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Aliases for MGST1 Gene

Aliases for MGST1 Gene

  • Microsomal Glutathione S-Transferase 1 2 3
  • GST12 3 4 6
  • Microsomal GST-1 3 4
  • Microsomal GST-I 3 4
  • EC 2.5.1.18 4 63
  • MGST 3 4
  • Glutathione S-Transferase 12 3
  • MGST-I 3

External Ids for MGST1 Gene

Previous HGNC Symbols for MGST1 Gene

  • GST12

Previous GeneCards Identifiers for MGST1 Gene

  • GC12P016240
  • GC12P016644
  • GC12P016400
  • GC12P016391
  • GC12P016500

Summaries for MGST1 Gene

Entrez Gene Summary for MGST1 Gene

  • The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for MGST1 Gene

MGST1 (Microsomal Glutathione S-Transferase 1) is a Protein Coding gene. Diseases associated with MGST1 include megalencephalic leukoencephalopathy with subcortical cysts. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include protein homodimerization activity and glutathione peroxidase activity. An important paralog of this gene is PTGES.

UniProtKB/Swiss-Prot for MGST1 Gene

  • Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity

Gene Wiki entry for MGST1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGST1 Gene

Genomics for MGST1 Gene

Regulatory Elements for MGST1 Gene

Genomic Location for MGST1 Gene

Start:
16,347,142 bp from pter
End:
16,609,259 bp from pter
Size:
262,118 bases
Orientation:
Plus strand

Genomic View for MGST1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGST1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGST1 Gene

Proteins for MGST1 Gene

  • Protein details for MGST1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P10620-MGST1_HUMAN
    Recommended name:
    Microsomal glutathione S-transferase 1
    Protein Accession:
    P10620
    Secondary Accessions:
    • A8K533
    • G5EA53

    Protein attributes for MGST1 Gene

    Size:
    155 amino acids
    Molecular mass:
    17599 Da
    Quaternary structure:
    • Homotrimer; The trimer binds only one molecule of glutathione.

    Alternative splice isoforms for MGST1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGST1 Gene

Proteomics data for MGST1 Gene at MOPED

Selected DME Specific Peptides for MGST1 Gene

Post-translational modifications for MGST1 Gene

  • Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for MGST1 Gene

Gene Families for MGST1 Gene

HGNC:
  • MGST :Glutathione S-transferases / Microsomal

Suggested Antigen Peptide Sequences for MGST1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P10620

UniProtKB/Swiss-Prot:

MGST1_HUMAN :
  • P10620
Family:
  • Belongs to the MAPEG family.
genes like me logo Genes that share domains with MGST1: view

Function for MGST1 Gene

Molecular function for MGST1 Gene

GENATLAS Biochemistry: microsomal glutathione-S-transferase 1,microsomal,GST superfamily,expressed in the liver and several other tissues
UniProtKB/Swiss-Prot CatalyticActivity: RX + glutathione = HX + R-S-glutathione
UniProtKB/Swiss-Prot EnzymeRegulation: Can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide. Activation also occurs via nitration of Tyr-93 by peroxynitrite (By similarity).
UniProtKB/Swiss-Prot Function: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity

Enzyme Numbers (IUBMB) for MGST1 Gene

Gene Ontology (GO) - Molecular Function for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004364 glutathione transferase activity IDA 20727966
GO:0004602 glutathione peroxidase activity IDA 20727966
GO:0005515 protein binding IPI 20195357
GO:0042802 identical protein binding --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with MGST1: view

Phenotypes for MGST1 Gene

GenomeRNAi human phenotypes for MGST1:
genes like me logo Genes that share phenotypes with MGST1: view

Animal Model Products

CRISPR Products

miRNA for MGST1 Gene

miRTarBase miRNAs that target MGST1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGST1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MGST1 Gene

Localization for MGST1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGST1 Gene

Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGST1 Gene COMPARTMENTS Subcellular localization image for MGST1 gene
Compartment Confidence
endoplasmic reticulum 5
mitochondrion 5
peroxisome 4
cytosol 2
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005739 mitochondrion IDA 20727966
GO:0005741 mitochondrial outer membrane IEA --
GO:0005743 mitochondrial inner membrane IEA --
GO:0005778 peroxisomal membrane ISS --
genes like me logo Genes that share ontologies with MGST1: view

Pathways for MGST1 Gene

genes like me logo Genes that share pathways with MGST1: view

Pathways by source for MGST1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MGST1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006749 glutathione metabolic process IEA --
GO:0006805 xenobiotic metabolic process TAS --
GO:0010243 response to organonitrogen compound IEA --
GO:0032496 response to lipopolysaccharide IEA --
GO:0033327 Leydig cell differentiation IEA --
genes like me logo Genes that share ontologies with MGST1: view

Compounds for MGST1 Gene

(12) HMDB Compounds for MGST1 Gene

Compound Synonyms Cas Number PubMed IDs
2-Hydroxyestrone-1-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-1-S-glutathione
Not Available
2-Hydroxyestrone-4-S-glutathione
  • 2,3-dihydroxy-1,3,5[10]-estratriene-17-one-4-S-glutathione
Not Available
4-Hydroxyestrone-2-S-glutathione
  • 3,4-dihydroxy-1,3,5[10]-estratriene-17-one-2-S-glutathione
Not Available
Adrenochrome
  • adrenochrome oxidised
54-06-8
Estrone-2,3-quinone
  • catecholestrogen quinone
40551-33-5

