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Aliases for MET Gene

Aliases for MET Gene

  • MET Proto-Oncogene, Receptor Tyrosine Kinase 2 3 5
  • Tyrosine-Protein Kinase Met 3 4
  • Scatter Factor Receptor 3 4
  • Proto-Oncogene C-Met 3 4
  • HGF/SF Receptor 3 4
  • HGF Receptor 3 4
  • SF Receptor 3 4
  • EC 2.7.10.1 4 63
  • Met Proto-Oncogene Tyrosine Kinase 3
  • Hepatocyte Growth Factor Receptor 2
  • Soluble MET Variant 12 3
  • Met Proto-Oncogene 2
  • EC 2.7.10 63
  • DFNB97 3
  • AUTS9 3
  • RCCP2 3
  • C-Met 3
  • HGFR 3
  • OSFD 3

External Ids for MET Gene

Previous GeneCards Identifiers for MET Gene

  • GC07P114790
  • GC07P115853
  • GC07P115866
  • GC07P115906
  • GC07P116099
  • GC07P116312
  • GC07P110678

Summaries for MET Gene

Entrez Gene Summary for MET Gene

  • The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for MET Gene

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MET include renal cell carcinoma, papillary and deafness, autosomal recessive, 97. Among its related pathways are Regulation of retinoblastoma protein and MicroRNAs in cancer. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is RYK.

UniProtKB/Swiss-Prot for MET Gene

  • Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.

  • Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Tocris Summary for MET Gene

  • The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Gene Wiki entry for MET Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MET Gene

Genomics for MET Gene

Regulatory Elements for MET Gene

Promoters for MET Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MET on UCSC Golden Path with GeneCards custom track

Genomic Location for MET Gene

Chromosome:
7
Start:
116,672,390 bp from pter
End:
116,798,386 bp from pter
Size:
125,997 bases
Orientation:
Plus strand

Genomic View for MET Gene

Genes around MET on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MET Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MET Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MET Gene

Proteins for MET Gene

  • Protein details for MET Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08581-MET_HUMAN
    Recommended name:
    Hepatocyte growth factor receptor
    Protein Accession:
    P08581
    Secondary Accessions:
    • A1L467
    • B5A932
    • E7EQ94
    • O60366
    • Q12875
    • Q9UDX7
    • Q9UPL8

    Protein attributes for MET Gene

    Size:
    1390 amino acids
    Molecular mass:
    155541 Da
    Quaternary structure:
    • Heterodimer made of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1. Interacts when phosphorylated with downstream effectors including STAT3, PIK3R1, SRC, PCLG1, GRB2 and GAB1. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10. Interacts with PTPN1 and PTPN2.

    Three dimensional structures from OCA and Proteopedia for MET Gene

    Alternative splice isoforms for MET Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MET Gene

Proteomics data for MET Gene at MOPED

Post-translational modifications for MET Gene

  • Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2.
  • Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation.
  • Ubiquitination at Lys 962
  • Glycosylation at Asn 45, Asn 106, Asn 149, Asn 202, Asn 399, Asn 405, Asn 607, Asn 635, Asn 785, Asn 879, and Asn 930
  • Modification sites at PhosphoSitePlus

Other Protein References for MET Gene

Assay Products

  • Cloud-Clone Corp Assay Kits for MET

Domains & Families for MET Gene

Graphical View of Domain Structure for InterPro Entry

P08581

UniProtKB/Swiss-Prot:

MET_HUMAN :
  • The kinase domain is involved in SPSB1 binding.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
Domain:
  • The kinase domain is involved in SPSB1 binding.
  • The beta-propeller Sema domain mediates binding to HGF.
  • Contains 3 IPT/TIG domains.
  • Contains 1 protein kinase domain.
  • Contains 1 Sema domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family.
genes like me logo Genes that share domains with MET: view

