Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MEST Gene

Aliases for MEST Gene

  • Mesoderm Specific Transcript 2 3
  • PEG1 3 4 6
  • Paternally-Expressed Gene 1 Protein 3 4
  • Mesoderm Specific Transcript (Mouse) Homolog 2
  • Mesoderm Specific Transcript Homolog (Mouse) 2
  • Mesoderm-Specific Transcript Homolog Protein 3
  • Paternally-Expressed Gene 1 2
  • EC 3.-.-.- 4

External Ids for MEST Gene

Summaries for MEST Gene

Entrez Gene Summary for MEST Gene

  • This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

GeneCards Summary for MEST Gene

MEST (Mesoderm Specific Transcript) is a Protein Coding gene. Diseases associated with MEST include silver-russell syndrome. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for MEST Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEST Gene

Genomics for MEST Gene

Genomic Location for MEST Gene

Start:
130,486,171 bp from pter
End:
130,506,297 bp from pter
Size:
20,127 bases
Orientation:
Plus strand

Genomic View for MEST Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEST Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEST Gene

Regulatory Elements for MEST Gene

Proteins for MEST Gene

  • Protein details for MEST Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EB52-MEST_HUMAN
    Recommended name:
    Mesoderm-specific transcript homolog protein
    Protein Accession:
    Q5EB52
    Secondary Accessions:
    • B2R6S1
    • O14973
    • O15007
    • Q6AI49
    • Q92571

    Protein attributes for MEST Gene

    Size:
    335 amino acids
    Molecular mass:
    38830 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MEST Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MEST Gene

Proteomics data for MEST Gene at MOPED

Post-translational modifications for MEST Gene

No data available for DME Specific Peptides for MEST Gene

Domains for MEST Gene

Protein Domains for MEST Gene

Suggested Antigen Peptide Sequences for MEST Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EB52

UniProtKB/Swiss-Prot:

MEST_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily.:
    • Q5EB52
genes like me logo Genes that share domains with MEST: view

No data available for Gene Families for MEST Gene

Function for MEST Gene

Molecular function for MEST Gene

GENATLAS Biochemistry: mesoderm-specific transcript,expressed in fetal tissues from the paternal chromosome and in hydatidiform mole of androgenic origin,identical to the murine imprinted gene Peg1,unlikely to be a contributor to Silver-Russell syndrome with aberrant imprinting in invasive breast carcinomas

Enzyme Numbers (IUBMB) for MEST Gene

Gene Ontology (GO) - Molecular Function for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with MEST: view
genes like me logo Genes that share phenotypes with MEST: view

miRNA for MEST Gene

miRTarBase miRNAs that target MEST

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MEST Gene

Localization for MEST Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEST Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEST Gene COMPARTMENTS Subcellular localization image for MEST gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
extracellular 2
cytosol 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with MEST: view

Pathways for MEST Gene

SuperPathways for MEST Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEST Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007498 mesoderm development TAS 9158153
GO:0008152 metabolic process IEA --
GO:0010883 regulation of lipid storage IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with MEST: view

No data available for Pathways by source for MEST Gene

Transcripts for MEST Gene

Unigene Clusters for MEST Gene

Mesoderm specific transcript:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEST Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14a ·
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - - - - - - - -
SP6: - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - - - - - - - - - - -
SP10: - -
SP11: - - - - - - -
SP12: -
SP13: -
SP14:
SP15: - - - - - - -
SP16: - -

ExUns: 14b ^ 15a · 15b · 15c ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c · 18d
SP1: - -
SP2: - -
SP3: - -
SP4: - - - -
SP5:
SP6: - - - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for MEST Gene

GeneLoc Exon Structure for
MEST
ECgene alternative splicing isoforms for
MEST

Expression for MEST Gene

mRNA expression in normal human tissues for MEST Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEST Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (8.9), Adipose - Subcutaneous (6.0), and Adrenal Gland (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for MEST Gene

SOURCE GeneReport for Unigene cluster for MEST Gene Hs.270978

mRNA Expression by UniProt/SwissProt for MEST Gene

Q5EB52-MEST_HUMAN
Tissue specificity: Highly expressed in hydatidiform moles, but barely expressed in dermoid cysts. Biallelic expression is detected in blood lymphocytes. Seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes. Isoform 1 is expressed only from the paternal allele. Isoform 2 is expressed from both the paternal allele and the maternal allele.
genes like me logo Genes that share expressions with MEST: view

Orthologs for MEST Gene

This gene was present in the common ancestor of chordates.

