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Aliases for MEST Gene

Aliases for MEST Gene

  • Mesoderm Specific Transcript 2 3 5
  • Paternally-Expressed Gene 1 Protein 3 4
  • PEG1 3 4
  • Mesoderm Specific Transcript (Mouse) Homolog 2
  • Mesoderm Specific Transcript Homolog (Mouse) 2
  • Paternally-Expressed Gene 1 2
  • EC 3.-.-.- 4

External Ids for MEST Gene

Previous GeneCards Identifiers for MEST Gene

  • GC07P128602
  • GC07P129665
  • GC07P129679
  • GC07P129719
  • GC07P129913
  • GC07P130126
  • GC07P124488

Summaries for MEST Gene

Entrez Gene Summary for MEST Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

GeneCards Summary for MEST Gene

MEST (Mesoderm Specific Transcript) is a Protein Coding gene. Diseases associated with MEST include silver-russell syndrome. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEST Gene

Genomics for MEST Gene

Regulatory Elements for MEST Gene

Promoters for MEST Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MEST on UCSC Golden Path with GeneCards custom track

Genomic Location for MEST Gene

Chromosome:
7
Start:
130,486,171 bp from pter
End:
130,506,297 bp from pter
Size:
20,127 bases
Orientation:
Plus strand

Genomic View for MEST Gene

Genes around MEST on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MEST Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MEST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEST Gene

Proteins for MEST Gene

  • Protein details for MEST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EB52-MEST_HUMAN
    Recommended name:
    Mesoderm-specific transcript homolog protein
    Protein Accession:
    Q5EB52
    Secondary Accessions:
    • B2R6S1
    • O14973
    • O15007
    • Q6AI49
    • Q92571

    Protein attributes for MEST Gene

    Size:
    335 amino acids
    Molecular mass:
    38830 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEST Gene

Proteomics data for MEST Gene at MOPED

Post-translational modifications for MEST Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for MEST

No data available for DME Specific Peptides for MEST Gene

Domains & Families for MEST Gene

Protein Domains for MEST Gene

Suggested Antigen Peptide Sequences for MEST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EB52

UniProtKB/Swiss-Prot:

MEST_HUMAN :
  • Belongs to the AB hydrolase superfamily.
Family:
  • Belongs to the AB hydrolase superfamily.
genes like me logo Genes that share domains with MEST: view

No data available for Gene Families for MEST Gene

Function for MEST Gene

Molecular function for MEST Gene

GENATLAS Biochemistry:
mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome with aberrant imprinting in invasive breast carcinomas

Enzyme Numbers (IUBMB) for MEST Gene

genes like me logo Genes that share phenotypes with MEST: view

Animal Models for MEST Gene

MGI Knock Outs for MEST:

Animal Model Products

miRNA for MEST Gene

miRTarBase miRNAs that target MEST

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MEST Gene

Localization for MEST Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEST Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEST Gene COMPARTMENTS Subcellular localization image for MEST gene
Compartment Confidence
golgi apparatus 4
cytosol 2
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with MEST: view

Pathways & Interactions for MEST Gene

SuperPathways for MEST Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with MEST: view

No data available for Pathways by source and SIGNOR curated interactions for MEST Gene

Drugs & Compounds for MEST Gene

No Compound Related Data Available

Transcripts for MEST Gene

Unigene Clusters for MEST Gene

Mesoderm specific transcript:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEST Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: -
SP13: -
SP14:
SP15: - - - - - - -
SP16: - -

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MEST Gene

GeneLoc Exon Structure for
MEST
ECgene alternative splicing isoforms for
MEST

Expression for MEST Gene

mRNA expression in normal human tissues for MEST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEST Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x8.9), Adipose - Subcutaneous (x6.0), and Adrenal Gland (x4.0).

