Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MET Gene

Aliases for MET Gene

  • MET Proto-Oncogene, Receptor Tyrosine Kinase 2 3
  • Hepatocyte Growth Factor Receptor 2 3
  • Tyrosine-Protein Kinase Met 3 4
  • Scatter Factor Receptor 3 4
  • Proto-Oncogene C-Met 3 4
  • HGF/SF Receptor 3 4
  • HGF Receptor 3 4
  • SF Receptor 3 4
  • EC 2.7.10.1 4 64
  • Met Proto-Oncogene Tyrosine Kinase 3
  • Met Proto-Oncogene 2
  • EC 2.7.10 64
  • AUTS9 3
  • RCCP2 3
  • C-Met 3
  • HGFR 3

External Ids for MET Gene

Summaries for MET Gene

Entrez Gene Summary for MET Gene

  • The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MET Gene

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include tall cell variant papillary carcinoma and spinal chordoma. Among its related pathways are PI3K-Akt signaling pathway and Glioma. GO annotations related to this gene include protein tyrosine kinase activity and hepatocyte growth factor-activated receptor activity. An important paralog of this gene is TYRO3.

UniProtKB/Swiss-Prot for MET Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells

  • Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells

Tocris Summary for MET Gene

  • MET (Mesenchymal epithelial transition factor), also known as hepatocyte growth factor receptor (HGFR) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, MET expression is limited to stem and progenitor cells and is necessary for wound healing and hepatocyte regeneration. In the embryo, MET receptors are expressed on cells of epithelial origin. They are essential for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abberant activation of the HGF/MET pathway leads to a variety of cancers. MET mutation is associated with a poor prognosis as it can trigger tumor growth, angiogenesis and metastasis.

Gene Wiki entry for MET Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MET Gene

Genomics for MET Gene

Genomic Location for MET Gene

Start:
116,672,357 bp from pter
End:
116,798,386 bp from pter
Size:
126,030 bases
Orientation:
Plus strand

Genomic View for MET Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MET Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MET Gene

Regulatory Elements for MET Gene

Proteins for MET Gene

  • Protein details for MET Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08581-MET_HUMAN
    Recommended name:
    Hepatocyte growth factor receptor
    Protein Accession:
    P08581
    Secondary Accessions:
    • A1L467
    • B5A932
    • E7EQ94
    • O60366
    • Q12875
    • Q9UDX7
    • Q9UPL8

    Protein attributes for MET Gene

    Size:
    1390 amino acids
    Molecular mass:
    155541 Da
    Quaternary structure:
    • Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2.

    Three dimensional structures from OCA and Proteopedia for MET Gene

    Alternative splice isoforms for MET Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MET Gene

Proteomics data for MET Gene at MOPED

Post-translational modifications for MET Gene

  • Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys962
  • Glycosylation at Asn45, Asn106, Asn149, Asn202, Asn399, Asn405, Asn607, Asn635, Asn785, Asn879, and Asn930

Other Protein References for MET Gene

Domains for MET Gene

UniProtKB/Swiss-Prot:

MET_HUMAN
Domain:
  • The kinase domain is involved in SPSB1 binding:
    • P08581
  • The beta-propeller Sema domain mediates binding to HGF:
    • P08581
  • Contains 3 IPT/TIG domains.:
    • P08581
  • Contains 1 protein kinase domain.:
    • P08581
  • Contains 1 Sema domain.:
    • P08581
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.:
    • P08581
genes like me logo Genes that share domains with MET: view

Function for MET Gene

Molecular function for MET Gene

GENATLAS Biochemistry: met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity
UniProtKB/Swiss-Prot Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells
UniProtKB/Swiss-Prot Function: Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells

Enzyme Numbers (IUBMB) for MET Gene

Gene Ontology (GO) - Molecular Function for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004713 protein tyrosine kinase activity TAS --
GO:0004714 transmembrane receptor protein tyrosine kinase activity --
GO:0004872 receptor activity --
GO:0005008 hepatocyte growth factor-activated receptor activity IEA --
genes like me logo Genes that share ontologies with MET: view
genes like me logo Genes that share phenotypes with MET: view

Animal Models for MET Gene

MGI Knock Outs for MET:

No data available for Transcription Factor Targeting and HOMER Transcription for MET Gene