(1) Drugbank Compounds for MGST1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Glutathione
  • 5-L-Glutamyl-L-cysteinylglycine
70-18-8 target

(14) Novoseek inferred chemical compound relationships for MGST1 Gene

Compound -log(P) Hits PubMed IDs
gsts 78 3
1-chloro-24-dinitrobenzene 68.1 2
n-ethylmaleimide 62.5 2
ltc4 54.9 3
chlorambucil 42.2 1
genes like me logo Genes that share compounds with MGST1: view

Transcripts for MGST1 Gene

Unigene Clusters for MGST1 Gene

Microsomal glutathione S-transferase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MGST1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MGST1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: -
SP3: - -
SP4: - - - -
SP5:
SP6: - -

Relevant External Links for MGST1 Gene

GeneLoc Exon Structure for
MGST1
ECgene alternative splicing isoforms for
MGST1

Expression for MGST1 Gene

mRNA expression in normal human tissues for MGST1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGST1 Gene

This gene is overexpressed in Liver (9.0), Adrenal Gland (6.8), and Adipose - Visceral (Omentum) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MGST1 Gene

SOURCE GeneReport for Unigene cluster for MGST1 Gene Hs.389700

mRNA Expression by UniProt/SwissProt for MGST1 Gene

P10620-MGST1_HUMAN
Tissue specificity: Highly expressed in liver
genes like me logo Genes that share expressions with MGST1: view

In Situ Assay Products

Orthologs for MGST1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MGST1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGST1 35
  • 99.57 (n)
  • 99.35 (a)
MGST1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGST1 35
  • 87.31 (n)
  • 88.39 (a)
MGST1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MGST1 35
  • 88.6 (n)
  • 89.68 (a)
MGST1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mgst1 35
  • 79.35 (n)
  • 82.58 (a)
Mgst1 16
Mgst1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGST1 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgst1 35
  • 77.85 (n)
  • 83.23 (a)
chicken
(Gallus gallus)
Aves MGST1 35
  • 72.47 (n)
  • 67.74 (a)
MGST1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGST1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mgst1 35
  • 59.35 (n)
  • 58.71 (a)
zebrafish
(Danio rerio)
Actinopterygii mgst1.1 35
  • 57.36 (n)
  • 57.14 (a)
mgst1.1 36
  • 56 (a)
OneToMany
mgst1.2 36
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta GSTMIC1 35
  • 49.07 (n)
  • 47.22 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33177 36
  • 36 (a)
ManyToMany
CG33178 36
  • 33 (a)
ManyToMany
Mgstl 35
  • 51.54 (n)
  • 48.23 (a)
Mgstl 36
  • 44 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 44 (a)
OneToMany
Species with no ortholog for MGST1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MGST1 Gene

ENSEMBL:
Gene Tree for MGST1 (if available)
TreeFam:
Gene Tree for MGST1 (if available)

Paralogs for MGST1 Gene

Paralogs for MGST1 Gene

Selected SIMAP similar genes for MGST1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with MGST1: view

Variants for MGST1 Gene

Sequence variations from dbSNP and Humsavar for MGST1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11875 -- 16,364,060(+) ACTCA(A/G)CATCC utr-variant-3-prime, intron-variant, nc-transcript-variant, downstream-variant-500B
rs713593 -- 16,368,993(-) ATGTC(C/T)CTCTT intron-variant
rs1024834 -- 16,365,728(+) GAaca(C/T)gcacg intron-variant
rs1024835 -- 16,365,732(+) ATGCA(C/T)GCGTG intron-variant
rs1024836 -- 16,365,739(+) CGTGc(A/G)cgcgc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MGST1 Gene

Variant ID Type Subtype PubMed ID
nsv832338 CNV Gain 17160897
dgv1381n71 CNV Loss 21882294

Relevant External Links for MGST1 Gene

HapMap Linkage Disequilibrium report
MGST1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MGST1 Gene

Disorders for MGST1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MGST1 Gene including...

Search for MGST1 Gene in MalaCards »

(4) Novoseek inferred disease relationships for MGST1 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 0 1
inflammation 0 2
tumors 0 1
cancer 0 1

Relevant External Links for MGST1

Genetic Association Database (GAD)
MGST1
Human Genome Epidemiology (HuGE) Navigator
MGST1
genes like me logo Genes that share disorders with MGST1: view

No data available for UniProtKB/Swiss-Prot for MGST1 Gene

Publications for MGST1 Gene

  1. Structural organization of the human microsomal glutathione S- transferase gene (GST12). (PMID: 8812420) Kelner M.J. … Montoya M.A. (Genomics 1996) 3 4 23
  2. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. (PMID: 15338373) Schneider A. … Whitcomb D.C. (J. Gastroenterol. 2004) 3 23 48
  3. Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. (PMID: 16384981) Haines J.L. … Pericak-Vance M.A. (Invest. Ophthalmol. Vis. Sci. 2006) 3 23 48
  4. Microsomal glutathione S-transferase gene polymorphisms and colorectal cancer risk in a Han Chinese population. (PMID: 17483957) Zhang H. … Wu M. (Int J Colorectal Dis 2007) 3 23 48
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MGST1 Gene

Sources for MGST1 Gene

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