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Aliases for SCGB2A1 Gene

Aliases for SCGB2A1 Gene

  • Secretoglobin, Family 2A, Member 1 2 3
  • Lacryglobin 2 3 4
  • MGB2 3 4 6
  • Mammaglobin B 2 3
  • Mammaglobin 2 2 3
  • Mammaglobin-2 3 4
  • Lipophilin C 2 3
  • Lipophilin-C 3 4
  • LPNC 3 6
  • UGB3 3 4
  • Secretoglobin Family 2A Member 1 4
  • Mammaglobin-B 3
  • LIPHC 4
  • LPHC 3

External Ids for SCGB2A1 Gene

Previous Symbols for SCGB2A1 Gene

  • MGB2

Summaries for SCGB2A1 Gene

GeneCards Summary for SCGB2A1 Gene

SCGB2A1 (Secretoglobin, Family 2A, Member 1) is a Protein Coding gene. Diseases associated with SCGB2A1 include prostate cancer. GO annotations related to this gene include androgen binding. An important paralog of this gene is SCGB2A2.

UniProtKB/Swiss-Prot for SCGB2A1 Gene

  • May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Wiki entry for SCGB2A1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCGB2A1 Gene

Genomics for SCGB2A1 Gene

Genomic Location for SCGB2A1 Gene

Start:
62,208,668 bp from pter
End:
62,213,939 bp from pter
Size:
5,272 bases
Orientation:
Plus strand

Genomic View for SCGB2A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCGB2A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCGB2A1 Gene

Regulatory Elements for SCGB2A1 Gene

Transcription factor binding sites by QIAGEN in the SCGB2A1 gene promoter:

Proteins for SCGB2A1 Gene

  • Protein details for SCGB2A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75556-SG2A1_HUMAN
    Recommended name:
    Mammaglobin-B
    Protein Accession:
    O75556
    Secondary Accessions:

    Protein attributes for SCGB2A1 Gene

    Size:
    95 amino acids
    Molecular mass:
    10884 Da
    Quaternary structure:
    • Heterodimer of a lipophilin A and a lipophilin C (mammaglobin B) monomer associated head to head

neXtProt entry for SCGB2A1 Gene

Proteomics data for SCGB2A1 Gene at MOPED

Post-translational modifications for SCGB2A1 Gene

Other Protein References for SCGB2A1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCGB2A1 Gene

Domains for SCGB2A1 Gene

Gene Families for SCGB2A1 Gene

HGNC:
  • SCGB :Secretoglobins

Protein Domains for SCGB2A1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SG2A1_HUMAN
Family:
  • Belongs to the secretoglobin family. Lipophilin subfamily.:
    • O75556
genes like me logo Genes that share domains with SCGB2A1: view

Function for SCGB2A1 Gene

Molecular function for SCGB2A1 Gene

UniProtKB/Swiss-Prot Function: May bind androgens and other steroids, may also bind estramustine, a chemotherapeutic agent used for prostate cancer. May be under transcriptional regulation of steroid hormones

Gene Ontology (GO) - Molecular Function for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046982 protein heterodimerization activity IDA 9720917
genes like me logo Genes that share ontologies with SCGB2A1: view
genes like me logo Genes that share phenotypes with SCGB2A1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SCGB2A1 Gene

Localization for SCGB2A1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCGB2A1 Gene COMPARTMENTS Subcellular localization image for SCGB2A1 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16395610
genes like me logo Genes that share ontologies with SCGB2A1: view

Pathways for SCGB2A1 Gene

SuperPathways for SCGB2A1 Gene

No Data Available

Interacting Proteins for SCGB2A1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244930%0d%0a9606.ENSP00000303070%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000457230%0d%0a
Selected Interacting proteins: ENSP00000244930 O75556-SG2A1_HUMAN for SCGB2A1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for SCGB2A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030521 androgen receptor signaling pathway IDA 16020486
genes like me logo Genes that share ontologies with SCGB2A1: view

No data available for Pathways by source for SCGB2A1 Gene

Transcripts for SCGB2A1 Gene

mRNA/cDNA for SCGB2A1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCGB2A1 Gene