Localization for MET Gene

Subcellular locations from UniProtKB/Swiss-Prot for MET Gene

Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MET Gene COMPARTMENTS Subcellular localization image for MET gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
endosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 1846706
GO:0009925 basal plasma membrane IDA 15314156
GO:0009986 cell surface IDA 19581412
genes like me logo Genes that share ontologies with MET: view

Pathways for MET Gene

genes like me logo Genes that share pathways with MET: view

Gene Ontology (GO) - Biological Process for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0001886 endothelial cell morphogenesis IDA 14500721
GO:0001889 liver development IEA --
GO:0001890 placenta development IEA --
GO:0006468 protein phosphorylation --
genes like me logo Genes that share ontologies with MET: view

Compounds for MET Gene

(19) ApexBio Compounds for MET Gene

Compound Action Cas Number
(R)-Crizotinib selective, ATP-competitive, small molecule tyrosine kinase inhibitor of c-Met and ALK. [877399-52-5]
AMG-208 highly selective Met inhibitor. [1002304-34-8]
AMG-458 potent inhibitor of human and mouse Met. [913376-83-7]
BMS-777607 small-molecule Met-related kinases inhibitor of Met [1025720-94-8]
Cabozantinib (XL184, BMS-907351) Multi-target kinase inhibitor, inhibits c-Met, VEGFR2, and RET [849217-68-1]
c-Met inhibitor 1 inhibitor of c-Met [1357072-61-7]
EMD-1214063 inhibitor of MET tyrosine kinase [1100598-32-0]
INCB28060 novel, ATP-competitive inhibitor of Met [1029712-80-8]
JNJ-38877605 ATP-competitive inhibitor for the catalytic activity of Met [943540-75-8]
LY2801653 potent, orally bioavailable, small-molecule inhibitor of MET. [1206799-15-6]
MK-8033 c-MET inhibitor in clinical trials [1001917-37-8]
NVP-BVU972 selective and potent Met inhibitor [1185763-69-2]
PF-04217903 selective ATP-competitive Met inhibitor [956905-27-4]
PF-04217903 methanesulfonate MET inhibitor [956906-93-7]
PHA-665752 Potent, selective and ATP-competitive inhibitor of MET kinase. [477575-56-7]
SGX-523 exquisitely selective Met inhibitor [1022150-57-7]
SU11274 Selective inhibitor of MET tyrosine kinase activity [658084-23-2]
SU5416 VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist [204005-46-9]
Tivantinib (ARQ 197) orally available, small molecule inhibitor of the c-Met receptor tyrosine kinase. [905854-02-6]

(4) Tocris Compounds for MET Gene

Compound Action Cas Number
Crizotinib Potent c-MET/ALK inhibitor [877399-52-5]
PF 04217903 mesylate Highly selective c-Met inhibitor [956906-93-7]
PHA 665752 Potent and selective MET inhibitor [477575-56-7]
SU 11274 Selective inhibitor of MET kinase activity [658084-23-2]

(2) HMDB Compounds for MET Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(1) IUPHAR Ligand for MET Gene

Ligand Type Action Affinity Pubmed IDs
hepatocyte growth factor None None

(64) Novoseek inferred chemical compound relationships for MET Gene

Compound -log(P) Hits PubMed IDs
tyrosine 85.5 168
matrigel 62.1 4
vegf 57.2 62
phosphatidylinositol 54.5 22
gefitinib 51.9 10
genes like me logo Genes that share compounds with MET: view

Transcripts for MET Gene

Unigene Clusters for MET Gene

Met proto-oncogene (hepatocyte growth factor receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MET Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: - -
SP3:

Relevant External Links for MET Gene

GeneLoc Exon Structure for
MET
ECgene alternative splicing isoforms for
MET

Expression for MET Gene

mRNA expression in normal human tissues for MET Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MET Gene

SOURCE GeneReport for Unigene cluster for MET Gene Hs.132966

mRNA Expression by UniProt/SwissProt for MET Gene

P08581-MET_HUMAN
Tissue specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain.
genes like me logo Genes that share expressions with MET: view

Orthologs for MET Gene

This gene was present in the common ancestor of animals.