Function for MET Gene

Molecular function for MET Gene

GENATLAS Biochemistry:
met proto-oncogene,transmembrane receptor (tyrosine kinase) for hepatocyte growth factor,with two alternatively spliced isoforms,important regulator of cell proliferation and differentiation,organ regeneration,embryogenesis and tumorogenesis,amplified in the glioblastomas,mutated in childhood hepatocellular carcinomas and hereditary papillary renal carcinomas (role in the acceleration of carcinogenesis),paralog to MST1R
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
In its inactive state, the C-terminal tail interacts with the catalytic domain and inhibits the kinase activity. Upon ligand binding, the C-terminal tail is displaced and becomes phosphorylated, thus increasing the kinase activity.
UniProtKB/Swiss-Prot Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells.
UniProtKB/Swiss-Prot Function:
Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.

Enzyme Numbers (IUBMB) for MET Gene

Gene Ontology (GO) - Molecular Function for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity TAS --
GO:0017154 semaphorin receptor activity IEA --
genes like me logo Genes that share ontologies with MET: view
genes like me logo Genes that share phenotypes with MET: view

Human Phenotype Ontology for MET Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MET Gene

MGI Knock Outs for MET:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MET Gene

Localization for MET Gene

Subcellular locations from UniProtKB/Swiss-Prot for MET Gene

Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MET Gene COMPARTMENTS Subcellular localization image for MET gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 3
cytoskeleton 2
endoplasmic reticulum 2
nucleus 2
endosome 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009925 basal plasma membrane IDA 15314156
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 2819873
genes like me logo Genes that share ontologies with MET: view

Pathways & Interactions for MET Gene

genes like me logo Genes that share pathways with MET: view

SIGNOR curated interactions for MET Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MET Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction TAS 1846706
GO:0007166 cell surface receptor signaling pathway NAS 2819873
GO:0007411 axon guidance TAS --
GO:0018108 peptidyl-tyrosine phosphorylation TAS --
genes like me logo Genes that share ontologies with MET: view

Drugs & Compounds for MET Gene

(122) Drugs for MET Gene - From: Novoseek, HMDB, ClinicalTrials, DGIdb, ApexBio, DrugBank, IUPHAR, Tocris, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crizotinib Approved Pharma Inhibition, Biomarker, inhibitor, Target C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor, Potent c-MET/ALK inhibitor 92
Cometriq Approved November 2012 Pharma Inhibition, inhibitor, Biomarker RTK, HGFR, VEGFR2, KIT, Flt3, and Tie-2 inhibitor, cMET Inhibitors 0
cabozantinib Approved Pharma inhibitor, Target, antagonist Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 713
Docetaxel Approved May 1996, Investigational Pharma Microtubulin disassembly inhibitor, Tubulin and VEGF inhibitor, Taxanes 1844

(35) Additional Compounds for MET Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
K 252a
99533-80-9
PF 04217903 mesylate
956906-93-7

(5) Tocris Compounds for MET Gene

Compound Action Cas Number
K 252a Protein kinase inhibitor 99533-80-9
PF 04217903 mesylate Highly selective MET inhibitor 956906-93-7
PHA 665752 Potent and selective MET inhibitor 477575-56-7
SU 11274 Selective inhibitor of MET kinase activity 658084-23-2
SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 204005-46-9

