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Aliases for MGP Gene

Aliases for MGP Gene

  • Matrix Gla Protein 2 3
  • Cell Growth-Inhibiting Gene 36 Protein 3 4
  • MGLAP 3 4
  • NTI 3 6
  • GIG36 3

External Ids for MGP Gene

Summaries for MGP Gene

Entrez Gene Summary for MGP Gene

  • The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for MGP Gene

MGP (Matrix Gla Protein) is a Protein Coding gene. Diseases associated with MGP include acute apical periodontitis and keutel syndrome. Among its related pathways are Endochondral Ossification and PTM- gamma carboxylation, hypusine formation and arylsulfatase activation. GO annotations related to this gene include calcium ion binding and structural constituent of bone.

UniProtKB/Swiss-Prot for MGP Gene

  • Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation

Gene Wiki entry for MGP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MGP Gene

Genomics for MGP Gene

Genomic Location for MGP Gene

Start:
14,881,181 bp from pter
End:
14,885,926 bp from pter
Size:
4,746 bases
Orientation:
Minus strand

Genomic View for MGP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MGP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MGP Gene

Regulatory Elements for MGP Gene

Proteins for MGP Gene

  • Protein details for MGP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08493-MGP_HUMAN
    Recommended name:
    Matrix Gla protein
    Protein Accession:
    P08493
    Secondary Accessions:
    • A0M8W5
    • B2R519
    • J3KMX7
    • Q2TU41
    • Q567P9
    • Q6ICN5

    Protein attributes for MGP Gene

    Size:
    103 amino acids
    Molecular mass:
    12353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MGP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MGP Gene

Proteomics data for MGP Gene at MOPED

Post-translational modifications for MGP Gene

  • Requires vitamin K-dependent gamma-carboxylation for its function
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MGP Gene

No data available for DME Specific Peptides for MGP Gene

Domains for MGP Gene

UniProtKB/Swiss-Prot:

MGP_HUMAN
Domain:
  • Contains 1 Gla (gamma-carboxy-glutamate) domain.:
    • P08493
Family:
  • Belongs to the osteocalcin/matrix Gla protein family.:
    • P08493
genes like me logo Genes that share domains with MGP: view

No data available for Gene Families for MGP Gene

Function for MGP Gene

Molecular function for MGP Gene

GENATLAS Biochemistry: bone matrix GLA protein,vitamin K dependent,vitamin D regulated
UniProtKB/Swiss-Prot Function: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation

Gene Ontology (GO) - Molecular Function for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent TAS 9916809
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 15607035
GO:0008147 structural constituent of bone TAS 9916809
genes like me logo Genes that share ontologies with MGP: view
genes like me logo Genes that share phenotypes with MGP: view

Animal Models for MGP Gene

MGI Knock Outs for MGP:

miRNA for MGP Gene

miRTarBase miRNAs that target MGP

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MGP Gene

Localization for MGP Gene

Subcellular locations from UniProtKB/Swiss-Prot for MGP Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MGP Gene COMPARTMENTS Subcellular localization image for MGP gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005578 proteinaceous extracellular matrix TAS 9916809
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MGP: view

Pathways for MGP Gene

genes like me logo Genes that share pathways with MGP: view

Pathways by source for MGP Gene

Gene Ontology (GO) - Biological Process for MGP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001502 cartilage condensation TAS 9916809
GO:0001503 ossification IEA --
GO:0030154 cell differentiation IEA --
GO:0030500 regulation of bone mineralization IEA --
genes like me logo Genes that share ontologies with MGP: view

Compounds for MGP Gene

(14) Novoseek inferred chemical compound relationships for MGP Gene

Compound -log(P) Hits PubMed IDs
gamma-carboxyglutamic acid 92 31
vitamin k1 77.6 2
hydroxyapatite 60.6 9
warfarin 56.5 11
calcium 49 22
genes like me logo Genes that share compounds with MGP: view

Transcripts for MGP Gene

Unigene Clusters for MGP Gene

Matrix Gla protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MGP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -
SP2: -

Relevant External Links for MGP Gene

GeneLoc Exon Structure for
MGP
ECgene alternative splicing isoforms for
MGP

Expression for MGP Gene

mRNA expression in normal human tissues for MGP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MGP Gene

This gene is overexpressed in Artery - Aorta (12.2) and Artery - Coronary (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MGP Gene

SOURCE GeneReport for Unigene cluster for MGP Gene Hs.365706

genes like me logo Genes that share expressions with MGP: view

Orthologs for MGP Gene

This gene was present in the common ancestor of chordates.

