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Aliases for SCGB2A2 Gene

Aliases for SCGB2A2 Gene

  • Secretoglobin Family 2A Member 2 2 3 4
  • Secretoglobin, Family 2A, Member 2 3 5
  • Mammaglobin 1 2 3
  • MGB1 3 4
  • UGB2 3 4
  • Mammaglobin A 2
  • Mammaglobin-1 4

External Ids for SCGB2A2 Gene

Previous HGNC Symbols for SCGB2A2 Gene

  • MGB1

Previous GeneCards Identifiers for SCGB2A2 Gene

  • GC11P064551
  • GC11P063613
  • GC11P061812
  • GC11P061794
  • GC11P062038
  • GC11P058366

Summaries for SCGB2A2 Gene

GeneCards Summary for SCGB2A2 Gene

SCGB2A2 (Secretoglobin Family 2A Member 2) is a Protein Coding gene. Diseases associated with SCGB2A2 include breast cancer. An important paralog of this gene is SCGB2A1.

Gene Wiki entry for SCGB2A2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2A2 Gene

Genomics for SCGB2A2 Gene

Regulatory Elements for SCGB2A2 Gene

Enhancers for SCGB2A2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCGB2A2 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCGB2A2 Gene

Chromosome:
11
Start:
62,269,933 bp from pter
End:
62,273,160 bp from pter
Size:
3,228 bases
Orientation:
Plus strand

Genomic View for SCGB2A2 Gene

Genes around SCGB2A2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCGB2A2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCGB2A2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A2 Gene

Proteins for SCGB2A2 Gene

  • Protein details for SCGB2A2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13296-SG2A2_HUMAN
    Recommended name:
    Mammaglobin-A
    Protein Accession:
    Q13296
    Secondary Accessions:
    • A1A522
    • Q86WH8

    Protein attributes for SCGB2A2 Gene

    Size:
    93 amino acids
    Molecular mass:
    10499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SCGB2A2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCGB2A2 Gene

Proteomics data for SCGB2A2 Gene at MOPED

Post-translational modifications for SCGB2A2 Gene

  • Glycosylation at Asn 53 and Asn 68

Other Protein References for SCGB2A2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCGB2A2 Gene

Domains & Families for SCGB2A2 Gene

Gene Families for SCGB2A2 Gene

Protein Domains for SCGB2A2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2A2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q13296

UniProtKB/Swiss-Prot:

SG2A2_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A2: view

Function for SCGB2A2 Gene

genes like me logo Genes that share phenotypes with SCGB2A2: view

Animal Model Products

miRNA for SCGB2A2 Gene

miRTarBase miRNAs that target SCGB2A2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SCGB2A2 Gene

Localization for SCGB2A2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB2A2 Gene COMPARTMENTS Subcellular localization image for SCGB2A2 gene
Compartment Confidence
extracellular 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SCGB2A2 Gene

Pathways & Interactions for SCGB2A2 Gene

SuperPathways for SCGB2A2 Gene

No Data Available

Interacting Proteins for SCGB2A2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000227918%0d%0a9606.ENSP00000245932%0d%0a9606.ENSP00000244926%0d%0a
Selected Interacting proteins: Q13296-SG2A2_HUMAN ENSP00000227918 for SCGB2A2 Gene via UniProtKB STRING I2D

Gene Ontology (GO) - Biological Process for SCGB2A2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SCGB2A2 Gene

Drugs & Compounds for SCGB2A2 Gene

(1) Drugs for SCGB2A2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SCGB2A2: view

Transcripts for SCGB2A2 Gene

mRNA/cDNA for SCGB2A2 Gene

Unigene Clusters for SCGB2A2 Gene

Secretoglobin, family 2A, member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for SCGB2A2 Gene

GeneLoc Exon Structure for
SCGB2A2
ECgene alternative splicing isoforms for
SCGB2A2

Expression for SCGB2A2 Gene

mRNA expression in normal human tissues for SCGB2A2 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2A2 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x15.5), Skin - Not Sun Exposed (Suprapubic) (x14.0), Breast - Mammary Tissue (x13.0), and Cervix - Endocervix (x6.5).