(22) ApexBio Compounds for MET Gene

Compound Action Cas Number
(R)-Crizotinib C-MET/ALK inhibitor,potent and ATP-competitve 877399-52-5
AMG-208 C-Met inhibitor,potent and highly selective 1002304-34-8
AMG-458 Potent c-Met inhibitor 913376-83-7
BMS-777607 C-Met inhibitor, potent and selective 1025720-94-8
BMS-794833 Met/VEGFR-2 inhibitor,potent and ATP-competitive 1174046-72-0
Cabozantinib (XL184, BMS-907351) VEGFR2/Met/Ret/Kit/FLT//AXL inhibitor 849217-68-1
Cabozantinib malate (XL184) MET andVEGF receptor2 inhibitor 1140909-48-3
EMD-1214063 C-Met inhibitor,potent and selective 1100598-32-0
Foretinib (GSK1363089) VEGF and HGF receptor inhibitor 849217-64-7
Golvatinib (E7050) C-Met/VEGFR-2 inhibitor 928037-13-2
INCB28060 C-Met inhibitor,ATP-competitive and novel 1029712-80-8
JNJ-38877605 C-Met inhibitor,ATP-competitive 943540-75-8
MK-2461 C-Met (WT/mutants) inhibitor 917879-39-1
NVP-BVU972 C-Met inhibitor,potent and selective 1185763-69-2
PF-04217903 C-Met inhibitor,selective and ATP-competitive 956905-27-4
PHA-665752 C-Met inhibitor,potent and ATP-competitive 477575-56-7
SGX-523 MET inibitor, highly selective, ATP-competitive 1022150-57-7
SU11274 C-Met inhibitor,potent and selective 658084-23-2
SU5416 VEGF receptor inhibitor and AHR agonist 204005-46-9
TAE226 (NVP-TAE226) FAK inhibitor,potent and ATP-competitive 761437-28-9
Tivantinib (ARQ 197) C-Met inhibitor,non-ATP-competitive 905854-02-6
ZM 323881 HCl 193000-39-4
genes like me logo Genes that share compounds with MET: view

Drug Products

Transcripts for MET Gene

Unigene Clusters for MET Gene

Met proto-oncogene (hepatocyte growth factor receptor):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MET Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22a · 22b
SP1: -
SP2: - -
SP3:

Relevant External Links for MET Gene

GeneLoc Exon Structure for
MET
ECgene alternative splicing isoforms for
MET

Expression for MET Gene

mRNA expression in normal human tissues for MET Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for MET Gene

This gene is overexpressed in Serum (29.7), Amniocyte (16.0), Breast (8.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MET Gene



SOURCE GeneReport for Unigene cluster for MET Gene Hs.132966

mRNA Expression by UniProt/SwissProt for MET Gene

P08581-MET_HUMAN
Tissue specificity: Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also present in the brain.
genes like me logo Genes that share expression patterns with MET: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for MET Gene

Orthologs for MET Gene

This gene was present in the common ancestor of animals.

Orthologs for MET Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MET 35
  • 90.46 (n)
  • 91.59 (a)
MET 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MET 35
  • 90.92 (n)
  • 91.09 (a)
MET 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Met 35
  • 86.44 (n)
  • 89.63 (a)
Met 16
Met 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MET 35
  • 99.52 (n)
  • 99.78 (a)
MET 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Met 35
  • 85.17 (n)
  • 88.84 (a)
oppossum
(Monodelphis domestica)
Mammalia MET 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MET 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves MET 35
  • 72.08 (n)
  • 73.19 (a)
C-MET 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MET 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia met 35
  • 66.01 (n)
  • 64.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia met-A 35
zebrafish
(Danio rerio)
Actinopterygii Dr.18290 35
met 35
  • 56.06 (n)
  • 52.09 (a)
met 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F09A5.2 37
  • 31 (a)
F09G2.1 37
  • 31 (a)
F11E6.8 37
  • 46 (a)
kin-16 37
  • 36 (a)
kin-23 37
  • 33 (a)
R09D1.12 37
  • 33 (a)
R09D1.13 37
  • 31 (a)
T14E8.1a 37
  • 39 (a)
T14E8.1b 37
  • 39 (a)
svh-2 36
  • 19 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8531 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for MET:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MET Gene

ENSEMBL:
Gene Tree for MET (if available)
TreeFam:
Gene Tree for MET (if available)

