OneToMany
mgst1.2 36
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTMIC1 35
  • 49.07 (n)
  • 47.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mgstl 35
  • 51.54 (n)
  • 48.23 (a)
CG33177 36
  • 36 (a)
ManyToMany
CG33178 36
  • 33 (a)
ManyToMany
Mgstl 36
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for MGST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST1 Gene

ENSEMBL:
Gene Tree for MGST1 (if available)
TreeFam:
Gene Tree for MGST1 (if available)

Paralogs for MGST1 Gene

Paralogs for MGST1 Gene

(1) SIMAP similar genes for MGST1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MGST1: view

Variants for MGST1 Gene

Sequence variations from dbSNP and Humsavar for MGST1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2075237 -- 16,357,145(+) CTTCT(G/T)CTCCT intron-variant
rs2075238 -- 16,357,352(+) CCTCT(A/C/T)GGGCT intron-variant
rs2075239 -- 16,357,461(+) ATGGG(G/T)ACTCC intron-variant
rs2075240 -- 16,357,484(+) GGCTG(A/G)TCTTG intron-variant
rs7133802 -- 16,367,558(+) ATCCC(A/G)GAGTC intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MGST1 Gene

Variant ID Type Subtype PubMed ID
nsv832338 CNV Gain 17160897
dgv1381n71 CNV Loss 21882294

Variation tolerance for MGST1 Gene

Residual Variation Intolerance Score: 61.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.09% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for MGST1 Gene

Disorders for MGST1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for MGST1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
megalencephalic leukoencephalopathy with subcortical cysts
  • vacuolating megalencephalic leukoencephalopathy with subcortical cysts
- elite association - COSMIC cancer census association via MalaCards
Search MGST1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for MGST1

Genetic Association Database (GAD)
MGST1
Human Genome Epidemiology (HuGE) Navigator
MGST1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MGST1
genes like me logo Genes that share disorders with MGST1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MGST1 Gene

Publications for MGST1 Gene

  1. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PMID: 15338373) Schneider A. … Whitcomb D.C. (J. Gastroenterol. 2004) 3 23 48 67
  2. Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1. (PMID: 17297922) Busenlehner L.S. … Armstrong R.N. (Biochemistry 2007) 23 25 26
  3. Protection of cells from oxidative stress by microsomal glutathione transferase 1. (PMID: 17306223) Siritantikorn A. … Morgenstern R. (Biochem. Biophys. Res. Commun. 2007) 23 25 26
  4. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PMID: 17483957) Zhang H. … Wu M. (Int J Colorectal Dis 2007) 3 23
  5. Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. (PMID: 17714764) Prall W.C. … Aivado M. (Mech. Ageing Dev. 2007) 3 23

Products for MGST1 Gene

Sources for MGST1 Gene

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