Orthologs for MET Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MET 36
  • 99.52 (n)
  • 99.78 (a)
MET 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MET 36
  • 90.46 (n)
  • 91.59 (a)
MET 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MET 36
  • 90.92 (n)
  • 91.09 (a)
MET 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Met 36
  • 86.44 (n)
  • 89.63 (a)
Met 16
Met 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MET 37
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MET 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Met 36
  • 85.17 (n)
  • 88.84 (a)
chicken
(Gallus gallus)
Aves C-MET 37
  • 74 (a)
OneToOne
MET 36
  • 72.08 (n)
  • 73.19 (a)
lizard
(Anolis carolinensis)
Reptilia MET 37
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia met-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia met 36
  • 66.01 (n)
  • 64.33 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.18290 36
met 36
  • 56.06 (n)
  • 52.09 (a)
met 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea svh-2 37
  • 19 (a)
OneToMany
R09D1.13 38
  • 31 (a)
F11E6.8 38
  • 46 (a)
kin-16 38
  • 36 (a)
T14E8.1a 38
  • 39 (a)
F09G2.1 38
  • 31 (a)
F09A5.2 38
  • 31 (a)
T14E8.1b 38
  • 39 (a)
R09D1.12 38
  • 33 (a)
kin-23 38
  • 33 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8531 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToMany
Species with no ortholog for MET:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MET Gene

ENSEMBL:
Gene Tree for MET (if available)
TreeFam:
Gene Tree for MET (if available)

Paralogs for MET Gene

Paralogs for MET Gene

genes like me logo Genes that share paralogs with MET: view

Variants for MET Gene

Sequence variations from dbSNP and Humsavar for MET Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs1621 -- 116,797,552(+) TGCTT(A/G)CTACT utr-variant-3-prime
rs6566 -- 116,798,364(+) TTAAA(A/G)TAAAG utr-variant-3-prime
rs14456 -- 116,798,326(-) ACATA(C/T)GAAGT utr-variant-3-prime
rs16945 -- 116,798,600(+) TTACC(C/T)GGATT downstream-variant-500B
rs28841 -- 116,734,036(+) TAGTG(C/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MET Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv366908 CNV Insertion 16902084
esv1092803 CNV Insertion 17803354
esv274927 CNV Gain+Loss 21479260
nsv831107 CNV Gain 17160897

Relevant External Links for MET Gene

HapMap Linkage Disequilibrium report
MET
Human Gene Mutation Database (HGMD)
MET

Disorders for MET Gene

(2) OMIM Diseases for MET Gene (164860)

UniProtKB/Swiss-Prot

MET_HUMAN
  • Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
  • Note=Defects in MET may be associated with gastric cancer.
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:9927037}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Renal cell carcinoma papillary (RCCP) [MIM:605074]: A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. {ECO:0000269 PubMed:10327054, ECO:0000269 PubMed:10417759, ECO:0000269 PubMed:10433944, ECO:0000269 PubMed:9140397, ECO:0000269 PubMed:9563489}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.
  • Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies.

(96) Novoseek inferred disease relationships for MET Gene

Disease -log(P) Hits PubMed IDs
tumors 71.6 278
metastasis 69.6 154
cancer 65.5 163
papillary renal cancer hereditary 61.8 2
gastric carcinoma 60.2 57

Relevant External Links for MET

Genetic Association Database (GAD)
MET
Human Genome Epidemiology (HuGE) Navigator
MET
Tumor Gene Database (TGDB):
MET
genes like me logo Genes that share disorders with MET: view

Publications for MET Gene

  1. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. (PMID: 9140397) Schmidt L. … Zbar B. (Nat. Genet. 1997) 3 4 23
  2. Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase. (PMID: 1655790) Ferracini R. … Comoglio P.M. (J. Biol. Chem. 1991) 3 4 23
  3. Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM. (PMID: 12147692) Wang D. … Wu G. (J. Biol. Chem. 2002) 3 4 23
  4. The semaphorin 4D receptor controls invasive growth by coupling with Met. (PMID: 12198496) Giordano S. … Comoglio P.M. (Nat. Cell Biol. 2002) 3 4 23
  5. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. (PMID: 14559966) Schiering N. … Cristiani C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23

Products for MET Gene

  • Addgene plasmids for MET

Sources for MET Gene

Back to Top

Content