Paralogs for MET Gene

Paralogs for MET Gene

genes like me logo Genes that share paralogs with MET: view

Variants for MET Gene

Sequence variations from dbSNP and Humsavar for MET Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs35776110 - 116,700,043(+) GGCTG(C/T)GTATG intron-variant, reference, missense
VAR_006286 Renal cell carcinoma papillary (RCCP)
VAR_006287 Renal cell carcinoma papillary (RCCP)
VAR_006288 Renal cell carcinoma papillary (RCCP)
VAR_006289 Renal cell carcinoma papillary (RCCP)

Structural Variations from Database of Genomic Variants (DGV) for MET Gene

Variant ID Type Subtype PubMed ID
nsv7405 OTHER Inversion 18451855
nsv366908 CNV Insertion 16902084
esv1092803 CNV Insertion 17803354
esv274927 CNV Gain+Loss 21479260
nsv831107 CNV Gain 17160897

Variation tolerance for MET Gene

Residual Variation Intolerance Score: 22.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MET Gene

HapMap Linkage Disequilibrium report
MET
Human Gene Mutation Database (HGMD)
MET

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MET Gene

Disorders for MET Gene

MalaCards: The human disease database

(58) MalaCards diseases for MET Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
renal cell carcinoma, papillary
  • renal cell carcinoma
deafness, autosomal recessive, 97
  • dfnb97
hereditary papillary renal cell carcinoma
  • hereditary papillary renal carcinoma
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
autosomal recessive non-syndromic sensorineural deafness type dfnb
  • autosomal recessive isolated neurosensory deafness type dfnb
- elite association - COSMIC cancer census association via MalaCards
Search MET in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

MET_HUMAN
  • Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269 PubMed:9927037}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A common allele in the promoter region of the MET shows genetic association with susceptibility to autism in some families. Functional assays indicate a decrease in MET promoter activity and altered binding of specific transcription factor complexes.
  • Note=Activation of MET after rearrangement with the TPR gene produces an oncogenic protein.
  • Note=Defects in MET may be associated with gastric cancer.
  • Note=MET activating mutations may be involved in the development of a highly malignant, metastatic syndrome known as cancer of unknown primary origin (CUP) or primary occult malignancy. Systemic neoplastic spread is generally a late event in cancer progression. However, in some instances, distant dissemination arises at a very early stage, so that metastases reach clinical relevance before primary lesions. Sometimes, the primary lesions cannot be identified in spite of the progresses in the diagnosis of malignancies.
  • Renal cell carcinoma papillary (RCCP) [MIM:605074]: A subtype of renal cell carcinoma tending to show a tubulo-papillary architecture formed by numerous, irregular, finger-like projections of connective tissue. Renal cell carcinoma is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. {ECO:0000269 PubMed:10327054, ECO:0000269 PubMed:10417759, ECO:0000269 PubMed:10433944, ECO:0000269 PubMed:9140397, ECO:0000269 PubMed:9563489}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for MET

Genetic Association Database (GAD)
MET
Human Genome Epidemiology (HuGE) Navigator
MET
Tumor Gene Database (TGDB):
MET
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MET
genes like me logo Genes that share disorders with MET: view

No data available for Genatlas for MET Gene

Publications for MET Gene

  1. A genetic variant that disrupts MET transcription is associated with autism. (PMID: 17053076) Campbell D.B. … Levitt P. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 48 67
  2. A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss. (PMID: 25941349) Mujtaba G. … Naz S. (J. Med. Genet. 2015) 2 3
  3. c-Met overexpression contributes to the acquired apoptotic resistance of nonadherent ovarian cancer cells through a cross talk mediated by phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2. (PMID: 20126471) Tang M.K. … Wong A.S. (Neoplasia 2010) 3 23
  4. Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. (PMID: 19096300) Onozato R. … Mitsudomi T. (J Thorac Oncol 2009) 3 23
  5. c-Met-targeted RNA interference inhibits growth and metastasis of glioma U251 cells in vitro. (PMID: 19165419) Chu S.H. … Qiu J.H. (J. Neurooncol. 2009) 3 23

Products for MET Gene

  • Addgene plasmids for MET

Sources for MET Gene

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