Secretoglobin, family 2A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCGB2A1 Gene

No ASD Table

Relevant External Links for SCGB2A1 Gene

GeneLoc Exon Structure for
SCGB2A1
ECgene alternative splicing isoforms for
SCGB2A1

Expression for SCGB2A1 Gene

mRNA expression in normal human tissues for SCGB2A1 Gene

mRNA differential expression in normal tissues according to GTEx for SCGB2A1 Gene

This gene is overexpressed in Cervix - Endocervix (27.0), Uterus (7.7), and Fallopian Tube (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCGB2A1 Gene

SOURCE GeneReport for Unigene cluster for SCGB2A1 Gene Hs.97644

mRNA Expression by UniProt/SwissProt for SCGB2A1 Gene

O75556-SG2A1_HUMAN
Tissue specificity: Expressed in thymus, trachea, kidney, steroid responsive tissues (prostate, testis, uterus, breast and ovary) and salivary gland
genes like me logo Genes that share expressions with SCGB2A1: view

Orthologs for SCGB2A1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCGB2A1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCGB2A1 36
  • 99.18 (n)
  • 97.53 (a)
SCGB2A1 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCGB2A2 37
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 43 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Scgb2a2 37
  • 34 (a)
OneToMany
Species with no ortholog for SCGB2A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCGB2A1 Gene

ENSEMBL:
Gene Tree for SCGB2A1 (if available)
TreeFam:
Gene Tree for SCGB2A1 (if available)

Paralogs for SCGB2A1 Gene

Paralogs for SCGB2A1 Gene

Selected SIMAP similar genes for SCGB2A1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SCGB2A1: view

Variants for SCGB2A1 Gene

Sequence variations from dbSNP and Humsavar for SCGB2A1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1540183 -- 62,207,627(-) TTTCT(A/G)TCCAC upstream-variant-2KB
rs1729383 -- 62,213,540(+) CTGTT(G/T)GGCAT intron-variant
rs1792860 -- 62,209,149(-) TTCCA(C/T)ATTCA intron-variant
rs1792869 -- 62,209,087(-) TTGCC(A/C)CACTG intron-variant
rs1792902 -- 62,208,283(-) TTCTC(C/G)TTATT upstream-variant-2KB

Relevant External Links for SCGB2A1 Gene

HapMap Linkage Disequilibrium report
SCGB2A1

No data available for Structural Variations from Database of Genomic Variants (DGV) for SCGB2A1 Gene

Disorders for SCGB2A1 Gene

(1) MalaCards Diseases for SCGB2A1 Gene

Search for SCGB2A1 Gene in MalaCards »

(10) Novoseek inferred disease relationships for SCGB2A1 Gene

Disease -log(P) Hits PubMed IDs
breast cancer 43.2 10
ovarian cancer 41.3 5
primary tumor 41 2
ovarian carcinoma 29.2 2
metastasis 23.6 3
genes like me logo Genes that share disorders with SCGB2A1: view

No data available for UniProtKB/Swiss-Prot for SCGB2A1 Gene

Publications for SCGB2A1 Gene

  1. Identification of mammaglobin B, a novel member of the uteroglobin gene family. (PMID: 9806831) Becker R.M. … Fleming T.P. (Genomics 1998) 2 3 4 23
  2. Lipophilins: human peptides homologous to rat prostatein. (PMID: 10066439) Zhao C. … Lehrer R.I. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value. (PMID: 9504814) Molloy M.P. … Walsh B.J. (Electrophoresis 1997) 3 4 23
  4. Lipophilin, a novel heterodimeric protein of human tears. (PMID: 9720917) Lehrer R.I. … Glasgow B.J. (FEBS Lett. 1998) 3 4 23
  5. Lacryglobin in human tears, a potential marker for cancer. (PMID: 11446459) Evans V. … Willcox M.D. (Clin. Experiment. Ophthalmol. 2001) 3 23

Products for SCGB2A1 Gene

Sources for SCGB2A1 Gene

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