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Aliases for MEOX2 Gene

Aliases for MEOX2 Gene

  • Mesenchyme Homeobox 2 2 3 4
  • Growth Arrest-Specific Homeobox 2 3 4
  • MOX2 3 4
  • GAX 3 4
  • Mesenchyme Homeo Box 2 (Growth Arrest-Specific Homeo Box) 2
  • Mesenchyme Homeobox 2 (Growth Arrest-Specific Homeo Box) 2
  • Homeobox Protein MOX-2 3

External Ids for MEOX2 Gene

Previous Symbols for MEOX2 Gene

  • GAX

Summaries for MEOX2 Gene

Entrez Gene Summary for MEOX2 Gene

  • This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]

GeneCards Summary for MEOX2 Gene

MEOX2 (Mesenchyme Homeobox 2) is a Protein Coding gene. Diseases associated with MEOX2 include low compliance bladder and urethral intrinsic sphincter deficiency. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

UniProtKB/Swiss-Prot for MEOX2 Gene

  • Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Wiki entry for MEOX2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MEOX2 Gene

Genomics for MEOX2 Gene

Genomic Location for MEOX2 Gene

Start:
15,611,212 bp from pter
End:
15,686,812 bp from pter
Size:
75,601 bases
Orientation:
Minus strand

Genomic View for MEOX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MEOX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MEOX2 Gene

Regulatory Elements for MEOX2 Gene

Proteins for MEOX2 Gene

  • Protein details for MEOX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50222-MEOX2_HUMAN
    Recommended name:
    Homeobox protein MOX-2
    Protein Accession:
    P50222
    Secondary Accessions:
    • B2R8I7
    • O75263
    • Q9UPL6

    Protein attributes for MEOX2 Gene

    Size:
    304 amino acids
    Molecular mass:
    33594 Da
    Quaternary structure:
    • Interacts with RNF10.

neXtProt entry for MEOX2 Gene

Proteomics data for MEOX2 Gene at MOPED

Post-translational modifications for MEOX2 Gene

No Post-translational modifications

Other Protein References for MEOX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MEOX2 Gene

Domains for MEOX2 Gene

Gene Families for MEOX2 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

UniProtKB/Swiss-Prot:

MEOX2_HUMAN
Domain:
  • The polyhistidine repeat may act as a targeting signal to nuclear speckles.:
    • P50222
  • Contains 1 homeobox DNA-binding domain.:
    • P50222
genes like me logo Genes that share domains with MEOX2: view

Function for MEOX2 Gene

Molecular function for MEOX2 Gene

GENATLAS Biochemistry: mesenchyme homeo box, murine Mox2,homolog
UniProtKB/Swiss-Prot Function: Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.

Gene Ontology (GO) - Molecular Function for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 17074759
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 17074759
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 17074759
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IMP 17074759
GO:0003677 DNA binding --
genes like me logo Genes that share ontologies with MEOX2: view
genes like me logo Genes that share phenotypes with MEOX2: view

Animal Models for MEOX2 Gene

MGI Knock Outs for MEOX2:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MEOX2 Gene

Localization for MEOX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MEOX2 Gene

Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MEOX2 Gene COMPARTMENTS Subcellular localization image for MEOX2 gene
Compartment Confidence
nucleus 5
extracellular 2

Gene Ontology (GO) - Cellular Components for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22206000
GO:0005737 cytoplasm IDA 16335786
GO:0016607 nuclear speck IEA --
genes like me logo Genes that share ontologies with MEOX2: view

Pathways for MEOX2 Gene

SuperPathways for MEOX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MEOX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001757 somite specification IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development TAS 7713505
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with MEOX2: view

No data available for Pathways by source for MEOX2 Gene

Compounds for MEOX2 Gene

(4) Novoseek inferred chemical compound relationships for MEOX2 Gene

Compound -log(P) Hits PubMed IDs
matrigel 43.4 2
thymidine 32.6 3
histidine 28.5 1
nitric oxide 0 2
genes like me logo Genes that share compounds with MEOX2: view

Transcripts for MEOX2 Gene

mRNA/cDNA for MEOX2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(72) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MEOX2 Gene

Mesenchyme homeobox 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MEOX2 Gene

No ASD Table

Relevant External Links for MEOX2 Gene

GeneLoc Exon Structure for
MEOX2
ECgene alternative splicing isoforms for
MEOX2

Expression for MEOX2 Gene

mRNA expression in normal human tissues for MEOX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MEOX2 Gene

