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Aliases for CTAGE5 Gene

Aliases for CTAGE5 Gene

  • CTAGE Family Member 5 2 3 5
  • Meningioma Expressed Antigen 6 (Coiled-Coil Proline-Rich) 2 3
  • Meningioma-Expressed Antigen 6/11 3 4
  • CTAGE Family, Member 5 2 3
  • Protein CTAGE-5 3 4
  • MGEA11 3 4
  • MGEA6 3 4
  • MEA6 3 4
  • Cutaneous T-Cell Lymphoma-Associated Antigen 5 3
  • MEA11 4
  • MGEA 3

External Ids for CTAGE5 Gene

Previous HGNC Symbols for CTAGE5 Gene

  • MGEA
  • MGEA6

Previous GeneCards Identifiers for CTAGE5 Gene

  • GC14P038804
  • GC14P039734
  • GC14P019849

Summaries for CTAGE5 Gene

Entrez Gene Summary for CTAGE5 Gene

  • The protein encoded by this gene is a tumor-associated antigen found in cutaneous T-cell lymphoma and several other cancers. Autoantibodies against the encoded protein have been found in some cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CTAGE5 Gene

CTAGE5 (CTAGE Family Member 5) is a Protein Coding gene. Diseases associated with CTAGE5 include cutaneous t cell lymphoma and lymphoma. Among its related pathways are Transport to the Golgi and subsequent modification and Vesicle-mediated transport. GO annotations related to this gene include enzyme activator activity. An important paralog of this gene is CTAGE9.

UniProtKB/Swiss-Prot for CTAGE5 Gene

  • Tumor-associated antigen.

Gene Wiki entry for CTAGE5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTAGE5 Gene

Genomics for CTAGE5 Gene

Regulatory Elements for CTAGE5 Gene

Enhancers for CTAGE5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CTAGE5 on UCSC Golden Path with GeneCards custom track

Promoters for CTAGE5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CTAGE5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CTAGE5 Gene

Chromosome:
14
Start:
39,265,272 bp from pter
End:
39,388,513 bp from pter
Size:
123,242 bases
Orientation:
Plus strand

Genomic View for CTAGE5 Gene

Genes around CTAGE5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTAGE5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTAGE5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTAGE5 Gene

Proteins for CTAGE5 Gene

  • Protein details for CTAGE5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15320-CTGE5_HUMAN
    Recommended name:
    cTAGE family member 5
    Protein Accession:
    O15320
    Secondary Accessions:
    • B3KRA6
    • B4DQS6
    • D3DSA6
    • G3XAC5
    • O00169
    • Q6MZN2
    • Q6P2R8
    • Q86TF6
    • Q8IX92
    • Q8IX93

    Protein attributes for CTAGE5 Gene

    Size:
    804 amino acids
    Molecular mass:
    90996 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB86589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CTAGE5 Gene

neXtProt entry for CTAGE5 Gene

Proteomics data for CTAGE5 Gene at MOPED

Post-translational modifications for CTAGE5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CTAGE5 Gene

Domains & Families for CTAGE5 Gene

Gene Families for CTAGE5 Gene

Protein Domains for CTAGE5 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for CTAGE5 Gene

Graphical View of Domain Structure for InterPro Entry

O15320

UniProtKB/Swiss-Prot:

CTGE5_HUMAN :
  • Belongs to the cTAGE family.
Family:
  • Belongs to the cTAGE family.
genes like me logo Genes that share domains with CTAGE5: view

Function for CTAGE5 Gene

Molecular function for CTAGE5 Gene

UniProtKB/Swiss-Prot Function:
Tumor-associated antigen.

Gene Ontology (GO) - Molecular Function for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CTAGE5: view

Phenotypes for CTAGE5 Gene

GenomeRNAi human phenotypes for CTAGE5:
genes like me logo Genes that share phenotypes with CTAGE5: view

Animal Model Products

miRNA for CTAGE5 Gene

miRTarBase miRNAs that target CTAGE5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTAGE5 Gene

Localization for CTAGE5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTAGE5 Gene COMPARTMENTS Subcellular localization image for CTAGE5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
golgi apparatus 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with CTAGE5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CTAGE5 Gene

Pathways & Interactions for CTAGE5 Gene

genes like me logo Genes that share pathways with CTAGE5: view

Gene Ontology (GO) - Biological Process for CTAGE5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043085 positive regulation of catalytic activity TAS 9356211
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with CTAGE5: view

