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Aliases for SCGB2A1 Gene

Aliases for SCGB2A1 Gene

  • Secretoglobin, Family 2A, Member 1 2 3
  • Lacryglobin 2 3 4
  • Mammaglobin B 2 3
  • Mammaglobin 2 2 3
  • Mammaglobin-2 3 4
  • Lipophilin C 2 3
  • Lipophilin-C 3 4
  • MGB2 3 4
  • UGB3 3 4
  • Secretoglobin Family 2A Member 1 4
  • LIPHC 4
  • LPHC 3
  • LPNC 3

External Ids for SCGB2A1 Gene

Previous HGNC Symbols for SCGB2A1 Gene

  • MGB2

Previous GeneCards Identifiers for SCGB2A1 Gene

  • GC11P064489
  • GC11P063552
  • GC11P061751
  • GC11P061732
  • GC11P061976
  • GC11P058304

Summaries for SCGB2A1 Gene

GeneCards Summary for SCGB2A1 Gene

SCGB2A1 (Secretoglobin, Family 2A, Member 1) is a Protein Coding gene. Diseases associated with SCGB2A1 include ovarian cancer. GO annotations related to this gene include protein heterodimerization activity. An important paralog of this gene is SCGB2A2.

UniProtKB/Swiss-Prot for SCGB2A1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Wiki entry for SCGB2A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2A1 Gene

Genomics for SCGB2A1 Gene

Regulatory Elements for SCGB2A1 Gene

Transcription factor binding sites by QIAGEN in the SCGB2A1 gene promoter:

Genomic Location for SCGB2A1 Gene

Chromosome:
11
Start:
62,208,668 bp from pter
End:
62,213,939 bp from pter
Size:
5,272 bases
Orientation:
Plus strand

Genomic View for SCGB2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A1 Gene

Proteins for SCGB2A1 Gene

  • Protein details for SCGB2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75556-SG2A1_HUMAN
    Recommended name:
    Mammaglobin-B
    Protein Accession:
    O75556

    Protein attributes for SCGB2A1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10884 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head

neXtProt entry for SCGB2A1 Gene

Proteomics data for SCGB2A1 Gene at MOPED

Post-translational modifications for SCGB2A1 Gene

  • Glycosylation at Asn 68
  • Modification sites at PhosphoSitePlus

Other Protein References for SCGB2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SCGB2A1 Gene

Domains & Families for SCGB2A1 Gene

Gene Families for SCGB2A1 Gene

Protein Domains for SCGB2A1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SCGB2A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75556

UniProtKB/Swiss-Prot:

SG2A1_HUMAN :
  • Belongs to the secretoglobin family. Lipophilin subfamily.
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.
genes like me logo Genes that share domains with SCGB2A1: view

Function for SCGB2A1 Gene

Molecular function for SCGB2A1 Gene

UniProtKB/Swiss-Prot Function:
May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Ontology (GO) - Molecular Function for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view
genes like me logo Genes that share phenotypes with SCGB2A1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB2A1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCGB2A1 Gene

Localization for SCGB2A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB2A1 Gene COMPARTMENTS Subcellular localization image for SCGB2A1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for SCGB2A1 Gene

Pathways & Interactions for SCGB2A1 Gene

SuperPathways for SCGB2A1 Gene

No Data Available

Interacting Proteins for SCGB2A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244930%0d%0a9606.ENSP00000303070%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000457230%0d%0a
Selected Interacting proteins: O75556-SG2A1_HUMAN ENSP00000244930 for SCGB2A1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030521 androgen receptor signaling pathway IDA 16020486
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Pathways by source and SIGNOR curated interactions for SCGB2A1 Gene

Drugs & Compounds for SCGB2A1 Gene

No Compound Related Data Available

Transcripts for SCGB2A1 Gene

mRNA/cDNA for SCGB2A1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB2A1 Gene

Secretoglobin, family 2A, member 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCGB2A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A1 Gene

No ASD Table

Relevant External Links for SCGB2A1 Gene

GeneLoc Exon Structure for
SCGB2A1
ECgene alternative splicing isoforms for
SCGB2A1

Expression for SCGB2A1 Gene

mRNA expression in normal human tissues for SCGB2A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2A1 Gene

This gene is overexpressed in Cervix - Endocervix (x27.0), Uterus (x7.7), and Fallopian Tube (x4.5).

Protein differential expression in normal tissues from HIPED for SCGB2A1 Gene

This gene is overexpressed in Cervix (67.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCGB2A1 Gene



SOURCE GeneReport for Unigene cluster for SCGB2A1 Gene Hs.97644

mRNA Expression by UniProt/SwissProt for SCGB2A1 Gene

O75556-SG2A1_HUMAN
Tissue specificity: Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland
genes like me logo Genes that share expression patterns with SCGB2A1: view

Protein tissue co-expression partners for SCGB2A1 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SCGB2A1 Gene

Orthologs for SCGB2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB2A1 35
  • 99.18 (n)
  • 97.53 (a)
SCGB2A1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB2A2 36
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Scgb2a2 36
  • 34 (a)
OneToMany
Species with no ortholog for SCGB2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2A1 Gene

ENSEMBL:
Gene Tree for SCGB2A1 (if available)
TreeFam:
Gene Tree for SCGB2A1 (if available)

Paralogs for SCGB2A1 Gene

Paralogs for SCGB2A1 Gene

(1) SIMAP similar genes for SCGB2A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB2A1: view

Variants for SCGB2A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB2A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1540183 -- 62,207,627(-) TTTCT(A/G)TCCAC upstream-variant-2KB
rs1729383 -- 62,213,540(+) CTGTT(G/T)GGCAT intron-variant
rs1792860 -- 62,209,149(-) TTCCA(C/T)ATTCA intron-variant
rs1792869 -- 62,209,087(-) TTGCC(A/C)CACTG intron-variant
rs1792902 -- 62,208,283(-) TTCTC(C/G)TTATT upstream-variant-2KB

Variation tolerance for SCGB2A1 Gene

Residual Variation Intolerance Score: 74.07% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCGB2A1 Gene

HapMap Linkage Disequilibrium report
SCGB2A1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SCGB2A1 Gene

Disorders for SCGB2A1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SCGB2A1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ovarian cancer
  • tumor of the ovary
- elite association

Relevant External Links for SCGB2A1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCGB2A1
genes like me logo Genes that share disorders with SCGB2A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCGB2A1 Gene

Publications for SCGB2A1 Gene

  1. Identification of mammaglobin B, a novel member of the uteroglobin gene family. (PMID: 9806831) Becker R.M. … Fleming T.P. (Genomics 1998) 2 23 67
  2. Update of the human secretoglobin (SCGB) gene superfamily and an example of 'evolutionary bloom' of androgen-binding protein genes within the mouse Scgb gene superfamily. (PMID: 22155607) Jackson B.C. … Vasiliou V. (Hum. Genomics 2011) 2 67
  3. Tear lipocalin is the predominant phosphoprotein in human tear fluid. (PMID: 19951704) Zhao Z. … Willcox M.D. (Exp. Eye Res. 2010) 23 67
  4. Mammaglobin B is an independent prognostic marker in epithelial ovarian cancer and its expression is associated with reduced risk of disease recurrence. (PMID: 19635143) Tassi R.A. … Santin A.D. (BMC Cancer 2009) 23 67
  5. Sentinel lymph node molecular pathology in breast carcinoma. (PMID: 18382355) Denninghoff V. … Elsner B. (Diagn. Mol. Pathol. 2008) 23 67

Products for SCGB2A1 Gene

Sources for SCGB2A1 Gene

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