This gene is overexpressed in Nerve - Tibial (8.9), Adipose - Subcutaneous (5.9), Artery - Tibial (5.2), and Adipose - Visceral (Omentum) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for MEOX2 Gene

SOURCE GeneReport for Unigene cluster for MEOX2 Gene Hs.170355

mRNA Expression by UniProt/SwissProt for MEOX2 Gene

P50222-MEOX2_HUMAN
Tissue specificity: Embryo and placenta
genes like me logo Genes that share expressions with MEOX2: view

Orthologs for MEOX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for MEOX2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MEOX2 36
  • 99.23 (n)
  • 99.34 (a)
MEOX2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MEOX2 36
  • 93.95 (n)
  • 98.68 (a)
MEOX2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MEOX2 36
  • 93.29 (n)
  • 99.34 (a)
MEOX2 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Meox2 36
  • 89.44 (n)
  • 98.02 (a)
Meox2 16
Meox2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MEOX2 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MEOX2 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Meox2 36
  • 89.55 (n)
  • 97.69 (a)
chicken
(Gallus gallus)
Aves MEOX2 36
  • 84.11 (n)
  • 93.05 (a)
MEOX2 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MEOX2 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia meox2-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia meox2 36
  • 76.22 (n)
  • 84.67 (a)
Str.10254 36
zebrafish
(Danio rerio)
Actinopterygii LOC556898 36
  • 66.21 (n)
  • 70.31 (a)
MEOX2 (1 of 2) 37
  • 69 (a)
OneToMany
meox2b 37
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta btn 37
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 33 (a)
OneToMany
Species with no ortholog for MEOX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MEOX2 Gene

ENSEMBL:
Gene Tree for MEOX2 (if available)
TreeFam:
Gene Tree for MEOX2 (if available)

Paralogs for MEOX2 Gene

Selected SIMAP similar genes for MEOX2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with MEOX2: view

Variants for MEOX2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for MEOX2 Gene

P50222-MEOX2_HUMAN
The poly-His region of MEOX2 is polymorphic and the number of His varies in the population

Sequence variations from dbSNP and Humsavar for MEOX2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10777 -- 15,611,533(+) TAATT(G/T)TTTTA utr-variant-3-prime
rs17199 -- 15,612,145(-) TGGTC(A/C/G/T)TGCGT utr-variant-3-prime
rs758296 -- 15,667,534(+) GGCCA(A/G)GTCCC intron-variant
rs758297 -- 15,667,820(+) GTAGA(A/G)AAAAT intron-variant
rs917437 -- 15,657,051(+) gaaat(C/T)tacta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MEOX2 Gene

Variant ID Type Subtype PubMed ID
nsv523199 CNV Gain 19592680
nsv887735 CNV Loss 21882294
nsv464392 CNV Loss 19166990
nsv824016 CNV Loss 20364138
esv27709 CNV Loss 19812545
esv273709 CNV Insertion 20981092
nsv830911 CNV Gain 17160897
dgv7213n71 CNV Loss 21882294

Relevant External Links for MEOX2 Gene

HapMap Linkage Disequilibrium report
MEOX2
Human Gene Mutation Database (HGMD)
MEOX2

Disorders for MEOX2 Gene

(2) Novoseek inferred disease relationships for MEOX2 Gene

Disease -log(P) Hits PubMed IDs
hyperplasia 17.6 2
alzheimers disease 7.49 2

Relevant External Links for MEOX2

Genetic Association Database (GAD)
MEOX2
Human Genome Epidemiology (HuGE) Navigator
MEOX2
genes like me logo Genes that share disorders with MEOX2: view

No data available for UniProtKB/Swiss-Prot for MEOX2 Gene

Publications for MEOX2 Gene

  1. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. (PMID: 7607679) Grigoriou M. … Karagogeos D. (Genomics 1995) 3 4 23
  2. Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10. (PMID: 16335786) Lin J. … Wigle J.T. (Mol. Cell. Biochem. 2005) 3 4 23
  3. Molecular cloning and localization of the human GAX gene to 7p21. (PMID: 7713505) Lepage D.F. … Walsh K. (Genomics 1994) 2 3 4
  4. Inhibition of endothelial cell activation by the homeobox gene Gax. (PMID: 12842453) Gorski D.H. … Leal A.J. (J. Surg. Res. 2003) 3 23
  5. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. (PMID: 16116430) Wu Z. … Zlokovic B.V. (Nat. Med. 2005) 3 23

Products for MEOX2 Gene

Sources for MEOX2 Gene

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