No data available for SIGNOR curated interactions for CTAGE5 Gene

Drugs & Compounds for CTAGE5 Gene

No Compound Related Data Available

Transcripts for CTAGE5 Gene

Unigene Clusters for CTAGE5 Gene

CTAGE family, member 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTAGE5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b
SP1: -
SP2:
SP3: - -
SP4: - - -
SP5:

Relevant External Links for CTAGE5 Gene

GeneLoc Exon Structure for
CTAGE5
ECgene alternative splicing isoforms for
CTAGE5

Expression for CTAGE5 Gene

mRNA expression in normal human tissues for CTAGE5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTAGE5 Gene



SOURCE GeneReport for Unigene cluster for CTAGE5 Gene Hs.540038

mRNA Expression by UniProt/SwissProt for CTAGE5 Gene

O15320-CTGE5_HUMAN
Tissue specificity: Isoform 5A is expressed only in testis (at the protein level). Other isoforms are expressed in several other normal tissues, including brain, muscle and cranial skin. Isoform 5A (at protein level) and isoform 5B are expressed in cutaneous T-cell lymphoma (CTCL) cell lines, colorectal carcinomas, breast carcinomas and melanoma. Isoform 5B, but not isoform 5A, is expressed in head and neck squamous cell carcinoma.
genes like me logo Genes that share expression patterns with CTAGE5: view

Protein tissue co-expression partners for CTAGE5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for CTAGE5 Gene

Orthologs for CTAGE5 Gene

This gene was present in the common ancestor of animals.

Orthologs for CTAGE5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTAGE5 35
  • 88.49 (n)
  • 85.96 (a)
-- 36
  • 84 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CTAGE5 35
  • 90.87 (n)
  • 88.28 (a)
-- 36
  • 52 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ctage5 35
  • 83.31 (n)
  • 78.43 (a)
Ctage5 16
Ctage5 36
  • 77 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CTAGE5 35
  • 99.55 (n)
  • 99.26 (a)
CTAGE5 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912115 35
  • 83.55 (n)
  • 78.09 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
chicken
(Gallus gallus)
Aves MIA2 35
  • 70.56 (n)
  • 63.77 (a)
-- 36
  • 36 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ctage5 35
  • 58.43 (n)
  • 48.16 (a)
Str.4085 35
zebrafish
(Danio rerio)
Actinopterygii ctage5 35
  • 54.46 (n)
  • 45.05 (a)
zgc56047 35
ctage5 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tango1 36
  • 10 (a)
OneToMany
Species with no ortholog for CTAGE5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CTAGE5 Gene

ENSEMBL:
Gene Tree for CTAGE5 (if available)
TreeFam:
Gene Tree for CTAGE5 (if available)

Paralogs for CTAGE5 Gene

(11) SIMAP similar genes for CTAGE5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with CTAGE5: view

Variants for CTAGE5 Gene

Sequence variations from dbSNP and Humsavar for CTAGE5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_047889 -
VAR_047890 -
rs17855896 - 39,294,972(+) CTGAA(C/G)ATAGC reference, missense
rs10162564 - 39,299,939(+) ACTCC(A/G)AAGTA reference, missense
rs1950952 - 39,308,472(+) AGACT(C/G)AACAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CTAGE5 Gene

Variant ID Type Subtype PubMed ID
esv2748622 CNV Deletion 23290073
nsv84573 CNV Loss 16902084
esv1110364 CNV Deletion 17803354

Variation tolerance for CTAGE5 Gene

Residual Variation Intolerance Score: 69.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTAGE5 Gene

HapMap Linkage Disequilibrium report
CTAGE5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTAGE5 Gene

Disorders for CTAGE5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CTAGE5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
lymphoma
  • lymphoid cancer
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CTGE5_HUMAN
  • Note=Autoantibodies against CTAGE5 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).

Relevant External Links for CTAGE5

Genetic Association Database (GAD)
CTAGE5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTAGE5
genes like me logo Genes that share disorders with CTAGE5: view

No data available for Genatlas for CTAGE5 Gene

Publications for CTAGE5 Gene

  1. cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients. (PMID: 9356211) Heckel D. … Meese E. (Hum. Mol. Genet. 1997) 2 3 4 67
  2. MGEA6 is tumor-specific overexpressed and frequently recognized by patient-serum antibodies. (PMID: 11803467) Comtesse N. … Meese E. (Oncogene 2002) 3 23
  3. Serological detection of cutaneous T-cell lymphoma-associated antigens. (PMID: 11149944) Eichmueller S. … Schadendorf D. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3

Products for CTAGE5 Gene

Sources for CTAGE5 Gene

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