Protein differential expression in normal tissues from HIPED for SCGB2A2 Gene

This gene is overexpressed in Cervix (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB2A2 Gene



SOURCE GeneReport for Unigene cluster for SCGB2A2 Gene Hs.46452

mRNA Expression by UniProt/SwissProt for SCGB2A2 Gene

Q13296-SG2A2_HUMAN
Tissue specificity: Mammary gland specific. Over-expressed in breast cancer.
genes like me logo Genes that share expression patterns with SCGB2A2: view

Protein tissue co-expression partners for SCGB2A2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCGB2A2 Gene

Orthologs for SCGB2A2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCGB2A2 35
  • 67.78 (n)
  • 53.33 (a)
dog
(Canis familiaris)
Mammalia SCGB2A2 35
  • 67.38 (n)
  • 56.99 (a)
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 37 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia SCGB2A2 35
  • 98.57 (n)
  • 97.85 (a)
SCGB2A2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm2617 36
  • 35 (a)
ManyToMany
Species with no ortholog for SCGB2A2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2A2 Gene

ENSEMBL:
Gene Tree for SCGB2A2 (if available)
TreeFam:
Gene Tree for SCGB2A2 (if available)

Paralogs for SCGB2A2 Gene

Paralogs for SCGB2A2 Gene

(1) SIMAP similar genes for SCGB2A2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SCGB2A2: view

Variants for SCGB2A2 Gene

Sequence variations from dbSNP and Humsavar for SCGB2A2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7114227 -- 62,272,305(+) aaggg(A/G)gagtc intron-variant
rs7125138 -- 62,269,397(+) cattg(C/T)gaccg upstream-variant-2KB
rs7126448 -- 62,271,298(+) GGGCA(A/T)GAGAG intron-variant, downstream-variant-500B
rs7129637 -- 62,271,280(+) GTGGA(A/T)GATAA intron-variant, downstream-variant-500B
rs11603171 -- 62,272,775(+) TATTT(A/T)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCGB2A2 Gene

Variant ID Type Subtype PubMed ID
esv33305 CNV Loss 17666407

Variation tolerance for SCGB2A2 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB2A2 Gene

HapMap Linkage Disequilibrium report
SCGB2A2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCGB2A2 Gene

Disorders for SCGB2A2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB2A2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SCGB2A2

Genetic Association Database (GAD)
SCGB2A2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB2A2
genes like me logo Genes that share disorders with SCGB2A2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2A2 Gene

Publications for SCGB2A2 Gene

  1. Structure and transcriptional regulation of the human mammaglobin gene, a breast cancer associated member of the uteroglobin gene family localized to chromosome 11q13. (PMID: 9488047) Watson M.A. … Fleming T. (Oncogene 1998) 2 3 4 67
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 3
  3. Diagnostic utility of mammaglobin and GCDFP-15 in the identification of metastatic breast carcinoma in fluid specimens. (PMID: 19217055) Yan Z. … Chhieng D.C. (Diagn. Cytopathol. 2009) 3 23
  4. A small subgroup of operable breast cancer patients with poor prognosis identified by quantitative real-time RT-PCR detection of mammaglobin A and trefoil factor 1 mRNA expression in bone marrow. (PMID: 18846421) Tjensvoll K. … NordgAYrd O. (Breast Cancer Res. Treat. 2009) 3 23
  5. Analysis of the immunohistochemical expression of mammaglobin A in primary breast carcinoma and lymph node metastasis. (PMID: 19690758) Raica M. … MureA9an A. (Rom J Morphol Embryol 2009) 3 23

Products for SCGB2A2 Gene

Sources for SCGB2A2 Gene

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