Protein differential expression in normal tissues from HIPED for MEST Gene

This gene is overexpressed in Placenta (28.3) and Adipocyte (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for MEST Gene



SOURCE GeneReport for Unigene cluster for MEST Gene Hs.270978

mRNA Expression by UniProt/SwissProt for MEST Gene

Q5EB52-MEST_HUMAN
Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.
genes like me logo Genes that share expression patterns with MEST: view

In Situ Assay Products

No data available for Protein tissue co-expression partners for MEST Gene

Orthologs for MEST Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEST 35
  • 99.9 (n)
  • 100 (a)
MEST 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEST 36
  • 99 (a)
OneToOne
MEST 35
  • 91.94 (n)
  • 98.21 (a)
dog
(Canis familiaris)
Mammalia MEST 35
  • 93.03 (n)
  • 99.1 (a)
MEST 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mest 16
Mest 36
  • 98 (a)
OneToOne
Mest 35
  • 90.85 (n)
  • 97.91 (a)
oppossum
(Monodelphis domestica)
Mammalia MEST 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEST 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mest 35
  • 91.74 (n)
  • 98.51 (a)
chicken
(Gallus gallus)
Aves MEST 35
  • 72.53 (n)
  • 77.78 (a)
MEST 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEST 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mest 35
  • 69.34 (n)
  • 72.53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11262 35
zebrafish
(Danio rerio)
Actinopterygii mest 36
  • 71 (a)
OneToOne
mest 35
  • 68.31 (n)
  • 74.07 (a)
Species with no ortholog for MEST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEST Gene

ENSEMBL:
Gene Tree for MEST (if available)
TreeFam:
Gene Tree for MEST (if available)

Paralogs for MEST Gene

Pseudogenes.org Pseudogenes for MEST Gene

genes like me logo Genes that share paralogs with MEST: view

No data available for Paralogs for MEST Gene

Variants for MEST Gene

Sequence variations from dbSNP and Humsavar for MEST Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1990786 -- 130,485,660(+) GTATC(C/T)AAGGG upstream-variant-2KB
rs1990787 -- 130,485,907(+) CAAAT(A/G)TAAGG upstream-variant-2KB
rs1990788 -- 130,486,008(+) TCGCC(A/G)AAGAT upstream-variant-2KB
rs3778859 -- 130,493,344(+) AATTT(C/T)TGGAA intron-variant
rs6968284 -- 130,498,314(+) TAGGA(A/G)AGTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEST Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV Loss 17160897
nsv831131 CNV Loss 17160897

Variation tolerance for MEST Gene

Residual Variation Intolerance Score: 41.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.98; 20.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MEST Gene

HapMap Linkage Disequilibrium report
MEST
Human Gene Mutation Database (HGMD)
MEST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEST Gene

Disorders for MEST Gene

MalaCards: The human disease database

(1) MalaCards diseases for MEST Gene - From: GeneCards

Disorder Aliases PubMed IDs
silver-russell syndrome
  • silver russell dwarfism
- elite association - COSMIC cancer census association via MalaCards
Search MEST in MalaCards View complete list of genes associated with diseases

Relevant External Links for MEST

Genetic Association Database (GAD)
MEST
Human Genome Epidemiology (HuGE) Navigator
MEST
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MEST
genes like me logo Genes that share disorders with MEST: view

No data available for UniProtKB/Swiss-Prot and Genatlas for MEST Gene

Publications for MEST Gene

  1. Genomic imprinting and chromosomal localization of the human MEST gene. (PMID: 8884280) Nishita Y. … Takagi N. (Genomics 1996) 2 3 4 23 67
  2. Imprinting of PEG1/MEST isoform 2 in human placenta. (PMID: 16338457) McMinn J. … Tycko B. (Placenta 2006) 3 23
  3. Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression. (PMID: 10955473) Russo S. … Larizza L. (Clin. Dysmorphol. 2000) 3 23
  4. PEG1 expression in maternal uniparental disomy 7. (PMID: 9526615) Cuisset L. … Jeanpierre M. (Ann. Genet. 1997) 3 23
  5. PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer. (PMID: 23775149) Vidal A.C. … Hoyo C. (Clin Transl Oncol 2014) 3

Products for MEST Gene

Sources for MEST Gene

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