Orthologs for MGP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MGP 36
  • 99.35 (n)
  • 98.06 (a)
MGP 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGP 36
  • 83.82 (n)
  • 83.5 (a)
dog
(Canis familiaris)
Mammalia MGP 36
  • 85.11 (n)
  • 86.41 (a)
mouse
(Mus musculus)
Mammalia Mgp 36
  • 81.23 (n)
  • 83.5 (a)
Mgp 16
Mgp 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MGP 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mgp 36
  • 79.94 (n)
  • 79.61 (a)
chicken
(Gallus gallus)
Aves MGP 37
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MGP 37
  • 51 (a)
OneToOne
Species with no ortholog for MGP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MGP Gene

ENSEMBL:
Gene Tree for MGP (if available)
TreeFam:
Gene Tree for MGP (if available)

Paralogs for MGP Gene

No data available for Paralogs for MGP Gene

Variants for MGP Gene

Sequence variations from dbSNP and Humsavar for MGP Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs4236 - 14,882,147(-) GAGGG(A/G)CCAAA reference, missense
rs12304 -- 14,882,213(-) TTTGC(G/T)AACGC reference, stop-gained
rs13617 -- 14,882,978(-) AGTCC(A/G)AGAGA reference, missense
rs972744 -- 14,887,858(+) TTTCA(A/G)CCTCT upstream-variant-2KB
rs1049867 -- 14,882,019(-) ATATT(C/T)TCTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MGP Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
nsv898818 CNV Loss 21882294

Relevant External Links for MGP Gene

HapMap Linkage Disequilibrium report
MGP
Human Gene Mutation Database (HGMD)
MGP

Disorders for MGP Gene

(1) OMIM Diseases for MGP Gene (154870)

UniProtKB/Swiss-Prot

MGP_HUMAN
  • Keutel syndrome (KTLS) [MIM:245150]: An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. {ECO:0000269 PubMed:9916809}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(33) Novoseek inferred disease relationships for MGP Gene

Disease -log(P) Hits PubMed IDs
calcification 88.2 185
keutel syndrome 83.9 3
hyperphosphatemia 65.2 1
vitamin k deficiency 64 4
arterial vessels 58.8 3

Relevant External Links for MGP

Genetic Association Database (GAD)
MGP
Human Genome Epidemiology (HuGE) Navigator
MGP
genes like me logo Genes that share disorders with MGP: view

Publications for MGP Gene

  1. Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene. (PMID: 2394711) Cancela M.L. … Price P.A. (J. Biol. Chem. 1990) 2 3 4 23
  2. Conserved phosphorylation of serines in the Ser-X-Glu/Ser(P) sequences of the vitamin K-dependent matrix Gla protein from shark, lamb, rat, cow, and human. (PMID: 8061611) Price P.A. … Williamson M.K. (Protein Sci. 1994) 3 4 23
  3. Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome. (PMID: 9916809) Munroe P.B. … Chung E. (Nat. Genet. 1999) 3 4 23
  4. Polymorphisms of the human matrix gla protein (MGP) gene, vascular calcification, and myocardial infarction. (PMID: 11073842) Herrmann S.M. … Cambien F. (Arterioscler. Thromb. Vasc. Biol. 2000) 3 23 49
  5. Carboxyl-terminal proteolytic processing of matrix Gla protein. (PMID: 1939157) Hale J.E. … Price P.A. (J. Biol. Chem. 1991) 3 4 23

Products for MGP Gene

Sources for MGP Gene

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