Orthologs for MEST Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEST 35
  • 99.9 (n)
  • 100 (a)
MEST 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEST 35
  • 91.94 (n)
  • 98.21 (a)
MEST 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEST 35
  • 93.03 (n)
  • 99.1 (a)
MEST 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mest 35
  • 90.85 (n)
  • 97.91 (a)
Mest 16
Mest 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEST 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEST 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mest 35
  • 91.74 (n)
  • 98.51 (a)
chicken
(Gallus gallus)
Aves MEST 35
  • 72.53 (n)
  • 77.78 (a)
MEST 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEST 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mest 35
  • 69.34 (n)
  • 72.53 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11262 35
zebrafish
(Danio rerio)
Actinopterygii mest 35
  • 68.31 (n)
  • 74.07 (a)
mest 36
  • 71 (a)
OneToOne
Species with no ortholog for MEST:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEST Gene

ENSEMBL:
Gene Tree for MEST (if available)
TreeFam:
Gene Tree for MEST (if available)

Paralogs for MEST Gene

Pseudogenes.org Pseudogenes for MEST Gene

genes like me logo Genes that share paralogs with MEST: view

No data available for Paralogs for MEST Gene

Variants for MEST Gene

Sequence variations from dbSNP and Humsavar for MEST Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs765205 -- 130,500,925(+) AGAGA(A/C)GTGTT intron-variant
rs765206 -- 130,500,812(+) GCCGT(A/G)TACTC reference, missense, intron-variant
rs1005171 -- 130,504,561(+) CCCCT(C/G)TCTCA intron-variant
rs1008633 -- 130,503,579(+) tgagg(C/T)gggag intron-variant
rs1050582 -- 130,505,102(+) CTTAT(C/G)TGTTG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MEST Gene

Variant ID Type Subtype PubMed ID
nsv831130 CNV Loss 17160897
nsv831131 CNV Loss 17160897

Relevant External Links for MEST Gene

HapMap Linkage Disequilibrium report
MEST
Human Gene Mutation Database (HGMD)
MEST

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MEST Gene

Disorders for MEST Gene

(1) MalaCards Diseases for MEST Gene

Search for MEST Gene in MalaCards »

(1) Novoseek inferred disease relationships for MEST Gene

Disease -log(P) Hits PubMed IDs
growth retardation 58.8 1

Relevant External Links for MEST

Genetic Association Database (GAD)
MEST
Human Genome Epidemiology (HuGE) Navigator
MEST
genes like me logo Genes that share disorders with MEST: view

No data available for UniProtKB/Swiss-Prot for MEST Gene

Publications for MEST Gene

  1. Genomic imprinting and chromosomal localization of the human MEST gene. (PMID: 8884280) Nishita Y. … Takagi N. (Genomics 1996) 2 3 4 23
  2. Imprinting of PEG1/MEST isoform 2 in human placenta. (PMID: 16338457) McMinn J. … Tycko B. (Placenta 2006) 3 23
  3. Human PEG1/MEST, an imprinted gene on chromosome 7. (PMID: 9158153) Kobayashi S. … Ishino F. (Hum. Mol. Genet. 1997) 3 4
  4. Monoallelic expression of human PEG1/MEST is paralleled by parent- specific methylation in fetuses. (PMID: 9192843) Riesewijk A.M. … Kalscheuer V.M. (Genomics 1997) 3 4
  5. PEG1 expression in maternal uniparental disomy 7. (PMID: 9526615) Cuisset L. … Jeanpierre M. (Ann. Genet. 1997) 3 23

Products for MEST Gene

Sources for MEST Gene

Back to Top

Content